| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhao-Hui Wu, Shigeki Miyamot. Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress. The EMBO journal. vol 27. issue 14. 2008-07-30. PMID:18583959. |
activation of nf-kappab in response to dna double strand break (dsb) inducers can be mediated by atm (ataxia telangiectasia mutated)-dependent phosphorylation of nemo (nf-kappab essential modulator). |
2008-07-30 |
2023-08-12 |
Not clear |
| Simona Caporali, Lauretta Levati, Giuseppe Starace, Gianluca Ragone, Enzo Bonmassar, Ester Alvino, Stefania D'Atr. AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. Molecular pharmacology. vol 74. issue 1. 2008-07-25. PMID:18413665. |
in this study, we addressed the role of akt in cellular responses to the therapeutic methylating agent temozolomide (tmz), and we investigated the possible link between tmz-induced modulation of akt function and activation of ataxia-telangiectasia and rad3-related (atr)- and ataxia telangiectasia mutated (atm)-dependent signaling pathways. |
2008-07-25 |
2023-08-12 |
human |
| Jason S White, Serah Choi, Christopher J Bakkenis. Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity. Cell cycle (Georgetown, Tex.). vol 7. issue 9. 2008-07-18. PMID:18418045. |
mutations in the atm kinase cause the neurodegenerative disorder ataxia telangiectasia (a-t) and affected individuals are exquisitely radiation-sensitive and cancer-prone. |
2008-07-18 |
2023-08-12 |
Not clear |
| Bu Yin, Velibor Savic, Craig H Bassin. ATM prevents unattended DNA double strand breaks on site and in generations to come. Cancer biology & therapy. vol 6. issue 12. 2008-07-16. PMID:18087222. |
the ataxia telangiectasia mutated gene encodes the atm kinase, a central transducer of dna damage signals. |
2008-07-16 |
2023-08-12 |
Not clear |
| Paola Porcedda, Valentina Turinetto, Alfredo Brusco, Simona Cavalieri, Erica Lantelme, Luca Orlando, Umberto Ricardi, Antonio Amoroso, Dario Gregori, Claudia Giachin. A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasia. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 73. issue 6. 2008-07-15. PMID:18431795. |
ataxia telangiectasia (a-t) is a progressive neurodegenerative disease with onset in early childhood, caused by mutations in the atm (ataxia-telangiectasia mutated) gene. |
2008-07-15 |
2023-08-12 |
Not clear |
| Derek J Richard, Emma Bolderson, Liza Cubeddu, Ross I M Wadsworth, Kienan Savage, Girdhar G Sharma, Matthew L Nicolette, Sergie Tsvetanov, Michael J McIlwraith, Raj K Pandita, Shunichi Takeda, Ronald T Hay, Jean Gautier, Stephen C West, Tanya T Paull, Tej K Pandita, Malcolm F White, Kum Kum Khann. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature. vol 453. issue 7195. 2008-07-03. PMID:18449195. |
ataxia telangiectasia mutated (atm) kinase phosphorylates hssb1 in response to dna double-strand breaks (dsbs). |
2008-07-03 |
2023-08-12 |
human |
| Amit Kulkarni, Kumuda C Da. Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation. American journal of physiology. Lung cellular and molecular physiology. vol 294. issue 5. 2008-06-30. PMID:18344416. |
we have investigated the effect of hyperoxia on dna damage signaling and show that hyperoxia is a unique stress that activates the ataxia telangiectasia mutant (atm)- and rad3-related protein kinase (atr)-dependent p53 phosphorylations (ser6, -15, -37, and -392), phosphorylation of histone h2ax (ser139), and phosphorylation of checkpoint kinase 1 (chk1). |
2008-06-30 |
2023-08-12 |
Not clear |
| Stacey A Rimkus, Rebeccah J Katzenberger, Anthony T Trinh, Gerald E Dodson, Randal S Tibbetts, David A Wassarma. Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes & development. vol 22. issue 9. 2008-06-30. PMID:18408079. |
mutations in atm (ataxia telangiectasia mutated) result in ataxia telangiectasia (a-t), a disorder characterized by progressive neurodegeneration. |
2008-06-30 |
2023-08-12 |
human |
| Evi Soutoglou, Tom Mistel. Activation of the cellular DNA damage response in the absence of DNA lesions. Science (New York, N.Y.). vol 320. issue 5882. 2008-06-30. PMID:18483401. |
we show that prolonged binding of dna repair factors to chromatin can elicit the ddr in an atm (ataxia telangiectasia mutated)- and dnapk (dna-dependent protein kinase)-dependent manner in the absence of dna damage. |
2008-06-30 |
2023-08-12 |
Not clear |
| Elias A Rahal, Leigh A Henricksen, Yuling Li, John J Turchi, Katherine S Pawelczak, Kathleen Dixo. ATM mediates repression of DNA end-degradation in an ATP-dependent manner. DNA repair. vol 7. issue 3. 2008-06-24. PMID:18207464. |
ataxia telangiectasia mutated (atm) is a pi3-kinase-like kinase (pikk) associated with dna double-strand break (dsb) repair and cell cycle control. |
2008-06-24 |
2023-08-12 |
Not clear |
| Katherine Minter-Dykhouse, Irene Ward, Michael S Y Huen, Junjie Chen, Zhenkun Lo. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. The Journal of cell biology. vol 181. issue 5. 2008-06-24. PMID:18504301. |
although 53bp1 and mdc1 have been recently identified as critical upstream mediators in the cellular response to dna double-strand breaks, their relative hierarchy in the ataxia telangiectasia mutated (atm) signaling cascade remains controversial. |
2008-06-24 |
2023-08-12 |
mouse |
| Karen A Boehme, Roman Kulikov, Christine Blattne. p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 22. 2008-06-24. PMID:18505846. |
we show that p53 accumulates in lymphoblasts from patients with the hereditary disorder ataxia telangiectasia in response to ionizing radiation despite the absence of a functional atm kinase. |
2008-06-24 |
2023-08-12 |
Not clear |
| Samuel Sidi, Takaomi Sanda, Richard D Kennedy, Andreas T Hagen, Cicely A Jette, Raymond Hoffmans, Jennifer Pascual, Shintaro Imamura, Shuji Kishi, James F Amatruda, John P Kanki, Douglas R Green, Alan A D'Andrea, A Thomas Loo. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell. vol 133. issue 5. 2008-06-16. PMID:18510930. |
rather, an alternative apoptotic program is engaged that cell autonomously requires atm (ataxia telangiectasia mutated), atr (atm and rad3-related) and caspase-2, and is not affected by p53 loss or overexpression of bcl-2/xl. |
2008-06-16 |
2023-08-12 |
human |
| Kenneth Bødtker Schou, Linda Schneider, Søren Tvorup Christensen, Else Kay Hoffman. Early-stage apoptosis is associated with DNA-damage-independent ATM phosphorylation and chromatin decondensation in NIH3T3 fibroblasts. Cell biology international. vol 32. issue 1. 2008-06-12. PMID:17945518. |
the phosphorylation of protein kinase ataxia telangiectasia mutated (atm) and histone h2a.x was recently shown to occur concurrently with apoptotic dna fragmentation. |
2008-06-12 |
2023-08-12 |
Not clear |
| Masahiro Yamaguchi, Noriko Fujimori-Tonou, Yukihiro Yoshimura, Tsutomu Kishi, Hitoshi Okamoto, Ichiro Masa. Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53. Development (Cambridge, England). vol 135. issue 7. 2008-06-12. PMID:18287205. |
rna synthesis catalyzed by prim1 is important for the activation of the dna damage response, which may activate ataxia telangiectasia mutated (atm), checkpoint kinase 2 (chk2) and the tumor suppressor p53. |
2008-06-12 |
2023-08-12 |
zebrafish |
| J Brunet, S Gutiérrez-Enríquez, A Torres, V Bérez, S Sanjosé, J Galceran, A Izquierdo, J A Menéndez, J Gumà, J Borrà. ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations. Clinical genetics. vol 73. issue 5. 2008-06-03. PMID:18384426. |
heterozygous carriers of atm (ataxia telangiectasia mutated gene) mutations have increased risk of breast cancer (bc). |
2008-06-03 |
2023-08-12 |
Not clear |
| J Brunet, S Gutiérrez-Enríquez, A Torres, V Bérez, S Sanjosé, J Galceran, A Izquierdo, J A Menéndez, J Gumà, J Borrà. ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations. Clinical genetics. vol 73. issue 5. 2008-06-03. PMID:18384426. |
one patient (2.3%) carried the atm deleterious mutation (3802delg that causes ataxia telangiectasia in the homozygous state) and 13 patients carried the 10 atm unclassified variants. |
2008-06-03 |
2023-08-12 |
Not clear |
| Iran Malavazi, Joel Fernandes Lima, Patrícia Alves de Castro, Marcela Savoldi, Maria Helena de Souza Goldman, Gustavo Henrique Goldma. Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway. Genetics. vol 178. issue 2. 2008-06-02. PMID:18245360. |
ataxia telangiectasia mutated (atm) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the dna damage response in eukaryotic cells. |
2008-06-02 |
2023-08-12 |
Not clear |
| Iran Malavazi, Joel Fernandes Lima, Patrícia Alves de Castro, Marcela Savoldi, Maria Helena de Souza Goldman, Gustavo Henrique Goldma. Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway. Genetics. vol 178. issue 2. 2008-06-02. PMID:18245360. |
in humans, mutations in atm cause the devastating neurodegenerative disease ataxia telangiectasia. |
2008-06-02 |
2023-08-12 |
Not clear |
| Navjotsingh Pabla, Shuang Huang, Qing-Sheng Mi, Rene Daniel, Zheng Don. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. The Journal of biological chemistry. vol 283. issue 10. 2008-05-30. PMID:18162465. |
importantly, in the dna damage response, we demonstrate a critical role for atr, but not atm (ataxia telangiectasia mutated) or dna-pk (dna-dependent protein kinase), in cisplatin-induced p53 activation and apoptosis. |
2008-05-30 |
2023-08-12 |
mouse |