| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katsura Suzuki, Kiyoshi Inageda, Gen Nishitai, Masato Matsuok. Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: involvement of ATM pathway. Toxicology and applied pharmacology. vol 220. issue 1. 2007-05-11. PMID:17292432. |
the silencing of ataxia telangiectasia mutated (atm) expression using short-interference rna resulted in the marked suppression of ser15 phosphorylation in a549 cells exposed to navo(3). |
2007-05-11 |
2023-08-12 |
human |
| Janet E Baulch, Ming-Wen Li, Otto G Raab. Effect of ATM heterozygosity on heritable DNA damage in mice following paternal F0 germline irradiation. Mutation research. vol 616. issue 1-2. 2007-05-02. PMID:17161850. |
the ataxia telangiectasia mutated (atm) gene product maintains genome integrity and initiates cellular dna repair pathways following exposures to genotoxic agents. |
2007-05-02 |
2023-08-12 |
mouse |
| Geneviève Vaudan Vutskits, Patrick Salmon, Laurence Mayor, Laszlo Vutskits, Christophe Cudré-Mauroux, Jesus Soriano, Roberto Montesano, Philippe Maillet, André-Pascal Sappin. A role for atm in E-cadherin-mediated contact inhibition in epithelial cells. Breast cancer research and treatment. vol 99. issue 2. 2007-04-17. PMID:16541306. |
ataxia telangiectasia is a hereditary pleiomorphic syndrome caused by loss of atm, a phosphoprotein involved in multiple signaling pathways. |
2007-04-17 |
2023-08-12 |
Not clear |
| Ilka Dauth, Jana Krüger, Thomas G Hofman. Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. Cancer research. vol 67. issue 5. 2007-04-12. PMID:17332358. |
moreover, we show that hipk2 activation after ir is regulated by the dna damage checkpoint kinase ataxia telangiectasia mutated (atm). |
2007-04-12 |
2023-08-12 |
Not clear |
| M Oliva-Trastoy, V Berthonaud, A Chevalier, C Ducrot, M-C Marsolier-Kergoat, C Mann, F Leteurtr. The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase. Oncogene. vol 26. issue 10. 2007-04-10. PMID:16936775. |
in response to dna damage, ataxia telangiectasia mutated (atm) phosphorylates the chk2 tumour suppressor kinase at threonine 68 (thr68), allowing chk2 kinase dimerization and activation by autophosphorylations in the t-loop. |
2007-04-10 |
2023-08-12 |
Not clear |
| Julie Adam, Bryan Deans, John Thacke. A role for Xrcc2 in the early stages of mouse development. DNA repair. vol 6. issue 2. 2007-03-28. PMID:17116431. |
to look at the causes of lethality, and possibly to allow xrcc2-/- mice to survive to birth, we have produced double knockout mice deficient in either the p53 oncoprotein or ataxia telangiectasia mutated (atm). |
2007-03-28 |
2023-08-12 |
mouse |
| Ramune Reliene, Robert H Schiest. Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice. The Journal of nutrition. vol 137. issue 1 Suppl. 2007-03-27. PMID:17182831. |
ataxia telangiectasia (at), a human hereditary disorder resulting from mutations in the atm gene, is characterized by a high incidence of lymphoid malignancies, neurodegeneration, immunodeficiency, premature aging, elevated radiosensitivity, and genomic instability. |
2007-03-27 |
2023-08-12 |
mouse |
| S Burdak-Rothkamm, S C Short, M Folkard, K Rothkamm, K M Pris. ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells. Oncogene. vol 26. issue 7. 2007-03-20. PMID:16909103. |
inhibition of ataxia telangiectasia mutated (atm) protein and dna-pk could not suppress the induction of bystander gammah2ax foci whereas the mutation of atm- and rad3-related (atr) abrogated bystander foci induction. |
2007-03-20 |
2023-08-12 |
human |
| Min Hua Luo, Kyle Rosenke, Kamila Czornak, Elizabeth A Fortunat. Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. Journal of virology. vol 81. issue 4. 2007-03-20. PMID:17151099. |
human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (atm)- and atm-rad3-related kinase-mediated dna damage responses during lytic infection. |
2007-03-20 |
2023-08-12 |
human |
| Min Hua Luo, Kyle Rosenke, Kamila Czornak, Elizabeth A Fortunat. Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. Journal of virology. vol 81. issue 4. 2007-03-20. PMID:17151099. |
many viruses (herpes simplex virus type 1, polyomavirus, and human immunodeficiency virus type 1) require the activation of ataxia telangiectasia mutated protein (atm) and/or mre11 for a fully permissive infection. |
2007-03-20 |
2023-08-12 |
human |
| Linan Ha, Susan Ceryak, Steven R Patiern. Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. Carcinogenesis. vol 25. issue 11. 2007-03-12. PMID:15284180. |
previously we found that cr(vi) activates the ataxia telangiectasia mutated (atm) kinase. |
2007-03-12 |
2023-08-12 |
human |
| Sathyavageeswaran Shreeram, Weng Kee Hee, Oleg N Demidov, Calvina Kek, Hiroshi Yamaguchi, Albert J Fornace, Carl W Anderson, Ettore Appella, Dmitry V Bulavi. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. The Journal of experimental medicine. vol 203. issue 13. 2007-03-12. PMID:17158963. |
the ataxia telangiectasia mutated (atm) kinase is a key tumor suppressor that regulates numerous cell cycle checkpoints as well as apoptosis. |
2007-03-12 |
2023-08-12 |
mouse |
| S M Wuerzberger-Davis, Y Nakamura, B J Seufzer, S Miyamot. NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene. vol 26. issue 5. 2007-03-08. PMID:16862178. |
moreover, combinations of certain sumo stress and atm (ataxia telangiectasia mutated) activation conditions lead to nf-kappab activation without inducing dna damage. |
2007-03-08 |
2023-08-12 |
Not clear |
| Sarah E Golding, Elizabeth Rosenberg, Steven Neill, Paul Dent, Lawrence F Povirk, Kristoffer Valeri. Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response. Cancer research. vol 67. issue 3. 2007-03-01. PMID:17283137. |
first, we verified that this repair platform is amenable to pharmacologic manipulation and show that the ataxia telangiectasia mutated (atm) kinase is critical for hrr. |
2007-03-01 |
2023-08-12 |
human |
| J Reichenbach, R Schubert, J Feinberg, O Beck, M Rosewich, M A Rose, S Ziele. Impaired interferon-gamma production in response to live bacteria and Toll-like receptor agonists in patients with ataxia telangiectasia. Clinical and experimental immunology. vol 146. issue 3. 2007-02-20. PMID:17100756. |
ataxia telangiectasia (at) is a pleiotropic autosomal recessive neurodegenerative disorder with associated immunodeficiency and cancer predisposition, caused by mutational inactivation of the atm gene. |
2007-02-20 |
2023-08-12 |
Not clear |
| Toshiki Tanaka, H Dorota Halicka, Frank Traganos, Zbigniew Darzynkiewic. Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes. Cell cycle (Georgetown, Tex.). vol 5. issue 22. 2007-02-12. PMID:17106266. |
we could find no reports whether oxidative burst-mediated dna damage triggers in such cells histone h2ax-ser139 phosphorylation and activation of ataxia telangiectasia mutated (atm), the signals otherwise used to activate dna repair and checkpoint pathways in proliferating cells. |
2007-02-12 |
2023-08-12 |
human |
| Jochen G Schneider, Brian N Finck, Jie Ren, Kara N Standley, Masatoshi Takagi, Kirsteen H Maclean, Carlos Bernal-Mizrachi, Anthony J Muslin, Michael B Kastan, Clay F Semenkovic. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell metabolism. vol 4. issue 5. 2007-02-09. PMID:17084711. |
here, we show that deficiency of one or two alleles of atm, the protein mutated in the cancer-prone disease ataxia telangiectasia, worsens features of the metabolic syndrome, increases insulin resistance, and accelerates atherosclerosis in apoe-/- mice. |
2007-02-09 |
2023-08-12 |
mouse |
| Mukesh K Nyati, Felix Y Feng, Divya Maheshwari, Sooryanarayana Varambally, Steven P Zielske, Aarif Ahsan, Patrick Y Chun, Vinay A Arora, Mary A Davis, Mira Jung, Mats Ljungman, Christine E Canman, Arul M Chinnaiyan, Theodore S Lawrenc. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. Cancer research. vol 66. issue 24. 2007-01-25. PMID:17178844. |
ataxia telangiectasia mutated (atm) kinase plays a crucial role in the cellular response to dna damage and in radiation resistance. |
2007-01-25 |
2023-08-12 |
Not clear |
| Haiyan Qi, Chao-Po Lin, Xuan Fu, Laurence M Wood, Angela A Liu, Yuan-Chin Tsai, Yongjie Chen, Christopher M Barbieri, Daniel S Pilch, Leroy F Li. G-quadruplexes induce apoptosis in tumor cells. Cancer research. vol 66. issue 24. 2007-01-25. PMID:17178877. |
tg-odn-induced apoptosis was largely ataxia telangiectasia mutated (atm) dependent. |
2007-01-25 |
2023-08-12 |
mouse |
| Eirini Papadopoulou, Elias Davilas, Vasilios Sotiriou, Eleftherios Georgakopoulos, Stavroula Georgakopoulou, Alexander Koliopanos, Filipos Aggelakis, Konstantinos Dardoufas, Niki J Agnanti, Irini Karydas, Georgios Nasioula. Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer. Annals of the New York Academy of Sciences. vol 1075. 2007-01-10. PMID:17108217. |
the markers tested were: variations in the quantity of plasma dna, glutathione-s-transferase p1 gene (gstp1), ras association domain family 1a (rassf1a), and ataxia telangiectasia mutated (atm) methylation status in plasma, carcinoembryonic antigen (cea) and prostate-specific membrane antigen (psma) mrna in peripheral blood mononuclear cells (pbmc) and plasma samples from prostate cancer patients. |
2007-01-10 |
2023-08-12 |
Not clear |