| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samuel J Rose, Thomas F Pack, Sean M Peterson, Kaitlin Payne, Emiliana Borrelli, Marc G Caro. Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 5. 2019-02-06. PMID:29068002. |
to address this question, we employed a cell type-specific viral expression approach to restore d2r variants that preferentially engage either g-protein or β-arrestin signaling in 'indirect pathway' medium spiny neurons (imsns), because of their central role in dopamine circuitry. |
2019-02-06 |
2023-08-13 |
Not clear |
| Robert Lindroos, Matthijs C Dorst, Kai Du, Marko Filipović, Daniel Keller, Maya Ketzef, Alexander K Kozlov, Arvind Kumar, Mikael Lindahl, Anu G Nair, Juan Pérez-Fernández, Sten Grillner, Gilad Silberberg, Jeanette Hellgren Kotalesk. Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2. Frontiers in neural circuits. vol 12. 2019-02-01. PMID:29467627. |
striatal function depends on the balance between the direct pathway medium spiny neurons (d1-msns) that express d1 dopamine receptors and the indirect pathway msns that express d2 dopamine receptors. |
2019-02-01 |
2023-08-13 |
Not clear |
| Kazunori Suzuki, Akina Harada, Hirobumi Suzuki, Clizia Capuani, Annarosa Ugolini, Mauro Corsi, Haruhide Kimur. Combined treatment with a selective PDE10A inhibitor TAK-063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic-like effects without affecting plasma prolactin levels and cataleptic responses in rodents. Pharmacology research & perspectives. vol 6. issue 1. 2018-11-05. PMID:29417763. |
activation of indirect pathway medium spiny neurons (msns) via promotion of camp production is the principal mechanism of action of current antipsychotics with dopamine d |
2018-11-05 |
2023-08-13 |
Not clear |
| D Gagnon, S Petryszyn, M G Sanchez, C Bories, J M Beaulieu, Y De Koninck, A Parent, M Paren. Striatal Neurons Expressing D Scientific reports. vol 7. 2018-10-22. PMID:28128287. |
striatal neurons expressing d the loss of nigrostriatal dopamine neurons in parkinson's disease induces a reduction in the number of dendritic spines on medium spiny neurons (msns) of the striatum expressing d |
2018-10-22 |
2023-08-13 |
Not clear |
| Byeong Jun Kang, Shelly Sooyun Song, Lei Wen, Ki-Pyo Hong, George J Augustine, Ja-Hyun Bai. Effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization. The European journal of neuroscience. vol 46. issue 4. 2018-09-06. PMID:28708260. |
effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine d2 receptors in cocaine-induced behavioral sensitization. |
2018-09-06 |
2023-08-13 |
mouse |
| Byeong Jun Kang, Shelly Sooyun Song, Lei Wen, Ki-Pyo Hong, George J Augustine, Ja-Hyun Bai. Effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization. The European journal of neuroscience. vol 46. issue 4. 2018-09-06. PMID:28708260. |
dopamine d1 receptors (d1r) or d2 receptors (d2r) expressed in the medium spiny neurons (msns) of the nucleus accumbens (nac) play critical roles in the control of addictive behaviors. |
2018-09-06 |
2023-08-13 |
mouse |
| Qiaoling Cui, Qian Li, Hongyan Geng, Lei Chen, Nancy Y Ip, Ya Ke, Wing-Ho Yun. Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex-nucleus accumbens pathway in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 21. 2018-08-29. PMID:29735678. |
in addition, based on a brain-slice preparation obtained from drd2-egfp bac transgenic mice, we demonstrated direct innervation of d2 receptor-expressing medium spiny neurons (d2-msns) in the nac by prelimbic cortical neurons, which is under the regulation by presynaptic dopamine receptors. |
2018-08-29 |
2023-08-13 |
mouse |
| Andrea Ruiz-Calvo, Irene B Maroto, Raquel Bajo-Grañeras, Anna Chiarlone, Ángel Gaudioso, José J Ferrero, Eva Resel, José Sánchez-Prieto, José A Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmá. Pathway-Specific Control of Striatal Neuron Vulnerability by Corticostriatal Cannabinoid CB1 Receptors. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 1. 2018-08-03. PMID:29121220. |
the vast majority of neurons within the striatum are gabaergic medium spiny neurons (msns), which receive glutamatergic input from the cortex and thalamus, and form two major efferent pathways: the direct pathway, expressing dopamine d1 receptor (d1r-msns), and the indirect pathway, expressing dopamine d2 receptor (d2r-msns). |
2018-08-03 |
2023-08-13 |
Not clear |
| Jessie Muir, Zachary S Lorsch, Charu Ramakrishnan, Karl Deisseroth, Eric J Nestler, Erin S Calipari, Rosemary C Bago. In Vivo Fiber Photometry Reveals Signature of Future Stress Susceptibility in Nucleus Accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 2. 2018-07-30. PMID:28589967. |
the nac consists largely of medium spiny neurons (msns), distinguished by their predominant expression of either d1 or d2 dopamine receptors. |
2018-07-30 |
2023-08-13 |
mouse |
| Cedric Yapo, Anu G Nair, Lorna Clement, Liliana R Castro, Jeanette Hellgren Kotaleski, Pierre Vincen. Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. The Journal of physiology. vol 595. issue 24. 2018-07-18. PMID:28782235. |
detection of phasic dopamine by d1 and d2 striatal medium spiny neurons. |
2018-07-18 |
2023-08-13 |
mouse |
| Cedric Yapo, Anu G Nair, Lorna Clement, Liliana R Castro, Jeanette Hellgren Kotaleski, Pierre Vincen. Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. The Journal of physiology. vol 595. issue 24. 2018-07-18. PMID:28782235. |
brief dopamine events are critical actors of reward-mediated learning in the striatum; the intracellular camp-protein kinase a (pka) response of striatal medium spiny neurons to such events was studied dynamically using a combination of biosensor imaging in mouse brain slices and in silico simulations. |
2018-07-18 |
2023-08-13 |
mouse |
| Cedric Yapo, Anu G Nair, Lorna Clement, Liliana R Castro, Jeanette Hellgren Kotaleski, Pierre Vincen. Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. The Journal of physiology. vol 595. issue 24. 2018-07-18. PMID:28782235. |
both d1 and d2 medium spiny neurons can sense brief dopamine transients in the sub-micromolar range. |
2018-07-18 |
2023-08-13 |
mouse |
| Cedric Yapo, Anu G Nair, Lorna Clement, Liliana R Castro, Jeanette Hellgren Kotaleski, Pierre Vincen. Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. The Journal of physiology. vol 595. issue 24. 2018-07-18. PMID:28782235. |
while dopamine transients profoundly change camp levels in both types of medium spiny neurons, the pka-dependent phosphorylation level remains unaffected in d2 neurons. |
2018-07-18 |
2023-08-13 |
mouse |
| Cedric Yapo, Anu G Nair, Lorna Clement, Liliana R Castro, Jeanette Hellgren Kotaleski, Pierre Vincen. Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. The Journal of physiology. vol 595. issue 24. 2018-07-18. PMID:28782235. |
simulations suggest that d2 medium spiny neurons could detect transient dips in dopamine level. |
2018-07-18 |
2023-08-13 |
mouse |
| Witold J Lipski, Sofia M Dibble, Linda Rinaman, Anthony A Grac. Psychogenic Stress Activates C-Fos in Nucleus Accumbens-Projecting Neurons of the Hippocampal Ventral Subiculum. The international journal of neuropsychopharmacology. vol 20. issue 10. 2018-06-05. PMID:28977522. |
artificial activation of the ventral subiculum can excite medium spiny neurons of the nucleus accumbens and can increase the excitability of mesolimbic dopamine neurons via a polysynaptic pathway through the basal ganglia. |
2018-06-05 |
2023-08-13 |
Not clear |
| Aphroditi A Mamaligas, Yuan Cai, Christopher P For. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission. Scientific reports. vol 6. 2018-06-01. PMID:27886263. |
to measure the functional consequence of dopamine release, d2-receptor synaptic activity was assessed via virally overexpressed potassium channels (girk2) in medium spiny neurons (msns). |
2018-06-01 |
2023-08-13 |
Not clear |
| Yifeng Cheng, Cathy C Y Huang, Tengfei Ma, Xiaoyan Wei, Xuehua Wang, Jiayi Lu, Jun Wan. Distinct Synaptic Strengthening of the Striatal Direct and Indirect Pathways Drives Alcohol Consumption. Biological psychiatry. vol 81. issue 11. 2018-02-26. PMID:27470168. |
the dorsomedial striatum (dms), a brain region critically involved in addiction, contains medium spiny neurons (msns) expressing dopamine d |
2018-02-26 |
2023-08-13 |
Not clear |
| Sidish Venkataraman, Catherine Claussen, Nachum Dafn. D1 and D2 specific dopamine antagonist modulate the caudate nucleus neuronal responses to chronic methylphenidate exposure. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 2. 2018-02-21. PMID:27853928. |
the cn is comprised of medium spiny neurons containing largely dopamine (da) d1 and d2 receptors. |
2018-02-21 |
2023-08-13 |
rat |
| Diane M Damez-Werno, HaoSheng Sun, Kimberly N Scobie, Ningyi Shao, Jaclyn Rabkin, Caroline Dias, Erin S Calipari, Ian Maze, Catherine J Pena, Deena M Walker, Michael E Cahill, Ramesh Chandra, Amy Gancarz, Ezekiell Mouzon, Joseph A Landry, Hannah Cates, Mary-Kay Lobo, David Dietz, C David Allis, Ernesto Guccione, Gustavo Turecki, Paola Defilippi, Rachael L Neve, Yasmin L Hurd, Li Shen, Eric J Nestle. Histone arginine methylation in cocaine action in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 34. 2018-01-26. PMID:27506785. |
such prmt6 down-regulation occurs selectively in nac medium spiny neurons (msns) expressing dopamine d2 receptors (d2-msns), with opposite regulation occurring in d1-msns, and serves to protect against cocaine-induced addictive-like behavioral abnormalities. |
2018-01-26 |
2023-08-13 |
mouse |
| Jan-Philip Schülke, Nicholas J Brando. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry. Advances in neurobiology. vol 17. 2018-01-23. PMID:28956328. |
pde10a is expressed in the medium spiny neurons of the striatum and works to limit cyclic nucleotide signaling in response to modulatory neurotransmitters like dopamine. |
2018-01-23 |
2023-08-13 |
Not clear |