| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mirela Cristea, Ernst H Oli. A G316A mutation of manganese lipoxygenase augments hydroperoxide isomerase activity: mechanism of biosynthesis of epoxyalcohols. The Journal of biological chemistry. vol 281. issue 26. 2006-08-18. PMID:16641090. |
lipoxygenases with r stereospecificity have a conserved gly residue, whereas (s)-lipoxygenases have an ala residue. |
2006-08-18 |
2023-08-12 |
Not clear |
| Larry E Wagner, Matthew J Betzenhauser, David I Yul. ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A. The Journal of biological chemistry. vol 281. issue 25. 2006-08-11. PMID:16621795. |
the s2- insp3r-1 containing the g1690a mutation was markedly less sensitive to agonist stimulation than wild type s2- insp3r-1 or receptors containing a similar (gly --> ala) mutation in the established nucleotide binding sites in insp3r-1 (the atpa and atpb sites). |
2006-08-11 |
2023-08-12 |
Not clear |
| Larry E Wagner, Matthew J Betzenhauser, David I Yul. ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A. The Journal of biological chemistry. vol 281. issue 25. 2006-08-11. PMID:16621795. |
ca2+ release was dramatically potentiated following activation of camp-dependent protein kinase in dt40-3ko cells transiently expressing wild type s2- insp3r or gly --> ala mutations in the atpa and atpb sites, but phosphorylation of the receptor and the potentiation of ca2+ release were absent in cells expressing the g1690a mutation in s2- insp3r. |
2006-08-11 |
2023-08-12 |
Not clear |
| Jhimli Dasgupta, Susmita Khamrui, Jiban K Dattagupta, Udayaditya Se. Spacer Asn determines the fate of Kunitz (STI) inhibitors, as revealed by structural and biochemical studies on WCI mutants. Biochemistry. vol 45. issue 22. 2006-08-04. PMID:16734415. |
in this paper, we have investigated the specific role of the spacer asn in the prevention of proteolysis through structural and biochemical studies on the mutants where asn14 of winged bean chymotrypsin inhibitor (wci) has been replaced by gly, ala, thr, leu, and gln. |
2006-08-04 |
2023-08-12 |
Not clear |
| Teodorico Tancredi, Giacomo Carrà, Remo Guerrini, Marika Arduin, Girolamo Calò, Domenico Regoli, Severo Salvadori, Piero Andrea Temuss. The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ. Chemistry (Weinheim an der Bergstrasse, Germany). vol 11. issue 7. 2006-08-03. PMID:15712334. |
this hypothesis is also consistent with previous data on this hinge region obtained by systematic substitution of thr, gly, and ala with pro. |
2006-08-03 |
2023-08-12 |
Not clear |
| Andrew J Thompson, Claire L Padgett, Sarah C R Lummi. Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop. The Journal of biological chemistry. vol 281. issue 24. 2006-08-01. PMID:16595668. |
in this study we have mutated 21 residues in or close to the 5-ht(3) receptor f-loop (ile(192) to gly(212)) to ala or to a residue with similar chemical properties. |
2006-08-01 |
2023-08-12 |
Not clear |
| Jorge Cebada, Ramón Alvarado-Alvarez, Elizabeth Becerra, Leticia Neri-Bazán, Luisa Rocha, Ubaldo Garcí. An improved method for long-term measuring of hemolymph fluctuations of non-essential amino acids, GABA and histamine from freely moving crayfish. Journal of neuroscience methods. vol 153. issue 1. 2006-07-27. PMID:16417925. |
asp, ala, tau, gaba and histamine (ha) reached its maximal concentrations at the daybreak, whereas glutamate (glu), gln and gly peaked at the end of the light period. |
2006-07-27 |
2023-08-12 |
Not clear |
| Marcello Lenucci, Gabriella Piro, Janice G Miller, Giuseppe Dalessandro, Stephen C Fr. Do polyamines contribute to plant cell wall assembly by forming amide bonds with pectins? Phytochemistry. vol 66. issue 21. 2006-07-25. PMID:16242166. |
the small proportion of radioactive material that stayed insoluble in both phenol and tfa was hydrolysable by driselase or hot 6m hcl, yielding 14c-oligopeptides and/or amino acids (including asp, glu, gly, ala and val); no free 14c-polyamines were released by hot hcl. |
2006-07-25 |
2023-08-12 |
Not clear |
| C S Lim, John J E Chua, Jamica Wilkerson, Vincent T K Cho. Differential dengue cross-reactive and neutralizing antibody responses in BALB/c and Swiss albino mice induced by immunization with flaviviral vaccines and by infection with homotypic dengue-2 virus strains. Viral immunology. vol 19. issue 1. 2006-07-19. PMID:16553548. |
amino acid disparities at positions 71 (glu --> ala), 112 (ser --> gly) and 124 (ile --> asn), which are found in dengue-2 neutralization escape mutants, were also found in the sing/99 strain. |
2006-07-19 |
2023-08-12 |
mouse |
| Xuhui Lai, Jifeng Weng, Xuelian Zhang, Wenjun Shi, Jingjing Zhao, Haipeng Wang, Honghai Wan. MSTF: a domain involved in bacterial metallopeptidases and surface proteins, mycobacteriophage tape-measure proteins and fungal proteins. FEMS microbiology letters. vol 258. issue 1. 2006-07-07. PMID:16630259. |
mstf is about 67-94 amino acids in length with one hxdhxh motif and some highly conserved residues including his, gly, ala and asp. |
2006-07-07 |
2023-08-12 |
Not clear |
| Robert Busch, Yoo-Kyeong Kim, Richard A Neese, Valerie Schade-Serin, Michelle Collins, Mohamad Awada, James L Gardner, Carine Beysen, Michael E Marino, Lisa M Misell, Marc K Hellerstei. Measurement of protein turnover rates by heavy water labeling of nonessential amino acids. Biochimica et biophysica acta. vol 1760. issue 5. 2006-07-05. PMID:16567052. |
here, we show by mass isotopomer distribution analysis (mida) of 2h2o-labeled rodent tissue proteins that metabolic 2h flux into c-h bonds of ala, gly, or gln used for protein synthesis is nearly complete. |
2006-07-05 |
2023-08-12 |
human |
| Kengo Kinoshita, Masami Kusunoki, Kiyoshi Miya. Analysis of the three dimensional structure of the CXGXC motif in the CMGCC and CAGYC regions of alpha-and beta-subunits of human chorionic gonadotropin: importance of glycine residue (G) in the motif. Endocrine journal. vol 53. issue 1. 2006-06-27. PMID:16543672. |
in calculating collision with surrounding atoms as a monomer the possible main chain models of the c(1)a(2)g(3)(x(3))y(4)c(5) motif in the beta-subunit showed that only alanine (ala) (a) or gly at site x(3) is allowed to alleviate the collision with the cysteine (cys) (c) residues which form a disulfide bridge. |
2006-06-27 |
2023-08-12 |
human |
| Bernhard Loll, Anna Zawacka, Jacek Biesiadka, Cordula Petter, Christine Rückert, Wolfram Saenger, Barbara Uchanska-Ziegler, Andreas Ziegle. Preliminary X-ray diffraction analysis of crystals from the recombinantly expressed human major histocompatibility antigen HLA-B*2704 in complex with a viral peptide and with a self-peptide. Acta crystallographica. Section F, Structural biology and crystallization communications. vol 61. issue Pt 10. 2006-06-02. PMID:16511201. |
the product of the human leukocyte antigen (hla) gene hla-b*2704 differs from that of the prototypical subtype hla-b*2705 by three amino acids at heavy-chain residues 77 (ser instead of asp), 152 (glu instead of val) and 211 (gly instead of ala). |
2006-06-02 |
2023-08-12 |
human |
| Saritha Baddam, Bruce E Bowle. Mutation of asparagine 52 to glycine promotes the alkaline form of iso-1-cytochrome c and causes loss of cooperativity in acid unfolding. Biochemistry. vol 45. issue 14. 2006-05-30. PMID:16584196. |
both the lys 79 --> ala and asn 52 --> gly mutations are expected to affect the buried hydrogen bond network of cytochrome c, suggesting that this network is an important modulator of the acid unfolding of cytochrome c. |
2006-05-30 |
2023-08-12 |
Not clear |
| Ilaria Bonaduce, Maria Perla Colombini, Stéphane Dirin. Identification of garlic in old gildings by gas chromatography-mass spectrometry. Journal of chromatography. A. vol 1107. issue 1-2. 2006-05-26. PMID:16413559. |
the average amino acidic composition was: glutamic acid (glu; 29%), aspartic acid (asp; 17%), serine (ser; 11%), alanine, glycine, valine, leucine, lysine and phenylalanine (ala, gly, val, leu, lys and phe; 5-6%), isoleucine, proline and tyrosine (ile, pro and tyr; 2-3%), methionine and hydroxyproline (met and hyp; 0.5%). |
2006-05-26 |
2023-08-12 |
Not clear |
| James M Kovacs, Colin T Mant, Robert S Hodge. Determination of intrinsic hydrophilicity/hydrophobicity of amino acid side chains in peptides in the absence of nearest-neighbor or conformational effects. Biopolymers. vol 84. issue 3. 2006-05-17. PMID:16315143. |
the results show that the intrinsic hydrophilicity/hydrophobicity of amino acid side chains in peptides (proteins) is independent of ph, buffer conditions, or whether c(8) or c(18) reversed-phase columns were used for 17 side chains (gly, ala, cys, pro, val, nval, leu, nleu, ile, met, tyr, phe, trp, ser, thr, asn, and gln) and dependent on ph and buffer conditions, including the type of salt or ion-pairing reagent for potentially charged side chains (orn, lys, his, arg, asp, and glu). |
2006-05-17 |
2023-08-12 |
Not clear |
| Eun Hwa Choi, Hee Sup Kim, Ki Ho Park, Hoan Jong Le. Genetic heterogeneity of the hexon gene of adenovirus type 3 over a 9-year period in Korea. Journal of medical virology. vol 78. issue 3. 2006-05-16. PMID:16419117. |
five of the 9 involved amino acid changes in loops 1 (gly to val at codon 205 and thr to ile at 211) and loop 2 (his to asn at 417, thr to ala at 429, and ala to asp at 439). |
2006-05-16 |
2023-08-12 |
Not clear |
| Monica E Hamburgh, Kenneth A Curr, Melissa Monaghan, Vasudev R Rao, Snehlata Tripathi, Bradley D Preston, Stefan Sarafianos, Eddy Arnold, Thomas Darden, Vinayaka R Prasa. Structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase. The Journal of biological chemistry. vol 281. issue 11. 2006-05-10. PMID:16423828. |
substitutions with asp, gly, ala, val, ser, thr, asn, or lys were created in recombinant hiv rt, and frameshift frequencies of the resulting mutant rts were measured. |
2006-05-10 |
2023-08-12 |
human |
| József Tözsér, Sergey Shulenin, Matthew R Young, Carlton J Briggs, Stephen Oroszla. Replication-dependent fitness recovery of Human immunodeficiency virus 1 harbouring mutations of Asn17 of the nucleocapsid protein. The Journal of general virology. vol 87. issue Pt 4. 2006-05-09. PMID:16528046. |
replication kinetic assays in h9 cells revealed that the replication of ala, ser and arg mutants was improved substantially compared with the gly variant; the infectivity of ala17 and ser17 viruses was equal to, and that of arg17 was almost equal to, the infectivity of the wild-type virus. |
2006-05-09 |
2023-08-12 |
human |
| Guiscard Seebohm, Nathalie Strutz-Seebohm, Oana N Ureche, Ravshan Baltaev, Angelika Lampert, Ganna Kornichuk, Kaichiro Kamiya, Thomas V Wuttke, Holger Lerche, Michael C Sanguinetti, Florian Lan. Differential roles of S6 domain hinges in the gating of KCNQ potassium channels. Biophysical journal. vol 90. issue 6. 2006-04-27. PMID:16326905. |
mutation of the putative gly hinge to ala in kcnq2 (kv7.2) abolished channel function. |
2006-04-27 |
2023-08-12 |
Not clear |