| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiuchen Zheng, Micheal T Kebede, Bethany Lee, Claire A Krasinski, Saadman Islam, Liliana A Wurfl, Merc M Kemeh, Valerie A Ivancic, Charles E Jakobsche, Donald E Spratt, Noel D Laz. Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme. Antioxidants (Basel, Switzerland). vol 10. issue 9. 2021-10-01. PMID:34572974. |
the insulin-degrading enzyme (ide) possesses a strong ability to degrade insulin and aβ42 that has been linked to the neurodegeneration in alzheimer's disease (ad). |
2021-10-01 |
2023-08-13 |
Not clear |
| Reem A Mohamed, Dalaal M Abdallah, Amany I El-Brairy, Kawkab A Ahmed, Hanan S El-Abha. Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation. Molecules (Basel, Switzerland). vol 26. issue 16. 2021-09-30. PMID:34443654. |
since westernized diet-induced insulin resistance is a risk factor in alzheimer's disease (ad) development, and lipopolysaccharide (lps) coexists with amyloid β (aβ)1-42 in these patients, our ad novel model was developed to resemble sporadic ad by injecting lps into high fat/fructose diet (hffd)-fed rats. |
2021-09-30 |
2023-08-13 |
rat |
| Yun Cao, Bingjin Liu, Weiqi Xu, Lin Wang, Fangxiao Shi, Na Li, Ying Lei, Jianzhi Wang, Qing Tian, Xinwen Zho. Inhibition of mTORC1 improves STZ-induced AD-like impairments in mice. Brain research bulletin. vol 162. 2021-09-29. PMID:32599128. |
alzheimer's disease (ad) and type 2 diabetes mellitus (t2dm) share some pathological features, including tau hyperphosphorylation and deficits in insulin signaling, but the underlying mechanism and effective drugs for treating ad are unknown. |
2021-09-29 |
2023-08-13 |
mouse |
| Vittorio Emanuele Bianchi, Pomares Fredy Herrera, Rizzi Laur. Effect of nutrition on neurodegenerative diseases. A systematic review. Nutritional neuroscience. vol 24. issue 10. 2021-09-27. PMID:31684843. |
mediet, nutritional support, and calorie-controlled diets play a protective effect against cognitive decline, alzheimer's disease (ad), parkinson disease (pd) while malnutrition and insulin resistance represent significant risk factors. |
2021-09-27 |
2023-08-13 |
Not clear |
| Giacoma Galizzi, Laura Palumbo, Antonella Amato, Alice Conigliaro, Domenico Nuzzo, Simona Terzo, Luca Caruana, Pasquale Picone, Riccardo Alessandro, Flavia Mulè, Marta Di Carl. Altered insulin pathway compromises mitochondrial function and quality control both in in vitro and in vivo model systems. Mitochondrion. vol 60. 2021-09-27. PMID:34454074. |
altered insulin signaling and insulin resistance are considered the link between alzheimer's disease (ad) and metabolic syndrome. |
2021-09-27 |
2023-08-13 |
mouse |
| Seyed Amir Hejazi, Kambiz Rohampour, Ehsan Sharifipour, Soruosh Sharifimoghadam, Sepideh Paybast, Abdoreza Ghoreishi, Navid Hassanzadeh, Mostafa Vahedia. The correlation of serum adiponectin and insulin resistance with the presence and severity of dementia in non-obese Alzheimer's patients. Clinical nutrition ESPEN. vol 40. 2021-09-24. PMID:33183566. |
the correlation of serum adiponectin and insulin resistance with the presence and severity of dementia in non-obese alzheimer's patients. |
2021-09-24 |
2023-08-13 |
Not clear |
| Seyed Amir Hejazi, Kambiz Rohampour, Ehsan Sharifipour, Soruosh Sharifimoghadam, Sepideh Paybast, Abdoreza Ghoreishi, Navid Hassanzadeh, Mostafa Vahedia. The correlation of serum adiponectin and insulin resistance with the presence and severity of dementia in non-obese Alzheimer's patients. Clinical nutrition ESPEN. vol 40. 2021-09-24. PMID:33183566. |
alteration in the insulin signaling could contribute to the development of alzheimer's disease (ad) through metabolic or inflammatory processes, adipokines could affect insulin dysregulation. |
2021-09-24 |
2023-08-13 |
Not clear |
| Ryan A Wirt, Lauren A Crew, Andrew A Ortiz, Adam M McNeela, Emmanuel Flores, Jefferson W Kinney, James M Hyma. Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer's disease. Communications biology. vol 4. issue 1. 2021-09-24. PMID:34480097. |
diabetes mellitus is a metabolic disease associated with dysregulated glucose and insulin levels and an increased risk of developing alzheimer's disease (ad) later in life. |
2021-09-24 |
2023-08-13 |
human |
| Steven Nguyen, William A Banks, Elizabeth M Rhe. Effects of Rapamycin on Insulin Brain Endothelial Cell Binding and Blood-Brain Barrier Transport. Medical sciences (Basel, Switzerland). vol 9. issue 3. 2021-09-23. PMID:34449653. |
insulin is also known to improve cognition in rodent models of alzheimer's disease. |
2021-09-23 |
2023-08-13 |
mouse |
| Tomasz Charytoniuk, Klaudia Sztolsztener, Ewa Harasim-Symbor, Klaudia Berk, Adrian Chabowski, Karolina Konstantynowicz-Nowick. Cannabidiol - A phytocannabinoid that widely affects sphingolipid metabolism under conditions of brain insulin resistance. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34435590. |
obesity-related insulin resistance (ir) and attenuated brain insulin signaling are significant risk factors for neurodegenerative disorders, e.g., alzheimer's disease. |
2021-09-22 |
2023-08-13 |
rat |
| Wilma Helena Oliveira, Clarissa Figueiredo Braga, Deniele Bezerra Lós, Shyrlene Meiry Rocha Araújo, MariaEduarda Rocha França, Eduardo Duarte-Silva, Gabriel Barros Rodrigues, Sura Wanessa Santos Rocha, Christina Alves Peixot. Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice. Experimental brain research. vol 239. issue 9. 2021-09-21. PMID:34283253. |
insulin deficiency or resistance can promote dementia and hallmarks of alzheimer's disease (ad). |
2021-09-21 |
2023-08-13 |
mouse |
| Mrunanjali Gaddam, Abhishek Singh, Nidhi Jain, Chaithanya Avanthika, Sharan Jhaveri, Ivonne De la Hoz, Sujana Sanka, Sri Rupa Gol. A Comprehensive Review of Intranasal Insulin and Its Effect on the Cognitive Function of Diabetics. Cureus. vol 13. issue 8. 2021-09-21. PMID:34540446. |
not only does this help in reducing the peripheral side effects of insulin, but it has also proven to play a role in improving the cognitive function of diabetics, especially those who have alzheimer's or mild cognitive impairment, as decreased levels of insulin in the brain has been shown to impact cognitive function negatively. |
2021-09-21 |
2023-08-13 |
human |
| A Ullah, N Ali, S Ahmad, S U Rahman, S Alghamdi, A M Bannunah, R Ali, A Aman, J Khan, H Hussain, M U K Sahibzad. Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review. Brazilian journal of biology = Revista brasleira de biologia. vol 83. 2021-09-17. PMID:34524376. |
disturbances in the action of gsk-3 enzyme may leads to various disease conditions that include insulin resistance leading to diabetes, neurological disease like alzheimer's disease and cancer. |
2021-09-17 |
2023-08-13 |
Not clear |
| Suélen Santos Alves, Rui Milton Patrício da Silva-Junior, Gabriel Servilha-Menezes, Jan Homolak, Melita Šalković-Petrišić, Norberto Garcia-Cairasc. Insulin Resistance as a Common Link Between Current Alzheimer's Disease Hypotheses. Journal of Alzheimer's disease : JAD. vol 82. issue 1. 2021-09-16. PMID:34024838. |
insulin resistance as a common link between current alzheimer's disease hypotheses. |
2021-09-16 |
2023-08-13 |
Not clear |
| Karen Salve Coutinho-Wolino, Ludmila F M de F Cardozo, Viviane de Oliveira Leal, Denise Mafra, Milena Barcza Stockler-Pint. Can diet modulate trimethylamine N-oxide (TMAO) production? What do we know so far? European journal of nutrition. vol 60. issue 7. 2021-09-15. PMID:33533968. |
trimethylamine n-oxide (tmao) is a metabolite that has attracted attention due to its positive association with several chronic non-communicable diseases such as insulin resistance, atherosclerotic plaque formation, diabetes, cancer, heart failure, hypertension, chronic kidney disease, liver steatosis, cardiac fibrosis, endothelial injury, neural degeneration and alzheimer's disease. |
2021-09-15 |
2023-08-13 |
Not clear |
| Nazia Siddiqui, Javed Ali, Suhel Parvez, Saima Zameer, Abul Kalam Najmi, Mohd Akhta. Linagliptin, a DPP-4 inhibitor, ameliorates Aβ (1-42) peptides induced neurodegeneration and brain insulin resistance (BIR) via insulin receptor substrate-1 (IRS-1) in rat model of Alzheimer's disease. Neuropharmacology. vol 195. 2021-09-13. PMID:34119519. |
linagliptin, a dpp-4 inhibitor, ameliorates aβ (1-42) peptides induced neurodegeneration and brain insulin resistance (bir) via insulin receptor substrate-1 (irs-1) in rat model of alzheimer's disease. |
2021-09-13 |
2023-08-13 |
rat |
| Guianfranco Mazzei, Ryohei Ikegami, Nona Abolhassani, Naoki Haruyama, Kunihiko Sakumi, Takashi Saito, Takaomi C Saido, Yusaku Nakabepp. A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App Aging cell. vol 20. issue 8. 2021-09-10. PMID:34245097. |
a high-fat diet exacerbates the alzheimer's disease pathology in the hippocampus of the app insulin resistance and diabetes mellitus are major risk factors for alzheimer's disease (ad), and studies with transgenic mouse models of ad have provided supportive evidence with some controversies. |
2021-09-10 |
2023-08-13 |
mouse |
| Rahul Agrawal, Candace M Reno, Sunny Sharma, Camille Christensen, Yiqing Huang, Simon J Fishe. Insulin action in the brain regulates both central and peripheral functions. American journal of physiology. Endocrinology and metabolism. vol 321. issue 1. 2021-09-09. PMID:34056920. |
decrements in brain insulin action (or brain insulin resistance) can be observed in obesity, type 2 diabetes (t2dm), aging, and alzheimer's disease (ad), indicating a possible link between metabolic and cognitive health. |
2021-09-09 |
2023-08-13 |
Not clear |
| Hongmei Zeng, Lijun Xu, Yeqing Zou, Sixiang Wan. Romidepsin and metformin nanomaterials delivery on streptozocin for the treatment of Alzheimer's disease in animal model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34323698. |
brain insulin signal anomalies are implicated in alzheimer's disease (ad) pathology. |
2021-09-08 |
2023-08-13 |
Not clear |
| Abdullah A Alkahtane, Hamzah A Alghamdi, Bader Almutairi, Mohd Muazzam Khan, Md Saquib Hasnain, Mohamed M Abdel-Daim, Wadha M Alghamdi, Saad Alkahtan. Inhibition of human amylin aggregation by Flavonoid Chrysin: An International journal of medical sciences. vol 18. issue 1. 2021-09-06. PMID:33390788. |
however, its etiology remains uncertain; it appears that type 2 diabetes mellitus and other prediabetic states of insulin resistance contribute to the intermittent alzheimer's disease presence. |
2021-09-06 |
2023-08-13 |
human |