| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Ha. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164876. |
western blot was used to detect the protein expressions of tryptophan hydroxylase 2(tph2), serotonin transporter(sert), and monoamine oxidase a(mao-a) in the hippocampus of rats. |
2022-09-27 |
2023-08-14 |
rat |
| Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Ha. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164876. |
the levels of 5-ht, 5-hiaa, and 5-ht/5-hiaa in the hippocampal area were decreased(p<0.01). |
2022-09-27 |
2023-08-14 |
rat |
| Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Ha. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164876. |
the levels of 5-ht, 5-hiaa, and 5-ht/5-hiaa in hippocampus were increased(p<0.05, p<0.01). |
2022-09-27 |
2023-08-14 |
rat |
| Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Ha. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164876. |
the results suggested that rehmanniae radix improved depression-like behavior of cums rats, and the mechanism might be related to the regulation of synthesis, transportation, and metabolism of 5-ht neurotransmitter in the hippocampus. |
2022-09-27 |
2023-08-14 |
rat |
| Clarissa A Moura, Fernanda C Cagni, Layse Rf Costa, Pamella Rf Tiago, Mikaël Croyal, Audrey Aguesse, Luis A Reyes-Castro, Elena Zambrano, Francisco Bolaños-Jiménez, Elaine Cristina Gaviol. MATERNAL STRESS DURING PREGNANCY IN MICE INDUCES SEX-DEPENDENT BEHAVIORAL ALTERATIONS IN OFFSPRING ALONG WITH IMPAIRED SEROTONIN AND KYNURENINE PATHWAYS OF TRYPTOPHAN METABOLISM. Developmental neuroscience. 2022-09-26. PMID:36162387. |
metabolites of the kyn and 5-ht pathways were measured in the hippocampus and brainstem by ultra-performance liquid chromatography-tandem mass spectrometry. |
2022-09-26 |
2023-08-14 |
mouse |
| Clarissa A Moura, Fernanda C Cagni, Layse Rf Costa, Pamella Rf Tiago, Mikaël Croyal, Audrey Aguesse, Luis A Reyes-Castro, Elena Zambrano, Francisco Bolaños-Jiménez, Elaine Cristina Gaviol. MATERNAL STRESS DURING PREGNANCY IN MICE INDUCES SEX-DEPENDENT BEHAVIORAL ALTERATIONS IN OFFSPRING ALONG WITH IMPAIRED SEROTONIN AND KYNURENINE PATHWAYS OF TRYPTOPHAN METABOLISM. Developmental neuroscience. 2022-09-26. PMID:36162387. |
female, but not male, prenatal stressed (pns) offspring displayed a depressive-like phenotype, mainly when in proestrus/diestrus, along with reduced hippocampal 5-ht levels and high serotonin turnover rate in hippocampus and brainstem. |
2022-09-26 |
2023-08-14 |
mouse |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
the effects of type ii pyrethroid lambda-cyhalothrin on dopamine (da) and serotonin (5-ht) synthesis in rat brain regions (striatum, hippocampus, prefrontal cortex, hypothalamus and midbrain) were studied. |
2022-09-20 |
2023-08-14 |
rat |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
the major decreases in da and 5-ht contents were observed in hippocampus and prefrontal cortex tissues. |
2022-09-20 |
2023-08-14 |
rat |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-08-14 |
rat |
| Zaiquan Dong, Qinglian Xie, Feiyu Xu, Xiaoling Shen, Yanni Hao, Jin Li, Haizhen Xu, Qiang Peng, Weihong Kuan. Neferine alleviates chronic stress-induced depression by regulating monoamine neurotransmitter secretion and gut microbiota structure. Frontiers in pharmacology. vol 13. 2022-09-19. PMID:36120376. |
moreover, both nef and flu treatments induced significant increases in the levels of anti-depressant neurotransmitters, including dopamine (da), serotonin (5-ht), and norepinephrine (ne), and also reduced pathological damage to the hippocampus of the depressed mice. |
2022-09-19 |
2023-08-14 |
mouse |
| Weiping Xiao, Jiaying Li, Xinjie Gao, Heng Yang, Jiabin Su, Ruiyuan Weng, Yanqin Gao, Wei Ni, Yuxiang G. Involvement of the gut-brain axis in vascular depression via tryptophan metabolism: A benefit of short chain fatty acids. Experimental neurology. 2022-09-13. PMID:36100045. |
a promoted conversion of tryptophan (trp) into kynurenine (kyn) instead of 5-hydroxytryptamine (5-ht) was observed in the hippocampus and gut of bccao rats. |
2022-09-13 |
2023-08-14 |
rat |
| Weiping Xiao, Jiaying Li, Xinjie Gao, Heng Yang, Jiabin Su, Ruiyuan Weng, Yanqin Gao, Wei Ni, Yuxiang G. Involvement of the gut-brain axis in vascular depression via tryptophan metabolism: A benefit of short chain fatty acids. Experimental neurology. 2022-09-13. PMID:36100045. |
enzyme-linked immunosorbent assays and quantitative rt-pcr suggested that scfa supplementation suppressed the conversion of trp to kyn and rescued the reduction in 5-ht levels in the hippocampus and gut. |
2022-09-13 |
2023-08-14 |
rat |
| Bongjun Sur, Bombi Le. Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder. Animal cells and systems. vol 26. issue 4. 2022-09-01. PMID:36046028. |
also, administration of lu restored the increased norepinephrine and decreased serotonin levels in the structures within the fear circuit, medial prefrontal cortex, and hippocampus. |
2022-09-01 |
2023-08-14 |
rat |
| Jiabin Hong, Xiaoxun Lu, Jieyu Wang, Mengzhu Jiang, Qian Liu, Juntong Lin, Wenjing Sun, Jing Zhang, Yanwei Shi, Xiaoshan Li. Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring. Ecotoxicology and environmental safety. vol 243. 2022-08-25. PMID:36007322. |
consistent with the increased 5-ht, the nissl body was reduced in the hippocampus of treatment group. |
2022-08-25 |
2023-08-14 |
mouse |
| Ehsan Hosseini, Mahsa Farid Habibi, Shirin Babri, Gisou Mohaddes, Hajar Abkhezr, Hamed Heydar. Maternal stress induced anxiety-like behavior exacerbated by electromagnetic fields radiation in female rats offspring. PloS one. vol 17. issue 8. 2022-08-23. PMID:35998127. |
the results of the current study, clarified that elf-emf can induce anxiety-like behavior which may be attributed to an increase in the pnmdar2/nmdar2 ratio and 24(s)-ohc in the hippocampus, and prenatal stress may contribute to anxiety via a decrease in serotonin and an increase in corticosterone in the hippocampus. |
2022-08-23 |
2023-08-14 |
rat |
| Wenfei Wang, Yichun Wang, Qiuting Guo, Huiting Li, Zhaoqiang Wang, Jia Li, Taotao Li, Tiantian Tang, Yujiao Wang, Yanzhuo Jia, Yao Wang, Junbo Zou, Yajun Shi, Dongyan Guo, Ming Yang, Xiaofei Zhang, Jing Su. Valerian essential oil for treating insomnia Frontiers in nutrition. vol 9. 2022-08-22. PMID:35990355. |
valerian essential oil was given orally for treatment and the contents of 5-hydroxytryptamine receptor 1 a (5-ht1ar), γ-aminobutyric acid (gaba), cyclic adenosine monophosphate (camp), and protein kinase a (pka) in the hippocampus of rats in each group were detected by enzyme-linked immunosorbent assay (elisa), western blot, polymerase chain reaction (pcr), and immunohistochemistry. |
2022-08-22 |
2023-08-14 |
rat |
| Laura Durieux, Karine Herbeaux, Christopher Borcuk, Cécile Hildenbrand, Virginie Andry, Yannick Goumon, Alexandra Barbelivien, Chantal Mathis, Demian Bataglia, Monique Majchrzak, Lucas Lecourtie. Functional brain-wide network mapping during acute stress exposure in rats: Interaction between the lateral habenula and cortical, amygdalar, hypothalamic and monoaminergic regions. The European journal of neuroscience. 2022-08-22. PMID:35993349. |
it has been known for decades that the main structures engaged during the stress response are the medial prefrontal cortex, the amygdala, the hippocampus, the hypothalamus, the monoaminergic systems (noradrenaline, dopamine, serotonin), and the periaqueductal gray. |
2022-08-22 |
2023-08-14 |
rat |
| Cong Lu, Zhen Wei, Yongquan Wang, Shuying Li, Litao Tong, Xinmin Liu, Bei Fan, Fengzhong Wan. Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity. Food & function. 2022-08-22. PMID:35993820. |
additionally, si administration regulated tryptophan (trp) metabolism by increasing 5-hydroxytryptamine (5-ht) levels, inhibiting the release of kynurenine (kyn) in the cortex and hippocampus, and elevating the expressions of synaptic plasticity-related protein markers such as postsynaptic density-95 (psd-95) and synaptophysin (syn). |
2022-08-22 |
2023-08-14 |
mouse |
| Eduardo Solórzano Hernández, José Miguel Cervantes Alfaro, Rosalinda Figueroa Rosales, Blanca Erika Gutiérrez Guzmán, Miguel Ángel López Vázquez, María Esther Olvera Corté. Septal medial/diagonal band of Broca citalopram infusion reduces place learning efficiency and alters septohippocampal theta learning-related activity in rats. Behavioural brain research. 2022-08-13. PMID:35963580. |
the suppression of hippocampal theta expression and the modulation of hippocampal learning and memory are attributed to serotonin. |
2022-08-13 |
2023-08-14 |
rat |
| Eduardo Solórzano Hernández, José Miguel Cervantes Alfaro, Rosalinda Figueroa Rosales, Blanca Erika Gutiérrez Guzmán, Miguel Ángel López Vázquez, María Esther Olvera Corté. Septal medial/diagonal band of Broca citalopram infusion reduces place learning efficiency and alters septohippocampal theta learning-related activity in rats. Behavioural brain research. 2022-08-13. PMID:35963580. |
these results support a role of serotonin, in acting on the ms/dbb in the fine tuning of hippocampal learning and memory efficiency through the modulation of learning-related theta activity power and septohipocampal synchronization. |
2022-08-13 |
2023-08-14 |
rat |