| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Hölsche. Protective properties of GLP-1 and associated peptide hormones in neurodegenerative disorders. British journal of pharmacology. 2021-05-29. PMID:33900631. |
type 2 diabetes mellitus and the associated desensitisation of insulin signalling has been identified as a risk factor for progressive neurodegenerative disorders such as alzheimer's disease, parkinson's disease and others. |
2021-05-29 |
2023-08-13 |
Not clear |
| Ricardo Augusto Leoni De Sousa, Alison R Harmer, Daniel Almeida Freitas, Vanessa Amaral Mendonça, Ana Cristina Rodrigues Lacerda, Hércules Ribeiro Leit. An update on potential links between type 2 diabetes mellitus and Alzheimer's disease. Molecular biology reports. vol 47. issue 8. 2021-05-26. PMID:32740795. |
alzheimer's disease (ad) and type 2 diabetes (t2d) major feature is insulin resistance. |
2021-05-26 |
2023-08-13 |
Not clear |
| Richard J Johnson, Fernando Gomez-Pinilla, Maria Nagel, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Laura G Sanchez-Lozada, Dean R Tolan, Miguel A Lanasp. Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2021-05-25. PMID:33024433. |
cerebral insulin resistance and mitochondrial dysfunction have emerged as important contributors to pathogenesis supporting our hypothesis that cerebral fructose metabolism is a key initiating pathway for alzheimer's disease. |
2021-05-25 |
2023-08-13 |
Not clear |
| Valentina Siino, Pia Jensen, Peter James, Sonya Vasto, Antonella Amato, Flavia Mulè, Giulia Accardi, Martin Røssel Larse. Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains. Nutrition and metabolic insights. vol 14. 2021-05-23. PMID:34017182. |
as an example, in post-mortem brain of patients with alzheimer's disease (ad), several studies have reported reduction of insulin, insulin-like growth factor 1 and insulin receptor and an increase in tau protein and glycogen-synthase kinase-3β compared to healthy controls suggesting an impairment of metabolism in the ad patient's brain. |
2021-05-23 |
2023-08-13 |
mouse |
| Jorge Berlanga-Acosta, Gerardo Guillén-Nieto, Nadia Rodríguez-Rodríguez, Maria Luisa Bringas-Vega, Diana García-Del-Barco-Herrera, Jorge O Berlanga-Saez, Ariana García-Ojalvo, Mitchell Joseph Valdés-Sosa, Pedro A Valdés-Sos. Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review. Frontiers in endocrinology. vol 11. 2021-05-21. PMID:33224105. |
insulin resistance at the crossroad of alzheimer disease pathology: a review. |
2021-05-21 |
2023-08-13 |
Not clear |
| Jorge Berlanga-Acosta, Gerardo Guillén-Nieto, Nadia Rodríguez-Rodríguez, Maria Luisa Bringas-Vega, Diana García-Del-Barco-Herrera, Jorge O Berlanga-Saez, Ariana García-Ojalvo, Mitchell Joseph Valdés-Sosa, Pedro A Valdés-Sos. Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review. Frontiers in endocrinology. vol 11. 2021-05-21. PMID:33224105. |
insulin resistance and impaired cerebral glucose metabolism are invariantly reported in alzheimer's disease (ad) and other neurodegenerative processes. |
2021-05-21 |
2023-08-13 |
Not clear |
| Syed Obaidur Rahman, Madhu Kaundal, Mohd Salman, Apeksha Shrivastava, Suhel Parvez, Bibhu Prasad Panda, Mymoona Akhter, Mohd Akhtar, Abul Kalam Najm. Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease. European journal of pharmacology. vol 889. 2021-05-14. PMID:32866503. |
alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of alzheimer's disease. |
2021-05-14 |
2023-08-13 |
rat |
| James Robbins, Oriol Busquets, Ming Tong, Suzanne M de la Mont. Dysregulation of Insulin-Linked Metabolic Pathways in Alzheimer's Disease: Co-Factor Role of Apolipoprotein E Journal of Alzheimer's disease reports. vol 4. issue 1. 2021-05-14. PMID:33344887. |
dysregulation of insulin-linked metabolic pathways in alzheimer's disease: co-factor role of apolipoprotein e brain insulin resistance and deficiency are well-recognized abnormalities in alzheimer's disease (ad) and likely mediators of impaired energy metabolism. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yanli Jiang, Longfei Li, Chun-Ling Dai, Ranran Zhou, Cheng-Xin Gong, Khalid Iqbal, Jin-Hua Gu, Fei Li. Effect of Peripheral Insulin Administration on Phosphorylation of Tau in the Brain. Journal of Alzheimer's disease : JAD. vol 75. issue 4. 2021-05-13. PMID:32417781. |
impaired brain insulin signaling is involved in alzheimer's disease pathogenesis. |
2021-05-13 |
2023-08-13 |
Not clear |
| Angeles Vinuesa, Carlos Pomilio, Amal Gregosa, Melisa Bentivegna, Jessica Presa, Melina Bellotto, Flavia Saravia, Juan Beauqui. Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-05-13. PMID:33967682. |
inflammation and insulin resistance as risk factors and potential therapeutic targets for alzheimer's disease. |
2021-05-13 |
2023-08-13 |
Not clear |
| Roger J Mullins, Thomas C Diehl, Chee W Chia, Dimitrios Kapogianni. Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer's Disease. Frontiers in aging neuroscience. vol 9. 2021-05-03. PMID:28515688. |
insulin resistance as a link between amyloid-beta and tau pathologies in alzheimer's disease. |
2021-05-03 |
2023-08-13 |
human |
| Roger J Mullins, Thomas C Diehl, Chee W Chia, Dimitrios Kapogianni. Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer's Disease. Frontiers in aging neuroscience. vol 9. 2021-05-03. PMID:28515688. |
current hypotheses and theories regarding the pathogenesis of alzheimer's disease (ad) heavily implicate brain insulin resistance (ir) as a key factor. |
2021-05-03 |
2023-08-13 |
human |
| Seham Zakaria Nassar, Noha Mohamed Badae, Yasmine Amr Iss. Effect of amylin on memory and central insulin resistance in a rat model of Alzheimer's disease. Archives of physiology and biochemistry. vol 126. issue 4. 2021-05-03. PMID:30449203. |
effect of amylin on memory and central insulin resistance in a rat model of alzheimer's disease. |
2021-05-03 |
2023-08-13 |
rat |
| Mohammad Hossein Esmaeili, Mohsen Enayati, Farhad Khabbaz Abkenar, Fereshte Ebrahimian, Ali-Akbar Salar. Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease. Behavioural brain research. vol 379. 2021-05-03. PMID:31733313. |
both preclinical and clinical studies have provided evidence that brain insulin resistance is associated with cognitive decline in patients with t2d and sporadic alzheimer disease (ad). |
2021-05-03 |
2023-08-13 |
rat |
| Mingcui Zheng, Pengwen Wan. Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer's disease. 3 Biotech. vol 11. issue 4. 2021-05-02. PMID:33927970. |
role of insulin receptor substance-1 modulating pi3k/akt insulin signaling pathway in alzheimer's disease. |
2021-05-02 |
2023-08-13 |
Not clear |
| Mingcui Zheng, Pengwen Wan. Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer's disease. 3 Biotech. vol 11. issue 4. 2021-05-02. PMID:33927970. |
alzheimer's disease (ad) is a progressive neurodegenerative disease, also regarded as "type 3 diabetes" for the last few years because of the brain insulin resistance (ir) and dysregulation of insulin signaling in the brain, which can further promote pathological progression of ad. |
2021-05-02 |
2023-08-13 |
Not clear |
| Yuesong Pan, Weiqi Chen, Hongyi Yan, Mengxing Wang, Xianglong Xian. Glycemic traits and Alzheimer's disease: a Mendelian randomization study. Aging. vol 12. issue 22. 2021-04-27. PMID:33202379. |
we used a two-sample mendelian randomization approach to evaluate the causal effect of six glycemic traits (type 2 diabetes, fasting glucose, fasting insulin, hemoglobin a1c, homeostasis model assessment- insulin resistance and homa-β-cell function) on alzheimer's disease. |
2021-04-27 |
2023-08-13 |
Not clear |
| Toshihiko Tashim. Shortcut Approaches to Substance Delivery into the Brain Based on Intranasal Administration Using Nanodelivery Strategies for Insulin. Molecules (Basel, Switzerland). vol 25. issue 21. 2021-04-21. PMID:33171799. |
recently, it has been revealed that insulin improved alzheimer's disease (ad)-related dementia. |
2021-04-21 |
2023-08-13 |
Not clear |
| Jhana O Hendrickx, Wim Martinet, Debby Van Dam, Guido R Y De Meye. Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer's Disease. Frontiers in molecular biosciences. vol 8. 2021-04-16. PMID:33855048. |
inflammation, nitro-oxidative stress, impaired autophagy, and insulin resistance as a mechanistic convergence between arterial stiffness and alzheimer's disease. |
2021-04-16 |
2023-08-13 |
Not clear |
| Igor Pomytkin, Vsevolod Pineli. Insulin Receptors and Intracellular Ca F1000Research. vol 9. 2021-04-14. PMID:33552476. |
central insulin resistance has been found in diverse brain disorders including alzheimer's disease (ad). |
2021-04-14 |
2023-08-13 |
Not clear |