| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter J Vento, Nathan W Burnham, Courtney S Rowley, Thomas C Jho. Learning From One's Mistakes: A Dual Role for the Rostromedial Tegmental Nucleus in the Encoding and Expression of Punished Reward Seeking. Biological psychiatry. vol 81. issue 12. 2018-03-02. PMID:27931744. |
the recently identified rostromedial tegmental nucleus (rmtg) encodes a wide variety of aversive stimuli and sends robust inhibitory projections to midbrain dopamine neurons, leading to the hypothesis that the rmtg provides a brake to reward signaling in response to aversive costs. |
2018-03-02 |
2023-08-13 |
Not clear |
| Chandni Sheth, Teri M Furlong, Kristen A Keefe, Sharif A Tah. The lateral hypothalamus to lateral habenula projection, but not the ventral pallidum to lateral habenula projection, regulates voluntary ethanol consumption. Behavioural brain research. vol 328. 2018-02-07. PMID:28432009. |
the lateral habenula (lhb) is an epithalamic brain region implicated in aversive processing via negative modulation of midbrain dopamine (da) and serotonin (5-ht) systems. |
2018-02-07 |
2023-08-13 |
Not clear |
| André Luiz Vieira Lockmann, Flávio Afonso Gonçalves Mourão, Marcio Flávio Dutra Morae. Auditory fear conditioning modifies steady-state evoked potentials in the rat inferior colliculus. Journal of neurophysiology. vol 118. issue 2. 2018-02-05. PMID:28446582. |
the rat inferior colliculus (ic) is a major midbrain relay for ascending inputs from the auditory brain stem and has been suggested to play a key role in the processing of aversive sounds. |
2018-02-05 |
2023-08-13 |
rat |
| Francesco Rigoli, Benjamin Chew, Peter Dayan, Raymond J Dola. Multiple value signals in dopaminergic midbrain and their role in avoidance contexts. NeuroImage. vol 135. 2018-01-23. PMID:27132047. |
multiple value signals in dopaminergic midbrain and their role in avoidance contexts. |
2018-01-23 |
2023-08-13 |
Not clear |
| P Medeiros, R L de Freitas, M O Silva, N C Coimbra, L Melo-Thoma. CB1 cannabinoid receptor-mediated anandamide signaling mechanisms of the inferior colliculus modulate the haloperidol-induced catalepsy. Neuroscience. vol 337. 2017-12-21. PMID:27595886. |
the inferior colliculus (ic), a midbrain structure that processes acoustic information of aversive nature, is distinguished from other auditory nuclei in the brainstem by its connections with structures of the motor system. |
2017-12-21 |
2023-08-13 |
rat |
| Manish K Madasu, Bright N Okine, Weredeselam M Olango, Kieran Rea, Róisín Lenihan, Michelle Roche, David P Fin. Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey. Pharmacological research. vol 113. issue Pt A. 2017-12-20. PMID:27520401. |
transient receptor potential subfamily v member 1 (trpv1) within the midbrain periaqueductal grey (pag) plays a key role in regulating both aversive and nociceptive behaviour. |
2017-12-20 |
2023-08-13 |
rat |
| Hideyuki Matsumoto, Ju Tian, Naoshige Uchida, Mitsuko Watabe-Uchid. Midbrain dopamine neurons signal aversion in a reward-context-dependent manner. eLife. vol 5. 2017-11-03. PMID:27760002. |
midbrain dopamine neurons signal aversion in a reward-context-dependent manner. |
2017-11-03 |
2023-08-13 |
mouse |
| Michael Anthony Savage, Richard McQuade, Alexander Thiel. Segregated fronto-cortical and midbrain connections in the mouse and their relation to approach and avoidance orienting behaviors. The Journal of comparative neurology. vol 525. issue 8. 2017-09-29. PMID:28177526. |
segregated fronto-cortical and midbrain connections in the mouse and their relation to approach and avoidance orienting behaviors. |
2017-09-29 |
2023-08-13 |
mouse |
| P Leon Brown, Paul D Shepar. Functional evidence for a direct excitatory projection from the lateral habenula to the ventral tegmental area in the rat. Journal of neurophysiology. vol 116. issue 3. 2017-08-28. PMID:27358317. |
this pathway may contribute to the role of midbrain dopamine neurons in processing aversive stimuli and salience. |
2017-08-28 |
2023-08-13 |
rat |
| Tiago V Maia, Michael J Fran. An Integrative Perspective on the Role of Dopamine in Schizophrenia. Biological psychiatry. vol 81. issue 1. 2017-08-09. PMID:27452791. |
reduced phasic responses for relevant stimuli help to explain negative symptoms and provide a unified explanation for the following experimental findings in schizophrenia, most of which have been shown to correlate with negative symptoms: reduced learning from rewards; blunted activation of the ventral striatum, midbrain, and other limbic regions for rewards and positive prediction errors; blunted activation of the ventral striatum during reward anticipation; blunted autonomic responding for relevant stimuli; blunted neural activation for aversive outcomes and aversive prediction errors; reduced willingness to expend effort for rewards; and psychomotor slowing. |
2017-08-09 |
2023-08-13 |
Not clear |
| Sebastian Hormigo, German Vega-Flores, Manuel A Castro-Alamanco. Basal Ganglia Output Controls Active Avoidance Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 40. 2017-07-24. PMID:27707965. |
the results highlight a midbrain circuit that gates avoidance responses, which can be targeted to ameliorate maladaptive avoidance in psychiatric disorders. |
2017-07-24 |
2023-08-13 |
mouse |
| P Leon Brown, Heather Palacorolla, Dana Brady, Katelyn Riegger, Greg I Elmer, Paul D Shepar. Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053043. |
these results are the first to show that rmtg neurons contribute directly to lhb-induced inhibition of da cell activity and support the widely held proposition that gabaergic neurons in the mesopontine tegmentum are an important component of a pathway that enables midbrain da neurons to encode the negative valence associated with failed expectations and aversive stimuli. |
2017-07-24 |
2023-08-13 |
rat |
| Rachel J Sizemore, Rong Zhang, Naili Lin, Liping Goddard, Timothy Wastney, Louise C Parr-Brownlie, John N J Reynolds, Dorothy E Oorscho. Marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons, and striatal spiny projection neurons in the rat. The Journal of comparative neurology. vol 524. issue 5. 2016-10-24. PMID:26355230. |
elucidating the link between cellular activity and goal-directed behavior requires a fuller understanding of the mechanisms underlying burst firing in midbrain dopaminergic neurons and those that suppress activity during aversive or non-rewarding events. |
2016-10-24 |
2023-08-13 |
rat |
| Gabriela O Bodea, Sandra Blaes. Establishing diversity in the dopaminergic system. FEBS letters. vol 589. issue 24 Pt A. 2016-04-29. PMID:26431946. |
midbrain dopaminergic neurons (mbdns) modulate cognitive processes, regulate voluntary movement, and encode reward prediction errors and aversive stimuli. |
2016-04-29 |
2023-08-13 |
Not clear |
| Marcus Lira Brandão, Amanda Ribeiro de Oliveira, Sangu Muthuraju, Ana Caroline Colombo, Viviane Mitsuko Saito, Teddy Talbo. Dual role of dopamine D(2)-like receptors in the mediation of conditioned and unconditioned fear. FEBS letters. vol 589. issue 22. 2016-02-15. PMID:25783771. |
dopamine appears to mediate conditioned fear by acting at rostral levels of the brain and regulate unconditioned fear at the midbrain level, likely by reducing the sensorimotor gating of aversive events. |
2016-02-15 |
2023-08-13 |
rat |
| Kristoffer Carl Aberg, Kimberly C Doell, Sophie Schwart. Hemispheric Asymmetries in Striatal Reward Responses Relate to Approach-Avoidance Learning and Encoding of Positive-Negative Prediction Errors in Dopaminergic Midbrain Regions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 43. 2016-02-02. PMID:26511241. |
moreover, using a computational modeling approach, we demonstrate that better encoding of positive (vs negative) pes in dopaminergic midbrain regions is associated with better approach (vs avoidance) learning, specifically in participants with larger reward responses in the left (vs right) ventral striatum. |
2016-02-02 |
2023-08-13 |
human |
| Daniele C Aguiar, Ana F Almeida-Santos, Fabricio A Moreira, Francisco S Guimarãe. Involvement of TRPV1 channels in the periaqueductal grey on the modulation of innate fear responses. Acta neuropsychiatrica. vol 27. issue 2. 2015-12-01. PMID:25529842. |
the transient receptor potential vanilloid type-1 channel (trpv1) is expressed in the midbrain periaqueductal grey (pag), a region of the brain related to aversive responses. |
2015-12-01 |
2023-08-13 |
rat |
| Kelly Hennigan, Kimberlee D'Ardenne, Samuel M McClur. Distinct midbrain and habenula pathways are involved in processing aversive events in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568114. |
distinct midbrain and habenula pathways are involved in processing aversive events in humans. |
2015-03-20 |
2023-08-13 |
Not clear |
| Kelly Hennigan, Kimberlee D'Ardenne, Samuel M McClur. Distinct midbrain and habenula pathways are involved in processing aversive events in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568114. |
emerging evidence implicates the midbrain dopamine system and its interactions with the lateral habenula in processing aversive information and learning to avoid negative outcomes. |
2015-03-20 |
2023-08-13 |
Not clear |
| Kelly Hennigan, Kimberlee D'Ardenne, Samuel M McClur. Distinct midbrain and habenula pathways are involved in processing aversive events in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568114. |
we examined neural responses to unexpected, aversive events using methods specialized for imaging the midbrain and habenula in humans. |
2015-03-20 |
2023-08-13 |
Not clear |