| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ola M Ghoneim, Diaa A Ibrahim, Ibrahim M El-Deeb, So Ha Lee, Raymond G Boot. A novel potential therapeutic avenue for autism: design, synthesis and pharmacophore generation of SSRIs with dual action. Bioorganic & medicinal chemistry letters. vol 21. issue 22. 2012-02-13. PMID:21982496. |
autism symptoms are currently modulated by selective serotonin reuptake inhibitors (ssris). |
2012-02-13 |
2023-08-12 |
Not clear |
| Kimberly L Simpson, Kristin J Weaver, Etienne de Villers-Sidani, Jordan Y-F Lu, Zhengwei Cai, Yi Pang, Federico Rodriguez-Porcel, Ian A Paul, Michael Merzenich, Rick C S Li. Perinatal antidepressant exposure alters cortical network function in rodents. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 45. 2012-01-25. PMID:22025710. |
these findings indicate that 5-ht homeostasis is required for proper brain maturation and that fetal/infant exposure to ssris should be examined in humans, particularly those with developmental dysfunction, such as autism. |
2012-01-25 |
2023-08-12 |
rat |
| Efrain C Azmitia, Jorawer S Singh, Patricia M Whitaker-Azmiti. Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21329710. |
increased serotonin axons (immunoreactive to 5-ht transporter) in postmortem brains from young autism donors. |
2012-01-18 |
2023-08-12 |
Not clear |
| Efrain C Azmitia, Jorawer S Singh, Patricia M Whitaker-Azmiti. Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21329710. |
morphometric analysis of the stained axons at all ages studied indicated that the number of serotonin axons was increased in both pathways and terminal regions in cortex from autism donors. |
2012-01-18 |
2023-08-12 |
Not clear |
| Efrain C Azmitia, Jorawer S Singh, Xiao P Hou, Jerzy Wegie. Dystrophic serotonin axons in postmortem brains from young autism patients. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:21901837. |
dystrophic serotonin axons in postmortem brains from young autism patients. |
2012-01-17 |
2023-08-12 |
Not clear |
| Efrain C Azmitia, Jorawer S Singh, Xiao P Hou, Jerzy Wegie. Dystrophic serotonin axons in postmortem brains from young autism patients. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:21901837. |
our review presents immunocytochemical evidence of an increase in 5-ht axons in postmortem brain tissue from autism donors aged 2.8-29 years relative to controls. |
2012-01-17 |
2023-08-12 |
Not clear |
| Efrain C Azmitia, Jorawer S Singh, Xiao P Hou, Jerzy Wegie. Dystrophic serotonin axons in postmortem brains from young autism patients. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:21901837. |
these findings provide morphological evidence for the involvement of serotonin neurons in the early etiology of autism, and suggest new therapies may be effective to blunt serotonin's trophic actions during early brain development in children. |
2012-01-17 |
2023-08-12 |
Not clear |
| Flora Tassone, Lihong Qi, Wenting Zhang, Robin L Hansen, Isaac N Pessah, Irva Hertz-Picciott. MAOA, DBH, and SLC6A4 variants in CHARGE: a case-control study of autism spectrum disorders. Autism research : official journal of the International Society for Autism Research. vol 4. issue 4. 2011-12-22. PMID:21538940. |
we examined three loci, serotonin transporter (slc6a4), dopamine β-hydroxylase (dbh), and the variable number of tandem repeat promoter of the monoamine oxidase a (maoa) for association with autism in participants from the childhood autism risks from genetics and the environment (charge ) study, the first large-scale population-based case-control investigation of both environmental and genetic contributions to autism risk. |
2011-12-22 |
2023-08-12 |
human |
| Kazuhiko Nakamura, Yasuhide Iwata, Ayyappan Anitha, Taishi Miyachi, Tomoko Toyota, Satoru Yamada, Masatsugu Tsujii, Kenji J Tsuchiya, Yoshimi Iwayama, Kazuo Yamada, Eiji Hattori, Hideo Matsuzaki, Kaori Matsumoto, Katsuaki Suzuki, Shiro Suda, Kiyokazu Takebayashi, Nori Takei, Hironobu Ichikawa, Toshiro Sugiyama, Takeo Yoshikawa, Norio Mor. Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 2. 2011-11-22. PMID:21118708. |
serotonin transporter (5-htt), which modulates serotonin levels, is a major therapeutic target in autism. |
2011-11-22 |
2023-08-12 |
Not clear |
| Dubravka Hranilovic, Sofia Blazevic, Nedjeljka Ivica, Lipa Cicin-Sain, Darko Oreskovi. The effects of the perinatal treatment with 5-hydroxytryptophan or tranylcypromine on the peripheral and central serotonin homeostasis in adult rats. Neurochemistry international. vol 59. issue 2. 2011-11-22. PMID:21672593. |
autism is a neurodevelopmental disorder in which 5ht homeostasis is disturbed both centrally and peripherally, but the relationship between the 5ht disturbances in the two compartments is not understood. |
2011-11-22 |
2023-08-12 |
rat |
| Dubravka Hranilovic, Sofia Blazevic, Nedjeljka Ivica, Lipa Cicin-Sain, Darko Oreskovi. The effects of the perinatal treatment with 5-hydroxytryptophan or tranylcypromine on the peripheral and central serotonin homeostasis in adult rats. Neurochemistry international. vol 59. issue 2. 2011-11-22. PMID:21672593. |
further studies are planned in order to explore the nature of the different disturbances of 5ht homeostasis induced by the two compounds, and their results are expected to shed some light on the role of hyperserotonemia in autism. |
2011-11-22 |
2023-08-12 |
rat |
| C Doyen, D Mighiu, K Kaye, C Colineaux, C Beaumanoir, Y Mouraeff, C Rieu, P Paubel, Y Contejea. Melatonin in children with autistic spectrum disorders: recent and practical data. European child & adolescent psychiatry. vol 20. issue 5. 2011-08-15. PMID:21359552. |
over the last 20 years, melatonin, a pineal hormone synthesized from serotonin, has been implicated in various studies on the autism spectrum disorder (asd) and altered melatonin levels were detected in subgroups of subjects with asd. |
2011-08-15 |
2023-08-12 |
human |
| Michelle D Carter, Charisma R Shah, Christopher L Muller, Jacqueline N Crawley, Ana M D Carneiro, Jeremy Veenstra-VanderWeel. Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directions. Autism research : official journal of the International Society for Autism Research. vol 4. issue 1. 2011-07-20. PMID:21254450. |
elevated whole blood serotonin 5-ht, or hyperserotonemia, is a common biomarker in autism spectrum disorder (asd). |
2011-07-20 |
2023-08-12 |
mouse |
| Jeremy Veenstra-Vanderweele, Tammy N Jessen, Brent J Thompson, Michelle Carter, Harish C Prasad, Jennifer A Steiner, James S Sutcliffe, Randy D Blakel. Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse. Journal of neurodevelopmental disorders. vol 1. issue 2. 2011-07-14. PMID:19960097. |
modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter gly56ala knock-in mouse. |
2011-07-14 |
2023-08-12 |
mouse |
| Jeremy Veenstra-Vanderweele, Tammy N Jessen, Brent J Thompson, Michelle Carter, Harish C Prasad, Jennifer A Steiner, James S Sutcliffe, Randy D Blakel. Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse. Journal of neurodevelopmental disorders. vol 1. issue 2. 2011-07-14. PMID:19960097. |
alterations in peripheral and central indices of serotonin (5-hydroxytryptamine, 5-ht) production, storage and signaling have long been associated with autism. |
2011-07-14 |
2023-08-12 |
mouse |
| Dea Adamsen, David Meili, Nenad Blau, Beat Thöny, Vincent Ramaeker. Autism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants. Molecular genetics and metabolism. vol 102. issue 3. 2011-06-06. PMID:21183371. |
the known gly56ala mutation in the serotonin transporter sert (or 5-htt), encoded by the slc6a4 gene, causes increased serotonin reuptake and has been associated with autism and rigid-compulsive behavior. |
2011-06-06 |
2023-08-12 |
Not clear |
| Valerio Napolioni, Federica Lombardi, Roberto Sacco, Paolo Curatolo, Barbara Manzi, Riccardo Alessandrelli, Roberto Militerni, Carmela Bravaccio, Carlo Lenti, Monica Saccani, Cindy Schneider, Raun Melmed, Tiziana Pascucci, Stefano Puglisi-Allegra, Karl-Ludvig Reichelt, Francis Rousseau, Patricia Lewin, Antonio M Persic. Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes. European journal of human genetics : EJHG. vol 19. issue 3. 2011-05-31. PMID:21102624. |
the integrin-β 3 gene (itgb3), located on human chromosome 17q21.3, was previously identified as a quantitative trait locus (qtl) for 5-ht blood levels and has been implicated as a candidate gene for autism spectrum disorder (asd). |
2011-05-31 |
2023-08-12 |
human |
| Valerio Napolioni, Federica Lombardi, Roberto Sacco, Paolo Curatolo, Barbara Manzi, Riccardo Alessandrelli, Roberto Militerni, Carmela Bravaccio, Carlo Lenti, Monica Saccani, Cindy Schneider, Raun Melmed, Tiziana Pascucci, Stefano Puglisi-Allegra, Karl-Ludvig Reichelt, Francis Rousseau, Patricia Lewin, Antonio M Persic. Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes. European journal of human genetics : EJHG. vol 19. issue 3. 2011-05-31. PMID:21102624. |
distinct markers, located toward the 5' and 3' ends of the gene, seemingly modulate 5-ht blood levels and autism liability, respectively. |
2011-05-31 |
2023-08-12 |
human |
| Emily Kistner-Griffin, Camille W Brune, Lea K Davis, James S Sutcliffe, Nancy J Cox, Edwin H Coo. Parent-of-origin effects of the serotonin transporter gene associated with autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156. issue 2. 2011-05-17. PMID:21302342. |
parent-of-origin effects of the serotonin transporter gene associated with autism. |
2011-05-17 |
2023-08-12 |
Not clear |
| Zainunisha Arieff, Mandeep Kaur, Hajirah Gameeldien, Lize van der Merwe, Vladimir B Baji. 5-HTTLPR polymorphism: analysis in South African autistic individuals. Human biology. vol 82. issue 3. 2011-03-03. PMID:20649385. |
the serotonin transporter promoter length polymorphism (5-hydroxytryptamine transporter length polymorphism; 5-httlpr) has long been implicated in autism and other psychiatric disorders. |
2011-03-03 |
2023-08-12 |
human |