| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Terry J Gaymes, Rose Ann Padua, Marika Pla, Stephen Orr, Nader Omidvar, Christine Chomienne, Ghulam J Mufti, Feyruz V Rassoo. Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis? Molecular cancer research : MCR. vol 4. issue 8. 2006-10-12. PMID:16877702. |
thus, increase in h2ax and ataxia telangiectasia mutated (atm) phosphorylation, early markers of dna damage, occurs rapidly following hdi administration. |
2006-10-12 |
2023-08-12 |
Not clear |
| Kensuke Kojima, Marina Konopleva, Teresa McQueen, Susan O'Brien, William Plunkett, Michael Andreef. Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood. vol 108. issue 3. 2006-10-05. PMID:16543464. |
low levels of atm (ataxia telangiectasia mutated) or high levels of mdm2 (murine double minute 2) did not prevent nutlin-3a from inducing apoptosis. |
2006-10-05 |
2023-08-12 |
Not clear |
| Simona Cavalieri, Ada Funaro, Paola Porcedda, Valentina Turinetto, Nicola Migone, Richard A Gatti, Alfredo Brusc. ATM mutations in Italian families with ataxia telangiectasia include two distinct large genomic deletions. Human mutation. vol 27. issue 10. 2006-10-02. PMID:16941484. |
atm mutations in italian families with ataxia telangiectasia include two distinct large genomic deletions. |
2006-10-02 |
2023-08-12 |
Not clear |
| Jin Hee Kim, Heon Kim, Kye Young Lee, Kang-Hyeon Choe, Jeong-Seon Ryu, Ho Il Yoon, Sook Whan Sung, Keun-Young Yoo, Yun-Chul Hon. Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk. Human molecular genetics. vol 15. issue 7. 2006-09-19. PMID:16497724. |
the ataxia telangiectasia mutated (atm) gene is known to be activated by dna damage and involved in cell cycle arrest, apoptosis and dna repair. |
2006-09-19 |
2023-08-12 |
human |
| Serene R Lai, Sharla M O Phipps, Liang Liu, Lucy G Andrews, Trygve O Tollefsbo. Epigenetic control of telomerase and modes of telomere maintenance in aging and abnormal systems. Frontiers in bioscience : a journal and virtual library. vol 10. 2006-09-18. PMID:15769667. |
diseases such as werner s syndrome, atm (ataxia telangiectasia mutated kinase), dkc (dyskeratosis congenita), and atherosclerosis have been linked to aberrant telomerase expression and other aging-related tissue malfunctions could be related to the presence of senescent cells changing the cellular microenvironment. |
2006-09-18 |
2023-08-12 |
human |
| David Dornan, Harumi Shimizu, Angie Mah, Tanay Dudhela, Michael Eby, Karen O'rourke, Somasekar Seshagiri, Vishva M Dixi. ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science (New York, N.Y.). vol 313. issue 5790. 2006-09-06. PMID:16931761. |
the ataxia telangiectasia mutated (atm) protein kinase is a critical component of a dna-damage response network configured to maintain genomic integrity. |
2006-09-06 |
2023-08-12 |
Not clear |
| Hyungshin Yim, In Sun Hwang, Joon-Seok Choi, Kwang-Hoon Chun, Ying Hua Jin, Young-Mi Ham, Kwang Youl Lee, Seung Ki Le. Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells. The Journal of cell biology. vol 174. issue 1. 2006-08-28. PMID:16801388. |
the expression of tcdc6 perturbs the loading of mcm2 but not orc2 onto chromatin and activates ataxia telangiectasia mutated (atm) and atm and rad-3 related (atr) kinase activities with kinetics similar to that of the phosphorylation of chk1/2. |
2006-08-28 |
2023-08-12 |
Not clear |
| L E Finlan, T R Hup. Epidermal stem cells and cancer stem cells: insights into cancer and potential therapeutic strategies. European journal of cancer (Oxford, England : 1990). vol 42. issue 9. 2006-08-24. PMID:16679013. |
furthermore, the review examines information regarding ataxia telangiectasia mutated (atm) kinase and key regulatory events that take place on p53, only within putative keratinocyte stem cells that are transcriptionally regulated by p63alphadeltan. |
2006-08-24 |
2023-08-12 |
human |
| Kenji E Orii, Youngsoo Lee, Naomi Kondo, Peter J McKinno. Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 26. 2006-08-23. PMID:16777961. |
moreover, dna damage-induced apoptosis required the ataxia telangiectasia mutated (atm) kinase after disruption of nhej, but not hr, during neurogenesis. |
2006-08-23 |
2023-08-12 |
Not clear |
| Lanelle Connolly, Michael Lasarev, Robert Jordan, Jeffrey L Schwartz, Mitchell S Turke. Atm haploinsufficiency does not affect ionizing radiation mutagenesis in solid mouse tissues. Radiation research. vol 166. issue 1 Pt 1. 2006-08-16. PMID:16808618. |
ataxia telangiectasia (at) is a hereditary disease with autosomal recessive inheritance of atm (ataxia telangiectasia mutation) alleles. |
2006-08-16 |
2023-08-12 |
mouse |
| Inbal Dar, Sharon Biton, Yosef Shiloh, Ari Barzila. Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 29. 2006-08-14. PMID:16855104. |
the primary transducer of the cellular response to the double-strand break, a highly cytotoxic dna lesion, is the nuclear protein kinase ataxia telangiectasia (a-t) mutated (atm), which phosphorylates numerous effectors that play key roles in the damage response pathways. |
2006-08-14 |
2023-08-12 |
mouse |
| Yue Zou, Yiyong Liu, Xiaoming Wu, Steven M Shel. Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. Journal of cellular physiology. vol 208. issue 2. 2006-08-11. PMID:16523492. |
in support, rpa is hyperphosphorylated upon dna damage or replication stress by checkpoint kinases including ataxia telangiectasia mutated (atm), atr (atm and rad3-related), and dna-dependent protein kinase (dna-pk). |
2006-08-11 |
2023-08-12 |
human |
| Kristina H Schmidt, Joann Wu, Richard D Kolodne. Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome protein. Molecular and cellular biology. vol 26. issue 14. 2006-08-11. PMID:16809776. |
the s-phase checkpoint kinase and telomere maintenance factor tel1, a homolog of the human ataxia telangiectasia (atm) protein, prevents these translocations, whereas the checkpoint kinase mec1, a homolog of the human atm-related protein, and the rad53 checkpoint kinase are not required. |
2006-08-11 |
2023-08-12 |
human |
| Bipasha Mukherjee, Chase Kessinger, Junya Kobayashi, Benjamin P C Chen, David J Chen, Aloke Chatterjee, Sandeep Burm. DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA repair. vol 5. issue 5. 2006-07-31. PMID:16567133. |
we have previously shown that ataxia telangiectasia mutated kinase (atm) is primarily responsible for h2ax phosphorylation in murine cells in response to ionizing radiation. |
2006-07-31 |
2023-08-12 |
mouse |
| Eun Kyung Choi, In Mi Ji, So Ryung Lee, Yeon Hee Kook, Robert J Griffin, Byung Uk Lim, Jin-Seok Kim, Doo Sung Lee, Chang Won Song, Heon Joo Par. Radiosensitization of tumor cells by modulation of ATM kinase. International journal of radiation biology. vol 82. issue 4. 2006-07-07. PMID:16690595. |
to elucidate the relationship between the radiation-induced activation of ataxia telangiectasia mutated (atm) kinase, g2 arrest and the caffeine-induced radiosensitization. |
2006-07-07 |
2023-08-12 |
Not clear |
| O Igoucheva, V Alexeev, K Yoo. Differential cellular responses to exogenous DNA in mammalian cells and its effect on oligonucleotide-directed gene modification. Gene therapy. vol 13. issue 3. 2006-06-29. PMID:16177821. |
in addition, the presented data indicate that the presence of exogenous dsdna triggered a dna damage response by activation of atr (ataxia telangiectasia-rad3-related) but not atm (ataxia telangiectasia mutated) pathway. |
2006-06-29 |
2023-08-12 |
Not clear |
| Keiji Suzuki, Hiroshi Okada, Motohiro Yamauchi, Yasuyoshi Oka, Seiji Kodama, Masami Watanab. Qualitative and quantitative analysis of phosphorylated ATM foci induced by low-dose ionizing radiation. Radiation research. vol 165. issue 5. 2006-06-29. PMID:16669703. |
we examined the formation of phosphorylated ataxia telangiectasia mutated (atm) foci in exponentially growing normal human diploid cells exposed to low doses of x rays. |
2006-06-29 |
2023-08-12 |
human |
| Denise L Stredrick, Montserrat Garcia-Closas, Marbin A Pineda, Parveen Bhatti, Bruce H Alexander, Michele M Doody, Jolanta Lissowska, Beata Peplonska, Louise A Brinton, Stephen J Chanock, Jeffery P Struewing, Alice J Sigurdso. The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer. Human mutation. vol 27. issue 6. 2006-06-26. PMID:16652348. |
homozygous mutation in the atm gene causes ataxia telangiectasia and heterozygous mutation carriers may be at increased risk of breast cancer. |
2006-06-26 |
2023-08-12 |
human |
| Jason A Aglipay, Sarah A Martin, Hideyuki Tawara, Sam W Lee, Toru Ouch. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. The Journal of biological chemistry. vol 281. issue 14. 2006-05-30. PMID:16452482. |
atm (ataxia telangiectasia mutated) is required for the early response to dna-damaging agents such as ionizing radiation (ir) that induce dna double-strand breaks. |
2006-05-30 |
2023-08-12 |
Not clear |
| Amanda S Coutts, Nicholas La Thangu. The p53 response during DNA damage: impact of transcriptional cofactors. Biochemical Society symposium. issue 73. 2006-05-25. PMID:16626298. |
dna damage induces the activity of p53, via damage sensors such as atm (ataxia telangiectasia mutated) and atr (ataxia telangiectasia-related), which leads to the transcriptional regulation of a variety of genes involved in cell cycle control and apoptosis. |
2006-05-25 |
2023-08-12 |
Not clear |