| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Marino, Daniëlle de Ridder, Ryan T Bishop, Nathalie Renema, Marco Ponzetti, Antonia Sophocleous, Mattia Capulli, Abdullah Aljeffery, Giovana Carrasco, Marianela Dalghi Gens, Asim Khogeer, Stuart H Ralston, Jürg Gertsch, Francois Lamoureux, Dominique Heymann, Nadia Rucci, Aymen I Idri. Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice. EBioMedicine. vol 44. 2019-12-10. PMID:31151929. |
monoacylglycerol lipase (magl) is an enzyme of the endocannabinoid system, and is responsible for the degradation of the most abundant endocannabinoid in bone, 2-arachidonoyl glycerol (2ag). |
2019-12-10 |
2023-08-13 |
mouse |
| Matteo Miceli, Silvana Casati, Roberta Ottria, Simone Di Leo, Ivano Eberini, Luca Palazzolo, Chiara Parravicini, Pierangela Ciuffred. Set-Up and Validation of a High Throughput Screening Method for Human Monoacylglycerol Lipase (MAGL) Based on a New Red Fluorescent Probe. Molecules (Basel, Switzerland). vol 24. issue 12. 2019-12-02. PMID:31208066. |
monoacylglycerol lipase (magl) is a serine hydrolase that has a key regulatory role in controlling the levels of 2-arachidonoylglycerol (2-ag), the main signaling molecule in the endocannabinoid system. |
2019-12-02 |
2023-08-13 |
human |
| Kerong Hai, Guo Chen, Xueyan Gou, Haixia Jiang, Deying Gong, Yan Cheng, Cansheng Gong, Xinghuan Li, Yuqi Liu, Huan Li, Gang Zhang, Linghui Yang, Bowen Ke, Jin Li. Monoacylglycerol Lipase Inactivation by Using URB602 Mitigates Myocardial Damage in a Rat Model of Cardiac Arrest. Critical care medicine. vol 47. issue 2. 2019-11-12. PMID:30431495. |
monoacylglycerol lipase participates in organ protection by regulating the hydrolysis of the endocannabinoid 2-arachidonoylglycerol. |
2019-11-12 |
2023-08-13 |
rat |
| Jason R Clapper, Cassandra L Henry, Micah J Niphakis, Anna M Knize, Aundrea R Coppola, Gabriel M Simon, Nhi Ngo, Rachel A Herbst, Dylan M Herbst, Alex W Reed, Justin S Cisar, Olivia D Weber, Andreu Viader, Jessica P Alexander, Mark L Cunningham, Todd K Jones, Iain P Fraser, Cheryl A Grice, R Alan B Ezekowitz, Gary P O'Neill, Jacqueline L Blankma. Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators. The Journal of pharmacology and experimental therapeutics. vol 367. issue 3. 2019-10-04. PMID:30305428. |
monoacylglycerol lipase inhibition in human and rodent systems supports clinical evaluation of endocannabinoid modulators. |
2019-10-04 |
2023-08-13 |
human |
| Jason R Clapper, Cassandra L Henry, Micah J Niphakis, Anna M Knize, Aundrea R Coppola, Gabriel M Simon, Nhi Ngo, Rachel A Herbst, Dylan M Herbst, Alex W Reed, Justin S Cisar, Olivia D Weber, Andreu Viader, Jessica P Alexander, Mark L Cunningham, Todd K Jones, Iain P Fraser, Cheryl A Grice, R Alan B Ezekowitz, Gary P O'Neill, Jacqueline L Blankma. Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators. The Journal of pharmacology and experimental therapeutics. vol 367. issue 3. 2019-10-04. PMID:30305428. |
monoacylglycerol lipase (mgll) is the primary degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-ag). |
2019-10-04 |
2023-08-13 |
human |
| Ming Jiang, Mario van der Stel. Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders. Journal of medicinal chemistry. vol 61. issue 20. 2019-09-30. PMID:30354159. |
monoacylglycerol lipase (mgll or magl) is a critical point of regulation of both endocannabinoid and eicosanoid signaling pathways in the brain, thereby providing novel therapeutic opportunities for neurological and neurodegenerative diseases. |
2019-09-30 |
2023-08-13 |
Not clear |
| Kenji Yoshida, Yoshihiro Kita, Suzumi M Tokuoka, Fumie Hamano, Maya Yamazaki, Kenji Sakimura, Masanobu Kano, Takao Shimiz. Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 2. 2019-08-26. PMID:30265576. |
here we describe a possible role in high-fat diet (hfd)-induced obesity for monoacylglycerol lipase (mgl), an enzyme that is also known to hydrolyze the endocannabinoid 2-arachidonoylglycerol in brain. |
2019-08-26 |
2023-08-13 |
mouse |
| Zachary A Curry, Jenny L Wilkerson, Deniz Bagdas, S Lauren Kyte, Nipa Patel, Giulia Donvito, Mohammed A Mustafa, Justin L Poklis, Micah J Niphakis, Ku-Lung Hsu, Benjamin F Cravatt, David A Gewirtz, M Imad Damaj, Aron H Lichtma. Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy. The Journal of pharmacology and experimental therapeutics. vol 366. issue 1. 2019-08-05. PMID:29540562. |
as inhibitors of monoacylglycerol lipase (magl), the primary hydrolytic enzyme of the endogenous cannabinoid, 2-arachidonyolglycerol, produces antinociceptive effects in numerous rodent models of pain, we investigated whether inhibitors of this enzyme (i.e., jzl184 and mjn110) would reverse paclitaxel-induced mechanical allodynia in mice. |
2019-08-05 |
2023-08-13 |
mouse |
| Alice L Chen, Kenneth M Lum, Pablo Lara-Gonzalez, Daisuke Ogasawara, Armand B Cognetta, Alan To, William H Parsons, Gabriel M Simon, Arshad Desai, Michael Petrascheck, Liron Bar-Peled, Benjamin F Cravat. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nature chemical biology. vol 15. issue 5. 2019-07-29. PMID:30911178. |
we identify jzl184-an inhibitor of the mammalian endocannabinoid (ecb) hydrolase monoacylglycerol lipase (magl or mgll)-as a potent inducer of longevity, a result that was initially perplexing as c. elegans does not possess an magl ortholog. |
2019-07-29 |
2023-08-13 |
caenorhabditis_elegans |
| Ana Gil-Ordóñez, Mar Martín-Fontecha, Silvia Ortega-Gutiérrez, María L López-Rodrígue. Monoacylglycerol lipase (MAGL) as a promising therapeutic target. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30059673. |
monoacylglycerol lipase (magl) has been characterized as the main enzyme responsible for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2-ag). |
2019-07-08 |
2023-08-13 |
Not clear |
| Maria A Sanchez-Rodriguez, Oscar Gomez, Pedro F Esteban, Daniel Garcia-Ovejero, Eduardo Molina-Holgad. The endocannabinoid 2-arachidonoylglycerol regulates oligodendrocyte progenitor cell migration. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30195734. |
by contrast, increasing the levels of endogenous 2-ag by blocking its degradation (impairing monoacylglycerol lipase activity with jzl-184) significantly increased opc migration, as did agonists of the cb1, cb2 or cb1/cb2 cannabinoid receptors. |
2019-07-08 |
2023-08-13 |
rat |
| Ran Cheng, Wakana Mori, Longle Ma, Mireille Alhouayek, Akiko Hatori, Yiding Zhang, Daisuke Ogasawara, Gengyang Yuan, Zhen Chen, Xiaofei Zhang, Hang Shi, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Yuji Nagai, Takafumi Minamimoto, Mona Svensson, Lu Wang, Yunfei Du, Mary Jo Ondrechen, Neil Vasdev, Benjamin F Cravatt, Christopher Fowler, Ming-Rong Zhang, Steven H Lian. In Vitro and in Vivo Evaluation of Journal of medicinal chemistry. vol 61. issue 6. 2019-04-17. PMID:29481079. |
in vitro and in vivo evaluation of monoacylglycerol lipase (magl) is the principle enzyme for metabolizing endogenous cannabinoid ligand 2-arachidonoyglycerol (2-ag). |
2019-04-17 |
2023-08-13 |
Not clear |
| Laura A McAllister, Christopher R Butler, Scot Mente, Steven V O'Neil, Kari R Fonseca, Justin R Piro, Julie A Cianfrogna, Timothy L Foley, Adam M Gilbert, Anthony R Harris, Christopher J Helal, Douglas S Johnson, Justin I Montgomery, Deane M Nason, Stephen Noell, Jayvardhan Pandit, Bruce N Rogers, Tarek A Samad, Christopher L Shaffer, Rafael G da Silva, Daniel P Uccello, Damien Webb, Michael A Brodne. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. Journal of medicinal chemistry. vol 61. issue 7. 2019-04-17. PMID:29498843. |
monoacylglycerol lipase (magl) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway and arachidonoyl signaling in the central nervous system (cns). |
2019-04-17 |
2023-08-13 |
Not clear |
| Md Rahmat Ali, Suresh Kumar, Nishtha Shalmali, Obaid Afzal, Sabir Azim, Damini Chanana, Ozair Alam, Yam Nath Paudel, Manju Sharma, Sandhya Baw. Development of Thiazole-5-carboxylate Derivatives as Selective Inhibitors of Monoacylglycerol Lipase as Target in Cancer. Mini reviews in medicinal chemistry. vol 19. issue 5. 2019-03-28. PMID:29962341. |
the signalling function of 2-arachidonoylglycerol (2-ag) in endocannabinoid system is delineated by monoacylglycerol lipase (magl). |
2019-03-28 |
2023-08-13 |
Not clear |
| Francisco Navarrete, M Salud García-Gutiérrez, Auxiliadora Aracil-Fernández, José L Lanciego, Jorge Manzanare. Cannabinoid CB1 and CB2 Receptors, and Monoacylglycerol Lipase Gene Expression Alterations in the Basal Ganglia of Patients with Parkinson's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 15. issue 2. 2019-03-13. PMID:29352424. |
cannabinoid cb1 and cb2 receptors, and monoacylglycerol lipase gene expression alterations in the basal ganglia of patients with parkinson's disease. |
2019-03-13 |
2023-08-13 |
Not clear |
| Jenny L Wilkerson, Zachary A Curry, Pamela D Kinlow, Brittany L Mason, Ku-Lung Hsu, Mario van der Stelt, Benjamin F Cravatt, Aron H Lichtma. Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice. Pain. vol 159. issue 6. 2019-02-19. PMID:29528965. |
in addition, we tested drugs targeting distinct components of the endocannabinoid system, including agonists at cannabinoid receptors type 1 (cb1) and type 2 (cb2), as well as inhibitors of the endocannabinoid-regulating enzymes fatty acid amide hydrolase and monoacylglycerol lipase. |
2019-02-19 |
2023-08-13 |
mouse |
| Mojgan Aghazadeh Tabrizi, Pier Giovanni Baraldi, Stefania Baraldi, Emanuela Ruggiero, Lucia De Stefano, Flavio Rizzolio, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Andrea Chicca, Margherita Lapillo, Jürg Gertsch, Clementina Manera, Marco Macchia, Adriano Martinelli, Carlotta Granchi, Filippo Minutolo, Tiziano Tuccinard. Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. Journal of medicinal chemistry. vol 61. issue 3. 2019-02-18. PMID:29309142. |
monoacylglycerol lipase (magl) is a serine hydrolase that plays an important role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol, which is implicated in many physiological processes. |
2019-02-18 |
2023-08-13 |
Not clear |
| Jian Zhang, Chu Che. Alleviation of Neuropathology by Inhibition of Monoacylglycerol Lipase in APP Transgenic Mice Lacking CB2 Receptors. Molecular neurobiology. vol 55. issue 6. 2019-02-11. PMID:28733897. |
inhibition of monoacylglycerol lipase (magl), the primary enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol (2-ag) in the brain, produces profound anti-inflammatory and neuroprotective effects and improves synaptic and cognitive functions in animal models of alzheimer's disease (ad). |
2019-02-11 |
2023-08-13 |
mouse |
| Brittany N Szafran, Jung Hwa Lee, Abdolsamad Borazjani, Peter Morrison, Grace Zimmerman, Kelly L Andrzejewski, Matthew K Ross, Barbara L F Kapla. Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions. Molecules (Basel, Switzerland). vol 23. issue 12. 2019-02-11. PMID:30513753. |
we investigated whether cpg- (unmethylated bacterial dna) and lps-induced il-6 levels in peripheral blood mononuclear cells (pbmcs) from non-hd and hd individuals modulated the activities of endocannabinoid hydrolases monoacylglycerol lipase (magl) and carboxylesterase (ces). |
2019-02-11 |
2023-08-13 |
mouse |
| Tomoteru Yamasaki, Wakana Mori, Yiding Zhang, Akiko Hatori, Masayuki Fujinaga, Hidekatsu Wakizaka, Yusuke Kurihara, Lu Wang, Nobuki Nengaki, Tomoyuki Ohya, Steven H Liang, Ming-Rong Zhan. First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [ NeuroImage. vol 176. 2019-02-01. PMID:29738910. |
first demonstration of in vivo mapping for regional brain monoacylglycerol lipase using pet with [ monoacylglycerol lipase (magl) is a main regulator of the endocannabinoid system within the central nervous system (cns). |
2019-02-01 |
2023-08-13 |
Not clear |