| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elise K Black, Jack K Phillips, Jack Seminetta, Julian Bailes, John M Lee, John D Fina. The effect of dietary supplementation with high- or low-dose omega-3 fatty acid on inflammatory pathology after traumatic brain injury in rats. Translational neuroscience. vol 12. issue 1. 2021-02-25. PMID:33623714. |
rats were subjected to an impact tbi and then euthanized 7 days post-injury and neuroinflammation quantified by histological detection of glial fibrillary acidic protein (gfap), a marker of astrocyte activation, and cd68, a marker of microglial activity. |
2021-02-25 |
2023-08-13 |
rat |
| Susan C Campbell, Carmen Muñoz-Ballester, Lata Chaunsali, William A Mills, Jennifer H Yang, Harald Sontheimer, Stefanie Robe. Potassium and glutamate transport is impaired in scar-forming tumor-associated astrocytes. Neurochemistry international. vol 133. 2021-02-23. PMID:31825815. |
using electrophysiology, immunohistochemistry, fluorescent in situ hybridization, and western blot analysis in different orthotopic xenograft and allograft models of human and mouse gliomas, we find that peritumoral astrocytes exhibit astrocyte scar formation characterized by proliferation, cellular hypertrophy, process elongation, and increased gfap and pstat3. |
2021-02-23 |
2023-08-13 |
mouse |
| Xiaogang Chen, Lin Zhang, Fu Hua, Yu Zhuang, Huan Liu, Shouguo Wan. EphA4 Obstructs Spinal Cord Neuron Regeneration by Promoting Excessive Activation of Astrocytes. Cellular and molecular neurobiology. 2021-02-17. PMID:33595805. |
we found that the levels of neurotrophic factors including nerve growth factor (ngf) and basic fibroblast growth factor (bfgf) increased significantly after sci (ngf peaked at 3 days and bfgf peaked at 7 days); the expression of laminin and fibronectin increased gradually after sci; the expression of inflammatory factors [interleukin (il)-1β and il-6] increased significantly from 4 h to 7 days after sci; and the levels of glial fibrillary acidic protein (gfap), a marker of astrocyte activation, and chondroitin sulphate proteoglycan (cspg), the main component of glial scars, both peaked at 7 days after sci. |
2021-02-17 |
2023-08-13 |
Not clear |
| Sebok K Halder, Richard Milne. The GFAP Monoclonal Antibody GA-5 Identifies Astrocyte Remodeling and Glio-Vascular Uncoupling During the Evolution of EAE. Cellular and molecular neurobiology. 2021-02-05. PMID:33544272. |
the gfap monoclonal antibody ga-5 identifies astrocyte remodeling and glio-vascular uncoupling during the evolution of eae. |
2021-02-05 |
2023-08-13 |
Not clear |
| Sebok K Halder, Richard Milne. The GFAP Monoclonal Antibody GA-5 Identifies Astrocyte Remodeling and Glio-Vascular Uncoupling During the Evolution of EAE. Cellular and molecular neurobiology. 2021-02-05. PMID:33544272. |
to examine how astrocyte activation is regulated at different phases of relapsing-remitting eae, we performed an immunofluorescent analysis of the spinal cord using the anti-glial fibrillary acidic protein (gfap) monoclonal antibody ga-5. |
2021-02-05 |
2023-08-13 |
Not clear |
| Maurício Dos Santos Pereira, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Be. Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson's Disease. Frontiers in pharmacology. vol 11. 2021-01-30. PMID:33510643. |
however, glutamate enhanced tnf-α secretion and gfap expression in astrocyte cultures and promoted iba-1 expression in microglial cultures. |
2021-01-30 |
2023-08-13 |
mouse |
| Jérôme Roy, Laurence Larroquet, Anne Surget, Anthony Lanuque, Franck Sandres, Frederic Terrier, Geneviève Corraze, Jetty Chung-Yung Lee, Sandrine Skiba-Cass. Impact on cerebral function in rainbow trout fed with plant based omega-3 long chain polyunsaturated fatty acids enriched with DHA and EPA. Fish & shellfish immunology. vol 103. 2021-01-25. PMID:32473359. |
however, the mrna expression of transcripts related to cell specification were down regulated, namely tmem119 markers of microglial cell in forebrain and midbrain, gfap markers of astrocyte in the midbrain, and rbfox3 markers of neurons in the midbrain and hindbrain in juveniles fed high ω-3 experimental diet. |
2021-01-25 |
2023-08-13 |
Not clear |
| Audrey Yi Tyan Peng, Ira Agrawal, Wan Yun Ho, Yi-Chun Yen, Ashley J Pinter, Jerry Liu, Qi Xuan Cheryl Phua, Katrianne Bethia Koh, Jer-Cherng Chang, Emma Sanford, Jodie Hon Kiu Man, Peiyan Wong, David H Gutmann, Greg Tucker-Kellogg, Shuo-Chien Lin. Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 46. 2021-01-25. PMID:33127758. |
herein, we show that tdp-43-deleted astrocytes exhibit a cell-autonomous increase in gfap immunoreactivity without affecting astrocyte or microglia proliferation. |
2021-01-25 |
2023-08-13 |
mouse |
| Elma Aflaki, Barbara K Stubblefield, Ryan P McGlinchey, Benjamin McMahon, Daniel S Ory, Ellen Sidransk. A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson's disease. Neurobiology of disease. vol 134. 2021-01-13. PMID:31669751. |
gd2 iastrocytes were morphologically different, with severe cytoskeletal hypertrophy, overlapping of astrocyte processes, pronounced up-regulation of gfap and s100β, and significant astrocyte proliferation, recapitulating the neuropathology observed in patients with gd2. |
2021-01-13 |
2023-08-13 |
Not clear |
| Matthew I Hiskens, Anthony G Schneiders, Mariana Angoa-Pérez, Rebecca K Vella, Andrew S Fennin. Blood biomarkers for assessment of mild traumatic brain injury and chronic traumatic encephalopathy. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. vol 25. issue 3. 2021-01-11. PMID:32096416. |
to date, neurofilament light (nf-l) may be the most suitable candidate for assessing neuronal damage, and glial fibrillary acidic protein (gfap) for assessing astrocyte activation, although further work is required. |
2021-01-11 |
2023-08-13 |
Not clear |
| D Ganguly, C D L Johnson, M K Gottipati, D Rende, D-A Borca-Tasciuc, R J Gilber. Specific Nanoporous Geometries on Anodized Alumina Surfaces Influence Astrocyte Adhesion and Glial Fibrillary Acidic Protein Immunoreactivity Levels. ACS biomaterials science & engineering. vol 4. issue 1. 2021-01-11. PMID:33418683. |
astrocyte gfap expression was lower when astrocytes were cultured on surfaces with small nanopores compared to the control and large pore surfaces. |
2021-01-11 |
2023-08-13 |
rat |
| Osama Al-Dalahmah, Alexander A Sosunov, A Shaik, Kenneth Ofori, Yang Liu, Jean Paul Vonsattel, Istvan Adorjan, Vilas Menon, James E Goldma. Single-nucleus RNA-seq identifies Huntington disease astrocyte states. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:32070434. |
in particular, the gene expression profiles of astrocytes in hd showed multiple signatures, varying in phenotype from cells that had markedly upregulated metallothionein and heat shock genes, but had not completely lost the expression of genes associated with normal protoplasmic astrocytes, to astrocytes that had substantially upregulated glial fibrillary acidic protein (gfap) and had lost expression of many normal protoplasmic astrocyte genes as well as metallothionein genes. |
2020-12-23 |
2023-08-13 |
Not clear |
| Jatuporn Namyen, Kannika Permpoonputtana, Chutikorn Nopparat, Jiraporn Tocharus, Chainarong Tocharus, Piyarat Govitrapon. Protective Effects of Melatonin on Methamphetamine-Induced Blood-Brain Barrier Dysfunction in Rat Model. Neurotoxicity research. vol 37. issue 3. 2020-12-04. PMID:31900895. |
our results also showed the protective effects of melatonin against meth neurotoxic profiles, characterized by reactive gliosis: microglia (integrin-αm) and astrocyte (gfap); an excessive upregulation of primary pro-inflammatory cytokines: interleukin-1β (il-1β), interleukin-6 (il-6), and tumor necrosis factor-α (tnf-α); activation of neuroinflammatory signaling: nuclear factor-kappa b (nf-κb); and suppression of anti-oxidative signaling: nuclear factor erythroid 2-related factor (nrf2), that may exacerbate bbb structural impairment. |
2020-12-04 |
2023-08-13 |
rat |
| Anne Groteklaes, Carina Bönisch, Britta Eiberger, Andrea Christ, Karl Schillin. Developmental Maturation of the Cerebellar White Matter-an Instructive Environment for Cerebellar Inhibitory Interneurons. Cerebellum (London, England). vol 19. issue 2. 2020-11-23. PMID:32002802. |
from p4 onward, cells expressing the oligodendrocytic or astrocyte markers, cnp-1, mbp or gfap, started to appear in the nascent wm. |
2020-11-23 |
2023-08-13 |
Not clear |
| Chenchen Xia, Manli Yin, Cong Wu, Yonghua Ji, You Zho. Neuroglial activation in the auditory cortex and medial geniculate body of salicylate-induced tinnitus rats. American journal of translational research. vol 12. issue 10. 2020-11-17. PMID:33194013. |
the expression level of gfap markedly increased in the a1 cortex of rats following acute and chronic treatments of salicylate, accompanied by increased endpoint and process length of astrocyte. |
2020-11-17 |
2023-08-13 |
rat |
| Chenchen Xia, Manli Yin, Cong Wu, Yonghua Ji, You Zho. Neuroglial activation in the auditory cortex and medial geniculate body of salicylate-induced tinnitus rats. American journal of translational research. vol 12. issue 10. 2020-11-17. PMID:33194013. |
the expression level of gfap and the morphology of astrocyte in the rat mgb remained almost constant following salicylate treatment. |
2020-11-17 |
2023-08-13 |
rat |
| Zohreh Zare, Mohsen Tehrani, Sam Zarbakhsh, Hamed Farzadmanesh, Sakineh Shafia, Mahmood Abedinzade, Anahita Ghanaat, Moslem Mohammad. Effects of Paraoxon Exposure on Expression of Apoptosis-Related Genes, Neuronal Survival, and Astrocyte Activation in Rat Prefrontal Cortex. Neurotoxicity research. vol 37. issue 2. 2020-11-12. PMID:31493121. |
in addition, neuronal injury and astrocyte activation were assessed using cresyl violet staining and glial fibrillary acidic protein (gfap) immune-positive cells, respectively. |
2020-11-12 |
2023-08-13 |
rat |
| Pernille Barkholt, Kristoffer T G Rigbolt, Mechthilde Falkenhahn, Thomas Hübschle, Uwe Schwahn, Maria Luisa Fernandez-Cachon, Thorsten Schmidt, Stefan Theis, Henrik H Hansen, Anders Hay-Schmidt, Philip J Pedersen, Niels Vrang, Jacob Jelsin. Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss. Scientific reports. vol 9. issue 1. 2020-11-02. PMID:31695063. |
rygb reduced gene expression of glial cell markers, including gfap, aif1 and timp1, confirmed by a lower number of gfap immunopositive astrocyte profiles in the arc. |
2020-11-02 |
2023-08-13 |
rat |
| Roberta Fusco, Enrico Gugliandolo, Rosalba Siracusa, Maria Scuto, Marika Cordaro, Ramona D'Amico, Maurizio Evangelista, Angelo Peli, Alessio Filippo Peritore, Daniela Impellizzeri, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paol. Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury. Biology. vol 9. issue 9. 2020-10-28. PMID:32825368. |
moreover, tbi fpr1 ko animals displayed reduced neural differentiation (evaluated by beta-iii tubulin expression) and upregulation of astrocyte differentiation (evaluated by gfap expression). |
2020-10-28 |
2023-08-13 |
mouse |
| Caitlin E Bromberg, Andrew M Condon, Samantha W Ridgway, Gokul Krishna, Pamela C Garcia-Filion, P David Adelson, Rachel K Rowe, Theresa Currier Thoma. Sex-Dependent Pathology in the HPA Axis at a Sub-acute Period After Experimental Traumatic Brain Injury. Frontiers in neurology. vol 11. 2020-10-28. PMID:33101162. |
gfap intensity and astrocyte numbers increased as a function of injury, indicative of astrocytosis. |
2020-10-28 |
2023-08-13 |
rat |