| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Pincheira, M Bravo, M H Navarrete, K Marcelain, J F López-Sáez, C de la Torr. Ataxia telangiectasia: G2 checkpoint and chromosomal damage in proliferating lymphocytes. Mutagenesis. vol 16. issue 5. 2001-11-01. PMID:11507241. |
while in controls both subpathways may be mediated by atm kinase, in ataxia telangiectasia cells caffeine-sensitive atr kinase and the caffeine-insensitive dna-pk kinases might be responsible for dna repair and the g(2) delay subpathways, respectively. |
2001-11-01 |
2023-08-12 |
Not clear |
| D Menéndez, G Mora, A M Salazar, P Ostrosky-Wegma. ATM status confers sensitivity to arsenic cytotoxic effects. Mutagenesis. vol 16. issue 5. 2001-11-01. PMID:11507245. |
recently it has been shown that atm protein, responsible for the autosomal recessive disorder ataxia telangiectasia (at), regulates p53. |
2001-11-01 |
2023-08-12 |
human |
| N Rhodes, T M Gilmer, T J Lansin. Expression and purification of active recombinant ATM protein from transiently transfected mammalian cells. Protein expression and purification. vol 22. issue 3. 2001-10-25. PMID:11483009. |
the gene mutated in the human disease ataxia telangiectasia (at), termed atm, encodes a large protein kinase involved in dna repair and cell cycle control. |
2001-10-25 |
2023-08-12 |
human |
| S Stilgenbauer, P Lichter, H Döhne. Genetic features of B-cell chronic lymphocytic leukemia. Reviews in clinical and experimental hematology. vol 4. issue 1. 2001-10-04. PMID:11486330. |
genes affected by common chromosome aberrations in cll appear to be p53 in cases with 17p deletion and ataxia telangiectasia mutated (atm), which is mutated in a subset of cases with 11q22-q23 aberrations. |
2001-10-04 |
2023-08-12 |
Not clear |
| S Angèle, P Tanière, J Hal. [What do we know about ATM protein expression in breast tissue?]. Bulletin du cancer. vol 88. issue 7. 2001-09-27. PMID:11495820. |
the atm gene, which encodes the atm protein, mutated in the disorder ataxia telangiectasia (at) could be such a susceptibility gene. |
2001-09-27 |
2023-08-12 |
Not clear |
| Y Lee, M J Chong, P J McKinno. Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517258. |
ataxia-telangiectasia (a-t) is a neurodegenerative syndrome resulting from dysfunction of atm (ataxia telangiectasia mutated). |
2001-09-20 |
2023-08-12 |
mouse |
| G G Oakley, L I Loberg, J Yao, M A Risinger, R L Yunker, M Zernik-Kobak, K K Khanna, M F Lavin, M P Carty, K Dixo. UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein. Molecular biology of the cell. vol 12. issue 5. 2001-09-13. PMID:11359916. |
here we show that uv-induced rpa-p34 hyperphosphorylation depends on expression of atm, the product of the gene mutated in the human genetic disorder ataxia telangiectasia (a-t). |
2001-09-13 |
2023-08-12 |
human |
| G S Stewart, J I Last, T Stankovic, N Haites, A M Kidd, P J Byrd, A M Taylo. Residual ataxia telangiectasia mutated protein function in cells from ataxia telangiectasia patients, with 5762ins137 and 7271T-->G mutations, showing a less severe phenotype. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11382771. |
we have assessed several ataxia telangiectasia mutated (atm)-dependent functions in cells derived from ataxia telangiectasia patients, carrying either an atm 5762ins137 splice site or a 7271t-->g missense mutation, with a less severe phenotype compared with the classical disorder. |
2001-09-06 |
2023-08-12 |
Not clear |
| J V Melo, A Kumberova, A G van Dijk, J M Goldman, M R Yuill. Investigation on the role of the ATM gene in chronic myeloid leukaemia. Leukemia. vol 15. issue 9. 2001-09-06. PMID:11516106. |
the ataxia telangiectasia gene, atm, is a candidate gene for this transformation because the complex karyotypes associated with bc of cml suggest that dna double-strand break repair is defective and because the abl pathway involves the interaction between the abl and the atm proteins. |
2001-09-06 |
2023-08-12 |
Not clear |
| G Buscemi, C Savio, L Zannini, F Miccichè, D Masnada, M Nakanishi, H Tauchi, K Komatsu, S Mizutani, K Khanna, P Chen, P Concannon, L Chessa, D Deli. Chk2 activation dependence on Nbs1 after DNA damage. Molecular and cellular biology. vol 21. issue 15. 2001-08-16. PMID:11438675. |
upon activation by low-dose ionizing radiation (ir), which occurs in an ataxia telangiectasia mutated (atm)-dependent manner, chk2 can phosphorylate the mitosis-inducing phosphatase cdc25c on an inhibitory site, blocking entry into mitosis, and p53 on a regulatory site, causing g(1) arrest. |
2001-08-16 |
2023-08-12 |
Not clear |
| L B Smilenov, D J Brenner, E J Hal. Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells. Cancer research. vol 61. issue 15. 2001-08-16. PMID:11479203. |
here, intralitter comparisons between wild-type mouse embryo fibroblasts and mouse embryo fibroblasts carrying ataxia telangiectasia mutated (atm) null mutation indicate that the heterozygous cells are more sensitive to radiation oncogenesis than their normal, litter-matched, counterparts. |
2001-08-16 |
2023-08-12 |
mouse |
| P J McKinno. Ataxia telangiectasia: new neurons and ATM. Trends in molecular medicine. vol 7. issue 6. 2001-07-26. PMID:11378498. |
ataxia telangiectasia: new neurons and atm. |
2001-07-26 |
2023-08-12 |
human |
| P J McKinno. Ataxia telangiectasia: new neurons and ATM. Trends in molecular medicine. vol 7. issue 6. 2001-07-26. PMID:11378498. |
despite the rarity of the human autosomal recessive disease ataxia telangiectasia (a-t) (affecting approximately 1/40000-1/100000), interest in the function of the mutated gene product (atm) in this syndrome is intense. |
2001-07-26 |
2023-08-12 |
human |
| M Gatei, B B Zhou, K Hobson, S Scott, D Young, K K Khann. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. The Journal of biological chemistry. vol 276. issue 20. 2001-07-05. PMID:11278964. |
ataxia telangiectasia mutated (atm) kinase and atm and rad3 related kinase mediate phosphorylation of brca1 at distinct and overlapping sites. |
2001-07-05 |
2023-08-12 |
Not clear |
| M Gatei, B B Zhou, K Hobson, S Scott, D Young, K K Khann. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. The Journal of biological chemistry. vol 276. issue 20. 2001-07-05. PMID:11278964. |
we also provide evidence that the rapid phosphorylation of brca1 at ser-1423 and ser-1524 after ir (but not after uv) is largely ataxia telangiectasia mutated (atm) kinase-dependent. |
2001-07-05 |
2023-08-12 |
Not clear |
| G Damia, L Filiberti, F Vikhanskaya, L Carrassa, Y Taya, M D'incalci, M Broggin. Cisplatinum and taxol induce different patterns of p53 phosphorylation. Neoplasia (New York, N.Y.). vol 3. issue 1. 2001-06-21. PMID:11326311. |
using two ataxia telangiectasia mutated (atm) cell lines, the role of atm in drug-induced p53 phosphorylations was investigated. |
2001-06-21 |
2023-08-12 |
human |
| M Hekmat-Nejad, Z You, M C Yee, J W Newport, K A Cimpric. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Current biology : CB. vol 10. issue 24. 2001-06-14. PMID:11137007. |
recent studies using xenopus extracts have demonstrated that activation of the replication checkpoint and phosphorylation of the chk1 kinase are dependent on rna primer synthesis by dna polymerase alpha, and it has been suggested that the atr kinase-so-called because it is related to the product of the gene that is mutated in ataxia telangiectasia (atm) and to rad3 kinase-may be an upstream component of this response. |
2001-06-14 |
2023-08-12 |
xenopus_laevis |
| K Tanaka, M N Boddy, X B Chen, C H McGowan, P Russel. Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1. Molecular and cellular biology. vol 21. issue 10. 2001-06-07. PMID:11313465. |
cds1 is regulated by a group of proteins that includes rad3, a kinase related to human checkpoint kinase atm (ataxia telangiectasia mutated). |
2001-06-07 |
2023-08-12 |
human |
| S Tribius, A Pidel, D Caspe. ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture. International journal of radiation oncology, biology, physics. vol 50. issue 2. 2001-06-07. PMID:11380241. |
in contrast, cells derived from individuals with ataxia telangiectasia (at), possessing mutations in the atm gene, demonstrate increased sensitivity to ionizing radiation. |
2001-06-07 |
2023-08-12 |
Not clear |
| I Rappold, K Iwabuchi, T Date, J Che. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. The Journal of cell biology. vol 153. issue 3. 2001-05-31. PMID:11331310. |
several observations suggest that 53bp1 is regulated by ataxia telangiectasia mutated (atm) after dna damage. |
2001-05-31 |
2023-08-12 |
Not clear |