| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raj C Shah, Dawn C Matthews, Randolph D Andrews, Ana W Capuano, Debra A Fleischman, James T VanderLugt, Jerry R Colc. An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease. Current Alzheimer research. vol 11. issue 6. 2015-02-26. PMID:24931567. |
an evaluation of msdc-0160, a prototype mtot modulating insulin sensitizer, in patients with mild alzheimer's disease. |
2015-02-26 |
2023-08-13 |
human |
| Raj C Shah, Dawn C Matthews, Randolph D Andrews, Ana W Capuano, Debra A Fleischman, James T VanderLugt, Jerry R Colc. An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease. Current Alzheimer research. vol 11. issue 6. 2015-02-26. PMID:24931567. |
alzheimer's disease (ad) is associated with insulin resistance and specific regional declines in cerebral metabolism. |
2015-02-26 |
2023-08-13 |
human |
| Vineet Kumar Khemka, Debajit Bagchi, Kausik Bandyopadhyay, Aritri Bir, Mrittika Chattopadhyay, Atanu Biswas, Debasis Basu, Sasanka Chakrabart. Altered serum levels of adipokines and insulin in probable Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 41. issue 2. 2015-02-09. PMID:24625795. |
altered serum levels of adipokines and insulin in probable alzheimer's disease. |
2015-02-09 |
2023-08-12 |
human |
| Wenqing Yang, Jing Ma, Zheng Liu, Yongliang Lu, Bin Hu, Huarong Y. Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 5. 2015-01-27. PMID:24337945. |
recent evidence indicates that severe abnormalities in brain glucose/energy metabolism and insulin signaling have been documented to take a pivotal role in early sporadic alzheimer's disease pathology. |
2015-01-27 |
2023-08-12 |
rat |
| Milene Vandal, Phillip J White, Cyntia Tremblay, Isabelle St-Amour, Geneviève Chevrier, Vincent Emond, Dominique Lefrançois, Jessica Virgili, Emmanuel Planel, Yves Giguere, Andre Marette, Frederic Calo. Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease. Diabetes. vol 63. issue 12. 2015-01-16. PMID:25008180. |
insulin reverses the high-fat diet-induced increase in brain aβ and improves memory in an animal model of alzheimer disease. |
2015-01-16 |
2023-08-13 |
mouse |
| Milene Vandal, Phillip J White, Cyntia Tremblay, Isabelle St-Amour, Geneviève Chevrier, Vincent Emond, Dominique Lefrançois, Jessica Virgili, Emmanuel Planel, Yves Giguere, Andre Marette, Frederic Calo. Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease. Diabetes. vol 63. issue 12. 2015-01-16. PMID:25008180. |
defects in insulin production and signaling are suspected to share a key role in diabetes and alzheimer disease (ad), two age-related pathologies. |
2015-01-16 |
2023-08-13 |
mouse |
| Sarah M Gray, Rick I Meijer, Eugene J Barret. Insulin regulates brain function, but how does it get there? Diabetes. vol 63. issue 12. 2015-01-16. PMID:25414013. |
insulin may even influence the development or progression of alzheimer disease. |
2015-01-16 |
2023-08-13 |
Not clear |
| Linda Adzovic, Luciano Domenic. Insulin induces phosphorylation of the AMPA receptor subunit GluR1, reversed by ZIP, and over-expression of Protein Kinase M zeta, reversed by amyloid beta. Journal of neurochemistry. vol 131. issue 5. 2015-01-14. PMID:25230927. |
these results indicate a new intracellular insulin signaling pathway, and, additionally, that insulin resistance in alzheimer's disease is a response to the production and accumulation of aβ. |
2015-01-14 |
2023-08-13 |
Not clear |
| J K Morris, E D Vidoni, R D Perea, R Rada, D K Johnson, K Lyons, R Pahwa, J M Burns, R A Hone. Insulin resistance and gray matter volume in neurodegenerative disease. Neuroscience. vol 270. 2015-01-13. PMID:24735819. |
insulin resistance was estimated in apparently healthy elderly control (hc, n=21) and neurodegenerative disease (alzheimer's disease (ad), n=20; parkinson's disease (pd), n=22) groups using homeostasis model assessment of insulin resistance 2 (homa2) and intravenous glucose tolerance test (ivgtt). |
2015-01-13 |
2023-08-13 |
human |
| Zainab Jahangir, Waqar Ahmad, Khadija Shabbir. Alternate Phosphorylation/O-GlcNAc Modification on Human Insulin IRSs: A Road towards Impaired Insulin Signaling in Alzheimer and Diabetes. Advances in bioinformatics. vol 2014. 2015-01-12. PMID:25580119. |
alternate phosphorylation/o-glcnac modification on human insulin irss: a road towards impaired insulin signaling in alzheimer and diabetes. |
2015-01-12 |
2023-08-13 |
human |
| Zainab Jahangir, Waqar Ahmad, Khadija Shabbir. Alternate Phosphorylation/O-GlcNAc Modification on Human Insulin IRSs: A Road towards Impaired Insulin Signaling in Alzheimer and Diabetes. Advances in bioinformatics. vol 2014. 2015-01-12. PMID:25580119. |
impaired insulin signaling has been thought of as important step in both alzheimer's disease (ad) and type 2 diabetes mellitus (t2dm). |
2015-01-12 |
2023-08-13 |
human |
| Christian Hölsche. New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases. Neural regeneration research. vol 9. issue 21. 2015-01-05. PMID:25558231. |
insulin signaling in the brains of people with alzheimer's disease or parkinson's disease is impaired. |
2015-01-05 |
2023-08-13 |
Not clear |
| Christian Hölsche. New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases. Neural regeneration research. vol 9. issue 21. 2015-01-05. PMID:25558231. |
in animal models of alzheimer's disease and parkinson's disease, insulin, glia-derived neurotrophic factor, or analogues of the incretin glucagon-like peptide-1 prevented neurodegenerative processes and improved neuronal and synaptic functionality in alzheimer's disease and parkinson's disease. |
2015-01-05 |
2023-08-13 |
Not clear |
| Xu Wang, Song Yu, Su-Jie Gao, Jiang-Ping Hu, Yue Wang, Hai-Xing Li. Insulin inhibits Abeta production through modulation of APP processing in a cellular model of Alzheimer's disease. Neuro endocrinology letters. vol 35. issue 3. 2014-12-29. PMID:24977973. |
insulin inhibits abeta production through modulation of app processing in a cellular model of alzheimer's disease. |
2014-12-29 |
2023-08-13 |
Not clear |
| Yanxing Chen, Yang Zhao, Chun-Ling Dai, Zhihou Liang, Xiaoqin Run, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice. Experimental neurology. vol 261. 2014-12-17. PMID:24918340. |
decreased brain insulin signaling has been found recently in alzheimer's disease (ad). |
2014-12-17 |
2023-08-13 |
mouse |
| Yu-Chen Chen, Yun Jiao, Ying Cui, Song-An Shang, Jie Ding, Yuan Feng, Wen Song, Sheng-Hong Ju, Gao-Jun Ten. Aberrant brain functional connectivity related to insulin resistance in type 2 diabetes: a resting-state fMRI study. Diabetes care. vol 37. issue 6. 2014-12-16. PMID:24658392. |
type 2 diabetes is characterized by insulin resistance, which is involved in the development of alzheimer disease. |
2014-12-16 |
2023-08-12 |
Not clear |
| Johanna Zemva, Markus Schuber. The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer's disease: possible therapeutic implications. CNS & neurological disorders drug targets. vol 13. issue 2. 2014-12-05. PMID:24059318. |
recent data suggest that brains of patients with alzheimer's disease (ad) are insulin and insulin-like growth factor-1 (igf-1) resistant. |
2014-12-05 |
2023-08-12 |
mouse |
| Johanna Zemva, Markus Schuber. The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer's disease: possible therapeutic implications. CNS & neurological disorders drug targets. vol 13. issue 2. 2014-12-05. PMID:24059318. |
whether the observed phenomenon of cerebral insulin and igf-1 resistance even at an early stage of alzheimer's disease is cause, consequence or possibly counter-regulation to ad-pathology needs further investigation and should lead to critical discussions. |
2014-12-05 |
2023-08-12 |
mouse |
| Mohammad A Kamal, Shubha Priyamvada, Arivarasu N Anbazhagan, Nasimudeen R Jabir, Shams Tabrez, Nigel H Grei. Linking Alzheimer's disease and type 2 diabetes mellitus via aberrant insulin signaling and inflammation. CNS & neurological disorders drug targets. vol 13. issue 2. 2014-12-05. PMID:24074448. |
linking alzheimer's disease and type 2 diabetes mellitus via aberrant insulin signaling and inflammation. |
2014-12-05 |
2023-08-12 |
Not clear |
| Yanxing Chen, Yanqiu Deng, Baorong Zhang, Cheng-Xin Gon. Deregulation of brain insulin signaling in Alzheimer's disease. Neuroscience bulletin. vol 30. issue 2. 2014-12-03. PMID:24652456. |
deregulation of brain insulin signaling in alzheimer's disease. |
2014-12-03 |
2023-08-12 |
Not clear |