| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Long He, Sun Ok Kim, Osong Kwon, Sook Jung Jeong, Min Soo Kim, Hee Gu Lee, Hiroyuki Osada, Mira Jung, Jong Seog Ahn, Bo Yeon Ki. ATM blocks tunicamycin-induced endoplasmic reticulum stress. FEBS letters. vol 583. issue 5. 2009-04-10. PMID:19302790. |
endoplasmic reticulum stress (er-stress) is associated with ataxia telangiectasia mutated (atm) gene. |
2009-04-10 |
2023-08-12 |
Not clear |
| Pradyumna Kumar Mishra, Hariom Panwar, Arpit Bhargava, Venkata Raghuram Gorantla, Subodh Kumar Jain, Smita Banerjee, Kewal Krishan Mauda. Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes. Journal of biochemical and molecular toxicology. vol 22. issue 6. 2009-04-08. PMID:19111005. |
evaluation of dna damage by ataxia telangiectasia mutated (atm) and gamma h2ax protein phosphorylation states; measure of apoptotic index through annexin-v/pi assay, apoptotic dna ladder assay, and mitochondrial depolarization; induction of oxidative stress by cm-h2dcfda and formation of 8-hydroxy-2' deoxy guanosine; levels of antioxidant defense system enzyme glutathione reductase; and multiplex cytometric bead array analysis to quantify the secreted levels of inflammatory cytokines, interleukin-8, interleukin-1beta, interleukin-6, interleukin-10, tumor necrosis factor, and interleukin-12p70 parameters were carried out. |
2009-04-08 |
2023-08-12 |
human |
| Hong Jiang, Beisha Tang, Zhengmao Hu, Kun Xia, Bo Xu, Jianguang Tang, Lu She. [ATM gene mutations in Chinese patients with ataxia telangiectasia]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 22. issue 2. 2009-04-02. PMID:15793768. |
[atm gene mutations in chinese patients with ataxia telangiectasia]. |
2009-04-02 |
2023-08-12 |
Not clear |
| Hideo Tsuji, Hiroko Ishii-Ohba, Yuko Noda, Eiko Kubo, Takeshi Furuse, Kouichi Tatsum. Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice. Mutation research. vol 660. issue 1-2. 2009-03-24. PMID:19000702. |
we compared the incidence and latency of thymic lymphomas, and associated rearrangements of the representative oncogene notch1 among rag2(-/-), ataxia telangiectasia mutated (atm)(-/-), and severe combined immune deficiency (scid) mice combined with rag2 deficiency. |
2009-03-24 |
2023-08-12 |
mouse |
| Chaoyang Wen, Xiang He, Hongfang Ma, Ningbo Hou, Congwen Wei, Ting Song, Yanhong Zhang, Liping Sun, Qingjun Ma, Hui Zhon. Hepatitis C virus infection downregulates the ligands of the activating receptor NKG2D. Cellular & molecular immunology. vol 5. issue 6. 2009-03-20. PMID:19118515. |
in our study, we found hcv infection could trigger dna damage response by both ataxia telangiectasia mutated (atm) and atm- and rad3-related (atr) pathways. |
2009-03-20 |
2023-08-12 |
Not clear |
| Daina Lim, Koh Mei-Xin Jocelyn, George Wai-Cheong Yip, Boon-Huat Ba. Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells. Cancer letters. vol 276. issue 1. 2009-03-18. PMID:19062161. |
to elucidate the underlying molecular mechanism, we examined the expression of cell cycle related genes in mt-2a-silenced cells and found a higher expression of the ataxia telangiectasia mutated (atm) gene concomitant with a lower expression of the cdc25a gene. |
2009-03-18 |
2023-08-12 |
Not clear |
| J Grosjean-Raillard, M Tailler, L Adès, J-L Perfettini, C Fabre, T Braun, S De Botton, P Fenaux, G Kroeme. ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene. vol 28. issue 8. 2009-03-18. PMID:19079347. |
here, we show that an mds/aml model cell line exhibits a constitutive interaction, within the nucleus, of activated, s1981-phosphorylated ataxia telangiectasia mutated (atm) with nemo. |
2009-03-18 |
2023-08-12 |
Not clear |
| Fuquan Zhang, Yong Xu, Pozi Liu, Hua Fan, Xuezhu Huang, Gaoxiang Sun, Yuqing Song, Pak C Sha. Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population. BMC medical genetics. vol 9. 2009-03-18. PMID:19115993. |
the blood-derived rna levels of the adenylosuccinate synthase (adss) and ataxia telangiectasia mutated (atm) genes were found to be down- and up-regulated, respectively, in schizophrenics compared with controls, and adss and atm were among eight biomarker genes to discriminate schizophrenics from normal controls. |
2009-03-18 |
2023-08-12 |
Not clear |
| Julia Leemput, Christel Masson, Karine Bigot, Abdelmounaim Errachid, Anouk Dansault, Alexandra Provost, Stéphanie Gadin, Said Aoufouchi, Maurice Menasche, Marc Abitbo. ATM localization and gene expression in the adult mouse eye. Molecular vision. vol 15. 2009-03-17. PMID:19234633. |
one major molecular factor in the ddr is the protein, ataxia telangiectasia mutated (atm). |
2009-03-17 |
2023-08-12 |
mouse |
| J-L Perfettini, R Nardacci, C Séror, M Bourouba, F Subra, L Gros, G Manic, A Amendola, P Masdehors, F Rosselli, D M Ojcius, C Auclair, H de Thé, M-L Gougeon, M Piacentini, G Kroeme. The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope. Cell death and differentiation. vol 16. issue 2. 2009-03-16. PMID:19023333. |
using a range of specific inhibitors of pml (the oncogenic pml/raralpha fusion product or specific small interfering rnas), we demonstrated that, in env-elicited syncytia, pml was required for activating phosphorylation of ataxia telangiectasia mutated (atm), which colocalized with pml in nuclear bodies, in a molecular complex that also involved topoisomerase iibeta-binding protein 1. |
2009-03-16 |
2023-08-12 |
human |
| L Ciapponi, G Cenc. Telomere capping and cellular checkpoints: clues from fruit flies. Cytogenetic and genome research. vol 122. issue 3-4. 2009-03-11. PMID:19188707. |
these include the mre11-rad50-nbs (mrn) complex and the ataxia telangiectasia mutated (atm) kinase, which are required to prevent telomeric fusions. |
2009-03-11 |
2023-08-12 |
human |
| Shikha Bose, Lee-Fah Yap, Matthew Fung, Jane Starzcynski, Amyza Saleh, Susan Morgan, Christopher Dawson, Marilyn B Chukwuma, Esther Maina, Maike Buettner, Wenbin Wei, John Arrand, Paul V H Lim, Lawrence S Young, Soo Hwang Teo, Tatjana Stankovic, Ciaran B J Woodman, Paul G Murra. The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. The Journal of pathology. vol 217. issue 3. 2009-02-20. PMID:19142888. |
a micro-array analysis using biopsies from patients with ebv-positive undifferentiated nasopharyngeal carcinoma (npc) and from cancer-free controls revealed down-regulation of tumour suppressor genes (tsg) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (atm) gene. |
2009-02-20 |
2023-08-12 |
Not clear |
| Kay E Gurley, Russell Moser, Yansong Gu, Paul Hasty, Christopher J Kem. DNA-PK suppresses a p53-independent apoptotic response to DNA damage. EMBO reports. vol 10. issue 1. 2009-02-13. PMID:19057578. |
this p53-independent apoptotic response was specific to the loss of dna-pk, as it was not seen in ligase iv (lig4)/p53 or ataxia telangiectasia mutated (atm)/p53 double-null mice. |
2009-02-13 |
2023-08-12 |
mouse |
| Ariel E Hirsch, David P Atencio, Barry S Rosenstei. Screening for ATM sequence alterations in African-American women diagnosed with breast cancer. Breast cancer research and treatment. vol 107. issue 1. 2009-02-03. PMID:17333338. |
women who are heterozygous for variants in the ataxia telangiectasia mutated (atm) gene, atm carriers, have been reported to be at increased risk for breast cancer compared with women who do not posses an alteration in this gene. |
2009-02-03 |
2023-08-12 |
Not clear |
| Erin R P Shull, Youngsoo Lee, Hironobu Nakane, Travis H Stracker, Jingfeng Zhao, Helen R Russell, John H J Petrini, Peter J McKinno. Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes & development. vol 23. issue 2. 2009-01-29. PMID:19171781. |
the mrn complex (mre11/rad50/nbs1) and atm (ataxia telangiectasia, mutated) are critical for the cellular response to dna damage. |
2009-01-29 |
2023-08-12 |
mouse |
| Erin R P Shull, Youngsoo Lee, Hironobu Nakane, Travis H Stracker, Jingfeng Zhao, Helen R Russell, John H J Petrini, Peter J McKinno. Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes & development. vol 23. issue 2. 2009-01-29. PMID:19171781. |
atm disruption causes ataxia telangiectasia (a-t), while mrn dysfunction can lead to a-t-like disease (atld) or nijmegen breakage syndrome (nbs). |
2009-01-29 |
2023-08-12 |
mouse |
| Nnennaya Kanu, Axel Behren. ATMINistrating ATM signalling: regulation of ATM by ATMIN. Cell cycle (Georgetown, Tex.). vol 7. issue 22. 2009-01-28. PMID:19001856. |
the checkpoint kinase atm (ataxia telangiectasia mutated) transduces genomic stress signals to halt cell cycle progression and promote dna repair in response to dna damage. |
2009-01-28 |
2023-08-12 |
Not clear |
| Cassandra J Adams, Anne L Graham, Martin Jansson, Amanda S Coutts, Mariola Edelmann, Linda Smith, Benedikt Kessler, Nicholas B La Thangu. ATM and Chk2 kinase target the p53 cofactor Strap. EMBO reports. vol 9. issue 12. 2009-01-23. PMID:18833288. |
the p53 cofactor strap (stress responsive activator of p300) is directly targeted by the dna damage signalling pathway where phosphorylation by atm (ataxia telangiectasia mutated) kinase facilitates nuclear accumulation. |
2009-01-23 |
2023-08-12 |
Not clear |
| Lufen Chang, Bingsen Zhou, Shuya Hu, Robin Guo, Xiyong Liu, Stephen N Jones, Yun Ye. ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 47. 2009-01-07. PMID:19015526. |
here, we demonstrate that p53r2 becomes rapidly phosphorylated at ser(72) by ataxia telangiectasia mutated (atm) within 30 min after genotoxic stress. |
2009-01-07 |
2023-08-12 |
Not clear |
| Simone Difilippantonio, Eric Gapud, Nancy Wong, Ching-Yu Huang, Grace Mahowald, Hua Tang Chen, Michael J Kruhlak, Elsa Callen, Ferenc Livak, Michel C Nussenzweig, Barry P Sleckman, André Nussenzwei. 53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature. vol 456. issue 7221. 2008-12-29. PMID:18931658. |
53bp1 is a dna-damage-response protein that is rapidly recruited to sites of chromosomal double-strand breaks, where it seems to function in a subset of ataxia telangiectasia mutated (atm) kinase-, h2a histone family member x (h2ax, also known as h2afx)- and mediator of dna damage checkpoint 1 (mdc1)-dependent events. |
2008-12-29 |
2023-08-12 |
mouse |