| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisabeth B Thubron, Hannah S Rosa, Angela Hodges, Sobha Sivaprasad, Paul T Francis, Ilse S Pienaar, Afshan N Mali. Regional mitochondrial DNA and cell-type changes in post-mortem brains of non-diabetic Alzheimer's disease are not present in diabetic Alzheimer's disease. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31388037. |
in the absence of diabetes, ad parietal cortices had decreased mtdna, reduced map2 (neuronal) and increased gfap (astrocyte) mrna, relative to nci. |
2020-10-27 |
2023-08-13 |
human |
| Muhammad Irfan Masood, Karl Herbert Schäfer, Mahrukh Naseem, Maximilian Weyland, Peter Meise. Troxerutin flavonoid has neuroprotective properties and increases neurite outgrowth and migration of neural stem cells from the subventricular zone. PloS one. vol 15. issue 8. 2020-10-26. PMID:32797057. |
differentiation experiments were carried out for a time span lasting from 48 h to 7 days utilizing ß-tubulin iii and gfap as neuronal and astrocyte marker respectively. |
2020-10-26 |
2023-08-13 |
mouse |
| Nagla A El-Sherbeeny, Nema Soliman, Amal M Youssef, Noha M Abd El-Fadeal, Taghrid B El-Abaseri, Abdullah A Hashish, Walid Kamal Abdelbasset, Gaber El-Saber Batiha, Sawsan A Zaiton. The protective effect of biochanin A against rotenone-induced neurotoxicity in mice involves enhancing of PI3K/Akt/mTOR signaling and beclin-1 production. Ecotoxicology and environmental safety. vol 205. 2020-10-21. PMID:32977283. |
importantly, bioa suppressed the striatal astrocyte marker [gfap]. |
2020-10-21 |
2023-08-13 |
mouse |
| Jiakai Sun, Jiawei Zhang, Kun Li, Qiao Zheng, Jiwei Song, Zhuowen Liang, Tan Ding, Lin Qiao, Jianxin Zhang, Xueyu Hu, Zhe Wan. Photobiomodulation Therapy Inhibit the Activation and Secretory of Astrocytes by Altering Macrophage Polarization. Cellular and molecular neurobiology. vol 40. issue 1. 2020-10-20. PMID:31446561. |
results showed that pbm inhibit the expression of the astrocyte markers glial fibrillary acidic protein (gfap) and the secretion of chondroitin sulfate proteoglycans (cspg) in the para-epicenter area, decrease the number of m1 macrophage in vivo. |
2020-10-20 |
2023-08-13 |
mouse |
| Jiakai Sun, Jiawei Zhang, Kun Li, Qiao Zheng, Jiwei Song, Zhuowen Liang, Tan Ding, Lin Qiao, Jianxin Zhang, Xueyu Hu, Zhe Wan. Photobiomodulation Therapy Inhibit the Activation and Secretory of Astrocytes by Altering Macrophage Polarization. Cellular and molecular neurobiology. vol 40. issue 1. 2020-10-20. PMID:31446561. |
however, pbm significantly inhibited the expression of gfap, decreased activation of astrocyte, and downregulated the expression of cspg by regulating m1 macrophages. |
2020-10-20 |
2023-08-13 |
mouse |
| Tomokatsu Yoshid. [Clinical characteristics and diagnostic criteria on Alexander disease]. Rinsho shinkeigaku = Clinical neurology. vol 60. issue 9. 2020-10-13. PMID:32779598. |
alexander disease (alxdrd) is a primary astrocyte disease caused by glial fibrillary acidic protein (gfap) gene mutation. |
2020-10-13 |
2023-08-13 |
Not clear |
| Gang Li, Yang Cao, Feifei Shen, Yangsong Wang, Liangjie Bai, Weidong Guo, Yunlong Bi, Gang Lv, Zhongkai Fa. Mdivi-1 Inhibits Astrocyte Activation and Astroglial Scar Formation and Enhances Axonal Regeneration after Spinal Cord Injury in Rats. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:27807407. |
western blot and immunofluorescent double-labeling showed that mdivi-1 markedly reduced the expression of the astrocyte marker glial fibrillary acidic protein (gfap), and a cell proliferation marker, proliferating cell nuclear antigen, in astrocytes 3 days after sci. |
2020-10-01 |
2023-08-13 |
rat |
| Francesca Siani, Rosaria Greco, Giovanna Levandis, Cristina Ghezzi, Francesca Daviddi, Chiara Demartini, Elisabetta Vegeto, Marie-Thérèse Fuzzati-Armentero, Fabio Blandin. Influence of Estrogen Modulation on Glia Activation in a Murine Model of Parkinson's Disease. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28620274. |
animals were sacrificed at different time points following 6-ohda injection and brain sections containing striatum and substantia nigra pars compacta (snc) underwent immunohistochemistry for tyrosine hydroxylase (th) (dopaminergic marker), immunofluorescence for iba1 and gfap (markers of microglia and astrocyte activation, respectively) and triple immunoflorescent to identify polarization of microglia toward the cytotoxic m1 (dapi/iba1/tnfα) or cytoprotective m2 (dapi/iba1/cd206) phenotype. |
2020-10-01 |
2023-08-13 |
mouse |
| Kazuo Nakamoto, Fuka Aizawa, Megumi Kinoshita, Yutaka Koyama, Shogo Tokuyam. Astrocyte Activation in Locus Coeruleus Is Involved in Neuropathic Pain Exacerbation Mediated by Maternal Separation and Social Isolation Stress. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:28701953. |
we measured expression of glial fibrillary acidic protein (gfap), an astrocyte maker, in each brain area by immunohistochemistry. |
2020-10-01 |
2023-08-13 |
mouse |
| Matthew Snelson, John C L Mamo, Virginie Lam, Corey Giles, Ryusuke Takech. Differential Effects of High-Protein Diets Derived from Soy and Casein on Blood-Brain Barrier Integrity in Wild-type Mice. Frontiers in nutrition. vol 4. 2020-10-01. PMID:28791293. |
moreover, cortical expression of glial fibrillary acidic protein (gfap) was significantly greater in mice fed the high-casein diet compared to control mice, indicating heightened astrocyte activation, whereas mice maintained on a soy-enriched diet showed no increase of gfap abundance. |
2020-10-01 |
2023-08-13 |
mouse |
| Maryam Anzabi, Maryam Ardalan, Nina K Iversen, Ali H Rafati, Brian Hansen, Leif Østergaar. Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29445328. |
glial fibrillary acid protein (gfap) immunostained hippocampal sections were examined by stereological techniques to detect differences in astrocyte morphology, and global spatial sampling method was used to quantify the length density of aquaporin-4 (aqp4) positive capillaries. |
2020-10-01 |
2023-08-13 |
mouse |
| Maryam Anzabi, Maryam Ardalan, Nina K Iversen, Ali H Rafati, Brian Hansen, Leif Østergaar. Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29445328. |
sah induced retraction of gfap positive astrocyte processes, accompanied by a significant reduction in the length density of aqp4 positive capillaries as well as narrowing of hippocampal capillaries. |
2020-10-01 |
2023-08-13 |
mouse |
| Yu Wang, Jia Xia, Mengjun Shen, Yifan Zhou, Zhe Wu, Yuhuan Shi, Jianrong Xu, Lina Hou, Rui Zhang, Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Yongfang Zhang, Hao Wan. Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of β-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30723404. |
additionally, the immunohistochemistry and elisa results revealed that microglia (ionized calcium-binding adapter molecule 1, iba1) and astrocyte (glial fibrillary acidic protein, gfap) activation and the secretion of relevant inflammatory factors (tnfα and il-6) induced by aβ were decreased by the bis-mep treatment. |
2020-10-01 |
2023-08-13 |
mouse |
| Chiu-Min Lin, Ching-Fang Yu, Hsueh-Ya Huang, Fang-Hsin Chen, Ji-Hong Hong, Chi-Shiun Chian. Distinct Tumor Microenvironment at Tumor Edge as a Result of Astrocyte Activation Is Associated With Therapeutic Resistance for Brain Tumor. Frontiers in oncology. vol 9. 2020-10-01. PMID:31106146. |
the correlation of caix staining with astrocyte activation marker, glial fibrillary acid protein (gfap), at the tumor edge indicated the involvement of astrocyte activation on the development of peripheral hypoxia. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jessika M Hutchinson, Lori G Isaacso. Elimination of microglia in mouse spinal cord alters the retrograde CNS plasticity observed following peripheral axon injury. Brain research. vol 1721. 2020-10-01. PMID:31295468. |
though baseline astrocyte activation and gfap protein expression were unaffected, microglia elimination led to increased activation and gfap protein post injury when compared with mice fed the control diet. |
2020-10-01 |
2023-08-13 |
mouse |
| Longfei Gao, Zhen Zhang, Jing Lu, Gang Pe. Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31327963. |
by introducing alexander disease (axd)-associated hotspot mutations (r79c, r239c) into gfap gene of hpscs and subsequently inducing astrocyte differentiation, we found that gfap mutations impaired mitochondrial transfer from astrocytes and reduced astrocytic cd38 expression. |
2020-10-01 |
2023-08-13 |
human |
| Xin-Rui Qi, Willem Kamphuis, Ling Sha. Astrocyte Changes in the Prefrontal Cortex From Aged Non-suicidal Depressed Patients. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31798416. |
the expression levels of astrocyte markers (glial fibrillary acidic protein (gfap), synemin-α, synemin-β, vimentin, nestin) in isolated gray matter from postmortem acc and dlpfc were determined to investigate the possible involvement of astrocytes in depression. |
2020-10-01 |
2023-08-13 |
human |
| Xin-Rui Qi, Willem Kamphuis, Ling Sha. Astrocyte Changes in the Prefrontal Cortex From Aged Non-suicidal Depressed Patients. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31798416. |
however, gfap immunohistochemistry showed that the area fraction of gfap immunoreactive astrocytes was decreased in the acc of bpd patients, while there were no changes in the cell density and integrated optical density (iod), indicating that there might be a reduction of gfap-positive astrocyte processes and remodeling of the astrocyte network in bpd. |
2020-10-01 |
2023-08-13 |
human |
| Murad-Ali Shah, Dong-Ju Park, Ju-Bin Kang, Myeong-Ok Kim, Phil-Ok Ko. Baicalin alleviates lipopolysaccharide-induced neuroglial activation and inflammatory factors activation in hippocampus of adult mice. Laboratory animal research. vol 36. 2020-10-01. PMID:32983956. |
ionized calcium binding adaptor molecule-1 (iba-1) and glial fibrillary acidic protein (gfap) are widely used as microglia and astrocyte markers, respectively. |
2020-10-01 |
2023-08-13 |
mouse |
| Min-Jeong Kang, Shin-Young Park, Joong-Soo Ha. Hippocalcin Is Required for Astrocytic Differentiation through Activation of Stat3 in Hippocampal Neural Precursor Cells. Frontiers in molecular neuroscience. vol 9. 2020-09-30. PMID:27840601. |
in addition, there was an increase in the number of cells expressing glial fibrillary acidic protein (gfap), an astrocyte marker, and in branch outgrowth, indicating astrocytic differentiation of the hnpcs. |
2020-09-30 |
2023-08-13 |
Not clear |