| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juha R Savinainen, Dina Navia-Paldanius, Jarmo T Laitine. A Sensitive and Versatile Fluorescent Activity Assay for ABHD12. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245904. |
in vitro, abhd12 together with monoacylglycerol lipase (magl) and abhd6 hydrolyzes also monoacylglycerols (mags) such as the primary endocannabinoid 2-arachidonoyl glycerol (2-ag). |
2017-12-07 |
2023-08-13 |
human |
| Molly S Crowe, Steven G Kinse. MAGL inhibition modulates gastric secretion and motility following NSAID exposure in mice. European journal of pharmacology. vol 807. 2017-12-05. PMID:28478068. |
the present study was designed to determine which ulcerogenic effects of the nsaid diclofenac sodium are reversed by blocking the endocannabinoid catabolic enzyme monoacylglycerol lipase (magl). |
2017-12-05 |
2023-08-13 |
mouse |
| Ioannis Karageorgos, Vitalii I Silin, Nikolai Zvonok, John Marino, David R Janero, Alexandros Makriyanni. The role of human monoacylglycerol lipase (hMAGL) binding pocket in breakup of unsaturated phospholipid membranes. Analytical biochemistry. vol 536. 2017-12-04. PMID:28822686. |
human monoacylglycerol lipase (hmagl) plays a key role in homeostatic tuning of the endocannabinoid signaling system and supports aggressive tumorogenesis, making this enzyme a promising therapeutic target. |
2017-12-04 |
2023-08-13 |
human |
| Russell L Carr, Nathan H Armstrong, Alenda T Buchanan, Jeffrey B Eells, Afzaal N Mohammed, Matthew K Ross, Carole A Nai. Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development. Neurotoxicology. vol 59. 2017-11-22. PMID:26642910. |
exposure to chlorpyrifos (cpf) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (faah) and monoacylglycerol lipase (magl), resulting in accumulation of their respective substrates anandamide (aea) and 2-arachidonylglycerol (2-ag). |
2017-11-22 |
2023-08-13 |
rat |
| Carlotta Granchi, Isabella Caligiuri, Filippo Minutolo, Flavio Rizzolio, Tiziano Tuccinard. A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017). Expert opinion on therapeutic patents. vol 27. issue 12. 2017-11-17. PMID:29053063. |
monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid 2-arachidonoylglycerol. |
2017-11-17 |
2023-08-13 |
Not clear |
| Yao Chen, Xiaojie Liu, Casey R Vickstrom, Michelle J Liu, Li Zhao, Andreu Viader, Benjamin F Cravatt, Qing-Song Li. Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum. eNeuro. vol 3. issue 3. 2017-10-31. PMID:27182552. |
neuronal and astrocytic monoacylglycerol lipase limit the spread of endocannabinoid signaling in the cerebellum. |
2017-10-31 |
2023-08-13 |
mouse |
| Yao Chen, Xiaojie Liu, Casey R Vickstrom, Michelle J Liu, Li Zhao, Andreu Viader, Benjamin F Cravatt, Qing-Song Li. Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum. eNeuro. vol 3. issue 3. 2017-10-31. PMID:27182552. |
monoacylglycerol lipase (magl) is the principal enzyme that degrades the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2017-10-31 |
2023-08-13 |
mouse |
| Lu Wang, Wakana Mori, Ran Cheng, Joji Yui, Akiko Hatori, Longle Ma, Yiding Zhang, Benjamin H Rotstein, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Yuji Nagai, Takafumi Minamimoto, Makoto Higuchi, Neil Vasdev, Ming-Rong Zhang, Steven H Lian. Synthesis and Preclinical Evaluation of Sulfonamido-based [(11)C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase. Theranostics. vol 6. issue 8. 2017-10-16. PMID:27279908. |
monoacylglycerol lipase (magl) is a 33 kda member of the serine hydrolase superfamily that preferentially degrades 2-arachidonoylglycerol (2-ag) to arachidonic acid in the endocannabinoid system. |
2017-10-16 |
2023-08-13 |
rat |
| Carlotta Granchi, Isabella Caligiuri, Eleonora Bertelli, Giulio Poli, Flavio Rizzolio, Marco Macchia, Adriano Martinelli, Filippo Minutolo, Tiziano Tuccinard. Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors. Journal of enzyme inhibition and medicinal chemistry. vol 32. issue 1. 2017-10-10. PMID:28936880. |
monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol. |
2017-10-10 |
2023-08-13 |
Not clear |
| Y Wang, N Gu, T Duan, P Kesner, F Blaskovits, J Liu, Y Lu, L Tong, F Gao, C Harris, K Mackie, J Li, Q Tan, M N Hill, Z Yuan, X Zhan. Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses. Molecular psychiatry. vol 22. issue 2. 2017-10-03. PMID:27001616. |
here we investigate the antidepressant actions of inhibitors of monoacylglycerol lipase (magl), the major degradative enzyme of the endocannabinoid 2-arachidonoylglycerol. |
2017-10-03 |
2023-08-13 |
mouse |
| Jenny L Wilkerson, Sudeshna Ghosh, Mohammed Mustafa, Rehab A Abdullah, Micah J Niphakis, Roberto Cabrera, Rafael L Maldonado, Benjamin F Cravatt, Aron H Lichtma. The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. Neuropharmacology. vol 114. 2017-07-11. PMID:27890602. |
inhibitors of the primary endocannabinoid catabolic enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) show opioid-sparing effects in preclinical models of pain. |
2017-07-11 |
2023-08-13 |
mouse |
| Sally Miller, Emma Leishman, Sherry Shujung Hu, Alhasan Elghouche, Laura Daily, Natalia Murataeva, Heather Bradshaw, Alex Straike. Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model. Investigative ophthalmology & visual science. vol 57. issue 7. 2017-06-12. PMID:27333182. |
endogenous cannabinoid (ecb) ligand, 2-arachidonoyl glycerol (2-ag), likewise activates cb1 and is metabolized by monoacylglycerol lipase (magl). |
2017-06-12 |
2023-08-13 |
Not clear |
| Niina Aaltonen, Ewa Kedzierska, Jolanta Orzelska-Górka, Marko Lehtonen, Dina Navia-Paldanius, Hermina Jakupovic, Juha R Savinainen, Tapio Nevalainen, Jarmo T Laitinen, Teija Parkkari, Mikko Gynthe. In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). The Journal of pharmacology and experimental therapeutics. vol 359. issue 1. 2017-05-26. PMID:27451409. |
monoacylglycerol lipase (magl) is a serine hydrolase that acts as a principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2017-05-26 |
2023-08-13 |
mouse |
| Arslan Arinc Kayacelebi, Celina Schauerte, Katharina Kling, Jan Herbers, Bibiana Beckmann, Stefan Engeli, Jens Jordan, Alexander A Zoerner, Dimitrios Tsika. Cross-validated stable-isotope dilution GC-MS and LC-MS/MS assays for monoacylglycerol lipase (MAGL) activity by measuring arachidonic acid released from the endocannabinoid 2-arachidonoyl glycerol. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1047. 2017-03-22. PMID:27511795. |
cross-validated stable-isotope dilution gc-ms and lc-ms/ms assays for monoacylglycerol lipase (magl) activity by measuring arachidonic acid released from the endocannabinoid 2-arachidonoyl glycerol. |
2017-03-22 |
2023-08-13 |
Not clear |
| Ozgur Yesilyurt, Mutlu Cayirli, Yusuf Serdar Sakin, Melik Seyrek, Ahmet Akar, Ahmet Dogru. Systemic and spinal administration of FAAH, MAGL inhibitors and dual FAAH/MAGL inhibitors produce antipruritic effect in mice. Archives of dermatological research. vol 308. issue 5. 2017-02-17. PMID:27126057. |
the increase of endocannabinoid tonus by inhibiting fatty acid amide hydrolase (faah) or monoacylglycerol lipase (magl) represents a promising therapeutic approach in a variety of disease to overcome serious central side effects of exocannabinoids. |
2017-02-17 |
2023-08-13 |
mouse |
| Wei Yan, Yang Yun, Tingting Ku, Guangke Li, Nan San. NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication. Scientific reports. vol 6. 2017-01-13. PMID:26928013. |
furthermore, increasing endocannabinoid 2-arachidonoylglycerol (2-ag) by inhibiting monoacylglycerol lipase (magl) prevented pge2 production, neuroinflammation-associated aβ42 accumulation, and neurodegeneration, indicating a therapeutic target for relieving cognitive impairment caused by no2 exposure. |
2017-01-13 |
2023-08-13 |
mouse |
| Caitlin E Carey, Arpana Agrawal, Bo Zhang, Emily D Conley, Louisa Degenhardt, Andrew C Heath, Daofeng Li, Michael T Lynskey, Nicholas G Martin, Grant W Montgomery, Ting Wang, Laura J Bierut, Ahmad R Hariri, Elliot C Nelson, Ryan Bogda. Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis. Journal of abnormal psychology. vol 124. issue 4. 2016-12-13. PMID:26595473. |
monoacylglycerol lipase (mgll) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: evidence from an endocannabinoid system-level analysis. |
2016-12-13 |
2023-08-13 |
Not clear |
| P H Gobira, A F Almeida-Santos, F S Guimaraes, F A Moreira, D C Aguia. Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 1. 2016-10-27. PMID:26628106. |
this endocannabinoid and its hydrolyzing enzyme, monoacylglycerol lipase (magl), are present in encephalic regions related to psychiatric disorders, including the midbrain dorsolateral periaqueductal grey (dlpag). |
2016-10-27 |
2023-08-13 |
Not clear |
| Shintaro Ogawa, Hiroshi Kunug. Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants. Current neuropharmacology. vol 13. issue 6. 2016-09-09. PMID:26630956. |
recently, endocannabinoid hydrolytic enzymes such as fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) have become new therapeutic targets in the treatment of mdd. |
2016-09-09 |
2023-08-13 |
Not clear |
| Jonathan W Lovelace, Alex Corches, Philip A Vieira, Alex S Hiroto, Ken Mackie, Edward Korzu. An animal model of female adolescent cannabinoid exposure elicits a long-lasting deficit in presynaptic long-term plasticity. Neuropharmacology. vol 99. 2016-08-30. PMID:25979486. |
increasing endocannabinoid levels by blockade of monoacylglycerol lipase, the primary enzyme responsible for degrading the endocannabinoid 2-arachidonoylglycerol (2-ag), with the specific inhibitor jzl 184 ameliorates ecb-ltd deficits. |
2016-08-30 |
2023-08-13 |
mouse |