| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baoxian Shi, Weihua Huang, Jieke Chen. Analysis of amino acids in human vascular endothelial (ECV-304) cells by microchip electrophoresis with fluorescence detection. Journal of separation science. vol 31. issue 6-7. 2008-07-08. PMID:18381688. |
detection limits for amino acids (alanine (ala), taurine (tau), glycine (gly), glutamic acid (glu), and aspartic acid (asp)) of 0.38-1.0 mum were achieved. |
2008-07-08 |
2023-08-12 |
human |
| Baoxian Shi, Weihua Huang, Jieke Chen. Analysis of amino acids in human vascular endothelial (ECV-304) cells by microchip electrophoresis with fluorescence detection. Journal of separation science. vol 31. issue 6-7. 2008-07-08. PMID:18381688. |
the average amount of amino acids in single ecv-304 cells is estimated to be 5.84 fmol for ala, 2.78 fmol for tau, 1.15 fmol for gly, 3.10 fmol for glu, and 1.30 fmol for asp. |
2008-07-08 |
2023-08-12 |
human |
| Jing-Fen Han, Xiao-Yang He, Jason S Herrington, Lori A White, Jun-Feng Zhang, Jun-Yan Hon. Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human CYP1B1 genetic variants. Drug metabolism and disposition: the biological fate of chemicals. vol 36. issue 4. 2008-06-23. PMID:18227148. |
although the phip-metabolizing activities of four variants (ala(119)ser, pro(379)leu, ala(443)gly, arg(48)gly/leu(432)val) were comparable with that of the expressed wild-type cyp1b1, five variants (trp(57)cys, gly(61)glu, arg(48)gly/ala(119)ser, arg(48)gly/ala(119)ser/leu(432)val, arg(48)gly/ala(119)ser/leu(432)val/ala(443)gly) exhibited more than 2-fold decrease in activity and a reduction in the catalytic efficiency (v(max)/k(m)) for both n- and 4-hydroxylation of phip. |
2008-06-23 |
2023-08-12 |
human |
| Divina Anunciado, Michael Agumeh, Bethany L Kormos, David L Beveridge, Joseph L Knee, Anne M Barange. Characterization of the dynamics of an essential helix in the U1A protein by time-resolved fluorescence measurements. The journal of physical chemistry. B. vol 112. issue 19. 2008-06-13. PMID:18293956. |
mutation of a residue on the beta-sheet that contacts helix c in the closed conformation dramatically destabilizes the complex (phe56ala) and alters the steady-state fluorescence, but not the time-resolved fluorescence anisotropy, of a trp in helix c. mutation of asp90 in the hinge region between helix c and the remainder of the protein to ala or gly subtly alters the dynamics of the u1a protein and destabilizes the complex. |
2008-06-13 |
2023-08-12 |
Not clear |
| David B Dahl, Zach Bohannan, Qianxing Mo, Marina Vannucci, Jerry Tsa. Assessing side-chain perturbations of the protein backbone: a knowledge-based classification of residue Ramachandran space. Journal of molecular biology. vol 378. issue 3. 2008-06-13. PMID:18377931. |
there were seven general groups based on the clusters from the complete ramachandran data: nonpolar/beta-branched (ile and val), asx (asn and asp), long (met, gln, arg, glu, lys, and leu), aromatic (phe, tyr, his, and cys), small (ala and ser), bulky (thr and trp), and, lastly, the singletons of gly and pro. |
2008-06-13 |
2023-08-12 |
Not clear |
| Nicholas R Stephens, Zhi Qi, Edgar P Spaldin. Glutamate receptor subtypes evidenced by differences in desensitization and dependence on the GLR3.3 and GLR3.4 genes. Plant physiology. vol 146. issue 2. 2008-06-04. PMID:18162597. |
previous studies of arabidopsis thaliana root cells showed that the amino acids alanine (ala), asparagine (asn), cysteine (cys), glu, glycine (gly), and serine trigger transient ca(2+) influx and membrane depolarization by a mechanism that depends on the glr3.3 gene. |
2008-06-04 |
2023-08-12 |
Not clear |
| Nicholas R Stephens, Zhi Qi, Edgar P Spaldin. Glutamate receptor subtypes evidenced by differences in desensitization and dependence on the GLR3.3 and GLR3.4 genes. Plant physiology. vol 146. issue 2. 2008-06-04. PMID:18162597. |
the results could be explained by a model in which one class of channels contained a subunit that was activated and therefore desensitized only by glu, while a second class could be activated and desensitized by ala, cys, glu, or gly. |
2008-06-04 |
2023-08-12 |
Not clear |
| Shouichi Higashi, Kaoru Miyazak. Identification of amino acid residues of the matrix metalloproteinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor. The Journal of biological chemistry. vol 283. issue 15. 2008-05-28. PMID:18238779. |
studies of chimeric proteases, consisting of various parts of the mmp-2 catalytic domain and those of mmp-7 (matrilysin) or mmp-9 (gelatinase b), further revealed that ala(88) and gly(94) in the non-prime side and tyr(145) and thr(146) in the prime side of the substrate-binding cleft of mmp-2 contribute separately to the selective inhibition. |
2008-05-28 |
2023-08-12 |
Not clear |
| Tze-Haw Howard Chen, Younsoo Bae, Darin Y Furgeso. Intelligent biosynthetic nanobiomaterials (IBNs) for hyperthermic gene delivery. Pharmaceutical research. vol 25. issue 3. 2008-05-19. PMID:17762916. |
intelligent biosynthetic nanobiomaterials (ibns) were constructed as recombinant diblock copolymers, notated as k8-elp(1-60), containing a cationic oligolysine (vgk8g) and a thermosensitive elastin-like polypeptide (elp) block with 60 repetitive pentapeptide units [(vpgxg)60; x is val, ala and gly in a 5:2:3 ratio]. |
2008-05-19 |
2023-08-12 |
Not clear |
| Gavin R Hedwig, Einar Høgseth, Harald Høilan. Volumetric properties of the glycyl group of proteins in aqueous solution at high pressures. Physical chemistry chemical physics : PCCP. vol 10. issue 6. 2008-05-01. PMID:18231691. |
sound speeds have been measured for aqueous solutions of alanine and the peptides alanylglycine (alagly), alanylglycylglycine (ala(gly)(2)), alanylglycylglycylglycine (ala(gly)(3)) and alanylglycylglycylglycylglycine (ala(gly)(4)) at t=298.15 k and at the pressures p=0.1, 5.0, 10.0, 20.0, 40.0, 60.0, 80.0 and 100.0 mpa. |
2008-05-01 |
2023-08-12 |
Not clear |
| Ronghu Wu, Terry B McMaho. Stabilization of zwitterionic structures of amino acids (Gly, Ala, Val, Leu, Ile, Ser and Pro) by ammonium ions in the gas phase. Journal of the American Chemical Society. vol 130. issue 10. 2008-04-21. PMID:18271581. |
stabilization of zwitterionic structures of amino acids (gly, ala, val, leu, ile, ser and pro) by ammonium ions in the gas phase. |
2008-04-21 |
2023-08-12 |
Not clear |
| Ronghu Wu, Terry B McMaho. Stabilization of zwitterionic structures of amino acids (Gly, Ala, Val, Leu, Ile, Ser and Pro) by ammonium ions in the gas phase. Journal of the American Chemical Society. vol 130. issue 10. 2008-04-21. PMID:18271581. |
the enthalpy changes for the association reactions of protonated gly, ala, val, leu, ile, ser, and pro with ammonia have been measured as -23.2, -21.9, -21.0, -20.8, -20.6, -22.6, and -20.4 kcal mol(-1), respectively. |
2008-04-21 |
2023-08-12 |
Not clear |
| Ronghu Wu, Terry B McMaho. Stabilization of zwitterionic structures of amino acids (Gly, Ala, Val, Leu, Ile, Ser and Pro) by ammonium ions in the gas phase. Journal of the American Chemical Society. vol 130. issue 10. 2008-04-21. PMID:18271581. |
stabilization of zwitterionic structures of a series of amino acids (gly, ala, val, ser, and pro) by various ammonium ions (nh4(+), ch3nh3(+), (ch3)2nh2(+), and (ch3)3nh+) has been investigated systematically. |
2008-04-21 |
2023-08-12 |
Not clear |
| Ronghu Wu, Terry B McMaho. Stabilization of zwitterionic structures of amino acids (Gly, Ala, Val, Leu, Ile, Ser and Pro) by ammonium ions in the gas phase. Journal of the American Chemical Society. vol 130. issue 10. 2008-04-21. PMID:18271581. |
first, as the pa of an amino acid increases, within a series of gly, ala, val, the zwitterionic structure becomes more energetically favorable relative to a non-zwitterionic isomer. |
2008-04-21 |
2023-08-12 |
Not clear |
| Gregory P Holland, Janelle E Jenkins, Melinda S Creager, Randolph V Lewis, Jeffery L Yarge. Solid-state NMR investigation of major and minor ampullate spider silk in the native and hydrated states. Biomacromolecules. vol 9. issue 2. 2008-04-14. PMID:18171016. |
this combination of nmr data demonstrates that water plasticizes mi and ma silk similarly, with an increase in chain dynamics observed in regions containing gly, glu, ser, tyr, leu, and a fraction of ala when the mi silk is hydrated. |
2008-04-14 |
2023-08-12 |
spider |
| Gregory P Holland, Janelle E Jenkins, Melinda S Creager, Randolph V Lewis, Jeffery L Yarge. Solid-state NMR investigation of major and minor ampullate spider silk in the native and hydrated states. Biomacromolecules. vol 9. issue 2. 2008-04-14. PMID:18171016. |
resonances that correspond to the poly(ala) and poly(gly ala) motifs of ma and mi silk are predominately rigid indicating that water does not penetrate these beta-sheet domains. |
2008-04-14 |
2023-08-12 |
spider |
| Yuxiang Zheng, William E Boeglin, Claus Schneider, Alan R Bras. A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality. The Journal of biological chemistry. vol 283. issue 8. 2008-04-10. PMID:18070874. |
site-directed mutagenesis of an active site ala (ala215), typically conserved as gly in r-lox, revealed that substitution with gly retained 9r specificity, whereas the larger val substitution switched oxygenation to 13s, implying that ala215 represents the functional equivalent of the gly in other r-lox. |
2008-04-10 |
2023-08-12 |
Not clear |
| Erwan Beauchamp, Diana Goenaga, Jérome Le Bloc'h, Daniel Catheline, Philippe Legrand, Vincent Riou. Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation. Biochimie. vol 89. issue 12. 2008-04-07. PMID:17716801. |
compared to an unmyristoylable mutant form of des1 (gly replaced by an ala), the dihydroceramide delta4-desaturase activity of the myristoylable des1-gly was reproducibly and significantly higher. |
2008-04-07 |
2023-08-12 |
rat |
| Kenji Ikehara, Yuka Niihar. Origin and evolutionary process of the genetic code. Current medicinal chemistry. vol 14. issue 30. 2008-04-01. PMID:18220756. |
we also introduce our hypothesis of the gadv-protein world hypothesis on the origin of life, where gadv stands for the four amino acids, gly[g], ala[a], asp[d] and val[v]. |
2008-04-01 |
2023-08-12 |
Not clear |
| Marié van der Merwe, Mary-Ann Bjornst. Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin. The Journal of biological chemistry. vol 283. issue 6. 2008-03-31. PMID:18056711. |
mutating gly to asp, glu, asn, gln, leu, or ala enhanced enzyme cpt sensitivity, with the acidic residues inducing the greatest increase in drug sensitivity in vivo and in vitro. |
2008-03-31 |
2023-08-12 |
Not clear |