| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi-Chen Zhu, Lu Liu, Wen-Zhuo Dai, Tao M. Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017447. |
we also found that crry protein expression in the hippocampus and cortex was significantly elevated in p301s mice (a mouse model widely used for investigating tau pathology) compared with that in wild-type mice. |
2022-01-12 |
2023-08-13 |
mouse |
| Ryszard Pluta, Sławomir Januszewski, Stanisław J Czuczwa. Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Disease Proteinopathy. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008731. |
in the hippocampus, studies have revealed dysregulation of the genes for the amyloid protein precursor metabolism and tau protein that is identical in nature to alzheimer's disease. |
2022-01-11 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Sławomir Januszewski, Stanisław J Czuczwa. Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Disease Proteinopathy. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008731. |
data indicate that amyloid and tau protein, derived from brain tissue and blood due to increased permeability of the blood-brain barrier after ischemia, play a key role in post-ischemic neurodegeneration of the hippocampus, with concomitant development of full-blown dementia. |
2022-01-11 |
2023-08-13 |
Not clear |
| Adam P Mecca, Ming-Kai Chen, Ryan S O'Dell, Mika Naganawa, Takuya Toyonaga, Tyler A Godek, Joanna E Harris, Hugh H Bartlett, Wenzhen Zhao, Emmie R Banks, Gessica S Ni, Kelly Rogers, Jean Dominique Gallezot, Jim Ropchan, Paul R Emery, Nabeel B Nabulsi, Brent C Vander Wyk, Amy F T Arnsten, Yiyun Huang, Richard E Carson, Christopher H van Dyc. Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease. Neurobiology of aging. vol 111. 2021-12-28. PMID:34963063. |
association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early alzheimer's disease. |
2021-12-28 |
2023-08-13 |
human |
| Xinping Song, Zijian Zhao, Yujuan Zhao, Qing Jin, Shengyu L. Protective effects of Journal of microbiology and biotechnology. vol 32. issue 3. 2021-12-26. PMID:34954699. |
we also found that supplementation of b. coagulans ja845 alleviated amyloid-beta deposits and hyperphosphorylated tau in hippocampus of d-gal/alcl3-induced ad model mice. |
2021-12-26 |
2023-08-13 |
mouse |
| Alireza Salami, Rolf Adolfsson, Micael Andersson, Kaj Blennow, Anders Lundquist, Annelie Nordin Adolfsson, Michael Schöll, Henrik Zetterberg, Lars Nyber. Association of APOE ɛ4 and Plasma p-tau181 with Preclinical Alzheimer's Disease and Longitudinal Change in Hippocampus Function. Journal of Alzheimer's disease : JAD. 2021-12-20. PMID:34924376. |
however, it remains unknown whether elevated tau accumulation on hippocampal functional changes would be more pronounced for apoe ɛ4 carriers. |
2021-12-20 |
2023-08-13 |
Not clear |
| YouJin Lee, Morgan R Miller, Marty A Fernandez, Elizabeth L Berg, Adriana M Prada, Qing Ouyang, Michael Schmidt, Jill L Silverman, Tracy L Young-Pearse, Eric M Morro. Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain. Brain : a journal of neurology. 2021-12-20. PMID:34928329. |
importantly, we subsequently observe biochemical and in situ evidence of both aβ and tau aggregation in the aged nhe6-null hippocampus and cortex (but not in the cerebellum). |
2021-12-20 |
2023-08-13 |
mouse |
| Kurt A Jellinge. Recent update on the heterogeneity of the Alzheimer's disease spectrum. Journal of neural transmission (Vienna, Austria : 1996). 2021-12-17. PMID:34919190. |
in addition to four major subtypes based on the distribution of tau pathology and brain atrophy (typical, limbic predominant, hippocampal sparing, and minimal atrophy), several other clinical variants (non-amnestic, corticobasal, behavioral/dysexecutive, posterior cortical variants, etc.) |
2021-12-17 |
2023-08-13 |
Not clear |
| Yunpeng Wang, Håkon Grydeland, James M Roe, Mengyu Pan, Fredrik Magnussen, Inge K Amlien, Leiv Otto Watne, Ane-Victoria Idland, Lars Bertram, Thomas E Gundersen, Alvaro Pascual-Leone, Maria Cabello-Toscano, Jose M Tormos, David Bartres-Faz, Christian A Drevon, Anders M Fjell, Kristine W Walhov. Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan. Brain, behavior, and immunity. 2021-12-17. PMID:34920091. |
hippocampal volume, brain amyloid-β (aβ) plaque levels, cerebrospinal fluid (csf) levels of aβ and tau species, and neurofilament protein light protein (nfl) were used as ad biomarkers in subsamples. |
2021-12-17 |
2023-08-13 |
Not clear |
| Kubra Celik Topkara, Erkan Kilinc, Ayhan Cetinkaya, Aslıhan Saylan, Serif Demi. Therapeutic effects of carvacrol on beta-amyloid-induced impairments in in-vitro and in-vivo models of Alzheimer's disease. The European journal of neuroscience. 2021-12-14. PMID:34904309. |
oxidant-antioxidant parameters (mda, h2o2, sod, and cat) and tau, aβ1-40 and aβ1-42 peptide levels in in-vitro supernatant or in-vivo serum and hippocampal samples were measured using elisa. |
2021-12-14 |
2023-08-13 |
rat |
| Chung-Sik Choi, Meredith Gwin, Sarah Voth, Claire Kolb, Chun Zhou, Amy R Nelson, Althea deWeever, Anna Koloteva, Naga S Annamdevula, James M Murphy, Brant M Wagener, Jean-Francois Pittet, Ssang-Taek S Lim, Ron Balczon, Troy Stevens, Mike T Li. Cytotoxic tau released from lung microvascular endothelial cells upon infection with P. aeruginosa promotes neuronal tauopathy. The Journal of biological chemistry. 2021-12-13. PMID:34896150. |
we previously hypothesized that the lung endothelium contributes to infection-related neurocognitive dysfunction, since bacteria-exposed endothelial cells release a form(s) of cytotoxic tau that is sufficient to impair long-term potentiation in the hippocampus. |
2021-12-13 |
2023-08-13 |
mouse |
| Jianfeng Wu, Qunxi Dong, Jie Zhang, Yi Su, Teresa Wu, Richard J Caselli, Eric M Reiman, Jieping Ye, Natasha Lepore, Kewei Chen, Paul M Thompson, Yalin Wan. Federated Morphometry Feature Selection for Hippocampal Morphometry Associated Beta-Amyloid and Tau Pathology. Frontiers in neuroscience. vol 15. 2021-12-13. PMID:34899166. |
federated morphometry feature selection for hippocampal morphometry associated beta-amyloid and tau pathology. |
2021-12-13 |
2023-08-13 |
human |
| Megan A Iida, Kurt Farrell, Jamie M Walker, Timothy E Richardson, Gabriel A Marx, Clare H Bryce, Dushyant Purohit, Gai Ayalon, Thomas G Beach, Eileen H Bigio, Etty P Cortes, Marla Gearing, Vahram Haroutunian, Corey T McMillan, Edward B Lee, Dennis W Dickson, Ann C McKee, Thor D Stein, John Q Trojanowski, Randall L Woltjer, Gabor G Kovacs, Julia K Kofler, Jeffrey Kaye, Charles L White, John F Crar. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta neuropathologica communications. vol 9. issue 1. 2021-12-11. PMID:34353357. |
we compared braak staging, which focuses on hierarchical neuroanatomical progression of ad tau and aβ pathology, with quantitative assessments of neurofibrillary burden using computer-derived positive pixel counts on digitized whole slide images of sections stained immunohistochemically with antibodies targeting abnormal hyperphosphorylated tau (p-tau) in the entorhinal region and hippocampus. |
2021-12-11 |
2023-08-13 |
human |
| Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research. vol 175. 2021-12-11. PMID:34838693. |
1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of aβ1-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. |
2021-12-11 |
2023-08-13 |
mouse |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
hippocampal sirt1 improves cognitive impairment by deacetylating tau protein in diabetic models. |
2021-12-11 |
2023-08-13 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
further study showed that the decreased level of sirt1 may result in the increase of acetylated tau protein in the hippocampus, which may mediate the development of diabetic cognitive impairment. |
2021-12-11 |
2023-08-13 |
rat |
| Almothana Alkasabera, Chike B Onyali, Comfort Anim-Koranteng, Hira E Shah, Aarthi Ethirajulu, Nitin Bhawnani, Jihan A Mostaf. The Effect of Type-2 Diabetes on Cognitive Status and the Role of Anti-diabetes Medications. Cureus. vol 13. issue 11. 2021-12-11. PMID:34877187. |
thirdly, multiple pathological studies showed that insulin and alzheimer's disease share many common lesions in the brain, such as beta-amyloid plaques, amylin-aβ plaques, hyper-phosphorylated tau protein, and brain atrophy, especially in the hippocampus. |
2021-12-11 |
2023-08-13 |
human |
| Xiao-Juan Wang, Lin Qi, Ya-Fang Cheng, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Li-Bo Zo. PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease. Acta pharmacologica Sinica. 2021-12-11. PMID:34893682. |
we showed that intracerebroventricular (icv) microinjection of forskolin (fsk, 80 μmol) induced tau hyperphosphorylation in the rat brain and resulted in significant spatial working memory impairments in y-maze test, accompanied by synaptic dysfunction (reduced expression of synaptic proteins synaptophysin and postsynaptic density protein 95), and neuronal loss in the hippocampus. |
2021-12-11 |
2023-08-13 |
rat |
| Zhao-Yan Cheng, Yu-Hui Hu, Qing-Peng Xia, Chen Wang, Ling H. DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model. Brain research bulletin. vol 175. 2021-12-10. PMID:34284074. |
moreover, our mechanism researches revealed that the drd1 signaling induced by a-68930 significantly rescued stz-induced mitochondrial biogenesis deficit, mitochondrial dysfunction, aβ overexpression, and tau phosphorylation in mice hippocampus and cortex and sh-sy5y cells, which may be mediated through stimulating ampk/pgc-1α pathway. |
2021-12-10 |
2023-08-13 |
mouse |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
first, event-based modelling revealed that the entorhinal cortex and brodmann area 35 show the earliest signs of tau accumulation followed by the anterior and posterior hippocampus, brodmann area 36 and the parahippocampal cortex. |
2021-12-09 |
2023-08-13 |
human |