| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martín F Adrover, Jung Hoon Shin, Veronica A Alvare. Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 9. 2014-04-22. PMID:24573277. |
in addition to dopamine (da), glutamate is packaged and released by a subset of mesolimbic da neurons, eliciting epscs onto medium spiny neurons in nac. |
2014-04-22 |
2023-08-12 |
mouse |
| Ruixi Luo, John G Partridge, Stefano Vicin. Distinct roles of synaptic and extrasynaptic GABAAreceptors in striatal inhibition dynamics. Frontiers in neural circuits. vol 7. 2014-04-08. PMID:24324406. |
striatonigral and striatopallidal projecting medium spiny neurons (msns) express dopamine d1 (d1+) and d2 receptors (d2+), respectively. |
2014-04-08 |
2023-08-12 |
mouse |
| Rachel J Smith, Mary Kay Lobo, Sade Spencer, Peter W Kaliva. Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways). Current opinion in neurobiology. vol 23. issue 4. 2014-02-27. PMID:23428656. |
medium spiny neurons (msns) in striatum are dichotomous in their expression of either d1 or d2 dopamine receptors, along with other receptors and neuropeptides. |
2014-02-27 |
2023-08-12 |
Not clear |
| Alessandra Bonito-Oliva, Simone Pallottino, Jesus Bertran-Gonzalez, Jean-Antoine Girault, Emmanuel Valjent, Gilberto Fison. Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1. Neuropharmacology. vol 72. 2014-02-11. PMID:23643747. |
we found that administration of haloperidol increased ser240/244 phosphorylation in a subpopulation of gaba-ergic medium spiny neurons (msns), which preferentially express dopamine d2 receptors (d2rs). |
2014-02-11 |
2023-08-12 |
Not clear |
| J Elliott Robinson, Meng Chen, Alice M Stamatakis, Michael C Krouse, Elaina C Howard, Sara Faccidomo, Clyde W Hodge, Eric W Fish, C J Malang. Levetiracetam has opposite effects on alcohol- and cocaine-related behaviors in C57BL/6J mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 7. 2014-01-24. PMID:23353709. |
electrophysiological recordings in vitro showed that lev reduced excitatory currents in both ventral tegmental area (vta) dopamine neurons and nucleus accumbens (nac) medium spiny neurons, consistent with a presynaptic effect. |
2014-01-24 |
2023-08-12 |
mouse |
| Caroline Fasano, Marie-Josée Bourque, Gabriel Lapointe, Damiana Leo, Dominic Thibault, Michael Haber, Christian Kortleven, Luc Desgroseillers, Keith K Murai, Louis-Éric Trudea. Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors. Neuropharmacology. vol 67. 2013-11-04. PMID:23231809. |
dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both d1 and d2 dopamine receptors. |
2013-11-04 |
2023-08-12 |
Not clear |
| Caroline Fasano, Marie-Josée Bourque, Gabriel Lapointe, Damiana Leo, Dominic Thibault, Michael Haber, Christian Kortleven, Luc Desgroseillers, Keith K Murai, Louis-Éric Trudea. Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors. Neuropharmacology. vol 67. 2013-11-04. PMID:23231809. |
variations of dopamine (da) levels induced by drugs of abuse or in the context of parkinson's disease modulate the number of dendritic spines in medium spiny neurons (msns) of the striatum, showing that da plays a major role in the structural plasticity of msns. |
2013-11-04 |
2023-08-12 |
Not clear |
| Rupa R Lalchandani, Marie-Sophie van der Goes, John G Partridge, Stefano Vicin. Dopamine D2 receptors regulate collateral inhibition between striatal medium spiny neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 35. 2013-10-28. PMID:23986243. |
dopamine d2 receptors regulate collateral inhibition between striatal medium spiny neurons. |
2013-10-28 |
2023-08-12 |
mouse |
| Christina Bocklisch, Vincent Pascoli, Jovi C Y Wong, David R C House, Cédric Yvon, Mathias de Roo, Kelly R Tan, Christian Lüsche. Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area. Science (New York, N.Y.). vol 341. issue 6153. 2013-10-28. PMID:24072923. |
we found that medium spiny neurons expressing dopamine (da) receptor type 1 (d1r-msns) of the nac project to the vta, strongly preferring the gaba neurons of the vta. |
2013-10-28 |
2023-08-12 |
Not clear |
| Chiara Fiorentini, Paola Savoia, Daria Savoldi, Alessandro Barbon, Cristina Missal. Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease. Neurobiology of disease. vol 54. 2013-10-21. PMID:23328768. |
one of the major molecular changes associated with lid is the increased activity of the extracellular signal-regulated kinases 1/2 (erk1/2) signaling in the medium spiny neurons of the striatum induced by malfunctioning in the dopamine d1 receptor (d1r)-mediated transmission. |
2013-10-21 |
2023-08-12 |
rat |
| Dong Kun Lee, Jeong Hwan Oh, Ju Hwan Yang, Buhyun Youn, Yoon-Bo Shim, Insop Shim, John Q Wang, Eun Sang Cho. Protein kinase G linked to dopamine D3 receptors in the dorsal striatum controls dopamine release, ΔFosB expression and locomotor activity after repeated cocaine administration. Neuroscience letters. vol 541. 2013-09-03. PMID:23428510. |
these findings suggest that activation of pkg after repeated cocaine administration is more sensitive to interact with d3 receptors in the dopamine terminals than those in medium spiny neurons. |
2013-09-03 |
2023-08-12 |
Not clear |
| Wengang Wang, Martin Darvas, Granville P Storey, Ian J Bamford, Jeffrey T Gibbs, Richard D Palmiter, Nigel S Bamfor. Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 25. 2013-08-30. PMID:23785153. |
an amphetamine challenge reversed cpd via a dopamine d1-receptor-dependent paradoxical presynaptic potentiation (ppp) that increased corticostriatal activity in direct pathway medium spiny neurons. |
2013-08-30 |
2023-08-12 |
mouse |
| J E Eipper-Mains, D D Kiraly, M O Duff, M J Horowitz, C J McManus, B A Eipper, B R Graveley, R E Main. Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome. Genes, brain, and behavior. vol 12. issue 1. 2013-07-03. PMID:23094851. |
the gabaergic medium spiny neurons of the nucleus accumbens (nac) exhibit changes in the expression of genes encoding receptors for glutamate and in the signaling pathways triggered by dopamine binding to g-protein-coupled dopamine receptors. |
2013-07-03 |
2023-08-12 |
mouse |
| Roland Bock, J Hoon Shin, Alanna R Kaplan, Alice Dobi, Eric Markey, Paul F Kramer, Christina M Gremel, Christine H Christensen, Martin F Adrover, Veronica A Alvare. Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use. Nature neuroscience. vol 16. issue 5. 2013-06-27. PMID:23542690. |
we found that individual variability in the development of highly motivated and perseverative behavior toward cocaine is associated with synaptic plasticity in medium spiny neurons expressing dopamine d2 receptors (d2-msns) in the nucleus accumbens (nac) of mice. |
2013-06-27 |
2023-08-12 |
mouse |
| Yasukazu Hozumi, Masahiko Watanabe, Kaoru Got. Signaling cascade of diacylglycerol kinase β in the pituitary intermediate lobe: dopamine D2 receptor/phospholipase Cβ4/diacylglycerol kinase β/protein kinase Cα. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 58. issue 2. 2013-05-08. PMID:19826069. |
we have previously shown that diacylglycerol kinase β (dgkβ) is coexpressed with dopamine d1 and d2 receptors in medium spiny neurons of the striatum, suggesting a plausible implication of dgkβ in dopaminergic transmission. |
2013-05-08 |
2023-08-12 |
Not clear |
| M L Perreault, A Hasbi, M Alijaniaram, B F O'Dowd, S R Georg. Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats. Neuroscience. vol 225. 2013-04-16. PMID:22986162. |
in adult rat striatum the dopamine d1-d2 receptor heteromer is expressed selectively in a subset of medium spiny neurons (msns) that coexpress the dopamine d1 and d2 receptors (d1r and d2r) as well as dynorphin (dyn) and enkephalin (enk), with higher coexpression in nucleus accumbens (nac) and much lower in the caudate putamen (cp). |
2013-04-16 |
2023-08-12 |
rat |
| Benjamin D Hobson, Kathryn E Merritt, Ryan K Bachtel. Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats. Neuropharmacology. vol 63. issue 6. 2013-01-10. PMID:22749927. |
adenosine receptors co-localize with dopamine receptors on medium spiny nucleus accumbens (nac) neurons where they antagonize dopamine receptor activity. |
2013-01-10 |
2023-08-12 |
rat |
| Wengang Wang, Dennis Dever, Janet Lowe, Granville P Storey, Anita Bhansali, Emily K Eck, Ioana Nitulescu, Jessica Weimer, Nigel S Bamfor. Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core. The Journal of physiology. vol 590. issue 16. 2013-01-08. PMID:22586226. |
at low cortical frequencies, dopamine d1 receptors promote glutamate release to both d1 and d2 receptor-expressing medium spiny neurons while d2 receptors specifically inhibit excitatory inputs to d2 receptor-expressing cells by decreasing exocytosis from cortical terminals with a low probability of release. |
2013-01-08 |
2023-08-12 |
mouse |
| Emanuela Santini, Michael Feyder, Giuseppe Gangarossa, Helen S Bateup, Paul Greengard, Gilberto Fison. Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism. The Journal of biological chemistry. vol 287. issue 33. 2012-11-05. PMID:22753408. |
here, we show that the abnormal phosphorylation of darpp-32 occurs specifically in medium spiny neurons (msns) expressing dopamine d1 receptors (d1r). |
2012-11-05 |
2023-08-12 |
mouse |
| Melissa L Perreault, Theresa Fan, Mohammed Alijaniaram, Brian F O'Dowd, Susan R Georg. Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2. PloS one. vol 7. issue 3. 2012-08-20. PMID:22428025. |
dopamine d1-d2 receptor heteromer in dual phenotype gaba/glutamate-coexpressing striatal medium spiny neurons: regulation of bdnf, gad67 and vglut1/2. |
2012-08-20 |
2023-08-12 |
Not clear |