| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lohitash Karumbaiah, Sharon E Norman, Nithish B Rajan, Sanjay Anand, Tarun Saxena, Martha Betancur, Radhika Patkar, Ravi V Bellamkond. The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain micromotion. Biomaterials. vol 33. issue 26. 2012-10-22. PMID:22681976. |
zymogram and western blot analysis revealed that mechanically strained astrocytes and microglia upregulated matrix metalloproteinases (mmps) 2 and 9, and other markers of reactive gliosis such as glial fibrillary acidic protein (gfap) and neurocan when compared to controls. |
2012-10-22 |
2023-08-12 |
rat |
| Alejandro M S Mayer, Marcio Guzman, Renee Peksa, Mary Hall, Michael J Fay, Peer B Jacobson, Anne M Romanic, Sarath P Gunaseker. Differential effects of domoic acid and E. coli lipopolysaccharide on tumor necrosis factor-alpha, transforming growth factor-beta1 and matrix metalloproteinase-9 release by rat neonatal microglia: evaluation of the direct activation hypothesis. Marine drugs. vol 5. issue 3. 2012-09-10. PMID:18458762. |
differential effects of domoic acid and e. coli lipopolysaccharide on tumor necrosis factor-alpha, transforming growth factor-beta1 and matrix metalloproteinase-9 release by rat neonatal microglia: evaluation of the direct activation hypothesis. |
2012-09-10 |
2023-08-12 |
rat |
| Alejandro M S Mayer, Marcio Guzman, Renee Peksa, Mary Hall, Michael J Fay, Peer B Jacobson, Anne M Romanic, Sarath P Gunaseker. Differential effects of domoic acid and E. coli lipopolysaccharide on tumor necrosis factor-alpha, transforming growth factor-beta1 and matrix metalloproteinase-9 release by rat neonatal microglia: evaluation of the direct activation hypothesis. Marine drugs. vol 5. issue 3. 2012-09-10. PMID:18458762. |
taken together our observations do not support the hypothesis that a short term (4 to 24 hours) in vitro exposure to domoic acid, at a concentration toxic to neuronal cells, activates rat neonatal microglia and the concomitant release of the pro-inflammatory mediators tumor necrosis factor-alpha (tnf-alpha) and matrix metalloproteinases-9 (mmp-9), as well as the anti-inflammatory cytokine transforming growth factor beta1 (tgf-beta1). |
2012-09-10 |
2023-08-12 |
rat |
| Hyeon-Sook Suh, Namjong Choi, Leonid Tarassishin, Sunhee C Le. Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12). PloS one. vol 7. issue 4. 2012-08-07. PMID:22509390. |
regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (mmp-12). |
2012-08-07 |
2023-08-12 |
human |
| Jing Zhang, Susobhan Sarkar, Rowena Cua, Yan Zhou, Walter Hader, V Wee Yon. A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis. Carcinogenesis. vol 33. issue 2. 2012-06-12. PMID:22159219. |
however, in coculture with microglia in a three-dimensional collagen gel matrix, the invasiveness of ccl2-overexpressing clones was increased. |
2012-06-12 |
2023-08-12 |
human |
| Margarita Calvo, David L H Bennet. The mechanisms of microgliosis and pain following peripheral nerve injury. Experimental neurology. vol 234. issue 2. 2012-05-04. PMID:21893056. |
a number of signalling pathways including growth factors such as neuregulin-1, matrix metalloproteases such as mmp-9 and multiple chemokines enable direct communication between injured primary afferents and microglia. |
2012-05-04 |
2023-08-12 |
Not clear |
| Jin-Sun Park, Jin A Shin, Ji-Sun Jung, Jin-Won Hyun, Thi Kim Van Le, Dong-Hyun Kim, Eun-Mi Park, Hee-Sun Ki. Anti-inflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22207656. |
in the present study, we found that a ginseng saponin metabolite, compound k [20-o-d-glucopyranosyl-20(s)-protopanaxadiol], inhibited the expressions of inducible nitric-oxide synthase, proinflammatory cytokines, monocyte chemotactic protein-1, matrix metalloproteinase-3, and matrix metalloproteinase-9 in lipopolysaccharide (lps)-stimulated bv2 microglial cells and primary cultured microglia. |
2012-05-04 |
2023-08-12 |
mouse |
| Jennifer V Welser-Alves, Amin Boroujerdi, Ulrich Tigges, Richard Milne. Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins. Journal of neuroinflammation. vol 8. 2012-04-16. PMID:22074485. |
the extracellular matrix (ecm) protein vitronectin promotes microglial activation, switching microglia into an activated phenotype. |
2012-04-16 |
2023-08-12 |
Not clear |
| Konrad Gabrusiewicz, Aleksandra Ellert-Miklaszewska, Maciej Lipko, Malgorzata Sielska, Marta Frankowska, Bozena Kaminsk. Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas. PloS one. vol 6. issue 8. 2012-04-13. PMID:21901144. |
microglia (brain resident macrophages) accumulate in malignant gliomas and instead of initiating the anti-tumor response, they switch to a pro-invasive phenotype, support tumor growth, invasion, angiogenesis and immunosuppression by release of cytokines/chemokines and extracellular matrix proteases. |
2012-04-13 |
2023-08-12 |
mouse |
| Wei-Lan Yeh, Dah-Yuu Lu, Houng-Chi Liou, Wen-Mei F. A forward loop between glioma and microglia: glioma-derived extracellular matrix-activated microglia secrete IL-18 to enhance the migration of glioma cells. Journal of cellular physiology. vol 227. issue 2. 2012-01-30. PMID:21442623. |
here, we found that c6 glioma--but not primary astrocyte-derived extracellular matrix (ecm) could activate microglia, including primary microglia and bv-2 cell line, and activated microglia-secreted interleukin (il)-18, a potent inflammatory cytokine of the il-1 family, to promote c6 migration. |
2012-01-30 |
2023-08-12 |
Not clear |
| Makoto Tsuda, Emika Toyomitsu, Miho Kometani, Hidetoshi Tozaki-Saitoh, Kazuhide Inou. Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. Journal of cellular and molecular medicine. vol 13. issue 9B. 2011-12-23. PMID:19298529. |
in the present study, we investigated the intracellular signal transduction pathway that promotes p2x(4)r expression in microglia in response to fibronectin, an extracellular matrix protein that has previously been shown to stimulate p2x(4)r expression. |
2011-12-23 |
2023-08-12 |
mouse |
| Nootchanat Mairuae, James R Connor, Poonlarp Cheepsunthor. Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia. Neuroscience letters. vol 500. issue 1. 2011-12-14. PMID:21683124. |
increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia. |
2011-12-14 |
2023-08-12 |
rat |
| Shintaro Iwama, Yoshihisa Sugimura, Haruyuki Suzuki, Hiromi Suzuki, Takashi Murase, Nobuaki Ozaki, Hiroshi Nagasaki, Hiroshi Arima, Yoshiharu Murata, Makoto Sawada, Yutaka Ois. Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. Glia. vol 59. issue 3. 2011-12-06. PMID:21264951. |
therefore, to clarify the role of microglial and astrocytic function in ods, we examined the time-dependent changes in distribution, morphology, proliferation, and mrna/protein expression of proinflammatory cytokines, neurotrophic factors, and matrix metalloproteinase (mmp) in microglia and astrocytes 2 days (early phase) and 5 days (late phase) after the rapid correction of hyponatremia in ods rats. |
2011-12-06 |
2023-08-12 |
rat |
| D S Markovic, K Vinnakota, N van Rooijen, J Kiwit, M Synowitz, R Glass, H Kettenman. Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression. Brain, behavior, and immunity. vol 25. issue 4. 2011-08-29. PMID:21324352. |
glioma cells release soluble factors, which induce the expression of membrane type 1 matrix metalloprotease (mt1-mmp) in tumor associated microglia and then exploit mt1-mmp mediated matrix degradation for invasion. |
2011-08-29 |
2023-08-12 |
mouse |
| Alejandro M S Mayer, Jonathan A Clifford, Monica Aldulescu, Jeffrey A Frenkel, Michael A Holland, Mary L Hall, Keith B Glaser, John Berr. Cyanobacterial Microcystis aeruginosa lipopolysaccharide elicits release of superoxide anion, thromboxane B₂, cytokines, chemokines, and matrix metalloproteinase-9 by rat microglia. Toxicological sciences : an official journal of the Society of Toxicology. vol 121. issue 1. 2011-08-16. PMID:21362633. |
cyanobacterial microcystis aeruginosa lipopolysaccharide elicits release of superoxide anion, thromboxane b₂, cytokines, chemokines, and matrix metalloproteinase-9 by rat microglia. |
2011-08-16 |
2023-08-12 |
human |
| Alejandro M S Mayer, Jonathan A Clifford, Monica Aldulescu, Jeffrey A Frenkel, Michael A Holland, Mary L Hall, Keith B Glaser, John Berr. Cyanobacterial Microcystis aeruginosa lipopolysaccharide elicits release of superoxide anion, thromboxane B₂, cytokines, chemokines, and matrix metalloproteinase-9 by rat microglia. Toxicological sciences : an official journal of the Society of Toxicology. vol 121. issue 1. 2011-08-16. PMID:21362633. |
after a 17-h exposure of microglia to m.aeruginosa lps, the following concentration-dependent responses were observed: 0.1-100 ng/ml m. aeruginosa lps enhanced o₂⁻ generation, with limited inflammatory mediator generation; 1000-10,000 ng/ml m. aeruginosa lps caused thromboxane b₂ (txb₂), matrix metalloproteinase-9 (mmp-9), and macrophage inflammatory protein-2 (mip-2/cxcl2) release, concurrent with maximal o₂⁻ generation; 100,000 ng/ml m. aeruginosa lps deactivated o₂⁻ production but maintained elevated levels of txb₂, mmp-9, tumor necrosis factor-α (tnf-α), interleukin 1-α (il-1α), and interleukin-6 (il-6), macrophage inflammatory protein 1α (mip-1α/ccl3), and mip-2/cxcl2, with concomitant lactic dehydrogenase release. |
2011-08-16 |
2023-08-12 |
human |
| Wendy C Huang, Yanli Qiao, Lijun Xu, Rachid Kacimi, Xiaoyun Sun, Rona G Giffard, Midori A Yenar. Direct protection of cultured neurons from ischemia-like injury by minocycline. Anatomy & cell biology. vol 43. issue 4. 2011-07-14. PMID:21267407. |
importantly, treatment of neuron cultures without added microglia with these same inhibitors of tissue plasminogen activator, matrix metalloproteinases, tnf-alpha and inducible nitric oxide synthase as well as minocycline also led to decreased cell death. |
2011-07-14 |
2023-08-12 |
Not clear |
| Colin L Willi. Glia-induced reversible disruption of blood-brain barrier integrity and neuropathological response of the neurovascular unit. Toxicologic pathology. vol 39. issue 1. 2011-06-23. PMID:21189317. |
we propose that adherens junction proteins and extracellular matrix remodeling provide a temporary size-selective barrier, whereas astrocyte and microglia activation direct tight-junction proteins to paracellular domains and restore bbb integrity. |
2011-06-23 |
2023-08-12 |
Not clear |
| Sandra L Silva, Catarina Osório, Ana R Vaz, Andreia Barateiro, Ana S Falcão, Rui F M Silva, Dora Brite. Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin. Journal of neurochemistry. vol 117. issue 3. 2011-06-10. PMID:21275990. |
conditioned medium from ucb-challenged neurons, although down-regulating tumor necrosis factor-α and interleukin-1β promoted the release of interleukin-6 and nitric oxide, the activation of matrix metalloproteinase-9, and cell death, as compared with ucb-direct effects on microglia. |
2011-06-10 |
2023-08-12 |
Not clear |
| Jian Wan. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Progress in neurobiology. vol 92. issue 4. 2011-03-15. PMID:20713126. |
this review summarizes recent progress made in preclinical models of ich, surveys preclinical and clinical studies of inflammatory cells (leukocytes, macrophages, microglia, and astrocytes) and inflammatory mediators (matrix metalloproteinases, nuclear factor erythroid 2-related factor 2, heme oxygenase, and iron), and highlights the emerging areas of therapeutic promise. |
2011-03-15 |
2023-08-12 |
Not clear |