| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Zhong, Alyson Bryson, Mark Eckersdorff, David O Ferguso. Rad50 depletion impacts upon ATR-dependent DNA damage responses. Human molecular genetics. vol 14. issue 18. 2006-02-10. PMID:16087684. |
it functions both in dna double-strand break repair and in controlling the ataxia telangiectasia mutated (atm) kinase during the response to these lesions. |
2006-02-10 |
2023-08-12 |
Not clear |
| Christopher J Winrow, Daniel G Pankratz, Cecile Rose T Vibat, T J Bowen, Marie A Callahan, Amy J Warren, Brian S Hilbush, Anthony Wynshaw-Boris, Karl W Hasel, Zoë Weaver, David J Lockhart, Carrolee Barlo. Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas. Human molecular genetics. vol 14. issue 18. 2006-02-10. PMID:16087685. |
ataxia telangiectasia (a-t) is an autosomal recessive disease caused by loss of function of the serine/threonine protein kinase atm (ataxia telangiectasia mutated). |
2006-02-10 |
2023-08-12 |
mouse |
| Zana P Desgranges, Jinwoo Ahn, Maria B Lazebnik, Todd Ashworth, Caleb Lee, Richard C Pestell, Naomi Rosenberg, Carol Prives, Ananda L Ro. Inhibition of TFII-I-dependent cell cycle regulation by p53. Molecular and cellular biology. vol 25. issue 24. 2006-01-26. PMID:16314517. |
most strikingly, upon cell cycle arrest resulting from genotoxic stress and p53 activation, tfii-i is ubiquitinated and targeted for proteasomal degradation in a p53- and atm (ataxia telangiectasia mutated)-dependent manner. |
2006-01-26 |
2023-08-12 |
Not clear |
| Shannon L Gibson, Ranjit S Bindra, Peter M Glaze. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer research. vol 65. issue 23. 2006-01-25. PMID:16322218. |
we show here that chk2 is phosphorylated on thr68 and thereby activated in cells in response to hypoxia, and that this phosphorylation is dependent on the damage response kinase ataxia telangiectasia mutated (atm) but not on the related kinase atm and rad3-related. |
2006-01-25 |
2023-08-12 |
Not clear |
| Akinori Hishiya, Masako Ito, Hiroyuki Aburatani, Noboru Motoyama, Kyoji Ikeda, Ken Watanab. Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation. Bone. vol 37. issue 4. 2006-01-24. PMID:16027059. |
ataxia telangiectasia mutated (atm) knockout mice as a model of osteopenia due to impaired bone formation. |
2006-01-24 |
2023-08-12 |
mouse |
| Akinori Hishiya, Masako Ito, Hiroyuki Aburatani, Noboru Motoyama, Kyoji Ikeda, Ken Watanab. Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation. Bone. vol 37. issue 4. 2006-01-24. PMID:16027059. |
atm is a member of the pi-3 kinase protein family, encoded by the gene, atm, responsible for ataxia telangiectasia (at). |
2006-01-24 |
2023-08-12 |
mouse |
| Hong Xie, Sandra S Wise, Amie L Holmes, Bo Xu, Timothy P Wakeman, Stephen C Pelsue, Narendra P Singh, John Pierce Wis. Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells. Mutation research. vol 586. issue 2. 2005-12-23. PMID:16112599. |
we also show that genotoxic concentrations of lead chromate activate the ataxia telangiectasia mutated (atm) protein, which is thought to play a central role in the early stages of dsb detection and controls cellular responses to this damage. |
2005-12-23 |
2023-08-12 |
human |
| Marina A Bellani, Peter J Romanienko, Damian A Cairatti, R Daniel Camerini-Oter. SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes. Journal of cell science. vol 118. issue Pt 15. 2005-12-15. PMID:15998665. |
we investigated the role in meiosis of the three kinases [atm (ataxia telangiectasia mutated), atr (ataxia-telangiectasia- and rad-3-related) and dna-pkcs (dna-dependent-protein-kinase catalytic subunit)] known to phosphorylate h2ax in mitotic cells. |
2005-12-15 |
2023-08-12 |
mouse |
| Xinqing Deng, Asa Ljunggren-Rose, Kevin Maas, Subramaniam Srira. Defective ATM-p53-mediated apoptotic pathway in multiple sclerosis. Annals of neurology. vol 58. issue 4. 2005-12-15. PMID:16178012. |
this defect is due to impaired constitutive expression and activation of atm (ataxia telangiectasia mutated), resulting in impaired stabilization of p53. |
2005-12-15 |
2023-08-12 |
Not clear |
| T J Bowen, Hiroyuki Yakushiji, Cristina Montagna, Sonia Jain, Thomas Ried, Anthony Wynshaw-Bori. Atm heterozygosity cooperates with loss of Brca1 to increase the severity of mammary gland cancer and reduce ductal branching. Cancer research. vol 65. issue 19. 2005-12-14. PMID:16204043. |
the role of homozygous ataxia telangiectasia mutated (atm) mutations in familial and sporadic forms of cancer is well established, but the contribution of atm heterozygosity to mammary gland and other cancers has been controversial. |
2005-12-14 |
2023-08-12 |
mouse |
| Kate C Shen, Henry Heng, Yaolin Wang, Shu Lu, Guo Liu, Chu-Xia Deng, S C Brooks, Y Alan Wan. ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development. Cancer research. vol 65. issue 19. 2005-12-14. PMID:16204044. |
the dna damage checkpoint protein kinase mutated in ataxia telangiectasia (atm) is involved in sensing and transducing dna damage signals by phosphorylating and activating downstream target proteins that are implicated in the regulation of cell cycle progression and dna repair. |
2005-12-14 |
2023-08-12 |
mouse |
| Alpna Tyagi, Rana P Singh, Chapla Agarwal, Sunitha Siriwardana, Robert A Sclafani, Rajesh Agarwa. Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis. vol 26. issue 11. 2005-12-13. PMID:15975956. |
further upstream, we observed that resveratrol causes phosphorylation of cell division cycle 25c (cdc25c) tyrosine phosphatase via the activation of checkpoint kinases chk1 and chk2, which in turn were activated via atm (ataxia telangiectasia mutated)/atr (ataxia telangiectasia-rad3-related) kinase in response to dna damage, as resveratrol also increased phospho-h2a.x (ser139), which is known to be phosphorylated by atm/atr in response to dna damage. |
2005-12-13 |
2023-08-12 |
human |
| Xiaolin Bi, Deepa Srikanta, Laura Fanti, Sergio Pimpinelli, RamaKrishna Badugu, Rebecca Kellum, Yikang S Ron. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 42. 2005-12-05. PMID:16203987. |
in higher eukaryotes, the ataxia telangiectasia mutated (atm) and atm and rad3-related (atr) checkpoint kinases play distinct, but partially overlapping, roles in dna damage response. |
2005-12-05 |
2023-08-12 |
drosophila_melanogaster |
| Belinda Austen, Judith E Powell, Azra Alvi, Ian Edwards, Laura Hooper, Jane Starczynski, A Malcolm R Taylor, Christopher Fegan, Paul Moss, Tatjana Stankovi. Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL. Blood. vol 106. issue 9. 2005-11-30. PMID:16014569. |
the ataxia telangiectasia mutated (atm) protein is the principal activator of the p53 protein in the response to dna double-strand breaks. |
2005-11-30 |
2023-08-12 |
Not clear |
| V Ashutosh Rao, Angela M Fan, Linghua Meng, Christopher F Doe, Phillip S North, Ian D Hickson, Yves Pommie. Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Molecular and cellular biology. vol 25. issue 20. 2005-11-21. PMID:16199871. |
ataxia telangiectasia mutated (atm) protein and at- and rad9-related protein kinases, but not dna-dependent protein kinase, appeared to play a redundant role in phosphorylating blm. |
2005-11-21 |
2023-08-12 |
Not clear |
| Yingli Sun, Xiaofeng Jiang, Shujuan Chen, Norvin Fernandes, Brendan D Pric. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 37. 2005-11-09. PMID:16141325. |
the ataxia telangiectasia mutant (atm) protein kinase regulates the cell's response to dna damage through the phosphorylation of proteins involved in cell-cycle checkpoints and dna repair. |
2005-11-09 |
2023-08-12 |
Not clear |
| Carole Berthet, Kenneth Raj, Philippe Saudan, Peter Bear. How adeno-associated virus Rep78 protein arrests cells completely in S phase. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 38. 2005-11-08. PMID:16157891. |
in addition, rep78, as well as rep68, produces nicks in the cellular chromatin, inducing a dna damage response mediated by ataxia telangiectasia mutated (atm) leading to g(1) and g(2) blocks. |
2005-11-08 |
2023-08-12 |
Not clear |
| Jean Dahl, John You, Thomas L Benjami. Induction and utilization of an ATM signaling pathway by polyomavirus. Journal of virology. vol 79. issue 20. 2005-11-08. PMID:16189003. |
we sought to determine whether this pathway depends in part on activation of the atm (ataxia telangiectasia mutated) kinase and whether the virus gains advantages from this pathway beyond that of entry into s. we show that polyomavirus infection activates the s- and g(2)-phase checkpoints in primary as well as established mouse cells. |
2005-11-08 |
2023-08-12 |
mouse |
| Catriona A L Clarke, Paul R Clark. DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. The Biochemical journal. vol 388. issue Pt 2. 2005-10-24. PMID:15707391. |
in this system, double-stranded dna oligonucleotides induce the phosphorylation of chk1 at activating sites targeted by atr [atm (ataxia telangiectasia mutated)- and rad3-related] and atm kinases. |
2005-10-24 |
2023-08-12 |
human |
| Sadayuki Ban, Yuichi Michikawa, Ken-ichi Ishikawa, Masashi Sagara, Koji Watanabe, Yutaka Shimada, Johji Inazawa, Takashi Ima. Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines. International journal of experimental pathology. vol 86. issue 4. 2005-09-20. PMID:16045545. |
because the donor of these cells was not diagnosed with ataxia telangiectasia, mutations in atm gene might have occurred during the initiation and progression of cancer. |
2005-09-20 |
2023-08-12 |
human |