| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Kellar, S N Lockhart, P Aisen, R Raman, R A Rissman, J Brewer, S Craf. Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 8. issue 3. 2021-10-27. PMID:34101779. |
intranasal insulin reduces white matter hyperintensity progression in association with improvements in cognition and csf biomarker profiles in mild cognitive impairment and alzheimer's disease. |
2021-10-27 |
2023-08-13 |
human |
| D Kellar, S N Lockhart, P Aisen, R Raman, R A Rissman, J Brewer, S Craf. Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 8. issue 3. 2021-10-27. PMID:34101779. |
intranasally administered insulin has shown promise in both rodent and human studies in alzheimer's disease; however, both effects and mechanisms require elucidation. |
2021-10-27 |
2023-08-13 |
human |
| Jesús Burillo, Patricia Marqués, Beatriz Jiménez, Carlos González-Blanco, Manuel Benito, Carlos Guillé. Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. Cells. vol 10. issue 5. 2021-10-26. PMID:34069890. |
insulin resistance and diabetes mellitus in alzheimer's disease. |
2021-10-26 |
2023-08-13 |
Not clear |
| Nicole M Ralbovsky, Igor K Ledne. Vibrational Spectroscopy for Detection of Diabetes: A Review. Applied spectroscopy. vol 75. issue 8. 2021-10-25. PMID:33988040. |
although t2dm is manageable through insulin therapy, the disorder itself is a risk factor for much more dangerous diseases including cardiovascular disease, kidney disease, retinopathy, alzheimer's disease, and more. |
2021-10-25 |
2023-08-13 |
Not clear |
| Joshua L Milstein, Heather A Ferri. The brain as an insulin-sensitive metabolic organ. Molecular metabolism. vol 52. 2021-10-22. PMID:33845179. |
brain insulin signaling is involved not only in brain homeostatic processes but also neuropathological processes such as cognitive decline and alzheimer's disease. |
2021-10-22 |
2023-08-13 |
Not clear |
| Yuan Zhu, Yi Huang, Jin Yang, Rong Tu, Xin Zhang, Wei-Wei He, Chang-Yue Hou, Xiao-Ming Wang, Ju-Ming Yu, Guo-Hui Jian. Intranasal insulin ameliorates neurological impairment after intracerebral hemorrhage in mice. Neural regeneration research. vol 17. issue 1. 2021-10-22. PMID:34100458. |
in alzheimer's disease and ischemic stroke, intranasal insulin can act as a neuroprotective agent. |
2021-10-22 |
2023-08-13 |
mouse |
| Eugenio Baron. Brain insulin resistance: an early risk factor for Alzheimer's disease development in Down syndrome. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269205. |
brain insulin resistance: an early risk factor for alzheimer's disease development in down syndrome. |
2021-10-22 |
2023-08-13 |
Not clear |
| Sarah Lee, Ming Tong, Steven Hang, Chetram Deochand, Suzanne de la Mont. CSF and Brain Indices of Insulin Resistance, Oxidative Stress and Neuro-Inflammation in Early versus Late Alzheimer's Disease. Journal of Alzheimer's disease & Parkinsonism. vol 3. 2021-10-21. PMID:25035815. |
csf and brain indices of insulin resistance, oxidative stress and neuro-inflammation in early versus late alzheimer's disease. |
2021-10-21 |
2023-08-13 |
Not clear |
| Joe A Adam, Hannah R Middlestead, Nicholas E Debono, Amir H Hirs. Effects of Shear Rate and Protein Concentration on Amyloidogenesis via Interfacial Shear. The journal of physical chemistry. B. vol 125. issue 36. 2021-10-19. PMID:34478304. |
human insulin served as a model protein for studying shear-induced fibrillization with relevance to amyloid diseases such as alzheimer's, parkinson's, prions, and type 2 diabetes. |
2021-10-19 |
2023-08-13 |
human |
| Aleksandra Sędzikowska, Leszek Szablewsk. Insulin and Insulin Resistance in Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 18. 2021-10-19. PMID:34576151. |
insulin and insulin resistance in alzheimer's disease. |
2021-10-19 |
2023-08-13 |
Not clear |
| Aleksandra Sędzikowska, Leszek Szablewsk. Insulin and Insulin Resistance in Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 18. 2021-10-19. PMID:34576151. |
the aim of this study is to describe the role played by insulin in the cns, in both healthy people and those with pathologies such as insulin resistance and alzheimer's disease. |
2021-10-19 |
2023-08-13 |
Not clear |
| Fruzsina Bagaméry, Kamilla Varga, Kitti Kecsmár, István Vincze, Éva Szökő, Tamás Táb. The Impact of Differentiation on Cytotoxicity and Insulin Sensitivity in Streptozotocin Treated SH-SY5Y Cells. Neurochemical research. vol 46. issue 6. 2021-10-12. PMID:33616807. |
recently neuronal insulin resistance was suggested playing a role in alzheimer's disease. |
2021-10-12 |
2023-08-13 |
Not clear |
| Susana Cardoso, Paula I Moreir. Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones. International review of neurobiology. vol 155. 2021-10-11. PMID:32854858. |
antidiabetic drugs for alzheimer's and parkinson's diseases: repurposing insulin, metformin, and thiazolidinediones. |
2021-10-11 |
2023-08-13 |
Not clear |
| Christian Hölsche. Evidence for pathophysiological commonalities between metabolic and neurodegenerative diseases. International review of neurobiology. vol 155. 2021-10-11. PMID:32854859. |
based on this, insulin has been tested in patients with alzheimer's disease, and it was found that memory formation was improved and brain pathology reduced. |
2021-10-11 |
2023-08-13 |
Not clear |
| Kerstin Heurling, Edvin Johansson, Antoine Leuz. Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer's disease - Learnings from brain imaging biomarkers. International review of neurobiology. vol 154. 2021-10-07. PMID:32739001. |
disturbances in brain energy metabolism in insulin resistance and diabetes and alzheimer's disease - learnings from brain imaging biomarkers. |
2021-10-07 |
2023-08-13 |
Not clear |
| Kerstin Heurling, Edvin Johansson, Antoine Leuz. Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer's disease - Learnings from brain imaging biomarkers. International review of neurobiology. vol 154. 2021-10-07. PMID:32739001. |
medical imaging techniques, such as structural and functional magnetic resonance imaging and positron emission tomography, have been used to gain a better understanding of the alterations of the metabolic processes in the brain relating to type 2 diabetes melltius, insulin resistance and alzheimer's disease. |
2021-10-07 |
2023-08-13 |
Not clear |
| Viplav Kshirsagar, Chetan Thingore, Archana Juveka. Insulin resistance: a connecting link between Alzheimer's disease and metabolic disorder. Metabolic brain disease. vol 36. issue 1. 2021-10-07. PMID:32986168. |
insulin resistance: a connecting link between alzheimer's disease and metabolic disorder. |
2021-10-07 |
2023-08-13 |
Not clear |
| Viplav Kshirsagar, Chetan Thingore, Archana Juveka. Insulin resistance: a connecting link between Alzheimer's disease and metabolic disorder. Metabolic brain disease. vol 36. issue 1. 2021-10-07. PMID:32986168. |
recent evidence suggests that alzheimer's disease (ad) is closely linked with insulin resistance, as seen in type 2 diabetes mellitus (t2dm). |
2021-10-07 |
2023-08-13 |
Not clear |
| Zongyang Li, Yuan Zhang, Yueyang Zheng, Wenlan Liu, Xiejun Zhang, Weiping Li, Di Zhang, Qian Cai, Sicen Wang, Xiangbao Meng, Guodong Huan. Intranasal 15d-PGJ2 ameliorates brain glucose hypometabolism via PPARγ-dependent activation of PGC-1α/GLUT4 signalling in APP/PS1 transgenic mice. Neuropharmacology. vol 196. 2021-10-01. PMID:34175325. |
targeting the common molecular mechanism of type 2 diabetes mellitus and alzheimer's disease (ad), including dysregulation of glucose metabolism, insulin resistance, and neuroinflammation, might be an efficient treatment strategy for ad. |
2021-10-01 |
2023-08-13 |
mouse |
| Evelyn Lazar, Ayesha Sherzai, Jennifer Adeghate, Dean Sherza. Gut dysbiosis, insulin resistance and Alzheimer's disease: review of a novel approach to neurodegeneration. Frontiers in bioscience (Scholar edition). vol 13. issue 1. 2021-10-01. PMID:34256527. |
gut dysbiosis, insulin resistance and alzheimer's disease: review of a novel approach to neurodegeneration. |
2021-10-01 |
2023-08-13 |
Not clear |