| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Predrag Slijepcevi. The role of DNA damage response proteins at telomeres--an "integrative" model. DNA repair. vol 5. issue 11. 2007-01-05. PMID:16798109. |
similarly, mouse and human cells defective in ataxia telangiectasia mutated (atm) have defective telomeres. |
2007-01-05 |
2023-08-12 |
mouse |
| Jirina Bartkova, Nousin Rezaei, Michalis Liontos, Panagiotis Karakaidos, Dimitris Kletsas, Natalia Issaeva, Leandros-Vassilios F Vassiliou, Evangelos Kolettas, Katerina Niforou, Vassilis C Zoumpourlis, Munenori Takaoka, Hiroshi Nakagawa, Frederic Tort, Kasper Fugger, Fredrik Johansson, Maxwell Sehested, Claus L Andersen, Lars Dyrskjot, Torben Ørntoft, Jiri Lukas, Christos Kittas, Thomas Helleday, Thanos D Halazonetis, Jiri Bartek, Vassilis G Gorgouli. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. vol 444. issue 7119. 2007-01-04. PMID:17136093. |
inhibiting the dna double-strand break response kinase ataxia telangiectasia mutated (atm) suppressed the induction of senescence and in a mouse model led to increased tumour size and invasiveness. |
2007-01-04 |
2023-08-12 |
mouse |
| R L Balleine, R Murali, A M Bilous, G Farshid, P Waring, P Provan, K Byth, H Thorne, J A Kir. Histopathological features of breast cancer in carriers of ATM gene variants. Histopathology. vol 49. issue 5. 2006-12-20. PMID:17064299. |
germline variants in the ataxia telangiectasia mutated (atm) gene have been implicated in increased breast cancer risk. |
2006-12-20 |
2023-08-12 |
Not clear |
| Geoff W Birrell, Katherine Kneebone, Michael Nefedov, Elena Nefedova, M N Jartsev, Midori Mitsui, Richard A Gatti, Martin F Lavi. ATM mutations, haplotype analysis, and immunological status of Russian patients with ataxia telangiectasia. Human mutation. vol 25. issue 6. 2006-12-15. PMID:15880721. |
atm mutations, haplotype analysis, and immunological status of russian patients with ataxia telangiectasia. |
2006-12-15 |
2023-08-12 |
Not clear |
| Geoff W Birrell, Katherine Kneebone, Michael Nefedov, Elena Nefedova, M N Jartsev, Midori Mitsui, Richard A Gatti, Martin F Lavi. ATM mutations, haplotype analysis, and immunological status of Russian patients with ataxia telangiectasia. Human mutation. vol 25. issue 6. 2006-12-15. PMID:15880721. |
mutations in the atm gene are responsible for the autosomal recessive disorder, ataxia telangiectasia (a-t). |
2006-12-15 |
2023-08-12 |
Not clear |
| Julia Kirshner, Michael F Jobling, Maria Jose Pajares, Shraddha A Ravani, Adam B Glick, Martin J Lavin, Sergei Koslov, Yosef Shiloh, Mary Helen Barcellos-Hof. Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer research. vol 66. issue 22. 2006-12-14. PMID:17090522. |
ionizing radiation causes dna damage that elicits a cellular program of damage control coordinated by the kinase activity of ataxia telangiectasia mutated protein (atm). |
2006-12-14 |
2023-08-12 |
human |
| Myriam Grattarola, Cristina Borghi, Laura Emionite, Patrizia Lulli, Luciana Chessa, Laura Vergan. Modifications of nuclear architecture and chromatin organization in ataxia telangiectasia cells are coupled to changes of gene transcription. Journal of cellular biochemistry. vol 99. issue 4. 2006-12-13. PMID:16795050. |
ataxia telangiectasia (at) is a rare genetic disorder caused by mutations of atm gene. |
2006-12-13 |
2023-08-12 |
Not clear |
| C N Andreassen, J Alsner, M Overgaard, F B Sørensen, J Overgaar. Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples. International journal of radiation biology. vol 82. issue 8. 2006-12-13. PMID:16966185. |
in two previously published studies, associations with risk of radiation-induced subcutaneous fibrosis were found for single nucleotide polymorphisms (snp) in tgfb1 (transforming growth factor beta 1 gene), xrcc1 (x-ray repair cross-complementing 1 gene), xrcc3 (x-ray repair cross-complementing 3 gene), sod2 (manganese superoxide dismutase gene) and atm (gene of ataxia telangiectasia mutated). |
2006-12-13 |
2023-08-12 |
Not clear |
| Tetsuo Nakajim. Signaling cascades in radiation-induced apoptosis: roles of protein kinase C in the apoptosis regulation. Medical science monitor : international medical journal of experimental and clinical research. vol 12. issue 10. 2006-12-13. PMID:17006414. |
interestingly, pkc-related signaling cascades have been found to be regulated in part by atm (the gene that is mutated in the human genetic disorder ataxia telangiectasia). |
2006-12-13 |
2023-08-12 |
human |
| Junqing Zhou, Chang Uk Lim, Jian Jian Li, Lu Cai, Ying Zhan. The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage. Cancer letters. vol 243. issue 1. 2006-12-06. PMID:16530324. |
ataxia telangiectasia mutated (atm) and ataxia telangiectasia and rad3-related (atr) kinases have been considered the primary activators of the cellular response to dna damage. |
2006-12-06 |
2023-08-12 |
human |
| Junqing Zhou, Chang Uk Lim, Jian Jian Li, Lu Cai, Ying Zhan. The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage. Cancer letters. vol 243. issue 1. 2006-12-06. PMID:16530324. |
in human beings, deficiency of these kinases leads to hereditary diseases, namely ataxia telangiectasia (at) with atm deficiency and atr-seckel with atr deficiency. |
2006-12-06 |
2023-08-12 |
human |
| Catherine Fan, Rebecca Quan, Xinchang Feng, Aubrey Gillis, Lizhi He, Edward D Matsumoto, Sam Salama, Jean-Claude Cutz, Anil Kapoor, Damu Tan. ATM activation is accompanied with earlier stages of prostate tumorigenesis. Biochimica et biophysica acta. vol 1763. issue 10. 2006-12-06. PMID:16997395. |
the atm (ataxia telangiectasia mutated) kinase plays an essential role in maintaining genome integrity by coordinating cell cycle arrest, apoptosis, and dna damage repair. |
2006-12-06 |
2023-08-12 |
Not clear |
| W Li, W Jian, X Xiaoping, L Yingfeng, X Tao, X Xiaoya. Enhanced radiation-mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated protein. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 16. issue 4. 2006-12-05. PMID:16884376. |
the ataxia telangiectasia-mutated (atm) protein, which is mutated in the inherited disease ataxia telangiectasia (at), is a key activator of cell cycle checkpoint, initiating cell response to dna damage and ensuring genomic stability. |
2006-12-05 |
2023-08-12 |
human |
| Nic Waddell, Jyoti Jonnalagadda, Anna Marsh, Scott Grist, Mark Jenkins, Karen Hobson, Malcolm Taylor, Geoff J Lindeman, Sean V Tavtigian, Graeme Suthers, David Goldgar, Peter J Oefner, Darrin Taylor, Sean Grimmond, Kum Kum Khanna, Georgia Chenevix-Trenc. Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling. Genes, chromosomes & cancer. vol 45. issue 12. 2006-11-28. PMID:17001622. |
mutations in atm are responsible for the autosomal recessive disorder ataxia telangiectasia. |
2006-11-28 |
2023-08-12 |
Not clear |
| Haruyuki Takemura, V Ashutosh Rao, Olivier Sordet, Takahisa Furuta, Ze-Hong Miao, Linghua Meng, Hongliang Zhang, Yves Pommie. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. The Journal of biological chemistry. vol 281. issue 41. 2006-11-27. PMID:16905549. |
chk2 activation was ataxia telangiectasia mutated (atm)-dependent and associated with phosphorylation of mre11 and nbs1. |
2006-11-27 |
2023-08-12 |
Not clear |
| Wynand P Roos, Bernd Kain. DNA damage-induced cell death by apoptosis. Trends in molecular medicine. vol 12. issue 9. 2006-11-08. PMID:16899408. |
dsbs are detected by atm (ataxia telangiectasia mutated) and atr (ataxia telangiectasia and rad3 related) proteins, which signal downstream to chk1, chk2 (checkpoint kinases) and p53. |
2006-11-08 |
2023-08-12 |
Not clear |
| Otto Appenzeller, Tamara Minko, Clifford Qualls, Vitaly Pozharov, Jorge Gamboa, Alfredo Gamboa, Rafica I Pakunl. Chronic hypoxia in Andeans; are there lessons for neurology at sea level? Journal of the neurological sciences. vol 247. issue 1. 2006-11-03. PMID:16733057. |
we focused on the cyto-neuro-protective genes, ataxia telangiectasia mutated (atm), heme-oxygenase-1 (hmox 1), heat shock protein-70 (hsp-70), heat shock protein-90 (hsp-90), and the neuroprotective enzyme, nicotinamide mononucleotide adenylyl transferase 1 (nnmat 1). |
2006-11-03 |
2023-08-12 |
Not clear |
| Nuri Gueven, John Luff, Cheng Peng, Kazuyuki Hosokawa, Steven E Bottle, Martin F Lavi. Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant. Free radical biology & medicine. vol 41. issue 6. 2006-10-24. PMID:16934683. |
mutations in the atm gene (mutated in ataxia telangiectasia) in both humans and mice predispose to lymphoid tumors. |
2006-10-24 |
2023-08-12 |
mouse |
| J Zhang, J M Lahti, A Bruce, L He, K Parihar, C Fan, J Grenet, L Liu, V J Kidd, S Cormier, D Tan. Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression. Oncogene. vol 25. issue 41. 2006-10-18. PMID:16636671. |
consistent with p53 ser15 being a target of ataxia telangiectasia mutated protein(atm)/atr (atm- and rad3-related) in the dna damage response, bcl-2 activates atm by inducing atm ser1981 phosphorylation, which is accompanied with the phosphorylaton of two additional atm substrates, chk2 thr68 and h2ax ser139. |
2006-10-18 |
2023-08-12 |
Not clear |
| Manuela Pellegrini, Arkady Celeste, Simone Difilippantonio, Rong Guo, Weidong Wang, Lionel Feigenbaum, André Nussenzwei. Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature. vol 443. issue 7108. 2006-10-13. PMID:16906133. |
the atm (ataxia telangiectasia mutated) protein kinase is activated under physiological and pathological conditions that induce dna double-strand breaks (dsbs). |
2006-10-13 |
2023-08-12 |
mouse |