| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gaofeng Qin, Yahan Wang, Zhenhong Liu, Lulu Mana, Shuaiyang Huang, Pengwen Wan. Shenzhiling oral solution promotes myelin repair through PI3K/Akt-mTOR pathway in STZ-induced SAD mice. 3 Biotech. vol 11. issue 7. 2021-07-24. PMID:34295606. |
a model of sporadic alzheimer's disease induced with bilateral intraventricular injection of streptozotocin leads to insulin resistance in the brain accompanied by memory decline, synaptic dysfunction, amyloid plaque deposition, oxidative stress, and neuronal apoptosis, all of which mimic the pathologies associated with sporadic alzheimer's disease. |
2021-07-24 |
2023-08-13 |
mouse |
| Devanshi Mishra, Chinmoy Sankar De. PKCα: Prospects in Regulating Insulin Resistance and AD. Trends in endocrinology and metabolism: TEM. vol 32. issue 6. 2021-07-22. PMID:33858742. |
previous studies report that pkcα abrogates peripheral insulin resistance, and recent publications show that it takes part in regulating alzheimer's disease (ad). |
2021-07-22 |
2023-08-13 |
Not clear |
| Chien-Ning Huang, Chau-Jong Wang, Chih-Li Lin, Hsin-Hua Li, An-Ting Yen, Chiung-Huei Pen. Abelmoschus esculentus subfractions attenuate Aβ and tau by regulating DPP-4 and insulin resistance signals. BMC complementary medicine and therapies. vol 20. issue 1. 2021-07-21. PMID:33267804. |
insulin resistance could be associated with the development of alzheimer disease (ad). |
2021-07-21 |
2023-08-13 |
Not clear |
| Suhadinie Gamage, Swetha Peddibhotla, P Hemachandra Reddy, Nikhil V Dhurandhar, Vijay Hegd. Improvement in Glycemic Control in Mice of Different Age Groups. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 129. issue 7. 2021-07-20. PMID:31340394. |
the declining ability to control blood glucose with advancement of age is an important health risk factor and may lead to insulin resistance, type-2-diabetes and alzheimer's disease. |
2021-07-20 |
2023-08-13 |
mouse |
| Jhana O Hendrickx, Sofie De Moudt, Elke Calus, Wim Martinet, Pieter-Jan D F Guns, Lynn Roth, Peter P De Deyn, Debby Van Dam, Guido R Y De Meye. Serum Corticosterone and Insulin Resistance as Early Biomarkers in the hAPP23 Overexpressing Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 13. 2021-07-19. PMID:34206322. |
serum corticosterone and insulin resistance as early biomarkers in the happ23 overexpressing mouse model of alzheimer's disease. |
2021-07-19 |
2023-08-13 |
mouse |
| Jhana O Hendrickx, Sofie De Moudt, Elke Calus, Wim Martinet, Pieter-Jan D F Guns, Lynn Roth, Peter P De Deyn, Debby Van Dam, Guido R Y De Meye. Serum Corticosterone and Insulin Resistance as Early Biomarkers in the hAPP23 Overexpressing Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 13. 2021-07-19. PMID:34206322. |
increasing epidemiological evidence highlights the association between systemic insulin resistance and alzheimer's disease (ad). |
2021-07-19 |
2023-08-13 |
mouse |
| Karina Sánchez-Alegría, Carlos Ernesto Bastián-Eugenio, Luis Vaca, Clorinda Aria. Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 7. 2021-07-16. PMID:34110637. |
particularly in the brain, insulin signaling disruption has been linked to cognitive decline and is considered a risk factor for alzheimer's disease. |
2021-07-16 |
2023-08-13 |
human |
| Kavya Jash, Piyush Gondaliya, Prathibha Kirave, Bhagyashri Kulkarni, Aditya Sunkaria, Kiran Kali. Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease. Drug development research. vol 81. issue 2. 2021-07-09. PMID:31820484. |
the problem of insulin deficiency and insulin resistance is well reported in diabetes but there are many studies which suggest dysregulation of insulin levels as a reason behind the development of alzheimer's. |
2021-07-09 |
2023-08-13 |
Not clear |
| Kavya Jash, Piyush Gondaliya, Prathibha Kirave, Bhagyashri Kulkarni, Aditya Sunkaria, Kiran Kali. Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease. Drug development research. vol 81. issue 2. 2021-07-09. PMID:31820484. |
emerging role of major factors like insulin imbalance, advanced glycation end products and micro-rna's involved in diabetes and alzheimer's have been discussed here. |
2021-07-09 |
2023-08-13 |
Not clear |
| Joshua A Kulas, Thaddeus K Weigel, Heather A Ferri. Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease. Drug development research. vol 81. issue 2. 2021-07-09. PMID:32022298. |
insulin resistance and impaired lipid metabolism as a potential link between diabetes and alzheimer's disease. |
2021-07-09 |
2023-08-13 |
Not clear |
| Jason Bini, Shivani Bhatt, Ansel T Hillmer, Jean-Dominique Gallezot, Nabeel Nabulsi, Richard Pracitto, David Labaree, Michael Kapinos, Jim Ropchan, David Matuskey, Robert S Sherwin, Ania M Jastreboff, Richard E Carson, Kelly Cosgrove, Yiyun Huan. Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study. Molecular imaging and biology. vol 22. issue 4. 2021-07-07. PMID:32133575. |
prolonged excess cortisol leads to visceral adiposity, insulin resistance, hyperglycemia, memory dysfunction, cognitive impairment, and more severe alzheimer's disease phenotypes. |
2021-07-07 |
2023-08-13 |
Not clear |
| Ansab Akhtar, Jatinder Dhaliwal, Sangeeta Pilkhwal Sa. 7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer's disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance. Psychopharmacology. vol 238. issue 7. 2021-07-05. PMID:33774703. |
7,8-dihydroxyflavone improves cognitive functions in icv-stz rat model of sporadic alzheimer's disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance. |
2021-07-05 |
2023-08-13 |
rat |
| Ansab Akhtar, Jatinder Dhaliwal, Sangeeta Pilkhwal Sa. 7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer's disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance. Psychopharmacology. vol 238. issue 7. 2021-07-05. PMID:33774703. |
intracerebroventricular (icv) streptozotocin (stz) mimics sporadic alzheimer's disease (sad) characterized by tau pathology and neurodegeneration arising from oxidative stress, mitochondrial dysfunction, and insulin resistance. |
2021-07-05 |
2023-08-13 |
rat |
| Shan Liu, Jiguo Gao, Mingqin Zhu, Kangding Liu, Hong-Liang Zhan. Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32829453. |
although a causal relationship between gut dysbiosis and neural dysfunction remains elusive, emerging evidence indicates that gut dysbiosis may promote amyloid-beta aggregation, neuroinflammation, oxidative stress, and insulin resistance in the pathogenesis of alzheimer's disease (ad). |
2021-07-01 |
2023-08-13 |
human |
| Zohreh Abbasi, Mohammad Mahdi Ghahramani Seno, Masoud Fereidon. A Neonatal Mild Defect in Brain Insulin Signaling Predisposes a Subclinical Model of Sporadic Alzheimer's to Develop the Disease. Journal of molecular neuroscience : MN. vol 71. issue 7. 2021-06-28. PMID:33492616. |
a neonatal mild defect in brain insulin signaling predisposes a subclinical model of sporadic alzheimer's to develop the disease. |
2021-06-28 |
2023-08-13 |
rat |
| Zohreh Abbasi, Mohammad Mahdi Ghahramani Seno, Masoud Fereidon. A Neonatal Mild Defect in Brain Insulin Signaling Predisposes a Subclinical Model of Sporadic Alzheimer's to Develop the Disease. Journal of molecular neuroscience : MN. vol 71. issue 7. 2021-06-28. PMID:33492616. |
brain insulin system dysfunction has been proposed as a key player in the pathogenesis of sporadic alzheimer's disease (sad). |
2021-06-28 |
2023-08-13 |
rat |
| Chiara Lanzillotta, Antonella Tramutola, Graziella Di Giacomo, Federico Marini, D Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Baron. Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome. Free radical biology & medicine. vol 165. 2021-06-28. PMID:33516914. |
dysregulation of brain insulin signaling with reduced downstream neuronal survival and plasticity mechanisms are fundamental abnormalities observed in alzheimer disease (ad). |
2021-06-28 |
2023-08-13 |
mouse |
| b' Miroslava Kac\\xc3\\xad\\xc5\\x99ov\\xc3\\xa1, Blanka \\xc5\\xbdelezn\\xc3\\xa1, Michaela Bla\\xc5\\xbekov\\xc3\\xa1, Martina Holubov\\xc3\\xa1, Andrea Popelov\\xc3\\xa1, Jaroslav Kune\\xc5\\xa1, Blanka \\xc5\\xa0ediv\\xc3\\xa1, Lenka Malet\\xc3\\xadnsk\\xc3\\xa. Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22. Journal of neuroinflammation. vol 18. issue 1. 2021-06-26. PMID:34158075.' |
obesity-induced insulin resistance (ir) and neuroinflammation seem to intensify neurodegeneration including alzheimer's disease. |
2021-06-26 |
2023-08-13 |
mouse |
| Diana C P Mejido, Julyanna A Peny, Marcelo N N Vieira, Sérgio T Ferreira, Fernanda G De Felic. Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease. Neuropharmacology. vol 171. 2021-06-25. PMID:32344008. |
insulin and leptin as potential cognitive enhancers in metabolic disorders and alzheimer's disease. |
2021-06-25 |
2023-08-13 |
Not clear |
| Diana C P Mejido, Julyanna A Peny, Marcelo N N Vieira, Sérgio T Ferreira, Fernanda G De Felic. Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease. Neuropharmacology. vol 171. 2021-06-25. PMID:32344008. |
we further discuss potential therapeutic approaches involving the use of insulin and leptin as cognitive enhancers in the context of metabolic disorders and alzheimer's disease. |
2021-06-25 |
2023-08-13 |
Not clear |