| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoon Seong Kim, Sung Soo Kim, Jeong Je Cho, Dong Hee Choi, Onyou Hwang, Dong Hoon Shin, Hong Sung Chun, M Flint Beal, Tong H Jo. Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 14. 2006-03-01. PMID:15814801. |
matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. |
2006-03-01 |
2023-08-12 |
mouse |
| Yoon Seong Kim, Sung Soo Kim, Jeong Je Cho, Dong Hee Choi, Onyou Hwang, Dong Hoon Shin, Hong Sung Chun, M Flint Beal, Tong H Jo. Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 14. 2006-03-01. PMID:15814801. |
we report here that the active form of matrix metalloproteinase-3 (mmp-3) was released into the serum-deprived media (sdm) of pc12 cells and other media of apoptotic neuronal cells within 2-6 h of treatment of the cells, and sdm and catalytic domain of recombinant mmp-3 (cmmp-3) activated microglia in primary microglia cultures as well as bv2 cells, a mouse microglia cell line. |
2006-03-01 |
2023-08-12 |
mouse |
| Carsten Hobohm, Albrecht Günther, Jens Grosche, Steffen Rossner, Dietmar Schneider, Gert Brückne. Decomposition and long-lasting downregulation of extracellular matrix in perineuronal nets induced by focal cerebral ischemia in rats. Journal of neuroscience research. vol 80. issue 4. 2005-07-25. PMID:15806566. |
in the homolateral ventroposterior thalamus, the delayed decrease in perineuronal matrix was related to the distribution pattern of activated microglia and massive neuronal degeneration. |
2005-07-25 |
2023-08-12 |
rat |
| Dmitry V Vasilyev, Michael E Baris. Regulation of the hyperpolarization-activated cationic current Ih in mouse hippocampal pyramidal neurones by vitronectin, a component of extracellular matrix. The Journal of physiology. vol 560. issue Pt 3. 2005-04-13. PMID:15319414. |
because the hyperpolarization-activated cation-selective current i(h) makes important contributions to neural excitability, we examined its long-term regulation by vitronectin, an extracellular matrix component commonly elevated at injury sites and detected immunochemically in activated microglia. |
2005-04-13 |
2023-08-12 |
mouse |
| Hong Liao, Wen-yu Bu, Ting-Hua Wang, Sohail Ahmed, Zhi-Cheng Xia. Tenascin-R plays a role in neuroprotection via its distinct domains that coordinate to modulate the microglia function. The Journal of biological chemistry. vol 280. issue 9. 2005-04-07. PMID:15615725. |
in the present study, we have investigated how domains of the extracellular matrix molecule tenascin-r (tn-r) modulate microglia function. |
2005-04-07 |
2023-08-12 |
Not clear |
| Young-Tae Kim, Robert W Hitchcock, Michael J Bridge, Patrick A Tresc. Chronic response of adult rat brain tissue to implants anchored to the skull. Biomaterials. vol 25. issue 12. 2004-09-14. PMID:14741588. |
we found that the reaction surrounding transcranially implanted hfms was significantly greater than that observed with intraparenchymally implanted materials including increases in immunoreactivity against gfap, vimentin, ed-1 labeled macrophages and microglia, and several extracellular matrix proteins including collagen, fibronectin, and laminin. |
2004-09-14 |
2023-08-12 |
rat |
| Hiroshi Nakanish. Neuronal and microglial cathepsins in aging and age-related diseases. Ageing research reviews. vol 2. issue 4. 2004-06-17. PMID:14522241. |
activated microglia also release some members of cathepsins to induce neuronal death by degrading extracellular matrix proteins. |
2004-06-17 |
2023-08-12 |
Not clear |
| G M Liuzzi, C M Mastroianni, T Latronico, F Mengoni, A Fasano, M Lichtner, V Vullo, P Ricci. Anti-HIV drugs decrease the expression of matrix metalloproteinases in astrocytes and microglia. Brain : a journal of neurology. vol 127. issue Pt 2. 2004-02-24. PMID:14662518. |
anti-hiv drugs decrease the expression of matrix metalloproteinases in astrocytes and microglia. |
2004-02-24 |
2023-08-12 |
human |
| A M Mayer, M Hall, M J Fay, P Lamar, C Pearson, W C Prozialeck, V K Lehmann, P B Jacobson, A M Romanic, T Uz, H Mane. Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia. BMC pharmacology. vol 1. 2004-01-05. PMID:11686853. |
effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia. |
2004-01-05 |
2023-08-12 |
rat |
| A M Mayer, M Hall, M J Fay, P Lamar, C Pearson, W C Prozialeck, V K Lehmann, P B Jacobson, A M Romanic, T Uz, H Mane. Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia. BMC pharmacology. vol 1. 2004-01-05. PMID:11686853. |
we tested the hypothesis that a short-term in vitro exposure to domoic acid, might lead to the activation of rat neonatal microglia and the concomitant release of the putative neurotoxic mediators tumor necrosis factor-alpha (tnf-alpha), matrix metalloproteinases-2 and-9 (mmp-2 and -9) and superoxide anion (o2-). |
2004-01-05 |
2023-08-12 |
rat |
| Elisabetta Vegeto, Silvia Belcredito, Sabrina Etteri, Serena Ghisletti, Alessia Brusadelli, Clara Meda, Andrée Krust, Sonia Dupont, Paolo Ciana, Pierre Chambon, Adriana Magg. Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 16. 2003-10-03. PMID:12878732. |
this effect occurs by limiting the expression of neuroinflammatory mediators, such as the matrix metalloproteinase 9 and lysosomal enzymes and complement c3 receptor, as well as by preventing morphological changes occurring in microglia during the inflammatory response. |
2003-10-03 |
2023-08-12 |
mouse |
| Hiroshi Nakanish. Microglial functions and proteases. Molecular neurobiology. vol 27. issue 2. 2003-08-13. PMID:12777686. |
furthermore, matrix metalloproteases secreted from microglia also receive great attention as mediators of inflammation and tissue degradation through processing of pro-inflammatory cytokines and damage to the blood-brain barrier. |
2003-08-13 |
2023-08-12 |
Not clear |
| Chia-Jen Siao, Susana R Fernandez, Stella E Tsirk. Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 8. 2003-05-30. PMID:12716930. |
these activated microglia then secrete additional tpa, which promotes extracellular matrix degradation, neurodegeneration, and self-proliferation. |
2003-05-30 |
2023-08-12 |
mouse |
| Karin Schüppel, Kurt Brauer, Wolfgang Härtig, Jens Grosche, Bernadette Earley, Brian E Leonard, Gert Brückne. Perineuronal nets of extracellular matrix around hippocampal interneurons resist destruction by activated microglia in trimethyltin-treated rats. Brain research. vol 958. issue 2. 2003-03-27. PMID:12470883. |
perineuronal nets of extracellular matrix around hippocampal interneurons resist destruction by activated microglia in trimethyltin-treated rats. |
2003-03-27 |
2023-08-12 |
rat |
| Stella E Tsirk. Tissue plasminogen activator as a modulator of neuronal survival and function. Biochemical Society transactions. vol 30. issue 2. 2002-11-12. PMID:12023855. |
plasmin then either promotes neuronal death via both the degradation of the extracellular matrix and the establishment of chemoattractant gradients for microglia, or facilitates neurite outgrowth through the processing of extracellular matrix proteoglycans. |
2002-11-12 |
2023-08-12 |
Not clear |
| A Subramanian, A Harris, K Piggott, C Shieff, R Bradfor. Metastasis to and from the central nervous system--the 'relatively protected site'. The Lancet. Oncology. vol 3. issue 8. 2002-09-06. PMID:12147436. |
tumour interactions with the blood-brain barrier, microglia, and various matrix proteins, cytokines, and growth factors have a central role. |
2002-09-06 |
2023-08-12 |
Not clear |
| C Kaur, A J Hao, C H Wu, E A Lin. Origin of microglia. Microscopy research and technique. vol 54. issue 1. 2002-05-07. PMID:11526953. |
a second major view has held that microglia are of neuroectodermal origin; the cells either originate from glioblasts or the germinal matrix. |
2002-05-07 |
2023-08-12 |
mouse |
| Richard Milner, Iain L Campbel. Cytokines regulate microglial adhesion to laminin and astrocyte extracellular matrix via protein kinase C-dependent activation of the alpha6beta1 integrin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 5. 2002-03-22. PMID:11880486. |
because astrocytes and their extracellular matrix (ecm) form a large part of the cns parenchyma, we undertook to study the adhesive interactions between microglia and these substrates in vitro. |
2002-03-22 |
2023-08-12 |
Not clear |
| L Yuan, A H Neufel. Activated microglia in the human glaucomatous optic nerve head. Journal of neuroscience research. vol 64. issue 5. 2001-07-26. PMID:11391707. |
in glaucomatous onhs, microglia become activated and phagocytic and produce cytokines, mediators, and enzymes that can alter the extracellular matrix. |
2001-07-26 |
2023-08-12 |
human |
| G A Rosenberg, L A Cunningham, J Wallace, S Alexander, E Y Estrada, M Grossetete, A Razhagi, K Miller, A Gearin. Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain research. vol 893. issue 1-2. 2001-06-21. PMID:11222998. |
immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of mmp-9 linked to stromelysin-1 and microglia in cell cultures. |
2001-06-21 |
2023-08-12 |
rat |