| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dustin K Williams, Clare Stokes, Nicole A Horenstein, Roger L Papk. Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site. The Journal of pharmacology and experimental therapeutics. vol 330. issue 1. 2009-07-27. PMID:19339660. |
alpha7 receptors with trp55 mutated to gly or tyr became less responsive to 4oh-gts-21, whereas mutation of the homologous trp57 in beta2 to gly, tyr, phe, or ala resulted in alpha4beta2 receptors that showed increased responses to 4oh-gts-21. |
2009-07-27 |
2023-08-12 |
human |
| James D Hoyer, Prabhjot Kaur, Elizabeth A Kozak, Sophia Lum, David N Alte. Five variants of the beta-globin gene without clinical or hematological effects: Hb Maryland [beta 47(CD6)Asp-->His], Hb Kent [beta 37(C3)Trp-->Cys], Hb Visayan [beta 136(H14)Gly-->Cys], Hb Cutlerville [beta 138(H16)Ala-->Val] and Hb Hornchurch [beta 43(CD2)Glu-->Lys]. Hemoglobin. vol 32. issue 5. 2009-07-10. PMID:18932072. |
five variants of the beta-globin gene without clinical or hematological effects: hb maryland [beta 47(cd6)asp-->his], hb kent [beta 37(c3)trp-->cys], hb visayan [beta 136(h14)gly-->cys], hb cutlerville [beta 138(h16)ala-->val] and hb hornchurch [beta 43(cd2)glu-->lys]. |
2009-07-10 |
2023-08-12 |
Not clear |
| Anthony Manson, Steven T Whitten, Josephine C Ferreon, Robert O Fox, Vincent J Hilse. Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity. Journal of the American Chemical Society. vol 131. issue 19. 2009-07-09. PMID:19397330. |
the mutated positions in sh3 were distant to the binding site and involved ala and gly substitutions of solvent exposed positions in the rt loop. |
2009-07-09 |
2023-08-12 |
Not clear |
| Franco O Tzul, Bruce E Bowle. Importance of contact persistence in denatured state loop formation: kinetic insights into sequence effects on nucleation early in folding. Journal of molecular biology. vol 390. issue 1. 2009-07-07. PMID:19426739. |
previously, we reported that the apparent pk(a) values of loop formation for the most flexible (all gly) and least flexible (all ala) insert were, within error, the same. |
2009-07-07 |
2023-08-12 |
Not clear |
| Ke Zhou, Reuben J Peter. Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants. Phytochemistry. vol 70. issue 3. 2009-06-09. PMID:19201430. |
given the role of the ser/thr side chain hydroxyl group in ligating one of the three catalytically requisite divalent metal ions and the loss of catalytic activity upon substitution with ala, it is surprising that gly is frequently found in this 'middle' position of the putative second divalent metal binding motif in plant tps. |
2009-06-09 |
2023-08-12 |
Not clear |
| Ke Zhou, Reuben J Peter. Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants. Phytochemistry. vol 70. issue 3. 2009-06-09. PMID:19201430. |
substitution of the corresponding thr in agas with ser or gly decreased catalytic activity much less than substitution with ala. we speculate that the ability of gly to partially restore activity relative to ala substitution for ser/thr stems from the associated reduction in steric volume enabling a water molecule to substitute for the hydroxyl group from ser/thr, potentially in a divalent metal ion coordination sphere. |
2009-06-09 |
2023-08-12 |
Not clear |
| Nathaniel L Elsen, Lucas J Bailey, Andrew D Hauser, Brian G Fo. Role for threonine 201 in the catalytic cycle of the soluble diiron hydroxylase toluene 4-monooxygenase. Biochemistry. vol 48. issue 18. 2009-06-09. PMID:19290655. |
thus, our previous finding that mutation of this residue to ala, gly, or ser had no impact on steady-state catalysis or coupling was surprising. |
2009-06-09 |
2023-08-12 |
Not clear |
| Salih Jabour, Mazen Y Hame. Binding of the Zn2+ ion to ferric uptake regulation protein from E. coli and the competition with Fe2+ binding: a molecular modeling study of the effect on DNA binding and conformational changes of Fur. Journal of computer-aided molecular design. vol 23. issue 4. 2009-06-08. PMID:19023664. |
the second zn2+ ion is bound to the iron activating site formed from the residues ile 50, his 71, asn 72, gly 97, asp 105 and ala 109. |
2009-06-08 |
2023-08-12 |
Not clear |
| Ping Wang, Gilles Ohanessian, Chrys Wesdemioti. Cu(II)-catalyzed reactions in ternary [Cu(AA)(AA - H)]+ complexes (AA = Gly, Ala, Val, Leu, Ile, t-Leu, Phe). European journal of mass spectrometry (Chichester, England). vol 15. issue 2. 2009-06-08. PMID:19423917. |
cu(ii)-catalyzed reactions in ternary [cu(aa)(aa - h)]+ complexes (aa = gly, ala, val, leu, ile, t-leu, phe). |
2009-06-08 |
2023-08-12 |
Not clear |
| Ping Wang, Gilles Ohanessian, Chrys Wesdemioti. Cu(II)-catalyzed reactions in ternary [Cu(AA)(AA - H)]+ complexes (AA = Gly, Ala, Val, Leu, Ile, t-Leu, Phe). European journal of mass spectrometry (Chichester, England). vol 15. issue 2. 2009-06-08. PMID:19423917. |
the amino acids examined include gly, ala, val, leu, ile, t-leu and phe. |
2009-06-08 |
2023-08-12 |
Not clear |
| Graham E Jackson, Andre N Mabula, Shane R Stone, Gerd Gäde, Katalin E Kövér, László Szilágyi, David van der Spoe. Solution conformations of an insect neuropeptide: crustacean cardioactive peptide (CCAP). Peptides. vol 30. issue 3. 2009-06-04. PMID:19103242. |
this peptide, found in various invertebrates, has the primary sequence pro(1) phe(2) cys(3) asn(4) ala(5) phe(6) thr(7) gly(8) cys(9) nh(2), with an intramolecular disulfide bridge between the two cysteine residues. |
2009-06-04 |
2023-08-12 |
Not clear |
| Juan J Garcia-Celma, Irina N Smirnova, H Ronald Kaback, Klaus Fendle. Electrophysiological characterization of LacY. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 18. 2009-05-29. PMID:19383792. |
in contrast, lacy mutants glu-325-->ala and cys-154-->gly, which bind ligand normally, but are severely defective with respect to lactose/h(+) symport, exhibit only a small electrogenic event on addition of lacy-specific substrates, representing 6% of the total charge displacement of the wild-type. |
2009-05-29 |
2023-08-12 |
Not clear |
| Ye Li, Ye-Qing Qian, Wen-Ming Ma, Wei-Jun Yan. Inhibition mechanism and the effects of structure on activity of male reproduction-related peptidase inhibitor Kazal-type (MRPINK) of Macrobrachium rosenbergii. Marine biotechnology (New York, N.Y.). vol 11. issue 2. 2009-05-19. PMID:18795369. |
nevertheless, whether the p(1) amino acid residue was leu, or even if it was replaced by lys, ala, or gly, domain-1 was ineffective to the activity. |
2009-05-19 |
2023-08-12 |
Not clear |
| Ahmad B Maarouf, Nan Sheng, Jingxin Chen, Katie L Winarski, Sora Okumura, Marcelo D Carattino, Cary R Boyd, Thomas R Kleyman, Shaohu Shen. Novel determinants of epithelial sodium channel gating within extracellular thumb domains. The Journal of biological chemistry. vol 284. issue 12. 2009-05-14. PMID:19158091. |
fourteen substitutions (ala, arg, asp, cys, gln, glu, his, ile, phe, pro, ser, thr, tyr, and val) significantly suppressed na(+) self-inhibition, whereas three mutations (asn, gly, and leu) moderately enhanced the inhibition. |
2009-05-14 |
2023-08-12 |
mouse |
| David M Wilson, Ralph E Hurd, Kayvan Keshari, Mark Van Criekinge, Albert P Chen, Sarah J Nelson, Daniel B Vigneron, John Kurhanewic. Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 14. 2009-05-06. PMID:19276112. |
this new approach was used to reproducibly and near-quantitatively (mean yield - 89.8%) resolve a mixture of amino acids gly, ser, val, leu, and ala in a single acquisition (3 s) with a signal enhancement of up to 1,400-fold as compared with thermal equilibrium. |
2009-05-06 |
2023-08-12 |
Not clear |
| De-yong Zhang, Fei-xue Cheng, Ju-e Cheng, Zhan-hong Zhang, Yong Li. [Cloning and prokaryotic expression of Rhodoblastus acidophilus 5-aminolevlinate synthase gene]. Wei sheng wu xue bao = Acta microbiologica Sinica. vol 47. issue 4. 2009-05-05. PMID:17944364. |
the conditions including strain, medium, substrate of ala synthesize (glycine and succinic acid), and ala dehydratase inhibitor (levulinic acid) were optimized for attainning the maximum yield of ala in e. coli. |
2009-05-05 |
2023-08-12 |
Not clear |
| De-yong Zhang, Fei-xue Cheng, Ju-e Cheng, Zhan-hong Zhang, Yong Li. [Cloning and prokaryotic expression of Rhodoblastus acidophilus 5-aminolevlinate synthase gene]. Wei sheng wu xue bao = Acta microbiologica Sinica. vol 47. issue 4. 2009-05-05. PMID:17944364. |
the ala production was established on e. coli m15, medium 1 supplied with 100mmol/l glycine and 50mmol/l succinic acid, and 40mmol/l levulinic acid. |
2009-05-05 |
2023-08-12 |
Not clear |
| Zhao-Zhen Ren, Yuan Zheng, Mi Sun, Jun-Zhong Liu, Yue-Jun Wan. [Purification and properties of an antimicrobial substance from marine Brevibacillus laterosporus Lh-1]. Wei sheng wu xue bao = Acta microbiologica Sinica. vol 47. issue 6. 2009-05-05. PMID:18271253. |
amino acid analysis of the purified r-1 showed that it was composed of leu, tyr, val, ile, lys, gly, met, ser and ala. |
2009-05-05 |
2023-08-12 |
Not clear |
| Massimo Pieri, Irene Carunchio, Livia Curcio, Nicola Biagio Mercuri, Cristina Zon. Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis. Experimental neurology. vol 215. issue 2. 2009-04-08. PMID:19071115. |
we first examined the passive membrane properties and the pattern of repetitive firing in cultured cortical neurons from control mice and transgenic mice expressing high levels of the human mutated protein (gly(93)-->ala, g93a). |
2009-04-08 |
2023-08-12 |
mouse |
| Yalin Wu, Denong Wan. A new class of natural glycopeptides with sugar moiety-dependent antioxidant activities derived from Ganoderma lucidum fruiting bodies. Journal of proteome research. vol 8. issue 2. 2009-04-06. PMID:18989955. |
on the basis of the results of amino acid composition and trypsin digestion, the peptide moiety, shown to consist of arg, ser, ala, and gly in a ratio of 1:1:2:2, exhibited the sequence of ser-arg-[(ala)2(gly)2] and was o-attached to the carbohydrate moiety via ser. |
2009-04-06 |
2023-08-12 |
Not clear |