| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sunmin Park, Da Sol Kim, Suna Kang, Hyun Jin Ki. The combination of luteolin and l-theanine improved Alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats. Nutrition research (New York, N.Y.). vol 60. 2019-05-24. PMID:30527255. |
the combination of luteolin and l-theanine improved alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats. |
2019-05-24 |
2023-08-13 |
rat |
| Sunmin Park, Da Sol Kim, Suna Kang, Hyun Jin Ki. The combination of luteolin and l-theanine improved Alzheimer disease-like symptoms by potentiating hippocampal insulin signaling and decreasing neuroinflammation and norepinephrine degradation in amyloid-β-infused rats. Nutrition research (New York, N.Y.). vol 60. 2019-05-24. PMID:30527255. |
the combination of luteolin and l-theanine prevented alzheimer disease-like symptom, possibly by improving hippocampal insulin signaling, norepinephrine metabolisms, and decreasing neuroinflammation. |
2019-05-24 |
2023-08-13 |
rat |
| Geisa Nogueira Salles, Fernanda Aparecida Dos Santos Pereira, Cristina Pacheco-Soares, Fernanda Roberta Marciano, Christian Hölscher, Thomas J Webster, Anderson Oliveira Lob. A Novel Bioresorbable Device as a Controlled Release System for Protecting Cells from Oxidative Stress from Alzheimer's Disease. Molecular neurobiology. vol 54. issue 9. 2019-05-23. PMID:27766537. |
in parallel, it is known that alzheimer's disease (ad) has been linked to impaired insulin signalling in the brain. |
2019-05-23 |
2023-08-13 |
Not clear |
| Aurélie Joly-Amado, Maud Gratuze, Hamza Benderradji, Didier Vieau, Luc Buée, David Blu. [Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies]. Medecine sciences : M/S. vol 34. issue 11. 2019-05-22. PMID:30526837. |
[brain insulin signaling and tau: impact for alzheimer's disease and tauopathies]. |
2019-05-22 |
2023-08-13 |
Not clear |
| Aurélie Joly-Amado, Maud Gratuze, Hamza Benderradji, Didier Vieau, Luc Buée, David Blu. [Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies]. Medecine sciences : M/S. vol 34. issue 11. 2019-05-22. PMID:30526837. |
alzheimer's disease (ad) is a neurodegenerative disease primarily characterized by cognitive deficits and neuropathological lesions such as tau aggregates and amyloid plaques, but also associated with metabolic and neuroendocrine abnormalities, such as impairment of cerebral insulin. |
2019-05-22 |
2023-08-13 |
Not clear |
| Francesca Triani, Antonella Tramutola, Fabio Di Domenico, Nidhi Sharma, D Allan Butterfield, Elizabeth Head, Marzia Perluigi, Eugenio Baron. Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 10. 2019-05-20. PMID:29981845. |
biliverdin reductase-a impairment links brain insulin resistance with increased aβ production in an animal model of aging: implications for alzheimer disease. |
2019-05-20 |
2023-08-13 |
Not clear |
| Sreelakshmi Thankappan, Somdatta Sen, Sarada Subramanian, Preeti Sinha, Meera Purushottam, Srikala Bharat. Insulin resistance in patients with Alzheimer's dementia: A controlled study from India. Asian journal of psychiatry. vol 38. 2019-05-01. PMID:30391679. |
insulin resistance in patients with alzheimer's dementia: a controlled study from india. |
2019-05-01 |
2023-08-13 |
Not clear |
| Syed Obaidur Rahman, Bibhu Prasad Panda, Suhel Parvez, Madhu Kaundal, Salman Hussain, Mohd Akhtar, Abul Kalam Najm. Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 110. 2019-04-18. PMID:30463045. |
neuroprotective role of astaxanthin in hippocampal insulin resistance induced by aβ peptides in animal model of alzheimer's disease. |
2019-04-18 |
2023-08-13 |
rat |
| Syed Obaidur Rahman, Bibhu Prasad Panda, Suhel Parvez, Madhu Kaundal, Salman Hussain, Mohd Akhtar, Abul Kalam Najm. Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 110. 2019-04-18. PMID:30463045. |
our study concludes preventive action of astaxanthin against hippocampal insulin resistance and alzheimer's disease complications, supporting potential role of hippocampal insulin resistance targeting against ad. |
2019-04-18 |
2023-08-13 |
rat |
| Kathleen T Watson, Tonita E Wroolie, Gabby Tong, Lara C Foland-Ross, Sophia Frangou, Manpreet Singh, Roger S McIntyre, Siena Roat-Shumway, Alison Myoraku, Allan L Reiss, Natalie L Rasgo. Neural correlates of liraglutide effects in persons at risk for Alzheimer's disease. Behavioural brain research. vol 356. 2019-04-16. PMID:30099030. |
insulin resistance (ir) is a metabolic state preceding development of type 2 diabetes (dm2), cardiovascular disease, and neurodegenerative disorders, including alzheimer's disease (ad). |
2019-04-16 |
2023-08-13 |
human |
| Nora O Abdel Rasheed, Nesrine S El Sayed, Aiman S El-Khati. Targeting central β2 receptors ameliorates streptozotocin-induced neuroinflammation via inhibition of glycogen synthase kinase3 pathway in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 86. 2019-04-15. PMID:29782959. |
intra-cerebroventricular injection of streptozotocin (stz) leads to insulin resistance brain state accompanied by memory decline, oxidative stress, and neuro-degeneration which mimic the pathologies associated with sporadic alzheimer's disease (sad). |
2019-04-15 |
2023-08-13 |
mouse |
| Mir Hilal Ahmad, Mahino Fatima, Amal Chandra Monda. Role of Hypothalamic-Pituitary-Adrenal Axis, Hypothalamic-Pituitary-Gonadal Axis and Insulin Signaling in the Pathophysiology of Alzheimer's Disease. Neuropsychobiology. vol 77. issue 4. 2019-04-15. PMID:30605907. |
role of hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis and insulin signaling in the pathophysiology of alzheimer's disease. |
2019-04-15 |
2023-08-13 |
Not clear |
| P Katsel, P Roussos, M S Beeri, M A Gama-Sosa, S Gandy, S Khan, V Haroutunia. Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents. PloS one. vol 13. issue 11. 2019-04-11. PMID:30383799. |
we showed previously that the neuropathological features of alzheimer's disease (ad were reduced in patients with diabetes who were treated with insulin and oral antidiabetic medications. |
2019-04-11 |
2023-08-13 |
Not clear |
| Qing-Hua Yang, Ling Guo, Qing Chen, Kai-Hui Wu, Yan-Jun Wu, Yan Jia, Shu-Juan Zhu, Cheng-Lin Tang, Hua-Jun Shen. [Kidney-reinforcing and Governor Vessel-regulating EA Intervention May Improve Learningmemory Possibly by Suppressing Formation of Senile Plaques in Hippocampus in APP/PS 1 Double Transgenic Alzheimer's Disease Mice]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 4. 2019-04-03. PMID:29888573. |
to observe the effect of electroacupuncture (ea) intervention on learning-memory ability and the expression of senile plaques (sp), amyloid precursor protein (app), β-secretase 1(bace 1) and insulin degrading enzyme (ide) in the hippocampus in app/presenilin 1 (ps 1) double transgenic alzheimer's disease (ad) mice, so as to reveal its mechanisms underlying improvement of ad. |
2019-04-03 |
2023-08-13 |
mouse |
| Manuel Rodriguez-Perdigon, Maite Solas, Maria Jesús Moreno-Aliaga, Maria Javier Ramire. Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26769360. |
lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating vglut1 expression in high-fat-fed rats: implications for alzheimer's disease. |
2019-03-28 |
2023-08-13 |
rat |
| Manuel Rodriguez-Perdigon, Maite Solas, Maria Jesús Moreno-Aliaga, Maria Javier Ramire. Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26769360. |
the concept of central insulin resistance and dysfunctional insulin signalling in sporadic alzheimer's disease (ad) is now widely accepted and diabetes is recognized as one of the main risk factors for developing ad. |
2019-03-28 |
2023-08-13 |
rat |
| Sima Kianpour Rad, Aditya Arya, Hamed Karimian, Priya Madhavan, Farzana Rizwan, Shajan Koshy, Girish Prabh. Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer's disease. Drug design, development and therapy. vol 12. 2019-03-26. PMID:30538427. |
mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and alzheimer's disease. |
2019-03-26 |
2023-08-13 |
Not clear |
| Gurdeep Marwarha, Othman Ghrib. Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease. CNS & neurological disorders drug targets. vol 16. issue 10. 2019-03-25. PMID:28745240. |
since its discovery, this protein complex has been implicated in numerous physiological and pathophysiological processes such as synaptic plasticity, learning and memory, inflammation, insulin resistance, and oxidative stress among other factors that are intricately involved and dysregulated in alzheimer's disease (ad). |
2019-03-25 |
2023-08-13 |
Not clear |
| Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucc. Pharmacogenetics of Angiotensin-Converting Enzyme Inhibitors in Patients with Alzheimer's Disease Dementia. Current Alzheimer research. vol 15. issue 4. 2019-03-04. PMID:29034839. |
while the angiotensin-converting enzyme degrades amyloid-β, angiotensinconverting enzyme inhibitors (aceis) may slow cognitive decline by way of cholinergic effects, by increasing brain substance p and boosting the activity of neprilysin, and by modulating glucose homeostasis and augmenting the secretion of adipokines to enhance insulin sensitivity in patients with alzheimer's disease dementia (ad). |
2019-03-04 |
2023-08-13 |
Not clear |
| Tingwei Wang, Cuiwei Xie, Pengfei Yu, Fangfang Fang, Jingying Zhu, Jie Cheng, Aihua Gu, Jun Wang, Hang Xia. Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer's Disease-like Neurotoxicity. Scientific reports. vol 7. issue 1. 2019-02-21. PMID:28790390. |
involvement of insulin signaling disturbances in bisphenol a-induced alzheimer's disease-like neurotoxicity. |
2019-02-21 |
2023-08-13 |
Not clear |