| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khurshid Jalal, Faisal Khan, Shazia Nawaz, Rushda Afroz, Kanwal Khan, Sadia Basharat Ali, Liangliang Hao, Saeed Ahmad Khan, Mohsin Kazi, Reaz Uddin, Darakhshan Jabeen Halee. Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 152. 2022-06-13. PMID:35696944. |
5-hydroxytryptamine (5-ht, serotonin) metabolism, and tryptophan (trp) levels in the midbrain (mb), hippocampus (hp), and prefrontal cortex (pfc) were also determined. |
2022-06-13 |
2023-08-14 |
rat |
| Philippe De Deurwaerdère, Maurizio Casarrubea, Daniel Cassar, Manuela Radic, Emilie Puginier, Abdeslam Chagraoui, Giuseppe Crescimanno, Vincenzo Crunelli, Giuseppe Di Giovann. Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in Genetic Absence Epilepsy Rats From Strasbourg and Non-epileptic Control Rats. Frontiers in cellular neuroscience. vol 16. 2022-06-09. PMID:35677756. |
these behavioral changes correlate with the reduction of 5-ht in the hippocampus and substantia nigra (sn) and noradrenaline (na) in the entopeduncular nucleus (epn) in vehicle-treated gaers compared to nec rats, which could contribute to their low anxiety status and hypermotility, respectively. |
2022-06-09 |
2023-08-14 |
rat |
| Natália Maria Simionato, Janaína da Silva Rocha-Lopes, Ricardo Borges Machado, Deborah Sucheck. Chronic rapid eye movement sleep restriction during juvenility has long-term effects on anxiety-like behaviour and neurotransmission of male Wistar rats. Pharmacology, biochemistry, and behavior. 2022-06-06. PMID:35662652. |
in a previous study, we showed that chronic sleep deprivation in juvenile-adolescent male rats led to increased anxiety-like behaviour and changes in noradrenaline and serotonin in the amygdala and hippocampus. |
2022-06-06 |
2023-08-14 |
rat |
| Natália Maria Simionato, Janaína da Silva Rocha-Lopes, Ricardo Borges Machado, Deborah Sucheck. Chronic rapid eye movement sleep restriction during juvenility has long-term effects on anxiety-like behaviour and neurotransmission of male Wistar rats. Pharmacology, biochemistry, and behavior. 2022-06-06. PMID:35662652. |
anxiety index was positively correlated with increased serotonin metabolism in the frontal cortex and greater dopamine metabolism in the ventral hippocampus, and negatively correlated with dopamine levels in the ventral hippocampus. |
2022-06-06 |
2023-08-14 |
rat |
| Mostofa Jamal, Asuka Ito, Takanori Miki, Shingo Suzuki, Ken-Ichi Ohta, Hiroshi Kinoshit. Ethanol concentration induces production of 3,4-dihydroxyphenylacetic acid and homovanillic acid in mouse brain through activation of monoamine oxidase pathway. Neuroscience letters. 2022-05-22. PMID:35598694. |
first, we aimed to investigate ex vivo the effects of ethanol (etoh) on levels of norepinephrine (ne), dopamine (da), serotonin (5-ht), and their metabolites in the frontal cortex, hippocampus, and striatum of aldh2-knockout (aldh2-ko) and wild-type (wt) mice. |
2022-05-22 |
2023-08-13 |
mouse |
| Caroline A Browne, Gerard Clarke, Patrick Fitzgerald, Joan O'Sullivan, Timothy G Dinan, John F Crya. Distinct post-sepsis induced neurochemical alterations in two mouse strains. Brain, behavior, and immunity. 2022-05-15. PMID:35569797. |
an increased plasma kynurenine/tryptophan ratio, hippocampal serotonin and brainstem dopamine turnover were evident in both strains, but the magnitude was greater in balb/c mice. |
2022-05-15 |
2023-08-13 |
mouse |
| Tara P Cominski, Victoria Stiritz, Kevin D Bec. The Effects of Mild Traumatic Brain Injury (mTBI) on Serotonergic Gene Expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554362. |
the hypothesis states that mtbi leads to altered expression of serotonin related genes in the raphe nuclei and/or raphe nuclei target regions including the prefrontal cortex, frontal cortex, and hippocampus. |
2022-05-13 |
2023-08-13 |
human |
| Ji-Yu Zhao, Jing Yan, Hong-Yang Wang, Qing-Qing Liu, Tian-Sheng Zhang, Chong-Yao Ha. [Effect of wheat-grain moxibustion on the expression of 5-HT and cortisol in the serum, and MR and GR in the hippocampus in rats with hypothyroidism complicated with depression]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 42. issue 5. 2022-05-11. PMID:35543943. |
[effect of wheat-grain moxibustion on the expression of 5-ht and cortisol in the serum, and mr and gr in the hippocampus in rats with hypothyroidism complicated with depression]. |
2022-05-11 |
2023-08-13 |
rat |
| Ji-Yu Zhao, Jing Yan, Hong-Yang Wang, Qing-Qing Liu, Tian-Sheng Zhang, Chong-Yao Ha. [Effect of wheat-grain moxibustion on the expression of 5-HT and cortisol in the serum, and MR and GR in the hippocampus in rats with hypothyroidism complicated with depression]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 42. issue 5. 2022-05-11. PMID:35543943. |
to observe the effect of wheat-grain moxibustion on behavior, 5-hydroxytryptamine (5-ht) and cortisol in the serum, mineralocorticoid receptor (mr) and glucocorticoid receptor (gr) in the hippocampus in rats with hypothyroidism complicated with depression, and to explore the possible mechanism of wheat-grain moxibustion on improving depression in rats with hypothyroidism. |
2022-05-11 |
2023-08-13 |
rat |
| Alexander S Zubov, Irina S Ivleva, Nina S Pestereva, Tatiana V Tiutiunnik, Dmitrtii S Traktirov, Marina N Karpenk. Glibenclamide alters serotonin and dopamine levels in the rat striatum and hippocampus, reducing cognitive impairment. Psychopharmacology. 2022-05-11. PMID:35545702. |
glibenclamide alters serotonin and dopamine levels in the rat striatum and hippocampus, reducing cognitive impairment. |
2022-05-11 |
2023-08-13 |
rat |
| Huawei Li, Peng Wang, Yunping Zhou, Fei Zhao, Xue Gao, Chunfeng Wu, Tianxia Wu, Liping Jiang, Dianliang Zhan. Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats. Genes, brain, and behavior. 2022-05-10. PMID:35535862. |
the concentrations of 5-ht and tph2 in the prefrontal and hippocampal tissues were lower, while ido1 was higher. |
2022-05-10 |
2023-08-13 |
rat |
| Lin-Ru Zhao, Pan He, Jie Li, Ya-Jun Zhang, Jing-Xing Jiang, Ying-Ru Wu, Yue Zhang, Jia Li, Cong Liu, Xu-Liang Ha. [Sleep-improving mechanism of Chaiqin Ningshen Granules in insomnia rats: based on hippocampal metabonomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 7. 2022-05-09. PMID:35534263. |
the results show that the drugs can significantly improve the mental state, liver depression, and blood stasis of rats, significantly increase the content of 5-hydroxytryptamine(5-ht) and gamma aminobutyric acid(gaba) in hippocampus(except low-dose cng), and significantly reduce the content of glucose(glu)(except low-dose cng). |
2022-05-09 |
2023-08-13 |
rat |
| Hongmei Wu, Gang Zhao, Sijin Liu, Quanzhi Zhang, Peng Wang, Yonggang Cao, Lijie W. Supplementation with Selenium Attenuates Autism-Like Behaviors and Improves Oxidative Stress, Inflammation and Related Gene Expression in an Autism Disease Model. The Journal of nutritional biochemistry. 2022-05-02. PMID:35500829. |
the administration of sodium selenite in btbr mice: (1) increased the expression of selp; (2) attenuated spatial learning, memory impairment and improved social behaviors; (3) changed the serum levels of 5-ht, da and glu; (4) decreased the levels of inflammatory cytokines il-6, il-1β, and tnf-α in serum and hippocampal tissue; (5) reduced the ros and mda contents and significantly increased sod activity, cat activity, gsh-px activity, and antioxidant gsh levels; and (6) protected against neuronal loss in the hippocampus. |
2022-05-02 |
2023-08-13 |
mouse |
| Smriti Patodia, Alyma Somani, Joan Liu, Alice Cattaneo, Beatrice Paradiso, Maria Garcia, Muhammad Othman, Beate Diehl, Orrin Devinsky, James D Mills, Jackie Foong, Maria Tho. Serotonin transporter in the temporal lobe, hippocampus and amygdala in SUDEP. Brain pathology (Zurich, Switzerland). 2022-04-28. PMID:35478467. |
serotonin transporter in the temporal lobe, hippocampus and amygdala in sudep. |
2022-04-28 |
2023-08-13 |
Not clear |
| Vivian B Neis, Isabel Werle, Morgana Moretti, Priscila B Rosa, Anderson Camargo, Yasmim de O Dalsenter, Nicolle Platt, Axel F Rosado, William D Engel, Gudrian Ricardo L de Almeida, Ingrid Selhorst, Alcir Luiz Dafre, Ana Lúcia S Rodrigue. Involvement of serotonergic neurotransmission in the antidepressant-like effect elicited by cholecalciferol in the chronic unpredictable stress model in mice. Metabolic brain disease. 2022-04-18. PMID:35435610. |
the ability of cholecalciferol to elicit an antidepressant-like effect and to modulate serotonin levels in the hippocampus and prefrontal cortex of mice subjected to chronic unpredictable stress (cus) was also investigated. |
2022-04-18 |
2023-08-13 |
mouse |
| Vivian B Neis, Isabel Werle, Morgana Moretti, Priscila B Rosa, Anderson Camargo, Yasmim de O Dalsenter, Nicolle Platt, Axel F Rosado, William D Engel, Gudrian Ricardo L de Almeida, Ingrid Selhorst, Alcir Luiz Dafre, Ana Lúcia S Rodrigue. Involvement of serotonergic neurotransmission in the antidepressant-like effect elicited by cholecalciferol in the chronic unpredictable stress model in mice. Metabolic brain disease. 2022-04-18. PMID:35435610. |
additionally, cus protocol (21 days) induced depressive-like behavior in the tail suspension test and decreased serotonin levels in the prefrontal cortex and hippocampus of mice. |
2022-04-18 |
2023-08-13 |
mouse |
| Vivian B Neis, Isabel Werle, Morgana Moretti, Priscila B Rosa, Anderson Camargo, Yasmim de O Dalsenter, Nicolle Platt, Axel F Rosado, William D Engel, Gudrian Ricardo L de Almeida, Ingrid Selhorst, Alcir Luiz Dafre, Ana Lúcia S Rodrigue. Involvement of serotonergic neurotransmission in the antidepressant-like effect elicited by cholecalciferol in the chronic unpredictable stress model in mice. Metabolic brain disease. 2022-04-18. PMID:35435610. |
cholecalciferol was also effective to abrogate cus-induced reduction on serotonin levels in the prefrontal cortex, but not in the hippocampus. |
2022-04-18 |
2023-08-13 |
mouse |
| Rebeca Vindas-Smith, Dayana Quesada, Mónica I Hernández-Solano, Maripaz Castro, Andrey Sequeira-Cordero, Jaime Fornaguera, Georgina Gómez, Juan C Brene. Fat intake and obesity-related parameters predict striatal BDNF gene expression and dopamine metabolite levels in cafeteria diet-fed rats. Neuroscience. 2022-04-10. PMID:35398176. |
the cafeteria diet increased bdnf expression in the dorsal striatum (ds), and norepinephrine, 5-ht, trkb, creb, and dnmt3a levels in the hippocampus. |
2022-04-10 |
2023-08-13 |
rat |
| Jia-Xing Liu, Jia-Han Li, Chen-Hui DU, Yan Ya. [Metabonomic study of biochemical changes in serum of PCPA-induced insomnia rats after treatment with Suanzaoren Decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347962. |
then pathological changes of the liver and brain were observed and biochemical indexes such as 5-hydroxytryptamine(5-ht), dopamine(da), glutamate(glu), γ-aminobutyric acid(gaba), and norepinephrine(ne) in the hippocampus and prostaglandin d2(pgd2), tumor necrosis factor-α(tnf-α), interleukin-1β(il-1β), and il-6 in the serum of rats were detected. |
2022-03-29 |
2023-08-13 |
rat |
| Jia-Xing Liu, Jia-Han Li, Chen-Hui DU, Yan Ya. [Metabonomic study of biochemical changes in serum of PCPA-induced insomnia rats after treatment with Suanzaoren Decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347962. |
the results showed that szrd could improve the pathological changes of brain and liver tissues, increase the levels of neurotransmitters 5-ht, da, and gaba in hippocampus and the level of pgd2 in hypothalamic-pituitary-adrenal axis(hpa axis), and reduce the levels of il-1β and tnf-α in serum of insomnia rats. |
2022-03-29 |
2023-08-13 |
rat |