| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eyassu Chernet, Laura J Martin, Dominic Li, Anne B Need, Vanessa N Barth, Karen S Rash, Lee A Phebu. Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: dopamine D2, serotonin 2A and NK-1 receptors as examples. Life sciences. vol 78. issue 4. 2005-12-15. PMID:16139310. |
high performance liquid chromatography combined with either single quad or triple quad mass spectral detectors (lc/ms) was used to measure the brain distribution of receptor occupancy tracers targeting dopamine d2, serotonin 5-ht2a and neurokinin nk-1 receptors using the ligands raclopride, mdl-100907 and gr205171, respectively. |
2005-12-15 |
2023-08-12 |
rat |
| Richard Delorme, Catalina Betancur, Jacques Callebert, Nadia Chabane, Jean-Louis Laplanche, Marie-Christine Mouren-Simeoni, Jean-Marie Launay, Marion Leboye. Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 8. 2005-11-29. PMID:15886722. |
we assessed whole blood serotonin (5-ht) concentration, platelet 5-ht transporter (5-htt) and 5-ht2a receptor-binding characteristics, and platelet inositol trisphosphate (ip3) content in a sample of ocd probands (n = 48) and their unaffected parents (n = 65), and compared them with sex- and age-matched controls (n = 113). |
2005-11-29 |
2023-08-12 |
human |
| Ariel R Ase, Ramin Raouf, Danny Bélanger, Edith Hamel, Philippe Séguél. Potentiation of P2X1 ATP-gated currents by 5-hydroxytryptamine 2A receptors involves diacylglycerol-dependent kinases and intracellular calcium. The Journal of pharmacology and experimental therapeutics. vol 315. issue 1. 2005-11-28. PMID:15958718. |
using the model of the isolated rat tail artery, we show that the vasoactive mediator 5-hydroxytryptamine (5-ht), via the 5-ht2a metabotropic receptor, regulates the desensitization kinetics of p2x1 responses by increasing their rate of recovery. |
2005-11-28 |
2023-08-12 |
rat |
| Sarah E Hopwood, Stefan Trap. TASK-like K+ channels mediate effects of 5-HT and extracellular pH in rat dorsal vagal neurones in vitro. The Journal of physiology. vol 568. issue Pt 1. 2005-11-28. PMID:16020457. |
a previous study has shown that 5-ht excites dvn in part by inhibition of a k+ current via postsynaptic 5-ht2a receptors. |
2005-11-28 |
2023-08-12 |
rat |
| Alessandro Serretti, Francesco Benedetti, Raffaella Zanardi, Enrico Smerald. The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 6. 2005-10-27. PMID:15939518. |
a polymorphism in the promoter region of the serotonin transporter (sertpr) was independently associated with efficacy for a range of treatments, other polymorphism located on the tryptophan hydroxylase gene, 5-ht2a receptor and g-protein beta 3 showed some association, while other candidate genes were not associated with treatment efficacy. |
2005-10-27 |
2023-08-12 |
Not clear |
| Gavin P Reynolds, Lucy A Templeman, Zhi Jun Zhan. The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 6. 2005-10-27. PMID:15953671. |
thus genetic polymorphisms of two central 5-ht receptors (5-ht2a and 2c), at which many of the newer antipsychotic drugs act, are prime candidates for pharmacogenetic analysis of the effects of these drugs in the treatment of schizophrenia. |
2005-10-27 |
2023-08-12 |
Not clear |
| Eric Lewin Altschuler, Richard E Kas. The atypical antipsychotic agents ziprasidone [correction of zisprasidone], risperdone and olanzapine as treatment for and prophylaxis against progressive multifocal leukoencephalopathy. Medical hypotheses. vol 65. issue 3. 2005-10-27. PMID:16004936. |
recently atwood and colleagues have found that the cellular receptor for jc virus is the serotonin 5ht2a receptor. |
2005-10-27 |
2023-08-12 |
Not clear |
| Eric Lewin Altschuler, Richard E Kas. The atypical antipsychotic agents ziprasidone [correction of zisprasidone], risperdone and olanzapine as treatment for and prophylaxis against progressive multifocal leukoencephalopathy. Medical hypotheses. vol 65. issue 3. 2005-10-27. PMID:16004936. |
in vitro they used the older antipsychotic medications chlorpromazine and clozapine to block the serotonin 5ht2a receptor and block jc virus cell entry. |
2005-10-27 |
2023-08-12 |
Not clear |
| Justin H Turner, John R Raymon. Interaction of calmodulin with the serotonin 5-hydroxytryptamine2A receptor. A putative regulator of G protein coupling and receptor phosphorylation by protein kinase C. The Journal of biological chemistry. vol 280. issue 35. 2005-10-25. PMID:15970592. |
these data indicate that the serotonin 5-ht2a receptor contains two high affinity cam-binding domains that may play important roles in signaling and function. |
2005-10-25 |
2023-08-12 |
Not clear |
| David V Herin, Shijing Liu, Thomas Ullrich, Kenner C Rice, Kathryn A Cunningha. Role of the serotonin 5-HT2A receptor in the hyperlocomotive and hyperthermic effects of (+)-3,4-methylenedioxymethamphetamine. Psychopharmacology. vol 178. issue 4. 2005-10-20. PMID:15765263. |
role of the serotonin 5-ht2a receptor in the hyperlocomotive and hyperthermic effects of (+)-3,4-methylenedioxymethamphetamine. |
2005-10-20 |
2023-08-12 |
Not clear |
| Eirik Qvigstad, Ivar Sjaastad, Trond Brattelid, Caroline Nunn, Fredrik Swift, Jon Arne Kro Birkeland, Kurt A Krobert, Geir Øystein Andersen, Ole M Sejersted, Jan-Bjørn Osnes, Finn Olav Levy, Tor Skomeda. Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Circulation research. vol 97. issue 3. 2005-10-20. PMID:16002744. |
the acute failing rat ventricle is, thus, dually regulated by serotonin through gq-coupled 5-ht2a receptors and gs-coupled 5-ht4 receptors. |
2005-10-20 |
2023-08-12 |
rat |
| Adair R S Santos, Vinicius M Gadotti, Gerson L Oliveira, Daiane Tibola, Ana Flavia Paszcuk, Amaro Neto, Humberto M Spindola, Márcia M Souza, Ana Lucia S Rodrigues, João B Calixt. Mechanisms involved in the antinociception caused by agmatine in mice. Neuropharmacology. vol 48. issue 7. 2005-10-11. PMID:15857629. |
treatment of mice with l-arginine (precursor of nitric oxide, 600 mg/kg), naloxone (opioid receptor antagonist, 1 mg/kg), p-chlorophenylalanine methyl ester (pcpa, an inhibitor of serotonin synthesis, 100 mg/kg once a day for 4 consecutive days), ketanserin (a 5-ht2a receptor antagonist, 0.3 mg/kg), ondansetron (a 5-ht3 receptor antagonist, 0.5 mg/kg), yohimbine (an alpha2-adrenoceptor antagonist, 0.15 mg/kg) or by efaroxan (an i1 imidazoline/alpha2-adrenoceptor antagonist, 1 mg/kg). |
2005-10-11 |
2023-08-12 |
mouse |
| B Sonier, C Lavigne, M Arseneault, R Ouellette, C Vaillancour. Expression of the 5-HT2A serotoninergic receptor in human placenta and choriocarcinoma cells: mitogenic implications of serotonin. Placenta. vol 26. issue 6. 2005-10-05. PMID:15950062. |
expression of the 5-ht2a serotoninergic receptor in human placenta and choriocarcinoma cells: mitogenic implications of serotonin. |
2005-10-05 |
2023-08-12 |
human |
| Christopher Bishop, Gregory S Daut, Paul D Walke. Serotonin 5-HT2A but not 5-HT2C receptor antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the D1 agonist SKF 82958. Neuropharmacology. vol 49. issue 3. 2005-10-04. PMID:15993442. |
serotonin 5-ht2a but not 5-ht2c receptor antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the d1 agonist skf 82958. |
2005-10-04 |
2023-08-12 |
rat |
| Masamichi Ohkura, Naoko Tanaka, Hideyuki Kobayashi, Akihiko Wada, Junichi Nakai, Ryuichi Yamamot. Insulin induces internalization of the 5-HT2A receptor expressed in HEK293 cells. European journal of pharmacology. vol 518. issue 1. 2005-09-23. PMID:15979608. |
in 5-ht2a-yfp-expressing cells, but not in yfp-expressing or non-expressing cells, 5-ht induced a transient increase in the intracellular ca(2+) concentration (ca(2+) transient) in the fluo 3 assay, suggesting that 5-ht2a-yfp possesses a function similar to the wild-type 5-ht2a receptor. |
2005-09-23 |
2023-08-12 |
Not clear |
| Yong-Xiao Cao, Lang-Chong He, Cang-Bao Xu, Guo-Gang Luo, Lars Edvinsso. Enhanced transcription of contractile 5-hydroxytryptamine 2A receptors via extracellular signal-regulated kinase 1/2 after organ culture of rat mesenteric artery. Basic & clinical pharmacology & toxicology. vol 96. issue 4. 2005-09-22. PMID:15755310. |
it is likely that the erk1/2 pathways were involved as a initial switch, since the selective erk1/2 pathway inhibitor sb386023 abolished both up-regulation of 5-ht2a mrna transcription and the enhanced contractile response to 5-ht. |
2005-09-22 |
2023-08-12 |
rat |
| Yong-Xiao Cao, Lang-Chong He, Cang-Bao Xu, Guo-Gang Luo, Lars Edvinsso. Enhanced transcription of contractile 5-hydroxytryptamine 2A receptors via extracellular signal-regulated kinase 1/2 after organ culture of rat mesenteric artery. Basic & clinical pharmacology & toxicology. vol 96. issue 4. 2005-09-22. PMID:15755310. |
these data reveal a role of erk1/2 in up-regulation of 5-ht2a receptors and suggest a possibility to inhibit the enhanced responses to 5-ht by inhibition of the erk1/2 pathway. |
2005-09-22 |
2023-08-12 |
rat |
| Jun Liu, Larry M Jorda. Stimulation of the parapyramidal region of the neonatal rat brain stem produces locomotor-like activity involving spinal 5-HT7 and 5-HT2A receptors. Journal of neurophysiology. vol 94. issue 2. 2005-09-22. PMID:15872068. |
previous studies suggest important roles for 5-ht7 and 5-ht2a receptors in the locomotor effects of 5-ht. |
2005-09-22 |
2023-08-12 |
rat |
| Jun Liu, Larry M Jorda. Stimulation of the parapyramidal region of the neonatal rat brain stem produces locomotor-like activity involving spinal 5-HT7 and 5-HT2A receptors. Journal of neurophysiology. vol 94. issue 2. 2005-09-22. PMID:15872068. |
here we show for the first time that activation of a discrete population of 5-ht neurons in the rodent brain stem produces locomotion and that the evoked locomotion requires 5-ht7 and 5-ht2a receptors. |
2005-09-22 |
2023-08-12 |
rat |
| Mario Alvarado, Alberto Coelho, Christian F Masaguer, Enrique Raviña, José Brea, J Fernando Padín, María I Loz. Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics. Bioorganic & medicinal chemistry letters. vol 15. issue 12. 2005-09-19. PMID:15878662. |
their binding affinities at dopamine d(2) and serotonin 5-ht2a and 5-ht2c receptors were determined, showing in some cases an atypical antipsychotic profile. |
2005-09-19 |
2023-08-12 |
Not clear |