| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jamie L Scholl, Rajeshwari R Solanki, Michael J Watt, Kenneth J Renner, Gina L Forste. Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus. Brain research. 2022-12-03. PMID:36462646. |
chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus. |
2022-12-03 |
2023-08-14 |
rat |
| Jamie L Scholl, Rajeshwari R Solanki, Michael J Watt, Kenneth J Renner, Gina L Forste. Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus. Brain research. 2022-12-03. PMID:36462646. |
interestingly, treatment with mifepristone alone reduced plasma corticosterone levels and increased serotonin transporter and gr expression in the ventral hippocampus but did not significantly affect oct3 expression or behavior. |
2022-12-03 |
2023-08-14 |
rat |
| Jamie L Scholl, Rajeshwari R Solanki, Michael J Watt, Kenneth J Renner, Gina L Forste. Chronic administration of glucocorticoid receptor ligands increases anxiety-like behavior and selectively increase serotonin transporters in the ventral hippocampus. Brain research. 2022-12-03. PMID:36462646. |
no treatment effects on oct3, serotonin transporter or gr expression were observed in the dmh, cea or dorsal hippocampus. |
2022-12-03 |
2023-08-14 |
rat |
| Ling Yang, Tung-Hu Tsa. Neuroprotective effect and herbal-drug pharmacokinetic interaction of Gastrodia elata extract on valproic acid. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-11-22. PMID:36411625. |
in addition, g. elata extract and vpa exerted synergistic anticonvulsive effects to decrease the seizure severity by protecting neurons in the hippocampus and altering the dopac and 5-ht levels. |
2022-11-22 |
2023-08-14 |
rat |
| Satya Kumar Avula, Ajmal Khan, Sobia Ahsan Halim, Najeeb Ur Rehman, Nasiara Karim, Imran Khan, Rene Csuk, Biswanath Das, Ahmed Al-Harras. Synthesis and antidepressant-like effects of new 5-epi-incensole and 5-epi- incensole acetate in chronic unpredictable mild stress model of depression; behavioural and biochemical correlates. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-11-22. PMID:36411640. |
the tested compounds also inhibited monoamine oxidase-a (mao) enzyme and increased the levels of brain noradrenaline (na) and 5-hydroxytryptamine (5-ht), decreased plasma corticosterone and pro-inflammatory cytokines including tnf-α, il-6 in hippocampal homogenates. |
2022-11-22 |
2023-08-14 |
mouse |
| Cai Zhang, Baiping Liu, Jodi Pawluski, Harry W M Steinbusch, U Kirthana Kunikullaya, Cai Son. The effect of chronic stress on behaviors, inflammation and lymphocyte subtypes in male and female rats. Behavioural brain research. 2022-11-22. PMID:36414104. |
results show that cums increased anhedonia and anxiety-like behaviors, along with increased serum corticosterone, hippocampal pro-inflammatory factors, cd11b, ifn-γ, il-6 and il-17, but decreased cd4, cd25, cd4/cd8 ratio, gfap, 5-hydroxytryptamine (5-ht) and ne concentrations, regardless of sex. |
2022-11-22 |
2023-08-14 |
rat |
| Ahmed I Foudah, Mohammed H Alqarni, Aftab Alam, Sushma Devi, Mohammad A Salkini, Prawez Ala. Rutin Improves Anxiety and Reserpine-Induced Depression in Rats. Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364141. |
this effect was mediated by increased serotonin, norepinephrine, and dopamine levels in cortical and hippocampal regions. |
2022-11-11 |
2023-08-14 |
rat |
| Niklas Reich, Christian Hölsche. Beyond Appetite: Acylated Ghrelin As A Learning, Memory and Fear Behavior-modulating Hormone. Neuroscience and biobehavioral reviews. 2022-11-11. PMID:36368526. |
as such, in this review, we i) evaluate what specific stages and forms of memory, as well as which respective brain areas are affected by acylated ghrelin, ii) illustrate the plasticity-associated signaling pathways of ag in the hippocampus, also involving memory resolution-enhancing neurogenesis, iii) elucidate how the peptide modulates neurotransmitter systems (glutamate, γ-aminobutyric acid, dopamine, serotonin), iv) clarify the role of ag in conditioned taste aversion, novelty learning and the formation of spatial, recognition, auditory fear, contextual fear and passive avoidance memories in the hippocampus and amygdala as well as v) solve the mystery behind ag, its impact on the 5-ht system, the recently established link to post-traumatic stress disorder and the either fear-suppressing or fear-potentiating effects under neutral and acutely stressed conditions or chronic stress, respectively. |
2022-11-11 |
2023-08-14 |
Not clear |
| Benneth Ben-Azu, Christian I Uruaka, Abayomi M Ajayi, Thiophilus Aghogho Jarikre, Kingsley E Nwangwa, Kingsley C Chilaka, Bienose S Chijioke, Marymagdalene G Omonyeme, Chineye B Ozege, Emmanuella C Ofili, Ebidenara B Warekoromor, Nwanneka L Edigbue, Ufoma V Esiekpe, Dabrechi E Akaenyi, Gladys O Ag. Reversal and Preventive Pleiotropic Mechanisms Involved in the Antipsychotic-Like Effect of Taurine, an Essential β-Amino Acid in Ketamine-Induced Experimental Schizophrenia in Mice. Neurochemical research. 2022-11-09. PMID:36350433. |
taurine reduced ketamine-induced dopamine and 5-hydroxytryptamine changes, and increased gad and bdnf levels in the striatum, prefrontal-cortex and hippocampus, suggesting increased gabaergic and neurotrophic transmissions. |
2022-11-09 |
2023-08-14 |
mouse |
| Marta Kędziora, Serena Boccella, Ida Marabese, Jakub Mlost, Rosmara Infantino, Sabatino Maione, Katarzyna Starowic. Inhibition of anandamide breakdown reduces pain and restores LTP and monoamine levels in the rat hippocampus via the CB Neuropharmacology. vol 222. 2022-11-07. PMID:36341807. |
a substantial body of evidence demonstrate that hippocampal neural circuits, especially monoamine dopamine and serotonin levels, contributes to negative affect and avoidance motivation experienced during pain. |
2022-11-07 |
2023-08-14 |
rat |
| Hakimeh Saadati, Safa Ghaheri, Farshid Sadegzadeh, Nona Sakhaie, Maryam Abdollahzade. Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal BDNF level following postnatal serotonin depletion in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-11-07. PMID:36342785. |
beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal bdnf level following postnatal serotonin depletion in male rats. |
2022-11-07 |
2023-08-14 |
rat |
| Hakimeh Saadati, Safa Ghaheri, Farshid Sadegzadeh, Nona Sakhaie, Maryam Abdollahzade. Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal BDNF level following postnatal serotonin depletion in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-11-07. PMID:36342785. |
therefore, the present study aimed to evaluate the influences of the ee housing (postnatal day: pnd21-60) following postnatal serotonin depletion (by para-chlorophenylalanine: pcpa, 100mg/kg, s.c, in pnd 10-20) on anxiety-related behaviors, cognitive functions, and brain-derived neurotrophic factor (bdnf) mrna expression in the hippocampus of male rats. |
2022-11-07 |
2023-08-14 |
rat |
| Yan Sun, Haiyan Zhu, Rongrong Cheng, Zhengquan Tang, Min Zhan. Outer membrane protein Amuc_1100 of Akkermansia muciniphila alleviates antibiotic-induced anxiety and depression-like behavior in mice. Physiology & behavior. 2022-11-06. PMID:36336146. |
in the present study, a depressed mouse model using a broad-spectrum cocktail mixture resulted in increased anxiety and depression-like behavior, decreased serum and hippocampal levels of 5-hydroxytryptamine (5-ht), and increased serum corticosterone (cort) levels. |
2022-11-06 |
2023-08-14 |
mouse |
| Jaqueline M Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S Guimarães, Leandro J Bertogli. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT Neuropharmacology. 2022-11-05. PMID:36334768. |
cannabidiol attenuates fear memory expression in female rats via hippocampal 5-ht growing evidence from male rodent and human studies suggests that cannabidiol (cbd) modulates the expression of aversive memories and anxiety-related responses. |
2022-11-05 |
2023-08-14 |
human |
| Jaqueline M Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S Guimarães, Leandro J Bertogli. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT Neuropharmacology. 2022-11-05. PMID:36334768. |
in subsequent experiments, we investigated the estrous cycle effects and the contribution of dorsal hippocampus (dh) serotonin 1a (5-ht1a) and cannabinoid types 1 (cb1) and 2 (cb2) receptors to cbd-induced effects on memory retrieval/expression. |
2022-11-05 |
2023-08-14 |
human |
| Elisabetta Gerace, Lorenzo Polenzani, Maurizio Magnani, Elisa Zianni, Gabriella Stocca, Fabrizio Gardoni, Domenico E Pellegrini-Giampietro, Renato Corradett. Antidepressant-induced increase in GluA2 expression does not translate in changes of AMPA receptor-mediated synaptic transmission at CA3/CA1 synapses in rats. Neuropharmacology. 2022-11-05. PMID:36334766. |
chronic treatment with serotonin selective reuptake inhibitors or tryciclic antidepressant drugs in rodents has been shown to increase the expression of glua1 and/or glua2 ampa receptor (ampar) subunits in several brain areas, including the hippocampus. |
2022-11-05 |
2023-08-14 |
rat |
| Irina I Belokopytova, Elena M Kondaurova, Elizabeth A Kulikova, Tatiana V Ilchibaeva, Vladimir S Naumenko, Nina K Popov. Effects of the Cc2d1a/Freud-1 Knockdown in the Hippocampus of BTBR Mice on the Autistic-Like Behavior, Expression of Serotonin 5-HT Biochemistry. Biokhimiia. vol 87. issue 10. 2022-10-23. PMID:36273889. |
effects of the cc2d1a/freud-1 knockdown in the hippocampus of btbr mice on the autistic-like behavior, expression of serotonin 5-ht the mechanisms of autism are of extreme interest due to the high prevalence of this disorder in the human population. |
2022-10-23 |
2023-08-14 |
mouse |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
both 5-ht and tryptophan hydroxylase-2 (tph2) were mainly present in the limbic systems of the cerebrum, such as the glomerular layer of the olfactory bulb, nucleus accumbens, cingulate, fimbria of the hippocampus, mediodorsal thalamic nucleus, habenular nucleus, ventromedial hypothalamus nucleus, lateral hypothalamus area, dorsal raphe nucleus and piriform cortex. |
2022-10-20 |
2023-08-14 |
mouse |
| Roberto De Gregorio, Galadu Subah, Jennifer C Chan, Luisa Speranza, Xiaolei Zhang, Aarthi Ramakrishnan, Li Shen, Ian Maze, Patric K Stanton, Ji Y Sz. Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons. Development (Cambridge, England). 2022-09-30. PMID:36178075. |
here, we identify in mice that serotonin uptake transporter (sert) in non-serotonergic neurons - hippocampal and prefrontal pyramidal neurons - confers sex-biased effects specifically during neural circuit development. |
2022-09-30 |
2023-08-14 |
mouse |
| Roberto De Gregorio, Galadu Subah, Jennifer C Chan, Luisa Speranza, Xiaolei Zhang, Aarthi Ramakrishnan, Li Shen, Ian Maze, Patric K Stanton, Ji Y Sz. Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons. Development (Cambridge, England). 2022-09-30. PMID:36178075. |
a set of gradient patterned ca3 pyramidal neurons transiently express sert to clear extracellular serotonin, coinciding with hippocampal synaptic circuit establishment. |
2022-09-30 |
2023-08-14 |
mouse |