| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simone Lauria, Cristiana Perrotta, Silvana Casati, Ilaria Di Renzo, Roberta Ottria, Ivano Eberini, Luca Palazzolo, Chiara Parravicini, Pierangela Ciuffred. Design, synthesis, molecular modelling and in vitro cytotoxicity analysis of novel carbamate derivatives as inhibitors of Monoacylglycerol lipase. Bioorganic & medicinal chemistry. vol 26. issue 9. 2018-12-31. PMID:29678535. |
monoacylglycerol lipase (magl) has an essential role in the catabolic pathway of the endocannabinoid 2-arachidonoylglycerol, which makes it a potential target for highly specific inhibitors for the treatment of a number of diseases. |
2018-12-31 |
2023-08-13 |
human |
| Guoxiang Fang, Ying Wan. Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats. Neurochemical research. vol 43. issue 9. 2018-12-31. PMID:29987693. |
expression of hippocampal cannabinoid type i receptor (cb1r), 2-arachidonoylglycerol (2-ag) and relative synthetase and degradative enzymes-diacylglycerol lipase (dagl) and monoacylglycerol lipase (magl) were also investigated. |
2018-12-31 |
2023-08-13 |
rat |
| Giulia Bononi, Carlotta Granchi, Margherita Lapillo, Massimiliano Giannotti, Daniela Nieri, Serena Fortunato, Maguie El Boustani, Isabella Caligiuri, Giulio Poli, Kathryn E Carlson, Sung Hoon Kim, Marco Macchia, Adriano Martinelli, Flavio Rizzolio, Andrea Chicca, John A Katzenellenbogen, Filippo Minutolo, Tiziano Tuccinard. Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors. European journal of medicinal chemistry. vol 157. 2018-10-29. PMID:30144699. |
monoacylglycerol lipase (magl) is the enzyme hydrolyzing the endocannabinoid 2-arachidonoylglycerol (2-ag) to free arachidonic acid and glycerol. |
2018-10-29 |
2023-08-13 |
Not clear |
| Rantaro Kamimura, Mohammad Z Hossain, Shumpei Unno, Hiroshi Ando, Yuji Masuda, Kojiro Takahashi, Masanori Otake, Isao Saito, Junichi Kitagaw. Inhibition of 2-arachydonoylgycerol degradation attenuates orofacial neuropathic pain in trigeminal nerve-injured mice. Journal of oral science. vol 60. issue 1. 2018-10-11. PMID:29503395. |
the present study used inferior orbital nerve (ion)-injured mice to investigate the effect of inhibiting monoacylglycerol lipase (magl), an enzyme that degrades the major endocannabinoid 2-arachydonoylgycerol (2-ag) in orofacial neuropathic pain. |
2018-10-11 |
2023-08-13 |
mouse |
| Mohammad-Reza Rahmani, Ali Shamsizadeh, Amir Moghadam-Ahmadi, Gholamreza Bazmandegan, Mohammad Allahtavakol. JZL184, as a monoacylglycerol lipase inhibitor, down-regulates inflammation in a cannabinoid pathway dependent manner. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-11. PMID:29864962. |
jzl184, as a monoacylglycerol lipase inhibitor, down-regulates inflammation in a cannabinoid pathway dependent manner. |
2018-10-11 |
2023-08-13 |
mouse |
| Gaetano Terrone, Alberto Pauletti, Alessia Salamone, Massimo Rizzi, Bianca R Villa, Luca Porcu, Mark J Sheehan, Edward Guilmette, Christopher R Butler, Justin R Piro, Tarek A Samad, Annamaria Vezzan. Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. Epilepsia. vol 59. issue 1. 2018-09-14. PMID:29171003. |
monoacylglycerol lipase (magl) is the key enzyme responsible for the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-ag) and a major contributor to the brain pool of arachidonic acid (aa). |
2018-09-14 |
2023-08-13 |
mouse |
| Jazmin Fontenot, Esteban C Loetz, Matthew Ishiki, Sondra T Blan. Monoacylglycerol lipase inhibition alters social behavior in male and female rats after post-weaning social isolation. Behavioural brain research. vol 341. 2018-09-04. PMID:29292159. |
the present study sought to determine whether this phenotype would be normalized by increasing levels of the endocannabinoid 2-arachidonoylglycerol (2-ag) using pharmacological inhibition of monoacylglycerol lipase (magl). |
2018-09-04 |
2023-08-13 |
rat |
| Qi-Nan Li, Zhi-Peng Huang, Qin-Lan Gu, Zhuo-Er Zhi, Yu-Han Yang, Long He, Kai-Li Chen, Jin-Xin Wan. Synthesis and biological evaluation of novel tanshinone IIA derivatives for treating pain. Chinese journal of natural medicines. vol 16. issue 2. 2018-08-14. PMID:29455726. |
monoacylglycerol lipase (magl) is an essential hydrolase in the endocannabinoid system and has been identified as a potential target for the treatment of pain. |
2018-08-14 |
2023-08-13 |
Not clear |
| Molly S Crowe, Catheryn D Wilson, Emma Leishman, Paul L Prather, Heather B Bradshaw, Matthew L Banks, Steven G Kinse. The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice. British journal of pharmacology. vol 174. issue 23. 2018-07-30. PMID:28963716. |
similarly, inhibition of the endogenous cannabinoid enzyme monoacylglycerol lipase (magl) has antinociceptive and anti-inflammatory properties but also induces sedation in mice at high doses. |
2018-07-30 |
2023-08-13 |
mouse |
| Xinwen Zhang, Stanley A Thaye. Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling. Neuropharmacology. vol 128. 2018-07-17. PMID:29061509. |
monoacylglycerol lipase inhibitor jzl184 prevents hiv-1 gp120-induced synapse loss by altering endocannabinoid signaling. |
2018-07-17 |
2023-08-13 |
rat |
| Laura Scalvini, Federica Vacondio, Michele Bassi, Daniele Pala, Alessio Lodola, Silvia Rivara, Kwang-Mook Jung, Daniele Piomelli, Marco Mo. Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL. Scientific reports. vol 6. 2018-05-15. PMID:27499063. |
the function of monoacylglycerol lipase (mgl), a key actor in the hydrolytic deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2ag), is tightly controlled by the cell's redox state: oxidative signals such as hydrogen peroxide suppress mgl activity in a reversible manner through sulfenylation of the peroxidatic cysteines, c201 and c208. |
2018-05-15 |
2023-08-13 |
human |
| Noemi Pasquarelli, Michael Engelskirchen, Johannes Hanselmann, Sascha Endres, Christoph Porazik, Hanna Bayer, Eva Buck, Meliha Karsak, Patrick Weydt, Boris Ferger, Anke Wittin. Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS. Neuropharmacology. vol 124. 2018-05-09. PMID:28373073. |
the neuroprotective and anti-inflammatory endocannabinoid 2-arachidonoylglycerol (2-ag), which is degraded by monoacylglycerol lipase (magl), accumulates in the spinal cords of transgenic models of als. |
2018-05-09 |
2023-08-13 |
mouse |
| Camilla P Dias-Rocha, Mariana M Almeida, Erika M Santana, Julia C B Costa, Juliana G Franco, Carmen C Pazos-Moura, Isis H Trevenzol. Maternal high-fat diet induces sex-specific endocannabinoid system changes in newborn rats and programs adiposity, energy expenditure and food preference in adulthood. The Journal of nutritional biochemistry. vol 51. 2018-05-09. PMID:29102876. |
the ecs consists mainly of endogenous ligands, cannabinoid receptors (cb1 and cb2), and the enzymes fatty acid anandamide hydrolase (faah) and monoacylglycerol lipase (magl). |
2018-05-09 |
2023-08-13 |
rat |
| Sang-Ho Choi, Allison L Arai, Yongshan Mou, Byeongteck Kang, Cecil Chern-Chyi Yen, John Hallenbeck, Afonso C Silv. Neuroprotective Effects of MAGL (Monoacylglycerol Lipase) Inhibitors in Experimental Ischemic Stroke. Stroke. vol 49. issue 3. 2018-03-15. PMID:29440474. |
magl (monoacylglycerol lipase) is an enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic acid and prostaglandins-substances that mediate tissue inflammatory response. |
2018-03-15 |
2023-08-13 |
Not clear |
| Marta Celorrio, Diana Fernández-Suárez, Estefanía Rojo-Bustamante, Víctor Echeverry-Alzate, María J Ramírez, Cecilia J Hillard, José A López-Moreno, Rafael Maldonado, Julen Oyarzábal, Rafael Franco, María S Aymeric. Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. Brain, behavior, and immunity. vol 57. 2018-01-11. PMID:27318096. |
modulation of the levels of the endocannabinoid 2-arachidonoyl-glycerol by inhibiting monoacylglycerol lipase alters glial phenotypes and provides neuroprotection in a mouse model of parkinson's disease. |
2018-01-11 |
2023-08-13 |
mouse |
| Christopher R Butler, Elizabeth M Beck, Anthony Harris, Zhen Huang, Laura A McAllister, Christopher W Am Ende, Kimberly Fennell, Timothy L Foley, Kari Fonseca, Steven J Hawrylik, Douglas S Johnson, John D Knafels, Scot Mente, G Stephen Noell, Jayvardhan Pandit, Tracy B Phillips, Justin R Piro, Bruce N Rogers, Tarek A Samad, Jane Wang, Shuangyi Wan, Michael A Brodne. Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase. Journal of medicinal chemistry. vol 60. issue 23. 2017-12-29. PMID:29148769. |
monoacylglycerol lipase (magl) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-ag) in the cns. |
2017-12-29 |
2023-08-13 |
Not clear |
| Iram P Rodriguez-Sanchez, Josee Guindon, Marco Ruiz, M Elizabeth Tejero, Gene Hubbard, Laura E Martinez-de-Villarreal, Hugo A Barrera-Saldaña, Edward J Dick, Anthony G Comuzzie, Natalia E Schlabritz-Loutsevitc. The endocannabinoid system in the baboon (Papio spp.) as a complex framework for developmental pharmacology. Neurotoxicology and teratology. vol 58. 2017-12-22. PMID:27327781. |
consumption of exogenous cannabinoids interferes with the endogenous cannabinoid (or "endocannabinoid" (ecb)) system (ecs), which comprises n-arachidonylethanolamide (anandamide, aea), 2-arachidonoyl glycerol (2-ag), endocannabinoid receptors (cannabinoid receptors 1 and 2 (cb1r and cb2r), encoded by cnr1 and cnr2, respectively), and synthesizing/degrading enzymes (faah, fatty-acid amide hydrolase; magl, monoacylglycerol lipase; dagl-α, diacylglycerol lipase-alpha). |
2017-12-22 |
2023-08-13 |
Not clear |
| Emma Leishman, Ben Cornett, Karl Spork, Alex Straiker, Ken Mackie, Heather B Bradsha. Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. Pharmacological research. vol 110. 2017-12-21. PMID:27109320. |
the enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) hydrolyze endogenous cannabinoids (ecbs), n-arachidonoyl ethanolamine (aea) and 2-arachidonoyl glycerol (2-ag), respectively. |
2017-12-21 |
2023-08-13 |
mouse |
| Wei Li, Cong-Li Zhang, Zheng-Guo Qi. Differential expression of endocannabinoid system-related genes in the dorsal hippocampus following expression and reinstatement of morphine conditioned place preference in mice. Neuroscience letters. vol 643. 2017-12-19. PMID:28192193. |
we found that expression of morphine cpp was associated with significant increases in mrna expression for the primary clearance routes for anandamide (aea) and 2-ag (fatty acid amide hydrolase [faah] and monoacylglycerol lipase [magl], respectively), but with reductions in cannabinoid 1 receptors (cb1r) and cb2r in dorsal hippocampus following the expression of cpp. |
2017-12-19 |
2023-08-13 |
mouse |
| Kwang-Mook Jung, Daniele Piomell. Assay of Monoacylglycerol Lipase Activity. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245902. |
monoacylglycerol lipase (mgl) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-ag). |
2017-12-07 |
2023-08-13 |
Not clear |