| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Algeciras, D H Dockrell, D H Lynch, C V Pay. CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis. The Journal of experimental medicine. vol 187. issue 5. 1998-03-24. PMID:9480981. |
altogether, these results provide a model with which to study the molecular mechanisms regulating lymphocyte survival after cd4 activation, and highlight the potential role of cd4 in controlling lymphocyte apoptosis under physiological conditions or in disease states such as hiv infection. |
1998-03-24 |
2023-08-12 |
human |
| C M Godard, H Serriès, C Fulachier, J C Cherman. Apoptosis of CD4+ T cells induced after contact with HIV1-infected or non-infected macrophages. Research in virology. vol 148. issue 6. 1998-03-16. PMID:9498010. |
one such proposed mechanism is the induction of apoptosis through cross-linking of the cd4 receptor by anti-cd4 antibodies or by the hiv1 envelope protein expressed at the surface of infected cells. |
1998-03-16 |
2023-08-12 |
human |
| C M Godard, H Serriès, C Fulachier, J C Cherman. Apoptosis of CD4+ T cells induced after contact with HIV1-infected or non-infected macrophages. Research in virology. vol 148. issue 6. 1998-03-16. PMID:9498010. |
cocultivating with mdms, either infected or not, in the presence of anti-cd4 mab leu-3a, also leads to mt4 cell death, with dna fragmentation being detected at 24-40 h. leu-3a induced apoptosis does not require cross-linking of cd4 by anti-immunoglobulin, showing that mdms provide an alternative to conventional cross-linking. |
1998-03-16 |
2023-08-12 |
human |
| B Combadière, C Reis e Sousa, R N Germain, M J Lenard. Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands. The Journal of experimental medicine. vol 187. issue 3. 1998-03-13. PMID:9449715. |
here we describe altered ligands for mature mouse cd4(+) t helper 1 cells that lead to t cell apoptosis by the selective expression of fas ligand (fasl) and tumor necrosis factor (tnf) without concomitant il-2, il-3, or interferon gamma production. |
1998-03-13 |
2023-08-12 |
mouse |
| L Conti, G Rainaldi, P Matarrese, B Varano, R Rivabene, S Columba, A Sato, F Belardelli, W Malorni, S Gessan. The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis of AIDS. The Journal of experimental medicine. vol 187. issue 3. 1998-03-13. PMID:9449720. |
although apoptosis is considered one of the major mechanisms of cd4(+) t cell depletion in hiv-infected patients, the virus-infected cells somehow appear to be protected from apoptosis, which generally occurs in bystander cells. |
1998-03-13 |
2023-08-12 |
human |
| C Guillerm, N Coudronnière, V Robert-Hebmann, C Devau. Delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of CD4. Journal of virology. vol 72. issue 3. 1998-03-12. PMID:9499024. |
delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of cd4. |
1998-03-12 |
2023-08-12 |
human |
| C Guillerm, N Coudronnière, V Robert-Hebmann, C Devau. Delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of CD4. Journal of virology. vol 72. issue 3. 1998-03-12. PMID:9499024. |
it has been reported previously that cells expressing a truncated form of cd4 which lacks the cytoplasmic tail of the molecule (truncation at position 402) were not sensitive to human immunodeficiency virus type 1 (hiv-1)-induced apoptosis in an acute-phase model of infection (j. corbeil, m. tremblay, and d. d. richman, j. exp. |
1998-03-12 |
2023-08-12 |
human |
| C Guillerm, N Coudronnière, V Robert-Hebmann, C Devau. Delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of CD4. Journal of virology. vol 72. issue 3. 1998-03-12. PMID:9499024. |
the role played by the cytoplasmic domain of cd4 in hiv-1-induced apoptosis was reexamined here with clones of a2.01 cells expressing different forms of cd4 and the dna intercalant yopro-1 assay. |
1998-03-12 |
2023-08-12 |
human |
| C Guillerm, N Coudronnière, V Robert-Hebmann, C Devau. Delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of CD4. Journal of virology. vol 72. issue 3. 1998-03-12. PMID:9499024. |
six days after virus exposure, we found evidence of apoptosis in a2.01 cells expressing the wild-type cd4 (a2.01/cd4), whereas enhanced apoptosis remained absent in cultures of a2.01/cd4.401 and a2.01/cd4.403 cells (a2.01 cells which express cd4.401 and cd4.403 molecules with truncations at positions 401 and 403, respectively). |
1998-03-12 |
2023-08-12 |
human |
| C Guillerm, N Coudronnière, V Robert-Hebmann, C Devau. Delayed human immunodeficiency virus type 1-induced apoptosis in cells expressing truncated forms of CD4. Journal of virology. vol 72. issue 3. 1998-03-12. PMID:9499024. |
the long lag time postinfection required for apoptosis to be observed in cultures of infected cells expressing truncated forms of cd4 was due to the delayed viral replication in these cells, as shown by monitoring of the viral reverse transcriptase activity and hiv-1 p24gag antigen expression. |
1998-03-12 |
2023-08-12 |
human |
| L Briant, V Robert-Hebmann, V Sivan, A Brunet, J Pouysségur, C Devau. Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-kappa B and AP-1 transcription factors. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 4. 1998-02-26. PMID:9469449. |
although the molecular mechanisms by which the hiv-1 triggers either t cell activation, anergy, or apoptosis remain poorly understood, it is well established that the interaction of hiv-1 envelope glycoproteins with cell surface cd4 delivers signals to the target cell, resulting in activation of transcription factors such as nf-kappa b and ap-1. |
1998-02-26 |
2023-08-12 |
Not clear |
| L Briant, V Robert-Hebmann, V Sivan, A Brunet, J Pouysségur, C Devau. Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-kappa B and AP-1 transcription factors. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 4. 1998-02-26. PMID:9469449. |
although the different cell lines studied expressed similar amounts of cd4 and p56(lck), hiv-1 replication and hiv-1-induced apoptosis were slightly delayed in cells expressing dominant negative forms of mek-1 or erk-1 compared with parental cem cells and cells expressing a constitutively active mutant form of mek-1 or wild-type erk-1. |
1998-02-26 |
2023-08-12 |
Not clear |
| W D Thomas, P Herse. CD4 T cells kill melanoma cells by mechanisms that are independent of Fas (CD95). International journal of cancer. vol 75. issue 3. 1998-02-20. PMID:9455798. |
we show that the cd4 t cells in 4 clones of t cells induced apoptosis in autologous melanoma cells by mhc-restricted mechanisms but lysed an allogeneic melanoma cell by a non-apoptotic mechanism. |
1998-02-20 |
2023-08-12 |
Not clear |
| S A Klein, J M Dobmeyer, T S Dobmeyer, D Falke, D Kabelitz, K Friese, E B Helm, D Hoelzer, R Rossol-Vot. TNF-alpha mediated apoptosis of CD4 positive T-lymphocytes. A model of T-cell depletion in HIV infected individuals. European journal of medical research. vol 1. issue 5. 1998-02-17. PMID:9374446. |
tnf-alpha mediated apoptosis of cd4 positive t-lymphocytes. |
1998-02-17 |
2023-08-12 |
Not clear |
| A Samuelsson, C Broström, N van Dijk, A Sönnerborg, F Chiod. Apoptosis of CD4+ and CD19+ cells during human immunodeficiency virus type 1 infection--correlation with clinical progression, viral load, and loss of humoral immunity. Virology. vol 238. issue 2. 1998-01-12. PMID:9400591. |
from these results we conclude that the extent of apoptosis in cultured cd4+ cells and cd19+ cells appears to parallel the decline in cd4 cell counts in infected individuals. |
1998-01-12 |
2023-08-12 |
human |
| P Secchiero, L Flamand, D Gibellini, E Falcieri, I Robuffo, S Capitani, R C Gallo, G Zaul. Human Herpesvirus 7 induces CD4(+) T-cell death by two distinct mechanisms: necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells. Blood. vol 90. issue 11. 1997-12-23. PMID:9373261. |
human herpesvirus 7 induces cd4(+) t-cell death by two distinct mechanisms: necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells. |
1997-12-23 |
2023-08-12 |
human |
| S M Tamma, N Chirmule, T W McCloskey, N Oyaizu, V S Kalyanaraman, S Pahw. Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis. Clinical immunology and immunopathology. vol 85. issue 2. 1997-12-16. PMID:9344703. |
the data presented here provide insight into the mechanism by which the interaction of hiv-1 envelope glycoproteins with cd4 molecules may alter tcr/cd3-activation-induced signal transduction resulting in anergy and apoptosis with consequent functional deficiency of cd4+ t cells. |
1997-12-16 |
2023-08-12 |
Not clear |
| P D Katsikis, M E Garcia-Ojeda, J F Torres-Roca, I M Tijoe, C A Smith, L A Herzenberg, L A Herzenber. Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection. The Journal of experimental medicine. vol 186. issue 8. 1997-11-21. PMID:9334376. |
we show that z-vad-fmk, a tripeptide inhibitor of ice homologues, can inhibit fas-induced apoptosis of peripheral blood cd4(+) and cd8+ t cells from asymptomatic hiv+ individuals. |
1997-11-21 |
2023-08-12 |
human |
| F T Hakim, R Cepeda, S Kaimei, C L Mackall, N McAtee, J Zujewski, K Cowan, R E Gres. Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood. vol 90. issue 9. 1997-11-18. PMID:9345067. |
when stimulated by mitogens, an increased susceptibility to apoptosis was observed in postchemotherapy cd4 cells as compared with those from normal donors. |
1997-11-18 |
2023-08-12 |
Not clear |
| F T Hakim, R Cepeda, S Kaimei, C L Mackall, N McAtee, J Zujewski, K Cowan, R E Gres. Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood. vol 90. issue 9. 1997-11-18. PMID:9345067. |
thus, cd4 recovery is constrained in adults by a limited thymic regenerative capacity and by an increased susceptibility to apoptosis within the expanding peripheral cd4 population. |
1997-11-18 |
2023-08-12 |
Not clear |