| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Auriel A Willette, Guofan Xu, Sterling C Johnson, Alex C Birdsill, Erin M Jonaitis, Mark A Sager, Bruce P Hermann, Asenath La Rue, Sanjay Asthana, Barbara B Bendli. Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes care. vol 36. issue 2. 2013-08-19. PMID:23069842. |
insulin resistance dysregulates glucose uptake and other functions in brain areas affected by alzheimer disease. |
2013-08-19 |
2023-08-12 |
Not clear |
| Auriel A Willette, Guofan Xu, Sterling C Johnson, Alex C Birdsill, Erin M Jonaitis, Mark A Sager, Bruce P Hermann, Asenath La Rue, Sanjay Asthana, Barbara B Bendli. Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes care. vol 36. issue 2. 2013-08-19. PMID:23069842. |
insulin resistance may play a role in alzheimer disease etiopathogenesis. |
2013-08-19 |
2023-08-12 |
Not clear |
| Auriel A Willette, Guofan Xu, Sterling C Johnson, Alex C Birdsill, Erin M Jonaitis, Mark A Sager, Bruce P Hermann, Asenath La Rue, Sanjay Asthana, Barbara B Bendli. Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes care. vol 36. issue 2. 2013-08-19. PMID:23069842. |
this longitudinal study examined whether insulin resistance among late middle-aged, cognitively healthy individuals was associated with 1) less gray matter in alzheimer disease-sensitive brain regions and 2) worse cognitive performance. |
2013-08-19 |
2023-08-12 |
Not clear |
| A I Duarte, E Candeias, S C Correia, R X Santos, C Carvalho, S Cardoso, A Plácido, M S Santos, C R Oliveira, P I Moreir. Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration. Biochimica et biophysica acta. vol 1832. issue 4. 2013-06-13. PMID:23314196. |
this is even more relevant since increasing evidence points t2d as a risk factor for alzheimer's disease (ad), supporting the hypothesis that ad is a "type 3 diabetes" or "brain insulin resistant state". |
2013-06-13 |
2023-08-12 |
Not clear |
| Insulin and Alzheimer disease-reply. Archives of neurology. vol 69. issue 5. 2013-06-12. PMID:23753784. |
insulin and alzheimer disease-reply. |
2013-06-12 |
2023-08-12 |
Not clear |
| Suzanne Craft, Brenna Cholerton, Laura D Bake. Insulin and Alzheimer's disease: untangling the web. Journal of Alzheimer's disease : JAD. vol 33 Suppl 1. 2013-06-06. PMID:22936011. |
insulin and alzheimer's disease: untangling the web. |
2013-06-06 |
2023-08-12 |
Not clear |
| Igor A Pomytki. H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria. Current neuropharmacology. vol 10. issue 4. 2013-06-05. PMID:23730255. |
in this view, the accumulation of dysfunctional mitochondria during chronological ageing and alzheimer's disease (ad) is a risk factor that may contribute to the development of dysfunctional cerebral insulin receptor signalling and insulin resistance. |
2013-06-05 |
2023-08-12 |
Not clear |
| Yan Yang, Delin Ma, Yuping Wang, Teng Jiang, Shuhong Hu, Muxun Zhang, Xuefeng Yu, Cheng-Xin Gon. Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes. Journal of Alzheimer's disease : JAD. vol 33. issue 2. 2013-05-28. PMID:22936005. |
we have found dysregulation of brain insulin signaling in both alzheimer's disease (ad) and type 2 diabetes (t2d), which correlates to hyperphosphorylation of tau, a key abnormal tau modification leading to neurofibrillary tangles. |
2013-05-28 |
2023-08-12 |
rat |
| Heather Kenna, Fumiko Hoeft, Ryan Kelley, Tonita Wroolie, Bevin DeMuth, Allan Reiss, Natalie Rasgo. Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22770543. |
fasting plasma insulin and the default mode network in women at risk for alzheimer's disease. |
2013-05-24 |
2023-08-12 |
human |
| Samer O Abdul-Hay, Amy L Lane, Thomas R Caulfield, Clémence Claussin, Juliette Bertrand, Amandine Masson, Shakeel Choudhry, Abdul H Fauq, Guhlam M Maharvi, Malcolm A Leissrin. Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. Journal of medicinal chemistry. vol 56. issue 6. 2013-05-23. PMID:23437776. |
insulin-degrading enzyme (ide) is an atypical zinc-metallopeptidase that degrades insulin and the amyloid ß-protein and is strongly implicated in the pathogenesis of diabetes and alzheimer's disease. |
2013-05-23 |
2023-08-12 |
Not clear |
| Alexandre P Muller, Eduardo Rigon Zimmer, Eduardo Kalinine, Clarissa B Haas, Jean Pierre Oses, Adriano Martimbianco de Assis, Antonio Galina, Diogo O Souza, Luis Valmor Portel. Physical exercise exacerbates memory deficits induced by intracerebroventricular STZ but improves insulin regulation of H₂O₂ production in mice synaptosomes. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22475793. |
insulin brain resistant state is associated with cognitive deficits and alzheimer's disease by mechanisms that may involve mitochondrial damage and oxidative stress. |
2013-05-15 |
2023-08-12 |
mouse |
| Fernanda G De Felic. Alzheimer's disease and insulin resistance: translating basic science into clinical applications. The Journal of clinical investigation. vol 123. issue 2. 2013-05-13. PMID:23485579. |
alzheimer's disease and insulin resistance: translating basic science into clinical applications. |
2013-05-13 |
2023-08-12 |
human |
| Fernanda G De Felic. Alzheimer's disease and insulin resistance: translating basic science into clinical applications. The Journal of clinical investigation. vol 123. issue 2. 2013-05-13. PMID:23485579. |
intriguingly, a connection between these diseases has been established during the past decade, since insulin resistance, a hallmark of type 2 diabetes, also develops in alzheimer brains. |
2013-05-13 |
2023-08-12 |
human |
| Fernanda G De Felic. Alzheimer's disease and insulin resistance: translating basic science into clinical applications. The Journal of clinical investigation. vol 123. issue 2. 2013-05-13. PMID:23485579. |
in this article, the molecular and cellular mechanisms underlying defective brain insulin signaling in ad are discussed, with emphasis on evidence that alzheimer's and diabetes share common inflammatory signaling pathways. |
2013-05-13 |
2023-08-12 |
human |
| Robert Nisticò, Virve Cavallucci, Sonia Piccinin, Simone Macrì, Marco Pignatelli, Bisan Mehdawy, Fabio Blandini, Giovanni Laviola, Davide Lauro, Nicola B Mercuri, Marcello D'Ameli. Insulin receptor β-subunit haploinsufficiency impairs hippocampal late-phase LTP and recognition memory. Neuromolecular medicine. vol 14. issue 4. 2013-05-07. PMID:22661254. |
since ir expression is diminished in type-2 diabetes as well as in alzheimer's disease (ad) patients, these data may provide a mechanistic link between insulin resistance, impaired synaptic transmission and cognitive decline in humans with metabolic disorders. |
2013-05-07 |
2023-08-12 |
mouse |
| Sónia C Correia, Renato X Santos, Cristina Carvalho, Susana Cardoso, Emanuel Candeias, Maria S Santos, Catarina R Oliveira, Paula I Moreir. Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation. Brain research. vol 1441. 2013-05-06. PMID:22290178. |
insulin signaling, glucose metabolism and mitochondria: major players in alzheimer's disease and diabetes interrelation. |
2013-05-06 |
2023-08-12 |
Not clear |
| Sónia C Correia, Renato X Santos, Cristina Carvalho, Susana Cardoso, Emanuel Candeias, Maria S Santos, Catarina R Oliveira, Paula I Moreir. Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation. Brain research. vol 1441. 2013-05-06. PMID:22290178. |
this review discusses clinical and biochemical features shared by alzheimer's disease and diabetes, giving special attention to the involvement of insulin signaling, glucose metabolism and mitochondria. |
2013-05-06 |
2023-08-12 |
Not clear |
| Taisa Oliveira Santos, Caio Henrique Yokoyama Mazucanti, Gilberto Fernando Xavier, Andréa Silva Torrã. Early and late neurodegeneration and memory disruption after intracerebroventricular streptozotocin. Physiology & behavior. vol 107. issue 3. 2013-05-03. PMID:22921433. |
glucose metabolism and insulin signaling disruptions in the brain have been proposed as a likely etiology of alzheimer's disease. |
2013-05-03 |
2023-08-12 |
rat |
| Emanuel Candeias, Ana I Duarte, Cristina Carvalho, Sónia C Correia, Susana Cardoso, Renato X Santos, Ana I Plácido, George Perry, Paula I Moreir. The impairment of insulin signaling in Alzheimer's disease. IUBMB life. vol 64. issue 12. 2013-04-30. PMID:23129399. |
the impairment of insulin signaling in alzheimer's disease. |
2013-04-30 |
2023-08-12 |
Not clear |
| Wei-Na Han, Christian Hölscher, Li Yuan, Wei Yang, Xiao-Hui Wang, Mei-Na Wu, Jin-Shun Q. Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats. Neurobiology of aging. vol 34. issue 2. 2013-04-29. PMID:22592020. |
type 2 diabetes mellitus is a risk factor of alzheimer's disease (ad), most likely linked to an impairment of insulin signaling in the brain. |
2013-04-29 |
2023-08-12 |
rat |