| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A V Beliaeva, A V Bacheva, E S Oksenoĭt, E N Lysogorskaia, V I Lozinskiĭ, I Iu Filippov. [Peptide synthesis in organic media with the use of subtilisin 72 immobilized on a poly(vinyl alcohol) cryogel]. Bioorganicheskaia khimiia. vol 31. issue 6. 2006-01-24. PMID:16363130. |
subtilisin 72 serine protease (ec 3.4.21.14) immobilized on a poly(vinyl alcohol) cryogel was used as a catalyst in the syntheses of n-protected peptide p-nitroanilides of the general formulas z(or boc)-xaa-phe-pna (xaa = leu or ala), z-ala-xaa-yaa-pna (xaa = leu or ala; yaa = leu or phe), and z-ala-ala-xaa-yaa-pna (xaa = leu, arg, or gly; yaa = phe, leu, gly, asp, or glu). |
2006-01-24 |
2023-08-12 |
Not clear |
| Damien Boeglin, William D Lubel. Aza-amino acid scanning of secondary structure suited for solid-phase peptide synthesis with fmoc chemistry and aza-amino acids with heteroatomic side chains. Journal of combinatorial chemistry. vol 7. issue 6. 2006-01-23. PMID:16283795. |
this method has proven effective for introducing aza-amino acid residues with aliphatic (ala, leu, val, and gly) and aromatic (phe, tyr, and trp) side chains. |
2006-01-23 |
2023-08-12 |
human |
| Ipsita Chanda, Archana Pan, Chitra Dutt. Proteome composition in Plasmodium falciparum: higher usage of GC-rich nonsynonymous codons in highly expressed genes. Journal of molecular evolution. vol 61. issue 4. 2006-01-13. PMID:16044241. |
at all stages of development, frequencies of residues encoded by gc-rich codons such as gly, ala, arg, and pro increase significantly in the products of the highly expressed genes. |
2006-01-13 |
2023-08-12 |
human |
| Yeong-Renn Chen, Chwen-Lih Chen, Liwen Zhang, Kari B Green-Church, Jay L Zweie. Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation. The Journal of biological chemistry. vol 280. issue 45. 2006-01-12. PMID:16150735. |
thus, two domains of the 51-kda subunit, gly(200)-ala-gly-ala-tyr-ile-cys(206)-gly-glu-glu-thr-ala-leu-ile-glu-ser-ile-glu-gly-lys(219) and ala(176)-tyr(177)-glu-ala-gly-leu-ile-gly-lys(184), were demonstrated to be susceptible to oxidative attack, and their oxidative modification results in decreased electron transfer activity. |
2006-01-12 |
2023-08-12 |
Not clear |
| Ernesto E Ambroggio, Frances Separovic, John H Bowie, Gerardo D Fidelio, Luis A Bagatoll. Direct visualization of membrane leakage induced by the antibiotic peptides: maculatin, citropin, and aurein. Biophysical journal. vol 89. issue 3. 2006-01-05. PMID:15994901. |
additionally, to study the relevance of the proline residue on the membrane-action properties of maculatin, the same experimental approach was used for maculatin-ala and maculatin-gly (pro-15 was replaced by ala or gly, respectively). |
2006-01-05 |
2023-08-12 |
Not clear |
| Chi Ming Yan. On the structural regularity in nucleobases and amino acids and relationship to the origin and evolution of the genetic code. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. vol 35. issue 3. 2005-12-30. PMID:16228642. |
in the rearranged code, five simple but stereo-structurally distinctive amino acids (gly, pro, val, thr and ala) and their codon quartets form a crossed intersection "core". |
2005-12-30 |
2023-08-12 |
Not clear |
| Chi Ming Yan. On the structural regularity in nucleobases and amino acids and relationship to the origin and evolution of the genetic code. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. vol 35. issue 3. 2005-12-30. PMID:16228642. |
secondly, a re-categorization of the amino acids according to their beta-carbon stereochemistry, verified by charge density (at beta-carbon) calculation, results in five groups of stereo-structurally distinctive amino acids, the group leaders of which are gly, pro, val, thr and ala, remarkably overlapping the above "core". |
2005-12-30 |
2023-08-12 |
Not clear |
| Gianguido Coffa, Claus Schneider, Alan R Bras. A comprehensive model of positional and stereo control in lipoxygenases. Biochemical and biophysical research communications. vol 338. issue 1. 2005-12-28. PMID:16111652. |
a key determinant is a single active site residue conserved as an ala in s lipoxygenases and a gly in r lipoxygenases; this residue controls r or s stereochemistry by switching the position of oxygenation on the reacting pentadiene of the substrate. |
2005-12-28 |
2023-08-12 |
Not clear |
| Sunitha Meruvu, Matthias Walther, Igor Ivanov, Sven Hammarström, Gerhard Fürstenberger, Peter Krieg, Pallu Reddanna, Hartmut Kuh. Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis. The Journal of biological chemistry. vol 280. issue 44. 2005-12-28. PMID:16129665. |
to search for sequence determinants of murine (12r)-lox, we carried out multiple amino acid sequence alignments and found that phe(390), gly(441), ala(455), and val(631) align with previously identified positional determinants of s-lox isoforms. |
2005-12-28 |
2023-08-12 |
mouse |
| Sunitha Meruvu, Matthias Walther, Igor Ivanov, Sven Hammarström, Gerhard Fürstenberger, Peter Krieg, Pallu Reddanna, Hartmut Kuh. Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis. The Journal of biological chemistry. vol 280. issue 44. 2005-12-28. PMID:16129665. |
mutation of gly(441) to ala, which caused drastic alterations in the reaction specificity of other lox isoforms, failed to induce major alterations in the positional specificity of mouse (12r)-lox, but markedly modified the enantioselectivity of the enzyme. |
2005-12-28 |
2023-08-12 |
mouse |
| Sunitha Meruvu, Matthias Walther, Igor Ivanov, Sven Hammarström, Gerhard Fürstenberger, Peter Krieg, Pallu Reddanna, Hartmut Kuh. Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis. The Journal of biological chemistry. vol 280. issue 44. 2005-12-28. PMID:16129665. |
when val(631), which aligns with the positional determinant ile(593) of rabbit 15-lox, was mutated to a less space-filling residue (ala or gly), we obtained an enzyme species with augmented catalytic activity and specifically altered reaction characteristics (major formation of chiral (11r)-hydroxyeicosatetraenoic acid methyl ester). |
2005-12-28 |
2023-08-12 |
mouse |
| Silvia Picossi, María Luz Montesinos, Rafael Pernil, Christiane Lichtlé, Antonia Herrero, Enrique Flore. ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120. Molecular microbiology. vol 57. issue 6. 2005-12-01. PMID:16135226. |
anabaena mutants of these orfs were strongly affected (1-12% of the wild-type activity) in the transport of pro, phe, leu and gly and also impaired (17-30% of the wild-type activity) in the transport of ala and ser. |
2005-12-01 |
2023-08-12 |
Not clear |
| Nathalie Dias, Jean-François Goossens, Brigitte Baldeyrou, Amélie Lansiaux, Pierre Colson, Alberto Di Salvo, Jeanne Bernal, Agnes Turnbull, David J Mincher, Christian Baill. Oxoazabenzo[de]anthracenes conjugated to amino acids: synthesis and evaluation as DNA-binding antitumor agents. Bioconjugate chemistry. vol 16. issue 4. 2005-11-30. PMID:16029036. |
we report the synthesis of an original series of oxoazabenzo[de]anthracenes conjugated to an amino acid: ala, phe, pro, lys, or gly (4a-e, respectively). |
2005-11-30 |
2023-08-12 |
human |
| Nathalie Dias, Jean-François Goossens, Brigitte Baldeyrou, Amélie Lansiaux, Pierre Colson, Alberto Di Salvo, Jeanne Bernal, Agnes Turnbull, David J Mincher, Christian Baill. Oxoazabenzo[de]anthracenes conjugated to amino acids: synthesis and evaluation as DNA-binding antitumor agents. Bioconjugate chemistry. vol 16. issue 4. 2005-11-30. PMID:16029036. |
melting temperature, fluorescence quenching, and surface plasmon resonance methods all indicated that the lysine derivative 4d binds to dna much more strongly that the pro, ala, and gly conjugates whereas the phe analogue showed the lowest dna binding capacity. |
2005-11-30 |
2023-08-12 |
human |
| Stephen A McCartney, Edward J Brignole, Keli N Kolegraff, Amy N Loveland, LaShon M Ussin, Wade Gibso. Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a. The Journal of biological chemistry. vol 280. issue 39. 2005-11-30. PMID:16036911. |
we found that imidazole can restore i-site cleavage to mutants inactivated by replacing the critical active site his with ala or with gly, which rescued better. |
2005-11-30 |
2023-08-12 |
human |
| Naoki Hosomi, Yasuko Kawamura-Konishi, Ryota Kawano, Ikuo Fujii, Haruo Suzuk. Site-directed mutagenesis study of the antibody 2D7 which catalyzes a reaction for insertion of Cu2+ into mesoporphyrin. Journal of bioscience and bioengineering. vol 99. issue 3. 2005-11-15. PMID:16233781. |
recombinant fab mutants, in which arg95 is replaced with ala (r95a), asp96 with asn (d96n) and met97 with gly (m97g), were examined in terms of the catalytic efficiency of the reaction (k/k(s)) and the dissociation constant for n-methyl mesoporphyrin binding (k(d)) and these values were compared with those of the wild type. |
2005-11-15 |
2023-08-12 |
Not clear |
| Fritz-Georg Lehnhardt, Christian Bock, Gabriele Röhn, Ralf-Ingo Ernestus, Mathias Hoeh. Metabolic differences between primary and recurrent human brain tumors: a 1H NMR spectroscopic investigation. NMR in biomedicine. vol 18. issue 6. 2005-11-07. PMID:15959923. |
compared with the respective primary astrocytomas, characteristic features of glioblastomas were significantly increased concentrations of alanine (ala) (p = 0.005), increased metabolite ratios of glycine (gly)/total creatine (tcr) (p = 0.0001) and glutamate (glu)/glutamine (gln) (p = 0.004). |
2005-11-07 |
2023-08-12 |
human |
| Fritz-Georg Lehnhardt, Christian Bock, Gabriele Röhn, Ralf-Ingo Ernestus, Mathias Hoeh. Metabolic differences between primary and recurrent human brain tumors: a 1H NMR spectroscopic investigation. NMR in biomedicine. vol 18. issue 6. 2005-11-07. PMID:15959923. |
meningiomas showed increased ala (p = 0.02) and metabolite ratios [gly, total choline (tcho), ala] over tcr (p = 0.001) relative to astrocytomas, and n-acetylaspartate and myo-inositol were absent. |
2005-11-07 |
2023-08-12 |
human |
| Pornpimon Kiatpapan, Yoshikatsu Murook. Genetic manipulation system in propionibacteria. Journal of bioscience and bioengineering. vol 93. issue 1. 2005-11-03. PMID:16233156. |
ala in propionibacteria could be synthesized via both the c4 pathway (condensation of glycine and succinyl coa) and the c5 pathway (from glutamate). |
2005-11-03 |
2023-08-12 |
Not clear |
| A Ano, H Funahashi, K Nakao, Y Nishizaw. Effect of glycine on 5-aminolevulinic acid biosynthesis in heterotrophic culture of Chlorella regularis YA-603. Journal of bioscience and bioengineering. vol 88. issue 1. 2005-10-31. PMID:16232574. |
on the other hand, the addition of glycine, which is a precursor of ala biosynthesis via the shemin pathway in animal cells and some bacteria, enhanced both the specific growth rate and ala production. |
2005-10-31 |
2023-08-12 |
Not clear |