| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arianna Bellucci, Luigi Bubacco, Francesca Longhena, Edoardo Parrella, Gaia Faustini, Vanessa Porrini, Federica Bono, Cristina Missale, Marina Pizz. Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson's Disease. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32265684. |
nuclear factor-κb (nf-κb) transcription factors, key regulators of inflammation and apoptosis, are involved in the brain programming of systemic aging as well as in the pathogenesis of several neurodegenerative diseases. |
2020-09-28 |
2023-08-13 |
mouse |
| Gemma Serrano-Heras, Inmaculada Díaz-Maroto, Beatriz Castro-Robles, Blanca Carrión, Ana B Perona-Moratalla, Julia Gracia, Sandra Arteaga, Francisco Hernández-Fernández, Jorge García-García, Oscar Ayo-Martín, Tomás Segur. Isolation and Quantification of Blood Apoptotic Bodies, a Non-invasive Tool to Evaluate Apoptosis in Patients with Ischemic Stroke and Neurodegenerative Diseases. Biological procedures online. vol 22. 2020-09-28. PMID:32765191. |
isolation and quantification of blood apoptotic bodies, a non-invasive tool to evaluate apoptosis in patients with ischemic stroke and neurodegenerative diseases. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hui Zhao, Yan Feng, Changjuan Wei, Yan Li, Hongshan Ma, Xuejiao Wang, Zhigang Cui, Wei-Na Jin, Fu-Dong Sh. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway. Neuroscience. vol 416. 2020-09-24. PMID:31374230. |
colivelin is a neuroprotective humanin family peptide with potent long-term capacity against aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. |
2020-09-24 |
2023-08-13 |
mouse |
| Bei Li, Yuan Zhao, ManYu Song, HaiLin Cui, XiuJing Feng, TianYuan Yang, Hong-Gang Fa. Role of c-Myc/chloride intracellular channel 4 pathway in lipopolysaccharide-induced neurodegenerative diseases. Toxicology. vol 429. 2020-08-17. PMID:31693917. |
lps-induced neuronal apoptosis leads to neurodegenerative diseases (nds). |
2020-08-17 |
2023-08-13 |
Not clear |
| Karin Aistleitner, Tina Clark, Cheryl Dooley, Ted Hackstad. Selective fragmentation of the trans-Golgi apparatus by Rickettsia rickettsii. PLoS pathogens. vol 16. issue 5. 2020-07-21. PMID:32421751. |
fragmentation of the golgi apparatus is observed during a number of physiological processes including mitosis and apoptosis, but also occurs in pathological states such as neurodegenerative diseases and some infectious diseases. |
2020-07-21 |
2023-08-13 |
Not clear |
| Wenqing Jiang, Peng Jin, Wenfeng Wei, Wei Jian. Apoptosis in cerebrospinal fluid as outcome predictors in severe traumatic brain injury: An observational study. Medicine. vol 99. issue 26. 2020-07-07. PMID:32590803. |
apoptosis plays a pathogenic role in a series of neurological disorders, from neurodegenerative diseases to acute neurological lesions.in this study, we analyzed the association between apoptosis and the glasgow outcome scale (gos), to examine the potential of apoptosis as a biomarker for a tbi outcome. |
2020-07-07 |
2023-08-13 |
human |
| Angélique Sadlon, Petros Takousis, Panagiotis Alexopoulos, Evangelos Evangelou, Inga Prokopenko, Robert Perneczk. miRNAs Identify Shared Pathways in Alzheimer's and Parkinson's Diseases. Trends in molecular medicine. vol 25. issue 8. 2020-06-30. PMID:31221572. |
mirnas relevant to both neurodegenerative diseases are related to axonal guidance, apoptosis, and inflammation, therefore, ad and pd likely arise from similar underlying biological pathway defects. |
2020-06-30 |
2023-08-13 |
Not clear |
| Wen Li, Yue Ma, Zhenshu Li, Xin Lv, Xinyan Wang, Dezheng Zhou, Suhui Luo, John X Wilson, Guowei Huan. Folic Acid Decreases Astrocyte Apoptosis by Preventing Oxidative Stress-Induced Telomere Attrition. International journal of molecular sciences. vol 21. issue 1. 2020-05-15. PMID:31861819. |
astrocytes are the most widely distributed cells in the brain, and astrocyte apoptosis may play an important role in the pathogenesis of neurodegenerative diseases. |
2020-05-15 |
2023-08-13 |
Not clear |
| Si-Tong Feng, Zhen-Zhen Wang, Yu-He Yuan, Hong-Mei Sun, Nai-Hong Chen, Yi Zhan. Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer's and Parkinson's disease models. Pharmacological research. vol 146. 2020-05-11. PMID:31271846. |
alzheimer's disease (ad) and parkinson's disease (pd) are recognized as the universal neurodegenerative diseases, with the involvement of misfolded proteins pathology, leading to oxidative stress, glial cells activation, neuroinflammation, mitochondrial dysfunction, and cellular apoptosis. |
2020-05-11 |
2023-08-13 |
rat |
| Celeste M Pilato, Jae Hong Park, Lingling Kong, Constantin d'Ydewalle, David Valdivia, Karen S Chen, Irene Griswold-Prenner, Charlotte J Sumne. Motor neuron loss in SMA is not associated with somal stress-activated JNK/c-Jun signaling. Human molecular genetics. vol 28. issue 19. 2020-05-11. PMID:31272106. |
the c-jun nh2-terminal kinases (jnks) are stress-activated kinases with multiple substrates including c-jun, which can be activated during neuronal injury and neurodegenerative disease leading to neuronal apoptosis. |
2020-05-11 |
2023-08-13 |
mouse |
| Yuanbo Wu, Meiqiao Chen, Jielong Jian. Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion. vol 49. 2020-05-06. PMID:31288090. |
most central pathological feature of the neurodegenerative diseases is apoptosis which is regulated by mitochondria. |
2020-05-06 |
2023-08-13 |
Not clear |
| Zhihao Qi, Zhen Huang, Feng Xie, Linxi Che. Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30515821. |
here, we will give a detailed review about the recent developments in regards to dynamin-related protein 1 (drp1) induced unbalanced mitochondrial dynamics, excessive mitochondrial division, and neuronal injury in neural system dysfunctions and neurodegenerative diseases, including the drp1 knockout induced mice embryonic death, the dysfunction of the drp1-dependent mitochondrial division induced neuronal cell apoptosis and impaired neuronal axonal transportation, the abnormal interaction between drp1 and amyloid β (aβ) in alzheimer's disease (ad), the mutant huntingtin (htt) in huntington's disease (hd), and the drp1-associated pathogenesis of other neurodegenerative diseases such as parkinson's disease (pd) and amyotrophic lateral sclerosis (als). drp1 is required for mitochondrial division determining the size, shape, distribution, and remodeling as well as maintaining of mitochondrial integrity in mammalian cells. |
2020-05-04 |
2023-08-13 |
mouse |
| Zhihao Qi, Zhen Huang, Feng Xie, Linxi Che. Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30515821. |
in addition, increasing reports indicate that the drp1 is involved in some cellular events of neuronal cells causing some neural system dysfunctions and neurodegenerative diseases, including impaired mitochondrial dynamics, apoptosis, and several posttranslational modification induced increased mitochondrial divisions. |
2020-05-04 |
2023-08-13 |
mouse |
| Dominique R Perez, Larry A Sklar, Alexandre Chigae. Clioquinol: To harm or heal. Pharmacology & therapeutics. vol 199. 2020-04-27. PMID:30898518. |
further understanding of clioquinol's role in the inhibition of camp efflux and promoting apoptosis might offer promise for the treatment of cancer and/or neurodegenerative diseases. |
2020-04-27 |
2023-08-13 |
Not clear |
| Haiyang Zhang, Mian Wei, Xiangyu Lu, Qinghong Sun, Chuqiao Wang, Jiuyan Zhang, Honggang Fa. Aluminum trichloride caused hippocampal neural cells death and subsequent depression-like behavior in rats via the activation of IL-1β/JNK signaling pathway. The Science of the total environment. vol 715. 2020-04-03. PMID:32007895. |
aluminum (al) is an inorganic pollutant that induces nerve cells apoptosis and necroptosis, thereby causing depression and neurodegenerative diseases. |
2020-04-03 |
2023-08-13 |
rat |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
abbreviation: aids: acquired immunodeficiency syndrome; atf6: activating transcription factor 6; atg6: autophagy-specific gene 6; bag3: bcl associated athanogene 3; bak: bcl-2-anatagonist/killer1; bax; bcl-2: associated x protein; bcl-2: b cell lymphoma 2x; bip: chaperon immunoglobulin heavy chain binding protein; card: caspase recruitment domain; cart: combination antiretroviral therapy; ccr5: c-c chemokine receptor type 5; cd4: cluster of differentiation 4; chop: c/ebp homologous protein; cxcr4: c-x-c chemokine receptor type 4; cyto c: cytochrome c; dcs: dendritic cells; edem1: er-degradation enhancing-a-mannosidase-like protein 1; env: envelope; er: endoplasmic reticulum; fasr: fas receptor;g2: gap 2; g2/m: gap2/mitosis; gfap: glial fibrillary acidic protein; gp120: glycoprotein120; gp41: glycoprotein41; hand: hiv associated neurodegenerative disease; hek: human embryonic kidney; hela: human cervical epithelial carcinoma; hiv: human immunodeficiency virus; ips-1: ifn-β promoter stimulator 1; ire-1: inositol requiring enzyme 1; irgm: immunity related gtpase family m protein; lamp2a: lysosome associated membrane protein 2a; lc3: microtubule associated light chain 3; mda5: melanoma differentiation associated gene 5; mef: mouse embryonic fibroblast; mmp: mitochondrial membrane permeabilization; nef: negative regulatory factor; oasis: old astrocyte specifically induced substrate; pamp: pathogen-associated molecular pattern; perk: pancreatic endoplasmic reticulum kinase; prr: pattern recognition receptor; puma: p53 upregulated modulator of apoptosis; rig-i: retinoic acid-inducible gene-i; tat: transactivator protein of hiv; tlr: toll-like receptor; ulk1: unc51 like autophagy activating kinase 1; upr: unfolded protein response; vpr: viral protein regulatory; xbp1: x-box binding protein 1. |
2020-03-05 |
2023-08-13 |
mouse |
| Hao Lin, Wan-Qi Yang, Zi Ye, Chong-Jing Zhan. Identification of Potent Caspase-8 Inhibitors from a Library of Fluorescent Natural Products Screened by an AIEgen-Based Light-Up Probe. Chembiochem : a European journal of chemical biology. vol 20. issue 10. 2020-02-25. PMID:30648790. |
caspase-8 is a key player in apoptosis, its inhibition having been found to be beneficial for treatment of inflammatory and neurodegenerative diseases. |
2020-02-25 |
2023-08-13 |
Not clear |
| Wensu Yuan, Carlos F Ibáñez, Zhi Li. Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub. Biological reviews of the Cambridge Philosophical Society. vol 94. issue 4. 2020-02-25. PMID:30762293. |
it is a primary mediator of a variety of biological activities, including apoptosis, cell survival and cytoskeletal changes, which are related to many neurodegenerative diseases, neurotrauma, and cancers. |
2020-02-25 |
2023-08-13 |
Not clear |
| Yujeong Lee, Jung-Hyun Cho, Seulah Lee, Wonjong Lee, Seung-Cheol Chang, Hae Young Chung, Hyung Ryong Moon, Jaewon Le. Neuroprotective effects of MHY908, a PPAR α/γ dual agonist, in a MPTP-induced Parkinson's disease model. Brain research. vol 1704. 2020-02-11. PMID:30273550. |
a number of ppar agonists have been shown to have neuroprotective properties in the presence of oxidative stress, neuroinflammatory response, and apoptosis in various neurodegenerative disease. |
2020-02-11 |
2023-08-13 |
mouse |
| Yogesh Kumar Dhuriya, Divakar Sharma, Aijaz A Nai. Cellular demolition: Proteins as molecular players of programmed cell death. International journal of biological macromolecules. vol 138. 2020-01-28. PMID:31330212. |
furthermore, diminished forms of apoptosis result in cancer and autoimmune diseases, whereas unregulated apoptosis may also lead to the development of a myriad of neurodegenerative diseases. |
2020-01-28 |
2023-08-13 |
Not clear |