| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Igor Pomytkin, Vsevolod Pineli. Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions. Life (Basel, Switzerland). vol 11. issue 3. 2021-04-13. PMID:33810179. |
current hypotheses implicate insulin resistance of the brain as a pathogenic factor in the development of alzheimer's disease and other dementias, parkinson's disease, type 2 diabetes, obesity, major depression, and traumatic brain injury. |
2021-04-13 |
2023-08-13 |
Not clear |
| Matthias Gralle, Simon Labrecque, Charleen Salesse, Paul De Koninc. Spatial dynamics of the insulin receptor in living neurons. Journal of neurochemistry. vol 156. issue 1. 2021-04-12. PMID:31886886. |
it has been proposed that hippocampal insulin signaling is important for memory, that brain insulin signaling is deficient in alzheimer's disease, and that intranasal insulin treatment improves cognition, but the mechanisms remain unclear and do not seem to involve increased glucose uptake by neurons. |
2021-04-12 |
2023-08-13 |
rat |
| Chuanxi Li, Yingying Ma, Xiao Liu, Renliang Huang, Rongxin Su, Wei Qi, Jinjing Che, Zhimin H. Synergistic effect of polystyrene nanoplastics and contaminants on the promotion of insulin fibrillation. Ecotoxicology and environmental safety. vol 214. 2021-04-07. PMID:33691242. |
a variety of diseases such as alzheimer's disease are related to the generation of amyloid fibrils, and insulin is typically used as a model to study the fibrillation process. |
2021-04-07 |
2023-08-13 |
Not clear |
| Li-Min Lei, Xiao Lin, Feng Xu, Su-Kang Shan, Bei Guo, Fu-Xing-Zi Li, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Ling-Qing Yua. Exosomes and Obesity-Related Insulin Resistance. Frontiers in cell and developmental biology. vol 9. 2021-04-06. PMID:33816504. |
insulin resistance is a kind of pathological state, which is important in the pathogeneses of type 2 diabetes mellitus (t2dm), gestational diabetes mellitus and alzheimer's disease. |
2021-04-06 |
2023-08-13 |
Not clear |
| Suzanne Craft, Rema Raman, Tiffany W Chow, Michael S Rafii, Chung-Kai Sun, Robert A Rissman, Michael C Donohue, James B Brewer, Cecily Jenkins, Kelly Harless, Devon Gessert, Paul S Aise. Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA neurology. vol 77. issue 9. 2021-03-31. PMID:32568367. |
safety, efficacy, and feasibility of intranasal insulin for the treatment of mild cognitive impairment and alzheimer disease dementia: a randomized clinical trial. |
2021-03-31 |
2023-08-13 |
Not clear |
| Suzanne Craft, Rema Raman, Tiffany W Chow, Michael S Rafii, Chung-Kai Sun, Robert A Rissman, Michael C Donohue, James B Brewer, Cecily Jenkins, Kelly Harless, Devon Gessert, Paul S Aise. Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA neurology. vol 77. issue 9. 2021-03-31. PMID:32568367. |
insulin modulates aspects of brain function relevant to alzheimer disease and can be delivered to the brain using intranasal devices. |
2021-03-31 |
2023-08-13 |
Not clear |
| Suzanne Craft, Rema Raman, Tiffany W Chow, Michael S Rafii, Chung-Kai Sun, Robert A Rissman, Michael C Donohue, James B Brewer, Cecily Jenkins, Kelly Harless, Devon Gessert, Paul S Aise. Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA neurology. vol 77. issue 9. 2021-03-31. PMID:32568367. |
to date, the use of intranasal insulin to treat persons with mild cognitive impairment and alzheimer's disease dementia remains to be examined in a multi-site trial. |
2021-03-31 |
2023-08-13 |
Not clear |
| Thuy Trang Nguyen, Qui Thanh Hoai Ta, Thi Thuy Dung Nguyen, Thi Thuy Le, Van Giau V. Role of Insulin Resistance in the Alzheimer's Disease Progression. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32314178. |
role of insulin resistance in the alzheimer's disease progression. |
2021-03-29 |
2023-08-13 |
Not clear |
| Fruzsina Bagaméry, Kamilla Varga, Kitti Kecsmár, István Vincze, Éva Szökő, Tamás Táb. Lack of insulin resistance in response to streptozotocin treatment in neuronal SH-SY5Y cell line. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 1. 2021-03-26. PMID:31858268. |
recently, it is suggested that brain insulin resistance may contribute to the development of alzheimer's disease; therefore, there is a high interest in its investigation. |
2021-03-26 |
2023-08-13 |
Not clear |
| Leoné Malan, Mark Hamer, Roland von Känel, Roelof D van Wyk, Anne E Sumner, Peter M Nilsson, Gavin W Lambert, Hendrik S Steyn, Casper J Badenhorst, Nico T Mala. A Stress Syndrome Prototype Reflects Type 3 Diabetes and Ischemic Stroke Risk: The SABPA Study. Biology. vol 10. issue 2. 2021-03-16. PMID:33670473. |
type 3 diabetes (t3d) accurately reflects that dementia, e.g., alzheimer's disease, represents insulin resistance and neurodegeneration in the brain. |
2021-03-16 |
2023-08-13 |
human |
| Michal Baram, Yifat Mille. Inhibitory Activity of Insulin on Aβ Aggregation Is Restricted Due to Binding Selectivity and Specificity to Polymorphic Aβ States. ACS chemical neuroscience. vol 11. issue 3. 2021-03-03. PMID:31899862. |
clinical trials of intranasal insulin treatment for alzheimer's patients have shown cognitive and memory improvement, but the effect of insulin has shown a limitation. |
2021-03-03 |
2023-08-13 |
Not clear |
| Jiayuan Chen, Li Gao, Yao Zhang, Ya Su, Zheng Kong, Dongqing Wang, Ming Ya. Acteoside-improved streptozotocin-induced learning and memory impairment by upregulating hippocampal insulin, glucose transport, and energy metabolism. Phytotherapy research : PTR. vol 35. issue 1. 2021-02-23. PMID:33029835. |
alzheimer's disease (ad), a neurodegenerative disease, has been, by and large, correlated to insulin pathway, glucose level, and energy metabolism in the brain. |
2021-02-23 |
2023-08-13 |
Not clear |
| Manel Ben Aissa, Cutler T Lewandowski, Kiira M Ratia, Sue H Lee, Brian T Layden, Mary Jo LaDu, Gregory R J Thatche. Discovery of Nonlipogenic ABCA1 Inducing Compounds with Potential in Alzheimer's Disease and Type 2 Diabetes. ACS pharmacology & translational science. vol 4. issue 1. 2021-02-23. PMID:33615168. |
selective liver x receptor (lxr) agonists have been extensively pursued as therapeutics for alzheimer's disease and related dementia (adrd) and, for comorbidities such as type 2 diabetes (t2d) and cerebrovascular disease (cvd), disorders with underlying impaired insulin signaling, glucose metabolism, and cholesterol mobilization. |
2021-02-23 |
2023-08-13 |
Not clear |
| Rohith N Thota, Jessica I Rosato, Tracy L Burrows, Cintia B Dias, Kylie A Abbott, Ralph N Martins, Manohar L Gar. Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults. Nutrients. vol 12. issue 6. 2021-02-19. PMID:32486256. |
targeting kinases linked to insulin resistance (ir) and inflammation may help in reducing the risk of type 2 diabetes (t2d) and alzheimer's disease (ad) in its early stages. |
2021-02-19 |
2023-08-13 |
Not clear |
| Malena Dos Santos Guilherme, Victor F Zevallos, Aline Pesi, Nicolai M Stoye, Vu Thu Thuy Nguyen, Konstantin Radyushkin, Andreas Schwiertz, Ulrich Schmitt, Detlef Schuppan, Kristina Endre. Dietary Wheat Amylase Trypsin Inhibitors Impact Alzheimer's Disease Pathology in 5xFAD Model Mice. International journal of molecular sciences. vol 21. issue 17. 2021-02-18. PMID:32878020. |
for alzheimer's disease (ad), both inflammation and altered insulin resistance are major contributing factors, impacting onset as well as progression of this devastating brain disorder in patients. |
2021-02-18 |
2023-08-13 |
mouse |
| Rui Xiong, Xiu-Ling Wang, Jian-Ming Wu, Yong Tang, Wen-Qiao Qiu, Xin Shen, Jin-Feng Teng, Rong Pan, Ya Zhao, Lu Yu, Jian Liu, Hai-Xia Chen, Da-Lian Qin, Chong-Lin Yu, An-Guo W. Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway. Journal of ethnopharmacology. vol 251. 2021-02-10. PMID:31917277. |
polyphenols isolated from lychee seed inhibit alzheimer's disease-associated tau through improving insulin resistance via the irs-1/pi3k/akt/gsk-3β pathway. |
2021-02-10 |
2023-08-13 |
rat |
| Ansab Akhtar, Sangeeta Pilkhwal Sa. Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer's disease. Neurochemistry international. vol 135. 2021-01-25. PMID:32092326. |
insulin signaling pathway and related molecules: role in neurodegeneration and alzheimer's disease. |
2021-01-25 |
2023-08-13 |
Not clear |
| Sadegh Salarinasab, Leila Salimi, Neda Alidadiani, Elhameh Shokrollahi, Pishva Arzhanga, Saedeh Karbasforush, Faroogh Marofi, Mahdieh Nasirzadeh, Reza Rahbarghazi, Alireza Nourazarian, Masoud Nikanfa. Interaction of opioid with insulin/IGFs signaling in Alzheimer's disease. Journal of molecular neuroscience : MN. vol 70. issue 6. 2021-01-22. PMID:32026387. |
alzheimer's disease is also touted as type iii diabetes, showing an association with insulin signaling. |
2021-01-22 |
2023-08-13 |
Not clear |
| Sadegh Salarinasab, Leila Salimi, Neda Alidadiani, Elhameh Shokrollahi, Pishva Arzhanga, Saedeh Karbasforush, Faroogh Marofi, Mahdieh Nasirzadeh, Reza Rahbarghazi, Alireza Nourazarian, Masoud Nikanfa. Interaction of opioid with insulin/IGFs signaling in Alzheimer's disease. Journal of molecular neuroscience : MN. vol 70. issue 6. 2021-01-22. PMID:32026387. |
the large distribution of the insulin receptor on the cell surface and its regulatory role in the central nervous system suggests that the pathogenesis of alzheimer's disease could be ascribed to insulin signaling. |
2021-01-22 |
2023-08-13 |
Not clear |
| R Tural, N Altan, C Irkec, D Sahin, H Z Batur Caglaya. The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease. Bratislavske lekarske listy. vol 121. issue 11. 2021-01-19. PMID:33164543. |
the probable role of insulin resistance and sirt1 proteins in the alzheimer's disease. |
2021-01-19 |
2023-08-13 |
Not clear |