| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremy A Daniel, Manuela Pellegrini, Ji-Hoon Lee, Tanya T Paull, Lionel Feigenbaum, André Nussenzwei. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. The Journal of cell biology. vol 183. issue 5. 2008-12-29. PMID:19047460. |
cellular responses to both physiological and pathological dna double-strand breaks are initiated through activation of the evolutionarily conserved ataxia telangiectasia mutated (atm) kinase. |
2008-12-29 |
2023-08-12 |
mouse |
| Yuan He, Qianming Chen, Bingqi L. ATM in oral carcinogenesis: association with clinicopathological features. Journal of cancer research and clinical oncology. vol 134. issue 9. 2008-12-19. PMID:18288488. |
the ataxia telangiectasia mutated (atm) gene plays a critical role in dna damage response. |
2008-12-19 |
2023-08-12 |
Not clear |
| Belinda Austen, Giancarlo Barone, Anne Reiman, Philip J Byrd, Claire Baker, Jane Starczynski, Michael C Nobbs, Raymond P Murphy, Helen Enright, Elijah Chaila, John Quinn, Tatjana Stankovic, Guy Pratt, A Malcolm R Taylo. Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients. British journal of haematology. vol 142. issue 6. 2008-12-11. PMID:18573109. |
ataxia telangiectasia (a-t) patients have biallelic inactivation of the atm gene and exhibit a 200-fold-increased frequency of lymphoid tumours. |
2008-12-11 |
2023-08-12 |
Not clear |
| Thilakavathy Thangasamy, Sivanandane Sittadjody, Kirsten H Limesand, Randy Bur. Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine. Cellular oncology : the official journal of the International Society for Cellular Oncology. vol 30. issue 5. 2008-11-10. PMID:18791269. |
here, we demonstrate that tyrosinase which is commonly overexpressed in melanoma activates the bioflavonoid quercetin (qct) and promotes an ataxia telangiectasia mutated (atm)-dependent dna damage response. |
2008-11-10 |
2023-08-12 |
Not clear |
| Safak Yalcin, Xin Zhang, Julia P Luciano, Sathish Kumar Mungamuri, Dragan Marinkovic, Cécile Vercherat, Abby Sarkar, Marcos Grisotto, Reshma Taneja, Saghi Ghaffar. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. The Journal of biological chemistry. vol 283. issue 37. 2008-10-23. PMID:18424439. |
regulation of ros by the tumor suppressor protein ataxia telangiectasia mutated (atm) is critical for preserving the hematopoietic stem cell pool. |
2008-10-23 |
2023-08-12 |
Not clear |
| Andrea L Bredemeyer, Ching-Yu Huang, Laura M Walker, Craig H Bassing, Barry P Sleckma. Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 4. 2008-10-06. PMID:18684952. |
in contrast to wild-type cells, hybrid joint formation occurs at high levels in ataxia telangiectasia mutated (atm)-deficient lymphocytes, suggesting that atm functions to limit the formation of these aberrant joints. |
2008-10-06 |
2023-08-12 |
Not clear |
| Manabu Koike, Minako Mashino, Jun Sugasawa, Aki Koik. Histone H2AX phosphorylation independent of ATM after X-irradiation in mouse liver and kidney in situ. Journal of radiation research. vol 49. issue 4. 2008-09-16. PMID:18413980. |
although ataxia telangiectasia mutated (atm) kinase phosphorylates ser-139 of h2ax in vitro, the post-translational modification pattern and the modifier of h2ax in organs in vivo are not yet well understood. |
2008-09-16 |
2023-08-12 |
mouse |
| E R Staples, E M McDermott, A Reiman, P J Byrd, S Ritchie, A M R Taylor, E G Davie. Immunodeficiency in ataxia telangiectasia is correlated strongly with the presence of two null mutations in the ataxia telangiectasia mutated gene. Clinical and experimental immunology. vol 153. issue 2. 2008-09-15. PMID:18505428. |
a retrospective review of clinical history, immunological findings, ataxia telangiectasia mutated (atm) enzyme activity and atm mutation type was conducted on 80 consecutive patients attending the national clinic for ataxia telangiectasia, nottingham, uk between 1994 and 2006. |
2008-09-15 |
2023-08-12 |
Not clear |
| Q X Paulson, R V Pusapati, S Hong, R L Weaks, C J Conti, D G Johnso. Transgenic expression of E2F3a causes DNA damage leading to ATM-dependent apoptosis. Oncogene. vol 27. issue 36. 2008-09-11. PMID:18469863. |
many early stage human tumors display markers of a dna-damage response (ddr), including ataxia telangiectasia mutated (atm) kinase activation. |
2008-09-11 |
2023-08-12 |
mouse |
| Myriam Gorospe, Rafael de Cab. AsSIRTing the DNA damage response. Trends in cell biology. vol 18. issue 2. 2008-09-08. PMID:18215521. |
sirt1 was recently shown to deacetylate the nijmegen breakage syndrome (nbs1) protein, thereby rendering it phosphorylatable by ataxia telangiectasia mutated protein (atm). |
2008-09-08 |
2023-08-12 |
Not clear |
| Shane R Mayack, Amy J Wager. Osteolineage niche cells initiate hematopoietic stem cell mobilization. Blood. vol 112. issue 3. 2008-09-05. PMID:18456874. |
effects of mobilization on osteoblast number and function depend on the function of ataxia telangiectasia mutated (atm), the product of the atm gene, demonstrating a new role for atm in stem cell niche activity. |
2008-09-05 |
2023-08-12 |
mouse |
| Linda J Kuo, Li-Xi Yan. Gamma-H2AX - a novel biomarker for DNA double-strand breaks. In vivo (Athens, Greece). vol 22. issue 3. 2008-08-29. PMID:18610740. |
it is phosphorylated by kinases such as ataxia telangiectasia mutated (atm) and atm-rad3-related (atr) in the pi3k pathway. |
2008-08-29 |
2023-08-12 |
Not clear |
| Kai-Fu Tang, Hong Ren, Jia Cao, Gui-Li Zeng, Jing Xie, Min Chen, Lu Wang, Cai-Xia H. Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB. The Journal of cell biology. vol 182. issue 2. 2008-08-26. PMID:18644891. |
up-regulation of mica and micb by dicer knockdown is prevented by pharmacologic or genetic inhibition of dna damage pathway components, including ataxia telangiectasia mutated (atm) kinase, atm- and rad3-related kinase, or checkpoint kinase 1. |
2008-08-26 |
2023-08-12 |
human |
| Xiao-Ming Wang, Jiao Li, Xiao-Cheng Feng, Qiong Wang, Dong-Yin Guan, Zong-Hou She. Involvement of the role of Chk1 in lithium-induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells. Journal of cellular biochemistry. vol 104. issue 4. 2008-08-20. PMID:18247328. |
interestingly, the increase of chk1 activity by lithium may be independent of ataxia telangiectasia mutated (atm)/atm and rad3-related (atr) kinase. |
2008-08-20 |
2023-08-12 |
Not clear |
| Jean-Luc Perfettini, Roberta Nardacci, Mehdi Bourouba, Frédéric Subra, Laurent Gros, Claire Séror, Gwenola Manic, Filippo Rosselli, Alessandra Amendola, Peggy Masdehors, Luciana Chessa, Giuseppe Novelli, David M Ojcius, Jan Konrad Siwicki, Magdalena Chechlinska, Christian Auclair, José R Regueiro, Hugues de Thé, Marie-Lise Gougeon, Mauro Piacentini, Guido Kroeme. Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia. PloS one. vol 3. issue 6. 2008-08-20. PMID:18560558. |
dna damage can activate the oncosuppressor protein ataxia telangiectasia mutated (atm), which phosphorylates the histone h2ax within characteristic dna damage foci. |
2008-08-20 |
2023-08-12 |
human |
| Denis A Smirnov, Vivian G Cheun. ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs. American journal of human genetics. vol 83. issue 2. 2008-08-20. PMID:18674748. |
here, we studied ataxia telangiectasia (at), a classical recessive disorder caused by mutations in the ataxia telangiectasia mutated (atm) gene. |
2008-08-20 |
2023-08-12 |
human |
| Aaron A Goodarzi, Angela T Noon, Dorothee Deckbar, Yael Ziv, Yosef Shiloh, Markus Löbrich, Penny A Jegg. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Molecular cell. vol 31. issue 2. 2008-08-12. PMID:18657500. |
ataxia telangiectasia mutated (atm) signaling is essential for the repair of a subset of dna double-strand breaks (dsbs); however, its precise role is unclear. |
2008-08-12 |
2023-08-12 |
Not clear |
| S C Gehen, R J Staversky, R A Bambara, P C Keng, M A O'Reill. hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress. Oncogene. vol 27. issue 29. 2008-08-07. PMID:18332866. |
previous work showed that the pikk ataxia telangiectasia mutated (atm) but not atm and rad3 related phosphorylates p53 (ser15) during hyperoxia, a model of prolonged oxidative stress and dna damage. |
2008-08-07 |
2023-08-12 |
Not clear |
| Arif O Khan, Darren T Oystreck, Michel Koenig, Mustafa A Sali. Ophthalmic features of ataxia telangiectasia-like disorder. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. vol 12. issue 2. 2008-08-06. PMID:18083591. |
ataxia telangiectasia (at) is a recessive neurodegenerative disease due to a faulty repair mechanism for breaks in double-stranded dna (atm mutation). |
2008-08-06 |
2023-08-12 |
Not clear |
| Ying Yan, Claudine P Black, Phu T Cao, Jamie L Haferbier, Ryan H Kolb, Rebecca S Spieker, Alexandra M Ristow, Kenneth H Cowa. Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1. Cancer research. vol 68. issue 13. 2008-08-05. PMID:18593910. |
although brca1 expression is not required for ir-induced phosphorylation of ataxia telangiectasia mutated (atm)-ser1981, it is required for atm-mediated downstream signaling events, including ir-induced phosphorylation of chk2-thr68 and p53-ser20. |
2008-08-05 |
2023-08-12 |
Not clear |