| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenji Ikehar. Possible steps to the emergence of life: the [GADV]-protein world hypothesis. Chemical record (New York, N.Y.). vol 5. issue 2. 2005-08-11. PMID:15828060. |
we reached this hypothesis during studies on the origins of genes and the genetic code, where [g], [a], [d], and [v] refer to gly, ala, asp, and val, respectively. |
2005-08-11 |
2023-08-12 |
cattle |
| Xiu-yan Liu, Xiang-yang Xu, Qing-lan Ma, Wei-hong W. Biological formation of 5-aminolevulinic acid by photosynthetic bacteria. Journal of environmental sciences (China). vol 17. issue 1. 2005-08-11. PMID:15900779. |
under the optimal condition( ph 7.5, supplement of ala dehydratase(alad) inhibitor, levulinic acid(la) and precursors of ala synthesis, glycine and succinat, 3000 ix of light density), ala formation of mutant l-1 was up to 22.15 mg/l. |
2005-08-11 |
2023-08-12 |
Not clear |
| Zhicheng Lin, George R Uh. Proline mutations induce negative-dosage effects on uptake velocity of the dopamine transporter. Journal of neurochemistry. vol 94. issue 1. 2005-08-08. PMID:15953370. |
ala and gly substitutions for pro 101 (p101) located in transmembrane domain 2 of the dopamine transporter (dat) abolished transport activity but did not disrupt plasma membrane expression. |
2005-08-08 |
2023-08-12 |
Not clear |
| A Staffan Fraysse, Anders L B Møller, Lisbeth R Poulsen, Bernd Wollenweber, Morten J Buch-Pedersen, Michael G Palmgre. A systematic mutagenesis study of Ile-282 in transmembrane segment M4 of the plasma membrane H+-ATPase. The Journal of biological chemistry. vol 280. issue 23. 2005-08-02. PMID:15829483. |
thus, smaller side chains (gly, ala, and ser) at this position resulted in lower h(+) affinity and lowered levels of h(+) transport in vivo, whereas substitution with side chains of similar and larger size resulted in only minor effects. |
2005-08-02 |
2023-08-12 |
Not clear |
| I L Byko. [Valproate-dependent changes in the spectrum of free amino acids in rats: l-carnitine effects]. Eksperimental'naia i klinicheskaia farmakologiia. vol 68. issue 2. 2005-08-02. PMID:15934365. |
the va treatment led to a decrease in the concentration of ser, gln, and ala in the blood plasma and of gln, cys, phe, and his in the liver, and to an increase in the level of tau, thr, gly, alpha-aba, ile, and tyr in the liver. |
2005-08-02 |
2023-08-12 |
rat |
| Wenfang Xu, Qianbin L. Progress in the development of aminopeptidase N (APN/CD13) inhibitors. Current medicinal chemistry. Anti-cancer agents. vol 5. issue 3. 2005-07-28. PMID:15992355. |
aminopeptidase n (apn; cd13) is a member of zinc-containing ectoenzymes family involved in the degradation of neutral or basic amino acids (ala>phe>leu>gly) from n-terminal of bioactive peptides and amide or arylamide derivatives of amino acids. |
2005-07-28 |
2023-08-12 |
Not clear |
| Juke S Lolkema, Iwona Sobczak, Dirk-Jan Slotboo. Secondary transporters of the 2HCT family contain two homologous domains with inverted membrane topology and trans re-entrant loops. The FEBS journal. vol 272. issue 9. 2005-07-06. PMID:15853816. |
the loops between the fourth and fifth transmembrane segment in each domain are well conserved throughout the class and contain a high fraction of residues with small side chains, gly, ala and ser. |
2005-07-06 |
2023-08-12 |
Not clear |
| Rachel S Dickins, Andrei S Batsanov, Judith A K Howard, David Parker, Horst Puschmann, Stefania Salaman. Structural and NMR investigations of the ternary adducts of twenty alpha-amino acids and selected dipeptides with a chiral, diaqua-ytterbium complex. Dalton transactions (Cambridge, England : 2003). issue 1. 2005-06-30. PMID:15356744. |
crystal structures of nine chelated ybl1-amino acid adducts (gly, ala, ser, thr, met) confirm this. |
2005-06-30 |
2023-08-12 |
Not clear |
| Akira Onoda, Hitoshi Yamamoto, Yusuke Yamada, Keonil Lee, Seiji Adachi, Taka-Aki Okamura, Kumiko Yoshizawa-Kumagaye, Kiichiro Nakajima, Toru Kawakami, Saburo Aimoto, Norikazu Ueyam. Switching of turn conformation in an aspartate anion peptide fragment by NH . . . O- hydrogen bonds. Biopolymers. vol 80. issue 2-3. 2005-06-30. PMID:15633197. |
nmr structure analyses indicate that the asp o(delta) atoms of the aspartate peptide 2 are intramolecularly hydrogen-bonded with gly, ser, ala nh, and ser oh, supporting the rigid beta-turn-like conformation in acetonitrile solution. |
2005-06-30 |
2023-08-12 |
Not clear |
| M J Przydzial, I D Pogozheva, K E Bosse, S M Andrews, T A Tharp, J R Traynor, H I Mosber. Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the kappa-opioid receptor. The journal of peptide research : official journal of the American Peptide Society. vol 65. issue 3. 2005-06-23. PMID:15787963. |
accordingly, tetrapeptides were synthesized with phe(3) replaced by aliphatic (gly, ala, aib, cha), basic (lys, arg, homo-arg), or aromatic sides chains (trp, tyr, p-nh(2)phe), and with d-pen(4) replaced by d-cys(4), and binding affinities to stably expressed mu-, delta-, and kappa-receptors were determined. |
2005-06-23 |
2023-08-12 |
Not clear |
| Guiscard Seebohm, Peter Westenskow, Florian Lang, Michael C Sanguinett. Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels. The Journal of physiology. vol 563. issue Pt 2. 2005-06-17. PMID:15649981. |
val310 was also mutated to gly, ala or leu to explore the importance of amino acid side chain volume at this position. |
2005-06-17 |
2023-08-12 |
xenopus_laevis |
| Mark A Schneegur. Delta-aminolevulinic acid biosynthesis in Ustilago maydis. Journal of basic microbiology. vol 45. issue 2. 2005-06-07. PMID:15812861. |
a biosynthetic precursor of tetrapyrroles, delta-aminolevulinic acid (ala), can be formed via two pathways: enzymatic condensation of glycine and succinyl-coa by ala synthase in animal mitochondria and some fungi, and the c5 pathway converting glutamate to ala in plants, algae, archaea, and most bacteria. |
2005-06-07 |
2023-08-12 |
Not clear |
| Mark A Schneegur. Delta-aminolevulinic acid biosynthesis in Ustilago maydis. Journal of basic microbiology. vol 45. issue 2. 2005-06-07. PMID:15812861. |
a significant amount of radiolabel was incorporated into ala from 2-[14c]glycine. |
2005-06-07 |
2023-08-12 |
Not clear |
| Tetsuo Asakura, Kosuke Ohgo, Teppei Ishida, Paola Taddei, Patrizia Monti, Raghuvansh Kishor. Possible implications of serine and tyrosine residues and intermolecular interactions on the appearance of silk I structure of Bombyx mori silk fibroin-derived synthetic peptides: high-resolution 13C cross-polarization/magic-angle spinning NMR study. Biomacromolecules. vol 6. issue 1. 2005-06-02. PMID:15638554. |
the diagnostic line shape of the ala c(beta) peaks and the conformation-dependent (13)c chemical shifts of ala and gly resonances are presented to analyze and characterize the structural features. |
2005-06-02 |
2023-08-12 |
Not clear |
| Chomin Cunchillos, Guillaume Lecointr. Integrating the universal metabolism into a phylogenetic analysis. Molecular biology and evolution. vol 22. issue 1. 2005-05-19. PMID:15356277. |
catabolism precedes anabolism for asn, gln, arg, trp, his, tyr, and phe, and anabolism precedes catabolism for pro, ala, leu, val, ile, cys, gly, ser, and thr. |
2005-05-19 |
2023-08-12 |
Not clear |
| Yu Chen, Julien Delmas, Jacques Sirot, Brian Shoichet, Richard Bonne. Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability. Journal of molecular biology. vol 348. issue 2. 2005-05-12. PMID:15811373. |
substitutions val231-->ala and asp240-->gly, which convert ctx-m-14 into ctx-m-16, occur at either end of this strand. |
2005-05-12 |
2023-08-12 |
Not clear |
| Hiroshi Tachibana, Naohisa Matsumoto, Xun-Jia Cheng, Hideo Tsukamoto, Eisaku Yoshihar. Improved affinity of a human anti-Entamoeba histolytica Gal/GalNAc lectin Fab fragment by a single amino acid modification of the light chain. Clinical and diagnostic laboratory immunology. vol 11. issue 6. 2005-05-11. PMID:15539510. |
sequence analyses revealed that the substituted amino acids at ser91 were ala in five clones, gly in three clones, pro in two clones, and val in two clones, while the amino acid at position 96 was substituted with leu in three clones. |
2005-05-11 |
2023-08-12 |
human |
| Hiroshi Tachibana, Naohisa Matsumoto, Xun-Jia Cheng, Hideo Tsukamoto, Eisaku Yoshihar. Improved affinity of a human anti-Entamoeba histolytica Gal/GalNAc lectin Fab fragment by a single amino acid modification of the light chain. Clinical and diagnostic laboratory immunology. vol 11. issue 6. 2005-05-11. PMID:15539510. |
pro or gly substitution for ser91 caused an increased affinity of the fab, but substitution with ala or val did not. |
2005-05-11 |
2023-08-12 |
human |
| Mads Toustrup-Jensen, Bente Vilse. Interaction between the catalytic site and the A-M3 linker stabilizes E2/E2P conformational states of Na+,K+-ATPase. The Journal of biological chemistry. vol 280. issue 11. 2005-04-25. PMID:15574410. |
the consequences of mutations ile(265) --> ala, thr(267) --> ala, gly(271) --> ala, and gly(274) --> ala for the partial reaction steps of the na(+),k(+)-atpase transport cycle were analyzed. |
2005-04-25 |
2023-08-12 |
Not clear |
| Mads Toustrup-Jensen, Bente Vilse. Interaction between the catalytic site and the A-M3 linker stabilizes E2/E2P conformational states of Na+,K+-ATPase. The Journal of biological chemistry. vol 280. issue 11. 2005-04-25. PMID:15574410. |
it was found that mutation ile(265) --> ala displaces the e(1)-e(2) and e(1)p-e(2)p equilibria in favor of e(1)/e(1)p, whereas mutations thr(267) --> ala, gly(271) --> ala, and gly(274) --> ala displace these conformational equilibria in favor of e(2)/e(2)p. the mutations affect both the rearrangement of the cytoplasmic domains (seen by changes in phosphoenzyme properties and apparent atp/vanadate affinities) and the membrane sector (indicated by change in k(+)/rb(+) deocclusion rate). |
2005-04-25 |
2023-08-12 |
Not clear |