| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Lee, A Dritschilo, M Jun. Role of ATM in oxidative stress-mediated c-Jun phosphorylation in response to ionizing radiation and CdCl2. The Journal of biological chemistry. vol 276. issue 15. 2001-05-24. PMID:11278277. |
ionizing radiation-induced phosphorylation of the transcription factor c-jun is impaired in cells derived from individuals with ataxia telangiectasia (at), in which the atm gene is mutated. |
2001-05-24 |
2023-08-12 |
Not clear |
| K E Gurley, C J Kem. Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Current biology : CB. vol 11. issue 3. 2001-05-17. PMID:11231155. |
the gene product mutated in ataxia telangiectasia, atm, is a ubiquitously expressed 370 kda protein kinase that is a key mediator of the cellular response to dna damage [1]. |
2001-05-17 |
2023-08-12 |
mouse |
| Y Li, M P Carty, G G Oakley, M M Seidman, M Medvedovic, K Dixo. Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts. Environmental and molecular mutagenesis. vol 37. issue 2. 2001-05-17. PMID:11246219. |
expression of atm in ataxia telangiectasia fibroblasts rescues defects in dna double-strand break repair in nuclear extracts. |
2001-05-17 |
2023-08-12 |
human |
| S Peretz, R Jensen, R Baserga, P M Glaze. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172010. |
the atm gene is mutated in the syndrome of ataxia telangiectasia (at), associated with neurologic dysfunction, growth abnormalities, and extreme radiosensitivity. |
2001-04-19 |
2023-08-12 |
human |
| C Hensey, K Robertson, J Gautie. Expression and subcellular localization of X-ATM during early Xenopus development. Development genes and evolution. vol 210. issue 8-9. 2001-04-19. PMID:11180853. |
atm, the gene mutated in ataxia telangiectasia, is a protein essential for handling dna strand breaks. |
2001-04-19 |
2023-08-12 |
xenopus_laevis |
| V Gottifredi, S Shieh, Y Taya, C Prive. p53 accumulates but is functionally impaired when DNA synthesis is blocked. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 3. 2001-04-12. PMID:11158590. |
hu-induced stabilization of p53 neither requires functional atm (ataxia telangiectasia mutated), nor interferes with the gamma ir-dependent activation of the atm kinase. |
2001-04-12 |
2023-08-12 |
Not clear |
| J E Kim, J Che. Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 26. 2001-02-15. PMID:11114166. |
fkbp12-rapamycin-associated protein (frap; also named mtor or raft1), a member of the ataxia telangiectasia mutated (atm)-related kinase family, governs a rapamycin-sensitive membrane-to-cytoplasm signaling cascade that modulates translation initiation via p70 s6 kinase (p70(s6k)) and eif-4e binding protein 1 (4e-bp1). |
2001-02-15 |
2023-08-12 |
Not clear |
| S Angèle, I Treilleux, P Tanière, G Martel-Planche, M Vuillaume, C Bailly, A Brémond, R Montesano, J Hal. Abnormal expression of the ATM and TP53 genes in sporadic breast carcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 9. 2001-02-01. PMID:10999741. |
the ataxia telangiectasia gene (atm) has been implicated as a risk factor in the development of sporadic breast carcinomas. |
2001-02-01 |
2023-08-12 |
Not clear |
| S Angèle, I Treilleux, P Tanière, G Martel-Planche, M Vuillaume, C Bailly, A Brémond, R Montesano, J Hal. Abnormal expression of the ATM and TP53 genes in sporadic breast carcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 9. 2001-02-01. PMID:10999741. |
atm protein expression was analyzed by immunohistochemistry in 17 breast carcinomas with two monoclonal antibodies whose immunohistochemical use was first validated by comparing the immunoreactivity observed in spleen samples from ataxia telangiectasia and trauma patients. |
2001-02-01 |
2023-08-12 |
Not clear |
| K Laake, P Vu, T I Andersen, B Erikstein, R Kåresen, P E Lonning, E Skovlund, A L Børresen-Dal. Screening breast cancer patients for Norwegian ATM mutations. British journal of cancer. vol 83. issue 12. 2001-02-01. PMID:11104561. |
483 norwegian breast cancer patients were screened for six different ataxia telangiectasia mutated (atm) mutations previously found to account for 83% of the disease alleles in norwegian ataxia telangiectasia (at) patients. |
2001-02-01 |
2023-08-12 |
Not clear |
| D Q Yang, M B Kasta. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nature cell biology. vol 2. issue 12. 2001-01-26. PMID:11146653. |
here we report that atm, the protein product of the atm gene that is mutated in the disease ataxia telangiectasia, phosphorylates 4e-bp1 at ser 111 in vitro and that insulin treatment induces phosphorylation of 4e-bp1 at ser 111 in vivo in an atm-dependent manner. |
2001-01-26 |
2023-08-12 |
Not clear |
| D Q Yang, M B Kasta. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nature cell biology. vol 2. issue 12. 2001-01-26. PMID:11146653. |
through this mechanism, a lack of atm activity probably contributes to some of the metabolic abnormalities, such as poor growth and insulin resistance, reported in ataxia telangiectasia cells and patients with ataxia telangiectasia. |
2001-01-26 |
2023-08-12 |
Not clear |
| K J Alligood, M Milla, N Rhodes, B Ellis, K E Kilpatrick, A Lee, T M Gilmer, T J Lansin. Monoclonal antibodies generated against recombinant ATM support kinase activity. Hybridoma. vol 19. issue 4. 2001-01-18. PMID:11001404. |
we report on the rapid generation of two monoclonal antibodies, atm a16.35 and atm d16.11, that bind to the kinase domain of mutated ataxia telangiectasia (atm). |
2001-01-18 |
2023-08-12 |
Not clear |
| J C Mallory, T D Pete. Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 25. 2001-01-18. PMID:11095737. |
the closest relative of these proteins is the human ataxia telangiectasia mutated (atm) protein, a wortmannin-sensitive protein kinase that primarily phosphorylates serines in an sq motif. |
2001-01-18 |
2023-08-12 |
human |
| J Y Ahn, J K Schwarz, H Piwnica-Worms, C E Canma. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer research. vol 60. issue 21. 2000-11-30. PMID:11085506. |
in response to ionizing radiation (ir), the cell cycle checkpoint kinase, chk2 (hcds1), is phosphorylated and activated in an ataxia telangiectasia mutated (atm)-dependent manner. |
2000-11-30 |
2023-08-12 |
Not clear |
| Y Lee, D E Barnes, T Lindahl, P J McKinno. Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes & development. vol 14. issue 20. 2000-11-29. PMID:11040211. |
ataxia telangiectasia results from mutations of atm and is characterized by severe neurodegeneration and defective responses to dna damage. |
2000-11-29 |
2023-08-12 |
mouse |
| Y Lee, D E Barnes, T Lindahl, P J McKinno. Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes & development. vol 14. issue 20. 2000-11-29. PMID:11040211. |
therefore, atm could be important for preventing accumulation of dna-damaged cells in the nervous system that might eventually lead to the neurodegeneration observed in ataxia telangiectasia. |
2000-11-29 |
2023-08-12 |
mouse |
| X Tong, B Liu, Y Dong, Z Su. Cleavage of ATM during radiation-induced apoptosis: caspase-3-like apoptotic protease as a candidate. International journal of radiation biology. vol 76. issue 10. 2000-11-13. PMID:11057747. |
to study the relationship of ionizing radiation-induced apoptosis with the integrity of atm (mutated in ataxia telangiectasia) that has a critical role in dna damage sensing and repair, cell-cycle checkpoint controls and maintenance of genomic stability. |
2000-11-13 |
2023-08-12 |
Not clear |
| K Sugimoto, K Tamayose, M Takagi, K Yamada, M Sasaki, S Mizutani, K Oshim. Activation of an ataxia telangiectasia mutation-dependent intra-S-phase checkpoint by anti-tumour drugs in HL-60 and human lymphoblastoid cells. British journal of haematology. vol 110. issue 4. 2000-11-09. PMID:11054063. |
furthermore, two ataxia telangiectasia (at)-derived lymphoblastoid cell lines were impaired in the doxorubicin-induced s-phase retardation, which indicated that the process is at least partially dependent on ataxia telangiectasia mutated (atm) gene product. |
2000-11-09 |
2023-08-12 |
human |
| P J De Schouwer, M J Dyer, V B Brito-Babapulle, E Matutes, D Catovsky, M R Yuill. T-cell prolymphocytic leukaemia: antigen receptor gene rearrangement and a novel mode of MTCP1 B1 activation. British journal of haematology. vol 110. issue 4. 2000-11-09. PMID:11054065. |
as mutations of the ataxia telangiectasia (a-t) gene, atm, are frequent in t-pll and as atm seems to act as a tumour suppressor through a mechanism involving v(d)j recombination, we examined v(d)j recombination in t-pll. |
2000-11-09 |
2023-08-12 |
Not clear |