| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manfred Hallschmi. Intranasal Insulin for Alzheimer's Disease. CNS drugs. vol 35. issue 1. 2021-11-22. PMID:33515428. |
proof-of-concept studies and (pilot) clinical trials in individuals with mild cognitive impairment or alzheimer's disease indicate that acute and prolonged intranasal insulin administration enhances memory performance, and suggest that brain insulin resistance is a pathophysiological factor in alzheimer's disease with or without concomitant metabolic dysfunction. |
2021-11-22 |
2023-08-13 |
Not clear |
| Manfred Hallschmi. Intranasal Insulin for Alzheimer's Disease. CNS drugs. vol 35. issue 1. 2021-11-22. PMID:33515428. |
intranasally administered insulin is assumed to trigger improvements in synaptic plasticity and regional glucose uptake as well as alleviations of alzheimer's disease neuropathology; additional contributions of changes in hypothalamus-pituitary-adrenocortical axis activity and sleep-related mechanisms are discussed. |
2021-11-22 |
2023-08-13 |
Not clear |
| Manfred Hallschmi. Intranasal Insulin for Alzheimer's Disease. CNS drugs. vol 35. issue 1. 2021-11-22. PMID:33515428. |
while intranasal insulin delivery has been conclusively demonstrated to be effective and safe, the recent outcomes of large-scale clinical studies underline the need for further investigations, which might also yield new insights into sex differences in the response to intranasal insulin and contribute to the optimization of delivery devices to grasp the full potential of intranasal insulin for alzheimer's disease. |
2021-11-22 |
2023-08-13 |
Not clear |
| Erden Eren, Jack F V Hunt, Michelle Shardell, Sahil Chawla, Joyce Tran, Jeffrey Gu, Nick M Vogt, Sterling C Johnson, Barbara B Bendlin, Dimitrios Kapogianni. Extracellular vesicle biomarkers of Alzheimer's disease associated with sub-clinical cognitive decline in late middle age. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 9. 2021-11-19. PMID:32588967. |
neuronal extracellular vesicle (nev) tau and insulin signaling biomarkers may detect preclinical alzheimer's disease and age-associated cognitive decline. |
2021-11-19 |
2023-08-13 |
Not clear |
| Priyanka Sarkar, Premkumar Jayaraj, Ketaki Patwardhan, Samiksha Yeole, Sourajit Das, Yash Somaiya, Rajagopal Desikan, Kavitha Thirumuruga. In Silico Analysis to Link Insulin Resistance, Obesity and Ageing with Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 71. issue 12. 2021-11-19. PMID:34227035. |
in silico analysis to link insulin resistance, obesity and ageing with alzheimer's disease. |
2021-11-19 |
2023-08-13 |
human |
| Akram Tayanloo-Beik, Zahra Kiasalari, Mehrdad Roghan. Paeonol Ameliorates Cognitive Deficits in Streptozotocin Murine Model of Sporadic Alzheimer's Disease via Attenuation of Oxidative Stress, Inflammation, and Mitochondrial Dysfunction. Journal of molecular neuroscience : MN. 2021-11-19. PMID:34797511. |
intracerebroventricular (icv) microinjection of diabetogenic drug streptozotocin (stz) in rodents consistently produces a model of sporadic alzheimer's disease (sad) which is characterized by tau pathology and concomitant cognitive decline, insulin resistance, neuroinflammation, oxidative stress, and mitochondrial malfunction. |
2021-11-19 |
2023-08-13 |
rat |
| Yulia K Komleva, Ilia V Potapenko, Olga L Lopatina, Yana V Gorina, Anatoly Chernykh, Elena D Khilazheva, Alla B Salmina, Anton N Shuvae. NLRP3 Inflammasome Blocking as a Potential Treatment of Central Insulin Resistance in Early-Stage Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769018. |
nlrp3 inflammasome blocking as a potential treatment of central insulin resistance in early-stage alzheimer's disease. |
2021-11-18 |
2023-08-13 |
Not clear |
| Rofida A Saleh, Tarek F Eissa, Dalaal M Abdallah, Muhammed A Saad, Hanan S El-Abha. Peganum harmala enhanced GLP-1 and restored insulin signaling to alleviate AlCl Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34103557. |
the main constituents, harmine and harmaline, have displayed therapeutic efficacy against alzheimer's disease (ad); however, the p. harmala potential on sensitizing central insulin to combat ad remains to be clarified. |
2021-11-15 |
2023-08-13 |
rat |
| Christopher L Reading, Clarence N Ahlem, Michael F Murph. NM101 Phase III study of NE3107 in Alzheimer's disease: rationale, design and therapeutic modulation of neuroinflammation and insulin resistance. Neurodegenerative disease management. vol 11. issue 4. 2021-11-15. PMID:34251287. |
nm101 phase iii study of ne3107 in alzheimer's disease: rationale, design and therapeutic modulation of neuroinflammation and insulin resistance. |
2021-11-15 |
2023-08-13 |
Not clear |
| Piyali Majumder, Kaushik Chanda, Debajyoti Das, Brijesh Kumar Singh, Partha Chakrabarti, Nihar Ranjan Jana, Debashis Mukhopadhya. A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes. The Biochemical journal. vol 478. issue 17. 2021-11-15. PMID:34409981. |
alzheimer's disease (ad) and type 2 diabetes (t2d) share a common hallmark of insulin resistance. |
2021-11-15 |
2023-08-13 |
Not clear |
| Coad Thomas Do. Warm, Sweetened Milk at the Twilight of Immunity - Alzheimer's Disease - Inflammaging, Insulin Resistance, Frontiers in immunology. vol 12. 2021-11-11. PMID:34421917. |
warm, sweetened milk at the twilight of immunity - alzheimer's disease - inflammaging, insulin resistance, this article prosecutes a case against the zoonotic pathogen |
2021-11-11 |
2023-08-13 |
Not clear |
| Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E Fraser, María-Rosario Luqui. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33832546. |
our study shows, for the first time, that along with amylin, pancreatic α-synuclein, aβ, prp and tau may contribute together to the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in alzheimer's and parkinson's disease. |
2021-11-10 |
2023-08-13 |
human |
| Komal Jabeen, Kanwal Rehman, Muhammad Sajid Hamid Akas. Genetic mutations of APOEε4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer's disease. Journal of biochemical and molecular toxicology. 2021-11-10. PMID:34757642. |
genetic mutations of apoeε4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of alzheimer's disease. |
2021-11-10 |
2023-08-13 |
Not clear |
| Mengdai Xu, Hao Huang, Xiaoxing Mo, Yalun Zhu, Xi Chen, Xiaoqin Li, Xiaobo Peng, Zihui Xu, Liangkai Chen, Shuang Rong, Wei Yang, Shuang Liu, Liegang Li. Quercetin-3-O-Glucuronide Alleviates Cognitive Deficit and Toxicity in Aβ Molecular nutrition & food research. vol 65. issue 6. 2021-11-09. PMID:33141510. |
quercetin-3-o-glucuronide alleviates cognitive deficit and toxicity in aβ alzheimer's disease (ad) is characterized by amyloid-β (aβ) related imbalance, tau-hyperphosphorylation, and neuroinflammation, in which aβ and neuroinflammation can induce brain insulin resistance (ir). |
2021-11-09 |
2023-08-13 |
Not clear |
| K Allison Amick, Gargi Mahapatra, Jaclyn Bergstrom, Zhengrong Gao, Suzanne Craft, Thomas C Register, Carol A Shively, Anthony J A Molin. Brain region-specific disruption of mitochondrial bioenergetics in cynomolgus macaques fed a Western versus a Mediterranean diet. American journal of physiology. Endocrinology and metabolism. vol 321. issue 5. 2021-11-08. PMID:34569271. |
altogether, these data indicate that a western diet disrupts bioenergetic patterns across brain regions and that circulating blood glucose and insulin levels in western-diet fed animals influence bioenergetics in brain regions susceptible to alzheimer's disease and type 2 diabetes. |
2021-11-08 |
2023-08-13 |
human |
| Toshitaka Ochiai, Toshiharu Sano, Takeru Nagayama, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsub. Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease. Neurobiology of disease. vol 159. 2021-11-03. PMID:34537327. |
differential involvement of insulin receptor substrate (irs)-1 and irs-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of alzheimer's disease. |
2021-11-03 |
2023-08-13 |
mouse |
| Toshitaka Ochiai, Toshiharu Sano, Takeru Nagayama, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsub. Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease. Neurobiology of disease. vol 159. 2021-11-03. PMID:34537327. |
type 2 diabetes mellitus and its core pathology, insulin resistance, has also been implicated in the development of alzheimer's disease (ad) and amyloid-β deposition in humans. |
2021-11-03 |
2023-08-13 |
mouse |
| Adel A Gomaa, Hanan A Farghaly, Yasmin A Abdel-Wadood, Ghada A Goma. Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer's disease. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 11. 2021-11-01. PMID:34542667. |
boswellia serrata (b. serrata) is used traditionally to treat chronic inflammatory diseases such as type 2 diabetes (t2d), insulin resistance (ir), and alzheimer's disease (ad). |
2021-11-01 |
2023-08-13 |
human |
| Ansab Akhtar, Mahendra Bishnoi, Sangeeta Pilkhwal Sa. Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer's disease through modulation of brain insulin resistance induced tau pathology. Brain research bulletin. vol 164. 2021-10-29. PMID:32784004. |
sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of alzheimer's disease through modulation of brain insulin resistance induced tau pathology. |
2021-10-29 |
2023-08-13 |
rat |
| Simona Corina Trifu, Andrian Ţîbîrnă, Ana Miruna Drăgoi, Bogdan Mihai Criste. Immunological and hormonal mechanisms in Alzheimer's disease. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 61. issue 4. 2021-10-28. PMID:34171052. |
this mini review aims to highlight the mechanisms through which brain insulin resistance can lead to cognitive impairment and to make a short overview of the current findings which demonstrate why insulin may be a promising adjunctive treatment of alzheimer's dementia, for certain patients. |
2021-10-28 |
2023-08-13 |
Not clear |