| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naoki Yamamoto, Ryo Ishikuro, Mamoru Tanida, Kenji Suzuki, Yuri Ikeda-Matsuo, Kazuya Sobu. Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes. Neuroscience. vol 385. 2019-02-21. PMID:29932983. |
alzheimer's disease (ad) has been considered as a metabolic dysfunction disease associated with impaired insulin signaling. |
2019-02-21 |
2023-08-13 |
Not clear |
| I B Sukhov, K V Derkach, O V Chistyakova, V M Bondareva, A O Shpako. [FUNCTIONAL STATE OF THE HYPOTHALAMIC SIGNALING SYSTEMS IN RATS WITH TYPE 2 DIABETES MELLITUS TREATED WITH INTRANASAL INSULIN]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 52. issue 2. 2019-02-19. PMID:30695498. |
in the last years intranasally administered insulin (ii) is widely used to treat alzheimer's disease and other cognitive disorders. |
2019-02-19 |
2023-08-13 |
rat |
| Thanh Thanh L Nguyen, Lily C Chan, Kristin Borreginne, Rajas P Kale, Chunling Hu, Susannah J Ty. A review of brain insulin signaling in mood disorders: From biomarker to clinical target. Neuroscience and biobehavioral reviews. vol 92. 2019-02-11. PMID:29758232. |
the insulin signaling pathway mediates metabolic homeostasis and is important in the regulation of neurotrophic and synaptic plasticity processes, including those involved in neurodegenerative diseases like alzheimer's. |
2019-02-11 |
2023-08-13 |
Not clear |
| Taysa Bervian Bassani, Jéssica M Bonato, Meira M F Machado, Valentín Cóppola-Segovia, Eric L R Moura, Silvio M Zanata, Rúbia M M W Oliveira, Maria A B F Vita. Decrease in Adult Neurogenesis and Neuroinflammation Are Involved in Spatial Memory Impairment in the Streptozotocin-Induced Model of Sporadic Alzheimer's Disease in Rats. Molecular neurobiology. vol 55. issue 5. 2019-02-08. PMID:28623617. |
early impairments in cerebral glucose metabolism and insulin signaling pathways may participate in the pathogenesis of the sporadic form of alzheimer's disease (sad). |
2019-02-08 |
2023-08-13 |
human |
| Ana Knezovic, Jelena Osmanovic Barilar, Ana Babic, Robert Bagaric, Vladimir Farkas, Peter Riederer, Melita Salkovic-Petrisi. Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer's disease. Neuropharmacology. vol 135. 2019-02-04. PMID:29501615. |
insulin resistance and metabolic dysfunction in the brain are considered to be the pathophysiological core of sporadic alzheimer's disease (sad). |
2019-02-04 |
2023-08-13 |
rat |
| Fiona Brabazon, Sara Bermudez, Michael Shaughness, Guzal Khayrullina, Kimberly R Byrne. The effects of insulin on the inflammatory activity of BV2 microglia. PloS one. vol 13. issue 8. 2019-02-04. PMID:30148836. |
intranasal insulin administration is a promising treatment of alzheimer's disease and tbi. |
2019-02-04 |
2023-08-13 |
Not clear |
| Pasquale Picone, Maria Antonietta Sabatino, Lorena Anna Ditta, Antonella Amato, Pier Luigi San Biagio, Flavia Mulè, Daniela Giacomazza, Clelia Dispenza, Marta Di Carl. Nose-to-brain delivery of insulin enhanced by a nanogel carrier. Journal of controlled release : official journal of the Controlled Release Society. vol 270. 2019-01-28. PMID:29196041. |
recent evidences suggest that insulin delivery to the brain can be an important pharmacological therapy for some neurodegenerative pathologies, including alzheimer disease (ad). |
2019-01-28 |
2023-08-13 |
mouse |
| Smriti Gupta, Kamalendra Yadav, Shrikant S Mantri, Nitin K Singhal, Subramaniam Ganesh, Rajat Sandhi. Evidence for Compromised Insulin Signaling and Neuronal Vulnerability in Experimental Model of Sporadic Alzheimer's Disease. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29611103. |
evidence for compromised insulin signaling and neuronal vulnerability in experimental model of sporadic alzheimer's disease. |
2019-01-18 |
2023-08-13 |
Not clear |
| George S Bloom, John S Lazo, Andrés Norambuen. Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis. Neuropharmacology. vol 136. issue Pt B. 2019-01-17. PMID:28965829. |
reduced brain insulin signaling: a seminal process in alzheimer's disease pathogenesis. |
2019-01-17 |
2023-08-13 |
Not clear |
| Colin D Chapman, Helgi B Schiöth, Claudia A Grillo, Christian Benedic. Intranasal insulin in Alzheimer's disease: Food for thought. Neuropharmacology. vol 136. issue Pt B. 2019-01-17. PMID:29180222. |
intranasal insulin in alzheimer's disease: food for thought. |
2019-01-17 |
2023-08-13 |
Not clear |
| Colin D Chapman, Helgi B Schiöth, Claudia A Grillo, Christian Benedic. Intranasal insulin in Alzheimer's disease: Food for thought. Neuropharmacology. vol 136. issue Pt B. 2019-01-17. PMID:29180222. |
accumulating evidence suggests that disrupted brain insulin signaling promotes the development and progression of alzheimer's disease (ad), driving clinicians to target this circuitry. |
2019-01-17 |
2023-08-13 |
Not clear |
| A I Duarte, M S Santos, C R Oliveira, P I Moreir. Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease. Neuropharmacology. vol 136. issue Pt B. 2019-01-17. PMID:29471055. |
brain insulin signalling, glucose metabolism and females' reproductive aging: a dangerous triad in alzheimer's disease. |
2019-01-17 |
2023-08-13 |
Not clear |
| Christian Hölscher, Fernanda G De Felice, Nigel H Greig, Sergio T Ferreir. Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones? Neuropharmacology. vol 136. issue Pt B. 2019-01-17. PMID:29782874. |
are alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones? |
2019-01-17 |
2023-08-13 |
Not clear |
| Andrea Tumminia, Federica Vinciguerra, Miriam Parisi, Lucia Frittitt. Type 2 Diabetes Mellitus and Alzheimer's Disease: Role of Insulin Signalling and Therapeutic Implications. International journal of molecular sciences. vol 19. issue 11. 2019-01-15. PMID:30355995. |
type 2 diabetes mellitus and alzheimer's disease: role of insulin signalling and therapeutic implications. |
2019-01-15 |
2023-08-13 |
Not clear |
| Arnold N Onyang. Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance. Oxidative medicine and cellular longevity. vol 2018. 2018-12-19. PMID:30116482. |
insulin resistance (ir), a key component of the metabolic syndrome, precedes the development of diabetes, cardiovascular disease, and alzheimer's disease. |
2018-12-19 |
2023-08-13 |
Not clear |
| Eun Suk Song, David W Rodgers, Louis B Hers. Insulin-degrading enzyme is not secreted from cultured cells. Scientific reports. vol 8. issue 1. 2018-12-14. PMID:29402917. |
established roles include degrading insulin and the amyloid beta peptide (aβ), linking it to diabetes and alzheimer's disease. |
2018-12-14 |
2023-08-13 |
Not clear |
| Senthilkumar Sivanesan, Ravi Mundugaru, Jayakumar Rajada. Possible Clues for Brain Energy Translation via Endolysosomal Trafficking of APP-CTFs in Alzheimer's Disease. Oxidative medicine and cellular longevity. vol 2018. 2018-12-13. PMID:30420907. |
vascular dysfunctions, hypometabolism, and insulin resistance are high and early risk factors for alzheimer's disease (ad), a leading neurological disease associated with memory decline and cognitive dysfunctions. |
2018-12-13 |
2023-08-13 |
Not clear |
| Yanxing Chen, Zhangyu Guo, Yan-Fang Mao, Tingting Zheng, Baorong Zhan. Intranasal Insulin Ameliorates Cerebral Hypometabolism, Neuronal Loss, and Astrogliosis in Streptozotocin-Induced Alzheimer's Rat Model. Neurotoxicity research. vol 33. issue 4. 2018-12-11. PMID:28929339. |
intranasal insulin ameliorates cerebral hypometabolism, neuronal loss, and astrogliosis in streptozotocin-induced alzheimer's rat model. |
2018-12-11 |
2023-08-13 |
rat |
| Dawson Brown, Kelly J Giba. Metabolic syndrome marks early risk for cognitive decline with APOE4 gene variation: A case study. Diabetes & metabolic syndrome. vol 12. issue 5. 2018-12-11. PMID:29706312. |
a vast amount of research has been done on the apoe4 genetic marker for alzheimer's disease (ad), but its connection to metabolic processes associated with peripheral insulin resistance and cerebral glucose metabolism is still relatively unknown. |
2018-12-11 |
2023-08-13 |
Not clear |
| Chenchen Han, Yifan Li, Yang Wang, Dongqian Cui, Tingting Luo, Yuwen Zhang, Yang Ma, Wei We. Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 51. issue 2. 2018-12-11. PMID:30463058. |
however, the imbalance of grk2 expression and activity plays an important role in the development of iir-related diseases, such as hypertension, heart failure, alzheimer's disease, type 2 diabetes mellitus, insulin resistance, rheumatoid arthritis, thyroid cancer, multiple sclerosis, and liver cancer. |
2018-12-11 |
2023-08-13 |
Not clear |