| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guiscard Seebohm, Nathalie Strutz-Seebohm, Oana N Ureche, Ravshan Baltaev, Angelika Lampert, Ganna Kornichuk, Kaichiro Kamiya, Thomas V Wuttke, Holger Lerche, Michael C Sanguinetti, Florian Lan. Differential roles of S6 domain hinges in the gating of KCNQ potassium channels. Biophysical journal. vol 90. issue 6. 2006-04-27. PMID:16326905. |
mutation of the pro or gly of the pro-ala-gly motif to ala abolished kcnq1 function and introduction of gly in front of the ala-mutations partially recovered channel function, suggesting that flexibility at the pag is important for channel activation. |
2006-04-27 |
2023-08-12 |
Not clear |
| Alejandro Sosnik, Rana N S Sodhi, Peter M Brodersen, Michael V Sefto. Surface study of collagen/poloxamine hydrogels by a 'deep freezing' ToF-SIMS approach. Biomaterials. vol 27. issue 11. 2006-04-20. PMID:16332388. |
afterwards, the surface was studied by a 'deep freezing' tof-sims approach under progressive heating from -120 to -60 degrees c. the positive spectrum of collagen/poloxamine at -65 degrees c displayed distinct signals corresponding to different amino acid fragments such as ch4n+ (30 m/z, gly), c3hn2+ (43 m/z, arg), c2h6n+ (44 m/z, ala) and c4h5n2+(81m/z, his) and others corresponding to the peo and ppo blocks of poloxamine. |
2006-04-20 |
2023-08-12 |
Not clear |
| M Getie, C E H Schmelzer, R H H Neuber. Characterization of peptides resulting from digestion of human skin elastin with elastase. Proteins. vol 61. issue 3. 2006-04-17. PMID:16161116. |
elastase cleaves predominantly at the c-terminals of the amino acids gly, val, leu, ala, and ile, and to a lesser extent at phe, pro, glu, and arg. |
2006-04-17 |
2023-08-12 |
human |
| João C Setubal, Marcelo Reis, James Matsunaga, David A Haak. Lipoprotein computational prediction in spirochaetal genomes. Microbiology (Reading, England). vol 152. issue Pt 1. 2006-04-17. PMID:16385121. |
psort sensitivity (13-35 %) was considerably less than that of splip (93-100 %) or lipop (50-84 %) due in part to the requirement of psort for ala or gly at the -1 position, a rule based on e. coli lipoproteins. |
2006-04-17 |
2023-08-12 |
Not clear |
| D W Dean, T D Bidner, L L Souther. Glycine supplementation to low protein, amino acid-supplemented diets supports optimal performance of broiler chicks. Poultry science. vol 85. issue 2. 2006-04-14. PMID:16523629. |
addition of gly or the combination of gly, glu, asp, ala, and pro to the low cp diet increased g:f (p < 0.01) compared with chicks fed pc, and adg was not different from that of broilers fed the pc diet. |
2006-04-14 |
2023-08-12 |
Not clear |
| Shogo Endo, Yasushi Satoh, Kavita Shah, Kunio Takishim. A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivatives. Biochemical and biophysical research communications. vol 341. issue 1. 2006-04-06. PMID:16431218. |
substituting smaller amino acids (alanine [ala (a)] or glycine [gly (g)]) for glutamine [gln (q)] in subdomain v drastically increased the susceptibility of erk1/2 to 1-naphthyl pp1 (1na-pp1). |
2006-04-06 |
2023-08-12 |
Not clear |
| Alida Spalloni, Raffaella Geracitano, Nicola Berretta, Carmelo Sgobio, Giorgio Bernardi, Nicola B Mercuri, Patrizia Longone, Martine Ammassari-Teul. Molecular and synaptic changes in the hippocampus underlying superior spatial abilities in pre-symptomatic G93A+/+ mice overexpressing the human Cu/Zn superoxide dismutase (Gly93 --> ALA) mutation. Experimental neurology. vol 197. issue 2. 2006-04-03. PMID:16309674. |
there is evidence that mutations in the cu/zn superoxide dismutase (sod1) gene are implicated in about 20% of familiar als and transgenic mice overexpressing the human cu/zn superoxide dismutase (gly(93) --> ala) mutation show an als-like phenotype. |
2006-04-03 |
2023-08-12 |
mouse |
| Tracy Stites, David Storms, Kathryn Bauerly, James Mah, Calliandra Harris, Andrea Fascetti, Quinton Rogers, Eskouhie Tchaparian, Michael Satre, Robert B Rucke. Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice. The Journal of nutrition. vol 136. issue 2. 2006-03-29. PMID:16424117. |
in mice from dams fed a conventional laboratory diet, but switched at weaning to the basal diet, plasma glucose, ala, gly, and ser concentrations were elevated at 4 wk (pqq- vs. pqq+), but not at 8 wk. |
2006-03-29 |
2023-08-12 |
mouse |
| Jose Zavaleta, Dinora Chinchilla, Karla Martinez, Frank A Gome. Multiple-injection affinity capillary electrophoresis to examine binding constants between glycopeptide antibiotics and peptides. Journal of chromatography. A. vol 1105. issue 1-2. 2006-03-28. PMID:16325833. |
multiple-injection affinity capillary electrophoresis (miace) was used to determine binding constants (k(b)) between vancomycin, ristocetin, and teicoplanin from streptomyces orientalis, nocardia lurida, and actinoplanes teichomyceticus, respectively, and fluorenylmethoxycarbonyl (fmoc)-(gly, ala, val, and phe)-d-ala-d-ala peptides. |
2006-03-28 |
2023-08-12 |
Not clear |
| Yuji Honda, Motomitsu Kitaok. The first glycosynthase derived from an inverting glycoside hydrolase. The Journal of biological chemistry. vol 281. issue 3. 2006-03-17. PMID:16301312. |
nine amino acid residue mutants (asp-263 to gly, ala, val, thr, leu, asn, cys, pro, or ser) were found to possess glycosynthase activity forming x3 from alpha-x2f and x1. |
2006-03-17 |
2023-08-12 |
Not clear |
| Paola Taddei, Takayuki Arai, Alessandra Boschi, Patrizia Monti, Masuhiro Tsukada, Giuliano Fredd. In vitro study of the proteolytic degradation of Antheraea pernyi silk fibroin. Biomacromolecules. vol 7. issue 1. 2006-03-02. PMID:16398523. |
the chemical analysis of the enzyme-resistant fraction of ap-sf films at different times of degradation indicated that the proteolytic attack preferentially occurred in the less ordered gly rich sequences and that the contribution of the ala rich crystalline regions to the composition of biodegraded films became progressively larger. |
2006-03-02 |
2023-08-12 |
Not clear |
| James D Hoyer, Jason K Baxter, Anna M Moran, Kathleen S Kubic, W Christopher Ehman. Two unstable beta chain variants associated with beta-thalassemia: Hb Miami [beta116(G18)his-->Pro], and Hb Hershey [beta70(E14)Ala-->Gly], and a second unstable Hb variant at 170: Hb Abington [beta70(E14)Ala-->Pro]. Hemoglobin. vol 29. issue 4. 2006-02-27. PMID:16370483. |
two unstable beta chain variants associated with beta-thalassemia: hb miami [beta116(g18)his-->pro], and hb hershey [beta70(e14)ala-->gly], and a second unstable hb variant at 170: hb abington [beta70(e14)ala-->pro]. |
2006-02-27 |
2023-08-12 |
Not clear |
| Robert Wieczorek, J J Dannenber. The energetic and structural effects of single amino acid substitutions upon capped alpha-helical peptides containing 17 amino acid residues. An ONIOM DFT/AM1 study. Journal of the American Chemical Society. vol 127. issue 49. 2006-02-22. PMID:16332068. |
we evaluate the effect of the amino acid mutations of glycine, leucine, valine, phenylalanine, serine, and proline for the 10th alanine in the capped peptide, acetly(ala)(17)nh(2), upon the energies of the alpha-helices and beta-strands using oniom dft/am1 molecular orbital calculations. |
2006-02-22 |
2023-08-12 |
Not clear |
| Robert Wieczorek, J J Dannenber. The energetic and structural effects of single amino acid substitutions upon capped alpha-helical peptides containing 17 amino acid residues. An ONIOM DFT/AM1 study. Journal of the American Chemical Society. vol 127. issue 49. 2006-02-22. PMID:16332068. |
thus, ala --> pro significantly destabilizes both but destabilizes the alpha-helix more, while ala --> gly stabilizes both but stabilizes the beta-strand more. |
2006-02-22 |
2023-08-12 |
Not clear |
| Aichun Zhao, Tianfu Zhao, Yanghu Sima, Yuansong Zhang, Koichi Nakagaki, Yungen Miao, Kunihiro Shiomi, Zenta Kajiura, Yoko Nagata, Masao Nakagak. Unique molecular architecture of egg case silk protein in a spider, Nephila clavata. Journal of biochemistry. vol 138. issue 5. 2006-02-21. PMID:16272571. |
the assembled repeat units (a1b1) contain a high proportion of ala (30.41%), ser (25.15%), and residues with hydrophobic side chains (22.22% for gly, leu, ile, val and phe combined). |
2006-02-21 |
2023-08-12 |
spider |
| Yoshihiko Sakurai, Bo Tang, Edward F Rosloniec, John M Stuart, Andrew H Kang, Linda K Myer. Molecular characterization of an arthritogenic collagen peptide interacting with I-Ar. Immunology. vol 117. issue 1. 2006-02-06. PMID:16423049. |
analogue peptides with substitutions at positions 447 (ala --> val), 448 (gly --> ala) and 451 (gly --> ala) bound poorly to the i-a(r) molecule. |
2006-02-06 |
2023-08-12 |
mouse |
| Michael L Oldham, Alan R Brash, Marcia E Newcome. Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality. The Journal of biological chemistry. vol 280. issue 47. 2006-02-03. PMID:16162493. |
moreover, a structural basis for r chiral specificity is also revealed; creation of a small oxygen pocket next to gly(428) (ala in all s-lox isozymes) promoted c-8 oxygenation with r chirality on the activated fatty acid substrate. |
2006-02-03 |
2023-08-12 |
Not clear |
| Felicity K Kerr, Grace O'Brien, Noelene S Quinsey, James C Whisstock, Sarah Boyd, Maria Garcia de la Banda, Dion Kaiserman, Antony Y Matthews, Phillip I Bird, Robert N Pik. Elucidation of the substrate specificity of the C1s protease of the classical complement pathway. The Journal of biological chemistry. vol 280. issue 47. 2006-02-03. PMID:16169853. |
c1s prefers leu or val at p(3) and gly or ala residues at p(2). |
2006-02-03 |
2023-08-12 |
Not clear |
| Thomas A Anderson, Matthew H J Cordes, Robert T Saue. Sequence determinants of a conformational switch in a protein structure. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 51. 2006-01-31. PMID:16344489. |
here, we study arc mutants in which position 11 is occupied by gly, ala, val, ile, leu, met, phe, or tyr. |
2006-01-31 |
2023-08-12 |
Not clear |
| Gabriela Bosio, Susana Criado, Walter Massad, Felipe J Rodríguez Nieto, Mónica C Gonzalez, Norman A García, Daniel O Mártir. Kinetics of the interaction of sulfate and hydrogen phosphate radicals with small peptides of glycine, alanine, tyrosine and tryptophan. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. vol 4. issue 10. 2006-01-27. PMID:16189561. |
the kinetics and mechanism of the oxidation of glycine (gly), alanine (ala), tyrosine (tyr), tryptophan (trp) and some di-(gly-gly, ala-ala, gly-ala, gly-trp, trp-gly, gly-tyr, tyr-gly), tri-(gly-gly-gly, ala-gly-gly) and tetrapeptides (gly-gly-gly-gly) mediated by sulfate (so(4) (-)) and hydrogen phosphate (hpo(4) (-)) radicals was studied, employing the flash-photolysis technique. |
2006-01-27 |
2023-08-12 |
Not clear |