| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akira Kurose, Toshiki Tanaka, Xuan Huang, Frank Traganos, Wei Dai, Zbigniew Darzynkiewic. Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 69. issue 4. 2006-05-23. PMID:16528719. |
histone h2ax is phosphorylated on ser 139 in response to dsbs and one of the protein kinases that phosphorylate h2ax is ataxia telangiectasia mutated (atm); activation of atm is through its phosphorylation of ser 1981. |
2006-05-23 |
2023-08-12 |
Not clear |
| Cynthia L Innes, Alexandra N Heinloth, Kristina G Flores, Stella O Sieber, Paula B Deming, Pierre R Bushel, William K Kaufmann, Richard S Paule. ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts. Molecular cancer research : MCR. vol 4. issue 3. 2006-05-17. PMID:16547157. |
the heritable disorder ataxia telangiectasia (at) is caused by mutations in the at-mutated (atm) gene with manifestations that include predisposition to lymphoproliferative cancers and hypersensitivity to ionizing radiation (ir). |
2006-05-17 |
2023-08-12 |
human |
| Daniel R Kennedy, Terry A Beerma. The radiomimetic enediyne C-1027 induces unusual DNA damage responses to double-strand breaks. Biochemistry. vol 45. issue 11. 2006-05-16. PMID:16533058. |
cells lacking the protein kinase ataxia telangiectasia mutated (atm) have defective responses to dna double-strand breaks (dsbs), including an inability to activate damage response proteins such as p53. |
2006-05-16 |
2023-08-12 |
Not clear |
| Penny A Jeggo, Markus Löbric. Artemis links ATM to double strand break rejoining. Cell cycle (Georgetown, Tex.). vol 4. issue 3. 2006-05-05. PMID:15684609. |
ataxia telangiectasia mutated protein (atm) is a damage response kinase that initiates a signal transduction response to the presence of dna double strand breaks (dsbs) regulating cell cycle checkpoint arrest and apoptosis. |
2006-05-05 |
2023-08-12 |
Not clear |
| Hong Jiang, Beisha Tang, Kun Xia, Zhengmao Hu, Lu Shen, Jianguang Tang, Guohua Zhao, Yuhu Zhang, Fang Cai, Qian Pan, Zhigao Long, Guo Wang, Heping Da. Mutation analysis of the ATM gene in two Chinese patients with ataxia telangiectasia. Journal of the neurological sciences. vol 241. issue 1-2. 2006-04-25. PMID:16380133. |
mutation analysis of the atm gene in two chinese patients with ataxia telangiectasia. |
2006-04-25 |
2023-08-12 |
Not clear |
| Bunsyo Shiotani, Masahiko Kobayashi, Masahiko Watanabe, Ken-Ichi Yamamoto, Takashi Sugimura, Keiji Wakabayash. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Molecular cancer research : MCR. vol 4. issue 2. 2006-04-18. PMID:16513843. |
pierisin-1 treatment of hela cells was found to induce an intra-s-phase arrest through both ataxia telangiectasia mutated (atm) and rad3-related (atr) and atm pathways, and atr pathway also contributes to a g(2)-m-phase delay. |
2006-04-18 |
2023-08-12 |
Not clear |
| Chui Chui Ho, Wai Yi Siu, Anita Lau, Wan Mui Chan, Talha Arooz, Randy Y C Poo. Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways. Cancer research. vol 66. issue 4. 2006-04-13. PMID:16489026. |
moreover, p53 was still stabilized in ataxia telangiectasia cells or in cells treated with caffeine, suggesting that atm was not a critical determinant. |
2006-04-13 |
2023-08-12 |
Not clear |
| Timothy C Greiner, Chiranjib Dasgupta, Vincent V Ho, Dennis D Weisenburger, Lynette M Smith, James C Lynch, Julie M Vose, Kai Fu, James O Armitage, Rita M Braziel, Elias Campo, Jan Delabie, Randy D Gascoyne, Elaine S Jaffe, Hans K Muller-Hermelink, German Ott, Andreas Rosenwald, Louis M Staudt, Michael Y Im, Mazen W Karaman, Brian L Pike, Wing C Chan, Joseph G Haci. Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 7. 2006-04-07. PMID:16461462. |
mutation and genomic deletion status of ataxia telangiectasia mutated (atm) and p53 confer specific gene expression profiles in mantle cell lymphoma. |
2006-04-07 |
2023-08-12 |
Not clear |
| Timothy C Greiner, Chiranjib Dasgupta, Vincent V Ho, Dennis D Weisenburger, Lynette M Smith, James C Lynch, Julie M Vose, Kai Fu, James O Armitage, Rita M Braziel, Elias Campo, Jan Delabie, Randy D Gascoyne, Elaine S Jaffe, Hans K Muller-Hermelink, German Ott, Andreas Rosenwald, Louis M Staudt, Michael Y Im, Mazen W Karaman, Brian L Pike, Wing C Chan, Joseph G Haci. Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 7. 2006-04-07. PMID:16461462. |
although mantle cell lymphoma (mcl) frequently harbors inactivated ataxia telangiectasia mutated (atm) and p53 alleles, little is known about the molecular phenotypes caused by these genetic changes. |
2006-04-07 |
2023-08-12 |
Not clear |
| David Feldser, Margaret A Strong, Carol W Greide. Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 7. 2006-04-07. PMID:16467146. |
ataxia telangiectasia mutated (atm) is not required for telomerase-mediated elongation of short telomeres. |
2006-04-07 |
2023-08-12 |
mouse |
| David Feldser, Margaret A Strong, Carol W Greide. Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 7. 2006-04-07. PMID:16467146. |
in yeast, the ataxia telangiectasia mutated (atm) homolog, tel1, is necessary for normal telomere length regulation likely by altering telomere structure, allowing telomerase recruitment to short telomeres. |
2006-04-07 |
2023-08-12 |
mouse |
| Myriam Cuadrado, Barbara Martinez-Pastor, Matilde Murga, Luis I Toledo, Paula Gutierrez-Martinez, Eva Lopez, Oscar Fernandez-Capetill. ATM regulates ATR chromatin loading in response to DNA double-strand breaks. The Journal of experimental medicine. vol 203. issue 2. 2006-04-03. PMID:16461339. |
in this context, ataxia telangiectasia mutated (atm) and atm and rad-3-related (atr) protein kinases are the earliest signaling molecules that are known to initiate the transduction cascade at damage sites. |
2006-04-03 |
2023-08-12 |
Not clear |
| Lan Ma, John Wagner, John Jeremy Rice, Wenwei Hu, Arnold J Levine, Gustavo A Stolovitzk. A plausible model for the digital response of p53 to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 40. 2006-03-28. PMID:16186499. |
the persisting complexes are sensed by ataxia telangiectasia mutated (atm), a protein kinase that activates p53 once it is phosphorylated by dna damage. |
2006-03-28 |
2023-08-12 |
Not clear |
| Hui-Chun Wang, Wen-Cheng Chou, Sheau-Yann Shieh, Chen-Yang She. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer research. vol 66. issue 3. 2006-03-21. PMID:16452194. |
to further delineate this mechanism, the present study explored the connection between nhej and the cell-cycle checkpoint proteins, ataxia telangiectasia mutated (atm) and checkpoint kinase 2 (chk2), known to be involved in activating brca1, and tested the hypothesis that atm and chk2 promote precise end-joining by brca1. |
2006-03-21 |
2023-08-12 |
Not clear |
| Zhao-Hui Wu, Yuling Shi, Randal S Tibbetts, Shigeki Miyamot. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science (New York, N.Y.). vol 311. issue 5764. 2006-03-16. PMID:16497931. |
we show that nf-kappab essential modulator (nemo), the regulatory subunit of ikappab kinase (ikk) (which phosphorylates the nf-kappab inhibitor ikappab), associates with activated ataxia telangiectasia mutated (atm) after the induction of dna double-strand breaks. |
2006-03-16 |
2023-08-12 |
Not clear |
| T Tanaka, A Kurose, X Huang, W Dai, Z Darzynkiewic. ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis. Cell proliferation. vol 39. issue 1. 2006-03-14. PMID:16426422. |
damage that engenders dna double-strand breaks (dsbs) activates ataxia telangiectasia mutated (atm) kinase through its auto- or trans-phosphorylation on ser1981 and activated atm is one of the mediators of histone h2ax phosphorylation on ser139. |
2006-03-14 |
2023-08-12 |
Not clear |
| Richard C Hresko, Mike Mueckle. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. The Journal of biological chemistry. vol 280. issue 49. 2006-03-06. PMID:16221682. |
double-stranded dna-dependent protein kinase (dna-pk), ataxia telangiectasia mutated (atm) gene product, integrin-linked kinase (ilk), protein kinase calpha (pkcalpha), and mammalian target of rapamycin (mtor), when complexed to rapamycin-insensitive companion of mtor (rictor), have all been identified as playing a critical role in akt ser-473 phosphorylation. |
2006-03-06 |
2023-08-12 |
Not clear |
| Masatoshi Suzuki, Keiji Suzuki, Seiji Kodama, Masami Watanab. Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest. Biochemical and biophysical research communications. vol 340. issue 1. 2006-02-28. PMID:16360120. |
to determine the mechanism of persistent activation of p53, we examined phosphorylated ataxia telangiectasia mutated (atm) and phosphorylated histone h2ax foci formation after x-irradiation. |
2006-02-28 |
2023-08-12 |
human |
| Manabu Koike, Jun Sugasawa, Aki Koike, Yoko Kohn. p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure. Journal of radiation research. vol 46. issue 4. 2006-02-28. PMID:16394637. |
although it is well known that ataxia telangiectasia mutated (atm) kinase and dna-dependent protein kinase (dna-pk) can phosphorylate ser15/ser18 of p53 in vitro, the post-translational modification pattern and the modifier of p53 in the skin after exposure to high-dose x-rays are not yet well understood. |
2006-02-28 |
2023-08-12 |
mouse |
| Na Liu, George Stoica, Mingshan Yan, Virginia L Scofield, Wenan Qiang, William S Lynn, Paul K Y Won. ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 12. 2006-02-16. PMID:16189515. |
atm kinase, the product of the ataxia telangiectasia mutated (atm) gene, is activated by genomic damage. |
2006-02-16 |
2023-08-12 |
mouse |