| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhao Chen, Wei Ye, Zhe Long, Dongxue Ding, Huirong Peng, Xuan Hou, Rong Qiu, Kun Xia, Beisha Tang, Hong Jian. Targeted Next-Generation Sequencing Revealed Novel Mutations in Chinese Ataxia Telangiectasia Patients: A Precision Medicine Perspective. PloS one. vol 10. issue 10. 2016-06-02. PMID:26439923. |
ataxia telangiectasia (at) is an autosomal recessive disease characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia and immunodeficiency due to mutations in the atm gene. |
2016-06-02 |
2023-08-13 |
Not clear |
| Indrabahadur Singh, Nihan Ozturk, Julio Cordero, Aditi Mehta, Diya Hasan, Claudia Cosentino, Carlos Sebastian, Marcus Krüger, Mario Looso, Gianni Carraro, Saverio Bellusci, Werner Seeger, Thomas Braun, Raul Mostoslavsky, Guillermo Barret. High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX. Cell research. vol 25. issue 7. 2016-06-01. PMID:26045162. |
we combined proteomic, chip-seq, and transcriptome data to show that hmga2-induced transcription requires phosphorylation of the histone variant h2ax at s139 (h2axs139ph; γ-h2ax) mediated by the protein kinase ataxia telangiectasia mutated (atm). |
2016-06-01 |
2023-08-13 |
Not clear |
| Zhe-Wei Zhang, Jing Xiao, Wei Luo, Bo-Han Wang, Ji-Min Che. Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis. Chinese medical journal. vol 128. issue 21. 2016-05-23. PMID:26521794. |
caffeine suppresses ataxia telangiectasia and rad3 related and ataxia telangiectasia mutated (atm) activities; atm is the major kinase for dna damage detection. |
2016-05-23 |
2023-08-13 |
Not clear |
| Hajar Fahkri, Bingbing Zhang, Abul Fajol, Nati Hernando, Bernat Elvira, Julia G Mannheim, Bernd J Pichler, Christoph Daniel, Kerstin Amann, Atsushi Hirao, Jillian Haight, Tak W Mak, Florian Lang, Michael Fölle. Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and calcium-phosphate metabolism. Pflugers Archiv : European journal of physiology. vol 467. issue 9. 2016-05-18. PMID:25319519. |
checkpoint kinase 2 (chk2) is the main effector kinase of ataxia telangiectasia mutated (atm) and responsible for cell cycle regulation. |
2016-05-18 |
2023-08-13 |
mouse |
| Xiao-Li Liu, Tian Wang, Xiao-Jun Huang, Hai-Yan Zhou, Xing-Hua Luan, Jun-Yi Shen, Sheng-Di Chen, Li Ca. Novel ATM mutations with ataxia-telangiectasia. Neuroscience letters. vol 611. 2016-05-18. PMID:26628246. |
ataxia-telangiectasia mutated gene (atm) is one of the known genes to be associated with ataxia telangiectasia. |
2016-05-18 |
2023-08-13 |
Not clear |
| Sameer Agnihotri, Kelly Burrell, Pawel Buczkowicz, Marc Remke, Brian Golbourn, Yevgen Chornenkyy, Aaron Gajadhar, Nestor A Fernandez, Ian D Clarke, Mark S Barszczyk, Sanja Pajovic, Christian Ternamian, Renee Head, Nesrin Sabha, Robert W Sobol, Michael D Taylor, James T Rutka, Chris Jones, Peter B Dirks, Gelareh Zadeh, Cynthia Hawkin. ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Cancer discovery. vol 4. issue 10. 2016-05-16. PMID:25100205. |
in particular, the base excision repair (ber) pathway, including 3-methylpurine-dna glycosylase (mpg), as well as ataxia telangiectasia mutated (atm), were identified in our screen. |
2016-05-16 |
2023-08-13 |
Not clear |
| Madhuri Bhandaru, Magdalena Martinka, Kevin J McElwee, Anand Rott. Prognostic Significance of Nuclear Phospho-ATM Expression in Melanoma. PloS one. vol 10. issue 8. 2016-05-16. PMID:26275218. |
phosphorylation of ataxia telangiectasia mutated (atm) is one of the initial events that follow dna damage. |
2016-05-16 |
2023-08-13 |
Not clear |
| P Mehdipour, F Karami, Firouzeh Javan, M Mehrazi. Linking ATM Promoter Methylation to Cell Cycle Protein Expression in Brain Tumor Patients: Cellular Molecular Triangle Correlation in ATM Territory. Molecular neurobiology. vol 52. issue 1. 2016-05-02. PMID:25159481. |
ataxia telangiectasia mutated (atm) is a key gene in dna double-strand break (dsb), and therefore, most of its disabling genetic alterations play an important initiative role in many types of cancer. |
2016-05-02 |
2023-08-13 |
mouse |
| Yih-Wen Chen, Robert A Harris, Zafer Hatahet, Kai-ming Cho. Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 33. 2016-04-29. PMID:26240351. |
in comparison to wt mice, adipose tissue from pol η(-/-) mice exhibits increased dna damage and a greater dna damage response, indicated by up-regulation and/or phosphorylation of ataxia telangiectasia mutated (atm), phosphorylated h2ax (γh2ax), and poly[adp-ribose] polymerase 1 (parp-1). |
2016-04-29 |
2023-08-13 |
mouse |
| Siwei Liu, Lei Zhou, Yongshun Zhao, Yuhui Yua. β-elemene enhances both radiosensitivity and chemosensitivity of glioblastoma cells through the inhibition of the ATM signaling pathway. Oncology reports. vol 34. issue 2. 2016-04-28. PMID:26062577. |
treatment of gbm cells with β-elemene decreased the phosphorylation of ataxia telangiectasia mutated (atm), akt and erk following radiotherapy or chemotherapy. |
2016-04-28 |
2023-08-13 |
human |
| Fengmei Cui, Rong Fan, Qiu Chen, Yongming He, Man Song, Zengfu Shang, Shimeng Zhang, Wei Zhu, Jianping Cao, Hua Guan, Ping-Kun Zho. The involvement of c-Myc in the DNA double-strand break repair via regulating radiation-induced phosphorylation of ATM and DNA-PKcs activity. Molecular and cellular biochemistry. vol 406. issue 1-2. 2016-04-25. PMID:26049366. |
moreover, depression of c-myc largely attenuated the ionizing radiation-induced phosphorylation of the ataxia telangiectasia mutated (atm) and decreased the in vitro kinase activity of dna-pkcs. |
2016-04-25 |
2023-08-13 |
human |
| James Kain Ching, Larry D Spears, Jennifer L Armon, Allyson L Renth, Stanley Andrisse, Roy L Collins, Jonathan S Fishe. Impaired insulin-stimulated glucose transport in ATM-deficient mouse skeletal muscle. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 38. issue 6. 2016-04-22. PMID:23724874. |
there are reports that ataxia telangiectasia mutated (atm) plays a role in insulin-stimulated akt phosphorylation, although this is not the case in some cell types. |
2016-04-22 |
2023-08-12 |
mouse |
| Hong-Jen Lee, Li Lan, Guang Peng, Wei-Chao Chang, Ming-Chuan Hsu, Ying-Nai Wang, Chien-Chia Cheng, Leizhen Wei, Satoshi Nakajima, Shih-Shin Chang, Hsin-Wei Liao, Chung-Hsuan Chen, Martin Lavin, K Kian Ang, Shiaw-Yih Lin, Mien-Chie Hun. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell research. vol 25. issue 2. 2016-04-18. PMID:25601159. |
ataxia telangiectasia mutated (atm) mediates dna damage response by controling irradiation-induced foci formation, cell cycle checkpoint, and apoptosis. |
2016-04-18 |
2023-08-13 |
Not clear |
| Paolo Cremaschi, Matteo Oliverio, Valentina Leva, Silvia Bione, Roberta Carriero, Giulia Mazzucco, Andrea Palamidessi, Giorgio Scita, Giuseppe Biamonti, Alessandra Montecucc. Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells. PloS one. vol 10. issue 7. 2016-04-18. PMID:26151554. |
this replication stress elicits a constitutive phosphorylation of the ataxia telangiectasia mutated (atm) checkpoint kinase that fails to arrest cell cycle progression or to activate apoptosis or cell senescence. |
2016-04-18 |
2023-08-13 |
human |
| Yung-Jue Bang, Seock-Ah Im, Keun-Wook Lee, Jae Yong Cho, Eun-Kee Song, Kyung Hee Lee, Yeul Hong Kim, Joon Oh Park, Hoo Geun Chun, Dae Young Zang, Anitra Fielding, Jacqui Rowbottom, Darren Hodgson, Mark J O'Connor, Xiaolu Yin, Woo Ho Ki. Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 33. issue 33. 2016-04-18. PMID:26282658. |
gastric cancer cell lines, particularly those with low levels of ataxia telangiectasia mutated (atm), a key activator of dna damage response, are sensitive to the poly (adp-ribose) polymerase inhibitor olaparib. |
2016-04-18 |
2023-08-13 |
Not clear |
| Ebba Lohmann, Stefanie Krüger, Ann-Kathrin Hauser, Hasmet Hanagasi, Gamze Guven, Nihan Erginel-Unaltuna, Saskia Biskup, Thomas Gasse. Clinical variability in ataxia-telangiectasia. Journal of neurology. vol 262. issue 7. 2016-04-11. PMID:25957637. |
both mutations detected in atm have been shown to be pathogenic, and the α-fetoprotein, a marker of ataxia telangiectasia, was found to be increased. |
2016-04-11 |
2023-08-13 |
Not clear |
| Te-Chun Hsia, Ju-Hwa Lin, Shu-Chun Hsu, Nou-Ying Tang, Hsu-Feng Lu, Shin-Hwar Wu, Jaung-Geng Lin, Jing-Gung Chun. Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells. Environmental toxicology. vol 30. issue 10. 2016-04-08. PMID:24639390. |
cantharidin (5, 10, and 15 μm) treatment of nci-h460 cells reduced protein levels of ataxia telangiectasia mutated (atm), breast cancer 1, early onset (brca-1), 14-3-3 proteins sigma (14-3-3σ), dna-dependent serine/threonine protein kinase (dna-pk), o(6) -methylguanine-dna methyltransferase (mgmt), and mediator of dna damage checkpoint protein 1 (mdc1). |
2016-04-08 |
2023-08-12 |
human |
| Wen-Tsong Hsieh, Hui-Yi Lin, Jou-Hsuan Chen, Wen-Chung Lin, Yueh-Hsiung Kuo, W Gibson Wood, Hsu-Feng Lu, Jing-Gung Chun. Latex of Euphorbia antiquorum-induced S-phase arrest via active ATM kinase and MAPK pathways in human cervical cancer HeLa cells. Environmental toxicology. vol 30. issue 10. 2016-04-08. PMID:24706497. |
moreover, ea promoted the activation of ataxia telangiectasia mutated (atm) and check-point kinase-2 (chk2); however, it negatively regulated the expression of topoisomerases i and ii, cdc25a, and cdc25c signaling. |
2016-04-08 |
2023-08-13 |
human |
| Christine E Hellweg, Luis F Spitta, Bernd Henschenmacher, Sebastian Diegeler, Christa Baumstark-Kha. Transcription Factors in the Cellular Response to Charged Particle Exposure. Frontiers in oncology. vol 6. 2016-04-06. PMID:27047795. |
both p53 and nf-κb are activated after ionizing radiation exposure in an ataxia telangiectasia mutated (atm)-dependent manner. |
2016-04-06 |
2023-08-13 |
human |
| Sarah Osterwald, Katharina I Deeg, Inn Chung, Daniel Parisotto, Stefan Wörz, Karl Rohr, Holger Erfle, Karsten Ripp. PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening. Journal of cell science. vol 128. issue 10. 2016-04-05. PMID:25908860. |
these apb-dependent changes correlated with the induction of a dna damage response at telomeres in apbs as evident by a strong enrichment of the phosphorylated form of the ataxia telangiectasia mutated (atm) kinase. |
2016-04-05 |
2023-08-13 |
human |