| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marc-Antoine Lauzon, Nathalie Faucheu. A small peptide derived from BMP-9 can increase the effect of bFGF and NGF on SH-SY5Y cells differentiation. Molecular and cellular neurosciences. vol 88. 2019-01-31. PMID:29341901. |
we found that, in opposition to igf-2 or egf, the combination of spbmp-9 with bfgf or ngf can stimulate to a greater extent the neurite outgrowth and neuronal differentiation toward the cholinergic phenotype as shown by expression and localization of the neuronal markers nse and vacht and the staining of intracellular calcium. |
2019-01-31 |
2023-08-13 |
human |
| A Srivastava, S Singh, A Pandey, D Kumar, C S Rajpurohit, V K Khanna, A B Pan. Secretome of Differentiated PC12 Cells Enhances Neuronal Differentiation in Human Mesenchymal Stem Cells Via NGF-Like Mechanism. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29527653. |
experimental group co-exposed to ngf and cm showed an additive response via mapk signaling and directed the cells particularly towards cholinergic lineage. |
2018-12-17 |
2023-08-13 |
human |
| Maxime Assous, Jaime Kaminer, Fulva Shah, Arpan Garg, Tibor Koós, James M Teppe. Differential processing of thalamic information via distinct striatal interneuron circuits. Nature communications. vol 8. 2018-11-21. PMID:28604688. |
optogenetic activation of parafascicular inputs evokes suprathreshold monosynaptic glutamatergic excitation in ngf interneurons and a disynaptic, nicotinic excitation through cholinergic interneurons. |
2018-11-21 |
2023-08-13 |
Not clear |
| M Florencia Iulita, M Beatriz Bistué Millón, Rowan Pentz, Lisi Flores Aguilar, Sonia Do Carmo, Simon Allard, Bernadeta Michalski, Edward N Wilson, Adriana Ducatenzeiler, Martin A Bruno, Margaret Fahnestock, A Claudio Cuell. Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease. Neurobiology of disease. vol 108. 2018-07-23. PMID:28865749. |
the compromise in ngf metabolism and bdnf levels was accompanied by downregulation of cortical cholinergic synapses; strengthening the evidence that neurotrophin dysregulation affects cholinergic synapses and synaptic plasticity. |
2018-07-23 |
2023-08-13 |
human |
| M Florencia Iulita, M Beatriz Bistué Millón, Rowan Pentz, Lisi Flores Aguilar, Sonia Do Carmo, Simon Allard, Bernadeta Michalski, Edward N Wilson, Adriana Ducatenzeiler, Martin A Bruno, Margaret Fahnestock, A Claudio Cuell. Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease. Neurobiology of disease. vol 108. 2018-07-23. PMID:28865749. |
our findings suggest a differential temporal deregulation of ngf and bdnf neurotrophins, whereby deficits in bdnf mrna appear at early stages of intraneuronal aβ pathology, before alterations in ngf metabolism and cholinergic synapse loss manifest. |
2018-07-23 |
2023-08-13 |
human |
| Giancarlo Pepeu, Maria Grazia Giovannin. The fate of the brain cholinergic neurons in neurodegenerative diseases. Brain research. vol 1670. 2018-04-26. PMID:28652219. |
evidences indicate that β-amyloid disrupts ngf metabolism causing the degeneration of the cholinergic neurons which depend on ngf for their survival, namely the forebrain cholinergic neurons, sparing the midpontine and striatal neurons which express no specific ngf receptors. |
2018-04-26 |
2023-08-13 |
Not clear |
| Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissan. The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease Neuropathology. International journal of molecular sciences. vol 18. issue 6. 2018-03-26. PMID:28632177. |
dysfunction of nerve growth factor (ngf) and its high-affinity tropomyosin receptor kinase a (trka) receptor has been suggested to contribute to the selective degeneration of basal forebrain cholinergic neurons (bfcn) associated with the progressive cognitive decline in alzheimer's disease (ad). |
2018-03-26 |
2023-08-13 |
Not clear |
| Célia Faustino, Patrícia Rijo, Catarina Pinto Rei. Nanotechnological strategies for nerve growth factor delivery: Therapeutic implications in Alzheimer's disease. Pharmacological research. vol 120. 2018-01-05. PMID:28351757. |
neurotrophic factors, such as nerve growth factor (ngf), can prevent neuronal damage and rescue the cholinergic neurons that undergo cell death in ad, reverse deposition of extracellular amyloid plaques and improve cognitive deficits. |
2018-01-05 |
2023-08-13 |
Not clear |
| Pedro A Pereira, João P Rocha, Armando Cardoso, Manuel Vilela, Sérgio Sousa, M Dulce Madeir. Effects of chronic alcohol consumption, withdrawal and nerve growth factor on neuropeptide Y expression and cholinergic innervation of the rat dentate hilus. Neurotoxicology. vol 54. 2017-11-17. PMID:27090822. |
in addition, because alcohol consumption and withdrawal are associated with impaired nerve growth factor (ngf) trophic support and the administration of exogenous ngf alters the effects of those conditions on various cholinergic markers, we have also estimated the same morphological parameters in withdrawn rats infused intracerebroventricularly with ngf. |
2017-11-17 |
2023-08-13 |
rat |
| Pedro A Pereira, João P Rocha, Armando Cardoso, Manuel Vilela, Sérgio Sousa, M Dulce Madeir. Effects of chronic alcohol consumption, withdrawal and nerve growth factor on neuropeptide Y expression and cholinergic innervation of the rat dentate hilus. Neurotoxicology. vol 54. 2017-11-17. PMID:27090822. |
they also suggest that the normalizing effect of ngf on npy expression might rely on the ngf-induced improvement of cholinergic neurotransmission in the dentate hilus. |
2017-11-17 |
2023-08-13 |
rat |
| Helga Eyjolfsdottir, Maria Eriksdotter, Bengt Linderoth, Göran Lind, Bengt Juliusson, Philip Kusk, Ove Almkvist, Niels Andreasen, Kaj Blennow, Daniel Ferreira, Eric Westman, Inger Nennesmo, Azadeh Karami, Taher Darreh-Shori, Ahmadul Kadir, Agneta Nordberg, Erik Sundström, Lars-Olof Wahlund, Anders Wall, Maria Wiberg, Bengt Winblad, Åke Seiger, Lars Wahlberg, Per Almqvis. Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second-generation encapsulated cell biodelivery device. Alzheimer's research & therapy. vol 8. issue 1. 2017-10-13. PMID:27389402. |
targeted delivery of nerve growth factor (ngf) has emerged as a potential therapy for alzheimer's disease (ad) due to its regenerative effects on basal forebrain cholinergic neurons. |
2017-10-13 |
2023-08-13 |
Not clear |
| A Vega, A Cancino-Rodezno, P Valle-Leija, B M Sánchez-Tafolla, D Elinos, F Cifuentes, M A Morale. Neurotrophin-dependent plasticity of neurotransmitter segregation in the rat superior cervical ganglion in vivo. Developmental neurobiology. vol 76. issue 8. 2017-10-04. PMID:26562219. |
administration of ngf prevented changes in ngf content, kept ngf transcripts increased, and counteracted changes in segregation and in the number of cholinergic varicosities. |
2017-10-04 |
2023-08-13 |
rat |
| L Aloe, M L Rocco, E Stigliano, F Angelini, M Iacoangeli, V Frari, F Salvinell. Nasal HPpSIS administration enhances NGF and tumor suppressor protein, p73 in human brain cancer tissues: preliminary data. European review for medical and pharmacological sciences. vol 21. issue 3. 2017-07-26. PMID:28239803. |
we have recently reported that nasal administration of high-pressure isotonic physiological saline solution (hppsis) enhances the level of ngf and the expression of ngf receptors in neurons of the olfactory bulbs and forebrain cholinergic neurons of laboratory animals. |
2017-07-26 |
2023-08-13 |
human |
| S A Antonov, E S Manuilova, O V Dolotov, A G Kobylyansky, D R Safina, I A Grivenniko. Effect of Nerve Growth Factor on Neural Differentiation of Mouse Embryonic Stem Cells. Bulletin of experimental biology and medicine. vol 162. issue 5. 2017-07-18. PMID:28364186. |
the cholinergic, gabaergic, and catecholaminergic neurons derived from mouse embryonic stem cells in a culture medium supplemented with recombinant ngf were phenotyped and scored. |
2017-07-18 |
2023-08-13 |
mouse |
| Stephen D Skape. Nerve growth factor: a neuroimmune crosstalk mediator for all seasons. Immunology. vol 151. issue 1. 2017-05-31. PMID:28112808. |
the prototypical example and best-characterized neurotrophic factor is nerve growth factor (ngf), which is widely recognized as a target-derived factor responsible for the survival and maintenance of the phenotype of specific subsets of peripheral neurons and basal forebrain cholinergic nuclei during development and maturation. |
2017-05-31 |
2023-08-13 |
Not clear |
| Yung-Chih Kuo, Che-Yu Lin, Jay-Shake Li, Yung-I Lo. Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer's disease treatment. International journal of nanomedicine. vol 12. 2017-05-08. PMID:28280340. |
moreover, wga-grafted crm-cl/lip and wga-grafted ngf-cl/lip significantly improved the permeation of crm and ngf across the blood-brain barrier, reduced aβ plaque deposition and the malondialdehyde level, and increased the percentage of normal neurons and cholinergic activity in the hippocampus of ad rats. |
2017-05-08 |
2023-08-13 |
rat |
| N K Isaev, E V Stelmashook, E E Genrikh. Role of Nerve Growth Factor in Plasticity of Forebrain Cholinergic Neurons. Biochemistry. Biokhimiia. vol 82. issue 3. 2017-03-22. PMID:28320270. |
in the brain, ngf is produced in structures innervated by basal forebrain cholinergic neurons and retrogradely transported along the axons to the bodies of cholinergic neurons. |
2017-03-22 |
2023-08-13 |
Not clear |
| Yung-Chih Kuo, Yin-Jung Le. Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator-and apolipoprotein E-conjugated liposomes to the hippocampus. International journal of nanomedicine. vol 11. 2017-01-31. PMID:28008255. |
when compared with free ngf, ngf-sm-apoe-lip upregulated the expression of phosphorylated neurotrophic tyrosine kinase receptor type 1 on cholinergic neurons and significantly improved their survival. |
2017-01-31 |
2023-08-13 |
rat |
| Maria Florencia Iulita, Filippo Caraci, Augusto Claudio Cuell. A Link Between Nerve Growth Factor Metabolic Deregulation and Amyloid-β-Driven Inflammation in Down Syndrome. CNS & neurological disorders drug targets. vol 15. issue 4. 2016-12-30. PMID:26996175. |
in the mature and fully differentiated central nervous system, the phenotype of forebrain cholinergic neurons and their nerve terminals in cortex and hippocampus depend on the continuous endogenous supply of nerve growth factor (ngf). |
2016-12-30 |
2023-08-13 |
Not clear |
| Maria Florencia Iulita, Filippo Caraci, Augusto Claudio Cuell. A Link Between Nerve Growth Factor Metabolic Deregulation and Amyloid-β-Driven Inflammation in Down Syndrome. CNS & neurological disorders drug targets. vol 15. issue 4. 2016-12-30. PMID:26996175. |
individuals with alzheimer's disease and down syndrome exhibit prongf accumulation in cortex, yet cholinergic neurons become atrophic in both diseases, despite the apparent abundance of the ngf precursor. |
2016-12-30 |
2023-08-13 |
Not clear |