| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Emerit, M Edeas, F Bricair. Neurodegenerative diseases and oxidative stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 58. issue 1. 2004-09-28. PMID:14739060. |
cell energy impairment, apoptosis and overproduction of ros, is a final common pathogenic mechanism in aging and in neurodegenerative disease such as alzheimer's disease (ad), parkinson's disease (pd) and amyotrophic lateral sclerosis (als). |
2004-09-28 |
2023-08-12 |
Not clear |
| Wim Wätjen, Detmar Beyersman. Cadmium-induced apoptosis in C6 glioma cells: influence of oxidative stress. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 17. issue 1. 2004-09-03. PMID:14977363. |
because both apoptosis and oxidative stress are thought to play important roles in neurodegenerative diseases, low concentrations of cadmium that initiate programmed cell death may lead to a selective cell death in distinct brain regions via generation of oxidative stress. |
2004-09-03 |
2023-08-12 |
Not clear |
| Dennis W Dickso. Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? The Journal of clinical investigation. vol 114. issue 1. 2004-08-02. PMID:15232608. |
increasing evidence suggests that selective neuronal loss in neurodegenerative diseases involves activation of cysteine aspartyl proteases (caspases), which initiate and execute apoptosis. |
2004-08-02 |
2023-08-12 |
Not clear |
| Roberta De Simone, Maria Antonietta Ajmone-Cat, Luisa Minghett. Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. Molecular neurobiology. vol 29. issue 2. 2004-07-23. PMID:15126686. |
in the central nervous system (cns), apoptosis plays an important role during development and is a primary pathogenic mechanism in several adult neurodegenerative diseases. |
2004-07-23 |
2023-08-12 |
Not clear |
| Roberta De Simone, Maria Antonietta Ajmone-Cat, Luisa Minghett. Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. Molecular neurobiology. vol 29. issue 2. 2004-07-23. PMID:15126686. |
we propose that the anti-inflammatory microglial phenotype induced through the activation of the specific ps receptor (ptdserr), expressed by resting and activated microglial cells, could be relevant to the final outcome of neurodegenerative diseases, in which apoptosis seems to play a crucial role. |
2004-07-23 |
2023-08-12 |
Not clear |
| Alexandra Stolzing, Tilman Grun. Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 6. 2004-07-15. PMID:14766802. |
neuronal loss via apoptosis is a key element in numerous neurodegenerative diseases. |
2004-07-15 |
2023-08-12 |
rat |
| Thomas Mronga, Thomas Stahnke, Olaf Goldbaum, Christiane Richter-Landsber. Mitochondrial pathway is involved in hydrogen-peroxide-induced apoptotic cell death of oligodendrocytes. Glia. vol 46. issue 4. 2004-07-14. PMID:15095374. |
mitochondria are considered as a central control point of apoptosis, and mitochondrial dysfunction has been linked to neurodegenerative disease. |
2004-07-14 |
2023-08-12 |
rat |
| Cristina Colombo, Marco Cosentino, Franca Marino, Emanuela Rasini, Maria Ossola, Fabio Blandini, Anna Mangiagalli, Alberta Samuele, Marco Ferrari, Raffaella Bombelli, Sergio Lecchini, Giuseppe Nappi, Gianmario Frig. Dopaminergic modulation of apoptosis in human peripheral blood mononuclear cells: possible relevance for Parkinson's disease. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033811. |
dopamine (da) modulates apoptosis in neuronal and non-neuronal cells, and dopaminergic pathways contribute to neurodegenerative disease. |
2004-06-15 |
2023-08-12 |
human |
| Siew Boon Cheng Chew, Pui Ying Leung, Ronald Ray Fiscu. Preincubation with atrial natriuretic peptide protects NG108-15 cells against the toxic/proapoptotic effects of the nitric oxide donor S-nitroso- N-acetylpenicillamine. Histochemistry and cell biology. vol 120. issue 3. 2004-06-10. PMID:14504961. |
this neuroprotective mechanism involving cgmp may be especially important in protecting against the development of neurodegenerative diseases in which excess no is thought to contribute to neuronal apoptosis. |
2004-06-10 |
2023-08-12 |
Not clear |
| Peter C Waldmeier, William G Tatto. Interrupting apoptosis in neurodegenerative disease: potential for effective therapy? Drug discovery today. vol 9. issue 5. 2004-06-02. PMID:14980539. |
interrupting apoptosis in neurodegenerative disease: potential for effective therapy? |
2004-06-02 |
2023-08-12 |
Not clear |
| Peter C Waldmeier, William G Tatto. Interrupting apoptosis in neurodegenerative disease: potential for effective therapy? Drug discovery today. vol 9. issue 5. 2004-06-02. PMID:14980539. |
however, it has been established that apoptosis contributes to neuronal loss in most neurodegenerative diseases. |
2004-06-02 |
2023-08-12 |
Not clear |
| Esther B E Becker, Azad Bonn. Cell cycle regulation of neuronal apoptosis in development and disease. Progress in neurobiology. vol 72. issue 1. 2004-05-10. PMID:15019174. |
here, we will review the molecular mechanisms of neuronal cell death and survival with a focus on recent findings on cell cycle regulation of neuronal apoptosis in primary cultures of neurons, mouse models of neuronal diseases, and human neurodegenerative diseases. |
2004-05-10 |
2023-08-12 |
mouse |
| Sean P Cregan, Valina L Dawson, Ruth S Slac. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene. vol 23. issue 16. 2004-05-06. PMID:15077142. |
continued study of the mechanisms of apoptosis including caspase-independent death processes are likely to reveal novel therapeutic targets for the treatment of diverse human pathologies including cancer, neurodegenerative diseases and acute injuries such as stroke or myocardial infarction. |
2004-05-06 |
2023-08-12 |
human |
| Ciara A Ryan, Guy S Salvese. Caspases and neuronal development. Biological chemistry. vol 384. issue 6. 2004-05-03. PMID:12887052. |
the basic mechanisms that underlie apoptosis in neurodegenerative diseases are uncertain, although they likely represent the subversion of normal developmental programs. |
2004-05-03 |
2023-08-12 |
Not clear |
| G L Russo, M Russ. Ins and outs of apoptosis in cardiovascular diseases. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 13. issue 5. 2004-04-05. PMID:14717062. |
apoptosis, also known as programmed cell death (pcd), is genetically programmed "cell suicide" that plays an essential role in physiological processes such as embryo development, synaptogenesis, tissue turnover and the negative selection of t-cells, as well as in many diseases, such as cancer, and autoimmune and neurodegenerative diseases. |
2004-04-05 |
2023-08-12 |
Not clear |
| T R Rosenstock, A C P Carvalho, A Jurkiewicz, R Frussa-Filho, S S Smail. Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009678. |
mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid. |
2004-03-30 |
2023-08-12 |
Not clear |
| Manuchair Ebadi, Sushil K Sharm. Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease. Antioxidants & redox signaling. vol 5. issue 3. 2004-03-24. PMID:12880486. |
as apoptosis is critical to the progression of neurodegenerative disease, including pd, selegiline or selegiline-like compounds to be discovered in the future may be efficacious in treating pd. |
2004-03-24 |
2023-08-12 |
mouse |
| E A Martynov. [Regulation of caspase activity in apoptosis]. Bioorganicheskaia khimiia. vol 29. issue 5. 2004-03-01. PMID:14601408. |
in particular, the use of extracellular activators and inhibitors of caspases allows irreversible activation of apoptosis in tumor cells or the prevention of neuron death in neurodegenerative diseases. |
2004-03-01 |
2023-08-12 |
Not clear |
| Hyun Song, Young Choong Kim, Aree Moo. Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells. Biological & pharmaceutical bulletin. vol 26. issue 10. 2004-02-17. PMID:14519949. |
neuronal apoptosis may contribute to pathologic neuronal loss in certain disease states such as neurodegenerative diseases. |
2004-02-17 |
2023-08-12 |
rat |
| Jianfeng Li, Wenyan Li, Jialin Su, Weimin Liu, Bella T Altura, Burton M Altur. Hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. Brain research bulletin. vol 62. issue 2. 2004-02-06. PMID:14638383. |
hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. |
2004-02-06 |
2023-08-12 |
Not clear |