| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pegah Javadpour, Sahar Askari, Fatemeh Sadat Rashidi, Leila Dargahi, Abolhassan Ahmadiani, Rasoul Ghasem. Imipramine alleviates memory impairment and hippocampal apoptosis in STZ-induced sporadic Alzheimer's rat model: Possible contribution of MAPKs and insulin signaling. Behavioural brain research. vol 408. 2021-09-02. PMID:33775777. |
imipramine alleviates memory impairment and hippocampal apoptosis in stz-induced sporadic alzheimer's rat model: possible contribution of mapks and insulin signaling. |
2021-09-02 |
2023-08-13 |
rat |
| Xinyu Huang, Kangbai Huang, Zhaowei Li, Dongyan Bai, Yan Hao, Qinglong Wu, Wei Yi, Nenggui Xu, Youcan Pan, Liang Zhan. Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway. Brain research. vol 1740. 2021-09-01. PMID:32304687. |
to investigate the effect of electroacupuncture (ea) on cognitive function and insulin resistance (ir) in an al/d-gal-induced aging model for alzheimer's disease (ad) using ostuka long-evans tokushima fatty (oletf) rats. |
2021-09-01 |
2023-08-13 |
rat |
| Subrat Kumar Bhattamisra, Lee Yuen Shin, Hanis Izzati Binti Mohd Saad, Vikram Rao, Mayuren Candasamy, Manisha Pandey, Hira Choudhur. Interlink Between Insulin Resistance and Neurodegeneration with an Update on Current Therapeutic Approaches. CNS & neurological disorders drug targets. vol 19. issue 3. 2021-08-30. PMID:32418534. |
an extensive literature search was conducted using keywords "insulin"; "insulin resistance"; "alzheimer's disease"; "parkinson's disease" in public domains of google scholar, pubmed, and sciencedirect. |
2021-08-30 |
2023-08-13 |
Not clear |
| Maria Assunta Potenza, Luca Sgarra, Vanessa Desantis, Carmela Nacci, Monica Montagnan. Diabetes and Alzheimer's Disease: Might Mitochondrial Dysfunction Help Deciphering the Common Path? Antioxidants (Basel, Switzerland). vol 10. issue 8. 2021-08-30. PMID:34439505. |
indeed, the proposed definition of alzheimer's disease as type 3 diabetes (t3d) underlines the key role played by deranged insulin signaling to accumulation of aggregated amyloid beta (aβ) peptides in the senile plaques of the brain. |
2021-08-30 |
2023-08-13 |
Not clear |
| Antonella Caccamoa Ramona Belfiore, Salvatore Odd. Retraction notice to "Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease" [Neurobiology of Aging Volume 68, August 2018, Page 59-67]. Neurobiology of aging. vol 104. 2021-08-28. PMID:34162481. |
retraction notice to "genetically reducing mtor signaling rescues central insulin dysregulation in a mouse model of alzheimer's disease" [neurobiology of aging volume 68, august 2018, page 59-67]. |
2021-08-28 |
2023-08-13 |
mouse |
| Gilda E Ennis, Akshay Kohli, Erin M Jonaitis, Tobey J Betthauser, Jennifer M Oh, Chase E Taylor, Nathaniel Chin, Rebecca L Koscik, Bradley T Christian, Sanjay Asthana, Sterling C Johnson, Barbara B Bendli. The relationship of glucose-stimulated insulin secretion to cerebral glucose metabolism and cognition in healthy middle-aged and older adults. Neurobiology of aging. vol 105. 2021-08-27. PMID:34091125. |
insulin resistance (ir) has been related to reduced cerebral glucose metabolism in regions identified as hypometabolic in alzheimer's clinical syndrome. |
2021-08-27 |
2023-08-13 |
Not clear |
| Gilda E Ennis, Akshay Kohli, Erin M Jonaitis, Tobey J Betthauser, Jennifer M Oh, Chase E Taylor, Nathaniel Chin, Rebecca L Koscik, Bradley T Christian, Sanjay Asthana, Sterling C Johnson, Barbara B Bendli. The relationship of glucose-stimulated insulin secretion to cerebral glucose metabolism and cognition in healthy middle-aged and older adults. Neurobiology of aging. vol 105. 2021-08-27. PMID:34091125. |
insulin secretion (is) has been less studied than ir despite findings that decreased is is an early indicator of future type 2 diabetes and a potential predictor of alzheimer's clinical syndrome. |
2021-08-27 |
2023-08-13 |
Not clear |
| Hilaree N Frazier, Katie L Anderson, Adam O Ghoweri, Ruei-Lung Lin, Tara R Hawkinson, Gabriel J Popa, Pradoldej Sompol, Michael D Mendenhall, Christopher M Norris, Olivier Thibaul. Molecular elevation of insulin receptor signaling improves memory recall in aged Fischer 344 rats. Aging cell. vol 19. issue 10. 2021-08-26. PMID:32852134. |
as demonstrated by increased hippocampal insulin receptor density following learning in animal models and decreased insulin signaling, receptor density, and memory decline in aging and alzheimer's diseases, numerous studies have emphasized the importance of insulin in learning and memory processes. |
2021-08-26 |
2023-08-13 |
human |
| Daisuke Tanokashira, Wei Wang, Megumi Maruyama, Chiemi Kuroiwa, Morris F White, Akiko Taguch. Irs2 deficiency alters hippocampus-associated behaviors during young adulthood. Biochemical and biophysical research communications. vol 559. 2021-08-26. PMID:33940386. |
type 2 diabetes mellitus (t2dm), characterized by hyperglycemia and insulin resistance, has been recognized as a risk factor for cognitive impairment and dementia, including alzheimer's disease (ad). |
2021-08-26 |
2023-08-13 |
mouse |
| José C J M D S Menezes, Marc F Diederic. Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies. Pharmacological research. vol 167. 2021-08-19. PMID:33667686. |
deregulated insulin signaling can cause complications of obesity and diabetes, which can lead to cognitive disorders such as alzheimer's, parkinson's, and dementia; therefore, the therapeutic benefits of these biflavones in these areas are highlighted. |
2021-08-19 |
2023-08-13 |
Not clear |
| Hayma Hammoud, Olga Netsyk, Atieh S Tafreshiha, Sergiy V Korol, Zhe Jin, Jin-Ping Li, Bryndis Birni. Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease. Acta physiologica (Oxford, England). vol 232. issue 2. 2021-08-18. PMID:33559388. |
insulin differentially modulates gaba signalling in hippocampal neurons and, in an age-dependent manner, normalizes gaba-activated currents in the tg-appswe mouse model of alzheimer's disease. |
2021-08-18 |
2023-08-13 |
mouse |
| Hayma Hammoud, Olga Netsyk, Atieh S Tafreshiha, Sergiy V Korol, Zhe Jin, Jin-Ping Li, Bryndis Birni. Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease. Acta physiologica (Oxford, England). vol 232. issue 2. 2021-08-18. PMID:33559388. |
we examined if tonic γ-aminobutyric acid (gaba)-activated currents in primary hippocampal neurons were modulated by insulin in wild-type and tg-appswe mice, an alzheimer's disease (ad) model. |
2021-08-18 |
2023-08-13 |
mouse |
| Gilda E Ennis, Rebecca L Koscik, Yue Ma, Erin M Jonaitis, Carol A Van Hulle, Tobey J Betthauser, Allison M Randall, Nathaniel Chin, Corinne D Engelman, Rozalyn Anderson, Ivonne Suridjan, Gwendlyn Kollmorgen, Bradley T Christian, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B Bendli. Insulin resistance is related to cognitive decline but not change in CSF biomarkers of Alzheimer's disease in non-demented adults. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-08-18. PMID:34337133. |
insulin resistance is related to cognitive decline but not change in csf biomarkers of alzheimer's disease in non-demented adults. |
2021-08-18 |
2023-08-13 |
Not clear |
| Gilda E Ennis, Rebecca L Koscik, Yue Ma, Erin M Jonaitis, Carol A Van Hulle, Tobey J Betthauser, Allison M Randall, Nathaniel Chin, Corinne D Engelman, Rozalyn Anderson, Ivonne Suridjan, Gwendlyn Kollmorgen, Bradley T Christian, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B Bendli. Insulin resistance is related to cognitive decline but not change in CSF biomarkers of Alzheimer's disease in non-demented adults. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-08-18. PMID:34337133. |
we investigated whether insulin resistance (ir) was associated with longitudinal age-related change in cognition and biomarkers of alzheimer's disease (ad) pathology and neurodegeneration in middle-aged and older adults who were non-demented at baseline. |
2021-08-18 |
2023-08-13 |
Not clear |
| Henry Querfurth, Han-Kyu Le. Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration. Molecular neurodegeneration. vol 16. issue 1. 2021-08-13. PMID:34215308. |
however, in alzheimer's disease (ad), mtor alternately plays important pathogenic roles by inhibiting both insulin signaling and autophagic removal of β-amyloid (aβ) and phospho-tau (ptau) aggregates. |
2021-08-13 |
2023-08-13 |
Not clear |
| Ninghua Wu, Wu Liu, Jiawen Wang, Yanqi Han, Yu Ye, Xiufen Liu, Yuandong Yu, Qingjie Chen, Yongfen Bao, Chao Li. Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway. BioFactors (Oxford, England). vol 47. issue 4. 2021-08-10. PMID:33740285. |
ir (insulin resistance) in diabetic brain gave rise to the generation of toxic factor aβ42 and axon collapse which were the marker of ad (alzheimer's disease)-like lesions in the circumstance of diabetes mellitus. |
2021-08-10 |
2023-08-13 |
Not clear |
| Yuanting Ding, Heng Liu, Mofei Cen, Yuxiang Tao, Chencen Lai, Zhi Tan. Rapamycin Ameliorates Cognitive Impairments and Alzheimer's Disease-Like Pathology with Restoring Mitochondrial Abnormality in the Hippocampus of Streptozotocin-Induced Diabetic Mice. Neurochemical research. vol 46. issue 2. 2021-08-09. PMID:33140268. |
alzheimer's disease (ad) and diabetes mellitus (dm) share common pathophysiological findings, in particular, the mammalian target of rapamycin (mtor) has been strongly implied to link to ad, while it also plays a key role in the insulin signaling pathway. |
2021-08-09 |
2023-08-13 |
mouse |
| Zenghui Wei, Jagadish Koya, Sandra E Rezni. Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms. Frontiers in neuroscience. vol 15. 2021-08-06. PMID:34349617. |
insulin resistance exacerbates alzheimer disease via multiple mechanisms. |
2021-08-06 |
2023-08-13 |
Not clear |
| Karlo Toljan, Jan Homola. Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities. Handbook of clinical neurology. vol 179. 2021-07-28. PMID:34225969. |
the understanding of alzheimer's disease (ad) pathophysiology is an active area of research, and the traditional focus on hippocampus, amyloid and tau protein, and memory impairment has been expanded with components like neuroinflammation, insulin resistance, and circadian rhythm alterations. |
2021-07-28 |
2023-08-13 |
Not clear |
| Farzad Ghafouri, Abolfazl Bahrami, Mostafa Sadeghi, Seyed Reza Miraei-Ashtiani, Maryam Bakherad, Herman W Barkema, Samantha Laros. Omics Multi-Layers Networks Provide Novel Mechanistic and Functional Insights Into Fat Storage and Lipid Metabolism in Poultry. Frontiers in genetics. vol 12. 2021-07-27. PMID:34306005. |
module finding revealed three important and functional modules, which were involved in the peroxisome proliferator-activated receptor (ppar) signaling pathway, biosynthesis of unsaturated fatty acids, alzheimer's disease metabolic pathway, adipocytokine, insulin, pi3k-akt, mtor, and ampk signaling pathway. |
2021-07-27 |
2023-08-13 |
Not clear |