| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chuanzhong Ye, Qi Dai, Wei Lu, Qiuyin Cai, Ying Zheng, Xiao-Ou Shu, Kai Gu, Yu-Tang Gao, Wei Zhen. Two-stage case-control study of common ATM gene variants in relation to breast cancer risk. Breast cancer research and treatment. vol 106. issue 1. 2008-01-24. PMID:17431766. |
the ataxia telangiectasia mutated (atm) gene is a tumor suppressor gene that plays a critical role in cell cycle arrest, apoptosis, and dna repair. |
2008-01-24 |
2023-08-12 |
Not clear |
| J P Qi, S H Shao, Jinli Xie, Y Zh. A mathematical model of P53 gene regulatory networks under radiotherapy. Bio Systems. vol 90. issue 3. 2008-01-22. PMID:17512110. |
our model can successfully implement the kinetics of double strand breaks (dsbs) generating and their repair, ataxia telangiectasia mutated (atm) activation, as well as p53-mdm2 feedback regulating. |
2008-01-22 |
2023-08-12 |
Not clear |
| R Scott Williams, Jessica S Williams, John A Taine. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 85. issue 4. 2008-01-22. PMID:17713585. |
contributing to mrn regulatory roles, nbs1 harbors n-terminal phosphopeptide interacting fha and brct domains, as well as c-terminal ataxia telangiectasia mutated (atm) kinase and mre11 interaction domains. |
2008-01-22 |
2023-08-12 |
human |
| Jun Gao, Leah A Mitchell, Fredine T Lauer, Scott W Burchie. p53 and ATM/ATR regulate 7,12-dimethylbenz[a]anthracene-induced immunosuppression. Molecular pharmacology. vol 73. issue 1. 2008-01-16. PMID:17925458. |
ataxia telangiectasia mutated (atm) and atm and rad3-related protein (atr) are sensors for dna damage that signal p53 activation. |
2008-01-16 |
2023-08-12 |
mouse |
| Laurent Vespa, Ross T Warrington, Petr Mokros, Jiri Siroky, Dorothy E Shippe. ATM regulates the length of individual telomere tracts in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 46. 2008-01-10. PMID:17989233. |
we have previously shown that the absence of ataxia telangiectasia mutated (atm), a central regulator of the dna damage response, accelerates the onset of genome instability in telomerase-deficient arabidopsis, without increasing the rate of bulk telomere shortening. |
2008-01-10 |
2023-08-12 |
Not clear |
| Zhongsheng You, Julie M Bailis, Sam A Johnson, Stephen M Dilworth, Tony Hunte. Rapid activation of ATM on DNA flanking double-strand breaks. Nature cell biology. vol 9. issue 11. 2008-01-04. PMID:17952060. |
the tumour-suppressor gene atm, mutations in which cause the human genetic disease ataxia telangiectasia (a-t), encodes a key protein kinase that controls the cellular response to dna double-strand breaks (dsbs). |
2008-01-04 |
2023-08-12 |
human |
| Nadine K Kolas, J Ross Chapman, Shinichiro Nakada, Jarkko Ylanko, Richard Chahwan, Frédéric D Sweeney, Stephanie Panier, Megan Mendez, Jan Wildenhain, Timothy M Thomson, Laurence Pelletier, Stephen P Jackson, Daniel Duroche. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (New York, N.Y.). vol 318. issue 5856. 2007-12-19. PMID:18006705. |
moreover, we establish that mdc1 recruits rnf8 through phosphodependent interactions between the rnf8 forkhead-associated domain and motifs in mdc1 that are phosphorylated by the dna-damage activated protein kinase ataxia telangiectasia mutated (atm). |
2007-12-19 |
2023-08-12 |
Not clear |
| Sarah A Krueger, Spencer J Collis, Michael C Joiner, George D Wilson, Brian Marple. Transition in survival from low-dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM Ser1981 activity. International journal of radiation oncology, biology, physics. vol 69. issue 4. 2007-12-13. PMID:17967316. |
the aim of this study was to define the roles of ataxia telangiectasia mutated (atm) activity and the downstream atm-dependent g(2)-phase cell cycle checkpoint in overcoming hrs and triggering radiation resistance. |
2007-12-13 |
2023-08-12 |
Not clear |
| Belinda Austen, Anna Skowronska, Claire Baker, Judith E Powell, Anne Gardiner, David Oscier, Aneela Majid, Martin Dyer, Reiner Siebert, A Malcolm Taylor, Paul A Moss, Tatjana Stankovi. Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 25. issue 34. 2007-12-13. PMID:17968022. |
the ataxia telangiectasia mutated (atm) gene is located on chromosome 11q and loss of this region is common in b-cell chronic lymphocytic leukemia (cll). |
2007-12-13 |
2023-08-12 |
Not clear |
| Franck Meslin, Jerome Thiery, Catherine Richon, Abdelali Jalil, Salem Chouai. Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells. The Journal of biological chemistry. vol 282. issue 45. 2007-12-12. PMID:17855337. |
our data show furthermore that when t1 cells were treated with streptolysin-o/granzyme b, specific phosphorylation of p53 at ser-15 and ser-37 residues was observed subsequent to the activation of the stress kinases ataxia telangiectasia mutated (atm) and p38k. |
2007-12-12 |
2023-08-12 |
human |
| S Bose, J Starczynski, M Chukwuma, K Baumforth, W Wei, S Morgan, P Byrd, J Ying, R Grundy, J R Mann, Q Tao, A M R Taylor, P G Murray, T Stankovi. Down-regulation of ATM protein in HRS cells of nodular sclerosis Hodgkin's lymphoma in children occurs in the absence of ATM gene inactivation. The Journal of pathology. vol 213. issue 3. 2007-12-07. PMID:17876757. |
individuals with ataxia telangiectasia, caused by biallelic inactivation of the dna damage response gene, ataxia telangiectasia mutated (atm), have a higher risk of chl development. |
2007-12-07 |
2023-08-12 |
Not clear |
| Bing Liang, Jiajing Qiu, Kajan Ratnakumar, Brehon C Lauren. RSC functions as an early double-strand-break sensor in the cell's response to DNA damage. Current biology : CB. vol 17. issue 16. 2007-12-06. PMID:17689960. |
several proteins, including the mrx/n complex, tel1/atm (ataxia telangiectasia mutated), and mec1/atr (atm and rad3 related), have been proposed as sensors of dna damage, yet how they recognize the breaks is poorly understood. |
2007-12-06 |
2023-08-12 |
Not clear |
| Antoni Camins, Ester Verdaguer, Jaume Folch, Carlos Beas-Zarate, Anna Maria Canudas, Mercè Pallà. Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis. Current drug metabolism. vol 8. issue 7. 2007-12-06. PMID:17979659. |
recent findings have established that dna damage, and specifically ataxia telangiectasia mutated protein (atm), is key to the cascade of regulation of neuronal apoptosis. |
2007-12-06 |
2023-08-12 |
Not clear |
| Maurice Reimann, Christoph Loddenkemper, Cornelia Rudolph, Ines Schildhauer, Bianca Teichmann, Harald Stein, Brigitte Schlegelberger, Bernd Dörken, Clemens A Schmit. The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo. Blood. vol 110. issue 8. 2007-11-28. PMID:17562874. |
in this study, we generated ataxia telangiectasia mutated (atm)-proficient and -deficient b-cell lymphomas in emu-myc transgenic mice to examine the role of ddr defects in lymphomagenesis and treatment sensitivity. |
2007-11-28 |
2023-08-12 |
mouse |
| Toshiki Tanaka, Xuan Huang, H Dorota Halicka, Hong Zhao, Frank Traganos, Anthony P Albino, Wei Dai, Zbigniew Darzynkiewic. Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 71. issue 9. 2007-11-28. PMID:17622968. |
this review covers the topic of cytometric assessment of activation of ataxia telangiectasia mutated (atm) protein kinase and histone h2ax phosphorylation on ser139 in response to dna damage, particularly the damage that involves formation of dna double-strand breaks. |
2007-11-28 |
2023-08-12 |
Not clear |
| Jana Prokopcova, Zdenek Kleibl, Claire M Banwell, Petr Pohlreic. The role of ATM in breast cancer development. Breast cancer research and treatment. vol 104. issue 2. 2007-11-27. PMID:17061036. |
the ataxia telangiectasia mutated (atm) protein kinase has a crucial role in response to dna double-strand breaks. |
2007-11-27 |
2023-08-12 |
Not clear |
| Jana Prokopcova, Zdenek Kleibl, Claire M Banwell, Petr Pohlreic. The role of ATM in breast cancer development. Breast cancer research and treatment. vol 104. issue 2. 2007-11-27. PMID:17061036. |
hereditary mutations in the atm gene are the cause of a rare genomic instability syndrome ataxia telangiectasia (at) characterized, among others, by elevated cancer risk. |
2007-11-27 |
2023-08-12 |
Not clear |
| M Preyer, C-W Shu, J Y J Wan. Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals. Cell death and differentiation. vol 14. issue 6. 2007-11-27. PMID:17363963. |
the nuclear abl tyrosine kinase is activated by dna damage through ataxia telangiectasia mutated (atm). |
2007-11-27 |
2023-08-12 |
mouse |
| Payal Sipahimalani, John J Spinelli, Amy C MacArthur, Agnes Lai, Stephen R Leach, Rozmin T Janoo-Gilani, Diana L Palmquist, Joseph M Connors, Randy D Gascoyne, Richard P Gallagher, Angela R Brooks-Wilso. A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma. International journal of cancer. vol 121. issue 9. 2007-11-27. PMID:17640065. |
the ataxia telangiectasia mutated (atm) gene is critical for the detection and repair of dna double-stranded breaks. |
2007-11-27 |
2023-08-12 |
Not clear |
| Verónica Rodríguez-Bravo, Sandra Guaita-Esteruelas, Roger Florensa, Oriol Bachs, Neus Agel. Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951182. |
in xenopus, caffeine-sensitive kinases [ataxia telangiectasia mutated (atm) and atm-related protein (atr)] are essential in this checkpoint response, but in mammal cells an atr/atm-independent checkpoint response to dna synthesis inhibition exists. |
2007-11-26 |
2023-08-12 |
xenopus_laevis |