| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kai-Fu Tang, Cai-Xia He, Gui-Li Zeng, Jinfeng Wu, Guan-Bin Song, Yi-Song Shi, Wei-Guang Zhang, Ai-Long Huang, Alexander Steinle, Hong Re. Induction of MHC class I-related chain B (MICB) by 5-aza-2'-deoxycytidine. Biochemical and biophysical research communications. vol 370. issue 4. 2008-05-30. PMID:18395517. |
furthermore, the upregulation of micb was partially prevented by pharmacological or genetic inhibition of ataxia telangiectasia mutated (atm) kinase. |
2008-05-30 |
2023-08-12 |
Not clear |
| Xuan Fu, Shan Wan, Yi Lisa Lyu, Leroy F Liu, Haiyan Q. Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PloS one. vol 3. issue 4. 2008-05-28. PMID:18431490. |
the major player in response to dsbs is atm (ataxia telangiectasia mutated). |
2008-05-28 |
2023-08-12 |
Not clear |
| Kazuhiko Yamamoto, Abdallah Nihrane, Jason Aglipay, Juan Sironi, Steven Arkin, Jeffrey M Lipton, Toru Ouchi, Johnson M Li. Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: implications for carcinogenesis. Molecular medicine (Cambridge, Mass.). vol 14. issue 3-4. 2008-05-27. PMID:18224251. |
in primary fibroblasts with mutations in the core complex fanca protein, we discovered that basal expression and phosphorylation of atm (ataxia telangiectasia mutated) and p53 induced by irradiation (ir) or mitomycin c (mmc) were upregulated. |
2008-05-27 |
2023-08-12 |
Not clear |
| Sudhakar Sivasubramaniam, Xuemin Sun, Yen-Ru Pan, Shaohui Wang, Eva Y-H P Le. Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes & development. vol 22. issue 5. 2008-05-15. PMID:18283122. |
the activation of the ataxia telangiectasia mutated (atm) and atm/rad3-related (atr) kinases triggers a diverse cellular response including the initiation of dna damage-induced cell cycle checkpoints. |
2008-05-15 |
2023-08-12 |
Not clear |
| Osong Kwon, Kyung A Kim, Long He, Sun Ok Kim, Min Soo Kim, Eun Young Cha, Byung Dae Yoon, Dai Eun Sok, Mira Jung, Jong Seog Ahn, Bo Yeon Ki. Ionizing radiation can induce GSK-3beta phosphorylation and NF-kappaB transcriptional transactivation in ATM-deficient fibroblasts. Cellular signalling. vol 20. issue 4. 2008-05-08. PMID:18243662. |
dna damage by ionizing radiation (ir) can induce activations of both nf-kappab and p53 through the upstream kinase ataxia telangiectasia mutated (atm). |
2008-05-08 |
2023-08-12 |
Not clear |
| Hak-Su Kim, Jin-Taek Hwang, Hee Yun, Sung-Gil Chi, Su-Jae Lee, Insug Kang, Kyung-Sik Yoon, Won-Jae Choe, Sung-Soo Kim, Joohun H. Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53. The Journal of biological chemistry. vol 283. issue 7. 2008-05-05. PMID:18079115. |
we further showed that erk, but not atm (ataxia telangiectasia mutated) and atr (atm- and rad3-related) kinases, was involved in the hyper-induction of p53 by the inhibition of cisplatin-induced ampk. |
2008-05-05 |
2023-08-12 |
Not clear |
| K Lin, N Rockliffe, G G Johnson, P D Sherrington, A R Pettit. Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells. Oncogene. vol 27. issue 17. 2008-05-01. PMID:17982489. |
primary cll cells of defined ataxia telangiectasia mutated (atm)/p53 status were incubated with the hsp90 inhibitor geldanamycin (ga) and analysed by western blotting for the expression of p53, p21, mdm2 and akt. |
2008-05-01 |
2023-08-12 |
Not clear |
| Gang Wei, Karen DeFeo, Candace S Hayes, Patrick M Woster, Laura Mandik-Nayak, Susan K Gilmou. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer research. vol 68. issue 7. 2008-04-25. PMID:18381427. |
phosphorylation of ataxia telangiectasia mutated (atm) and its substrate p53 are significantly induced both in ker/odc and in k6/odc transgenic skin. |
2008-04-25 |
2023-08-12 |
mouse |
| Ariadni Mavrou, George Th Tsangaris, Eleftheria Roma, Aggeliki Kolialex. The ATM gene and ataxia telangiectasia. Anticancer research. vol 28. issue 1B. 2008-04-15. PMID:18383876. |
the atm gene and ataxia telangiectasia. |
2008-04-15 |
2023-08-12 |
Not clear |
| Andrea Berni, Roberta Meschini, Silvia Filippi, Fabrizio Palitti, Andrea De Amicis, Luciana Chess. L-carnitine enhances resistance to oxidative stress by reducing DNA damage in Ataxia telangiectasia cells. Mutation research. vol 650. issue 2. 2008-04-08. PMID:18201923. |
in this study, the modulating effect of l-carnitine on tert-butyl-hydroperoxide-induced dna damage was compared with that of mannitol, a well known scavenger of hydroxyl radicals, both in normal and ataxia telangiectasia mutated (atm)-deficient lymphoblastoid cell lines established from a. telangiectasia (a-t) patients. |
2008-04-08 |
2023-08-12 |
Not clear |
| Romina Marone, Vladimir Cmiljanovic, Bernd Giese, Matthias P Wyman. Targeting phosphoinositide 3-kinase: moving towards therapy. Biochimica et biophysica acta. vol 1784. issue 1. 2008-03-27. PMID:17997386. |
many of the present inhibitor series interfere with target of rapamycin (tor), dna-dependent protein kinase (dna-pk(cs)) and activity of the ataxia telangiectasia mutated gene product (atm). |
2008-03-27 |
2023-08-12 |
mouse |
| Hideaki Nakamur. hTERT-immortalized cells useful for analyzing effects of low-dose-rate radiation on human cells. Journal of radiation research. vol 49. issue 1. 2008-03-17. PMID:18160772. |
the activation of ataxia telangiectasia mutated (atm) protein was confirmed during low-dose-rate radiation, and may play an important role in repair of dna damage induced by low-dose-rate radiation. |
2008-03-17 |
2023-08-12 |
human |
| b' Venturina Stagni, Maria Giovanna di Bari, Silvia Cursi, Ivano Cond\\xc3\\xb2, Maria Teresa Cencioni, Roberto Testi, Yaniv Lerenthal, Enrico Cundari, Daniela Baril\\xc3\\xa. ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells. Blood. vol 111. issue 2. 2008-03-11. PMID:17932249.' |
ataxia telangiectasia (a-t) is a rare cancer-predisposing genetic disease, caused by the lack of functional atm kinase, a major actor of the double strand brakes (dsb) dna-damage response. |
2008-03-11 |
2023-08-12 |
Not clear |
| Elena Gorodetsky, Sarah Calkins, Julia Ahn, P J Brook. ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain. DNA repair. vol 6. issue 11. 2008-02-26. PMID:17706468. |
the genetic disease ataxia telangiectasia (at) results from mutations in the ataxia telangiectasia mutated (atm) gene. |
2008-02-26 |
2023-08-12 |
human |
| Berndt Müller, Jane Blackburn, Carmen Feijoo, Xiujie Zhao, Carl Smyth. DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication. The Journal of cell biology. vol 179. issue 7. 2008-02-25. PMID:18158334. |
interference with caffeine-sensitive checkpoint kinases ataxia telangiectasia and rad3 related (atr)/ataxia telangiectasia mutated (atm) does not affect histone mrna down- regulation, which indicates that atr/atm alone cannot account for such coupling. |
2008-02-25 |
2023-08-12 |
Not clear |
| Xu Li, Yung-Kang Lee, Jen-Chong Jeng, Yun Yen, David C Schultz, Hsiu-Ming Shih, David K An. Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression. The Journal of biological chemistry. vol 282. issue 50. 2008-02-15. PMID:17942393. |
here, we show that doxorubicin (dox) treatment induces kap1 phosphorylation at ser-824 via an ataxia telangiectasia mutated (atm)-dependent manner, correlating with the transcriptional de-repression of p21waf1/cip1 and gadd45alpha. |
2008-02-15 |
2023-08-12 |
Not clear |
| Daniel Alvira, Marc Yeste-Velasco, Jaume Folch, Gemma Casadesús, Mark A Smith, Mercè Pallàs, Antoni Camin. Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons. Journal of neuroscience research. vol 85. issue 14. 2008-02-14. PMID:17638302. |
the aim of the present study was to evaluate the neuroprotective effects of caffeine, an inhibitor of ataxia telangiectasia mutated (atm) enzyme and an antagonist of adenosine receptors, in two models of apoptosis in cerebellar granule neurons (cgns): the inhibition of mitochondrial complex i by the neurotoxin mpp(+) and serum and potassium deprivation. |
2008-02-14 |
2023-08-12 |
Not clear |
| Hiroyuki Takai, Richard C Wang, Kaori K Takai, Haijuan Yang, Titia de Lang. Tel2 regulates the stability of PI3K-related protein kinases. Cell. vol 131. issue 7. 2008-02-07. PMID:18160036. |
the effects of tel2 deletion correlated with significantly reduced protein levels for the pi3k-related kinases ataxia telangiectasia mutated (atm), atm and rad3 related (atr), dna-dependent protein kinase catalytic subunit ataxia (dna-pkcs). |
2008-02-07 |
2023-08-12 |
mouse |
| J-P Qi, S-H Shao, D-D Li, G-P Zho. A dynamic model for the p53 stress response networks under ion radiation. Amino acids. vol 33. issue 1. 2008-01-31. PMID:17072789. |
the model can be successfully used to simulate the dynamic processes of generating the double-strand breaks (dsbs) and their repairing, ataxia telangiectasia mutated (atm) activation, as well as the oscillations occurring in the p53-mdm2 feedback loop. |
2008-01-31 |
2023-08-12 |
Not clear |
| Yan Sun, Katie E Connors, Da-Qing Yan. AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. Molecular and cellular biochemistry. vol 306. issue 1-2. 2008-01-29. PMID:17786544. |
atm is a protein that is deficient in the disease ataxia telangiectasia (a-t). |
2008-01-29 |
2023-08-12 |
mouse |